Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 85374925

GI number: 85374925

Start: 2127695

End: 2128906

Strand: Reverse

Name: mltA [H]

Synonym: ELI_10490

Alternate gene names: 85374925

Gene position: 2128906-2127695 (Counterclockwise)

Preceding gene: 85374926

Following gene: 85374924

Centisome position: 69.75

GC content: 67.9

Gene sequence:

>1212_bases
ATGCGTCGCGGGATTGTTGTCGCAGCCTTGGCAAGCGCCCTTGCAGTACTGGCCGGCTGTTCGGTCATCCCCGAGAGCAA
GCCGCCCAGCCCCGTCATAGAGCAGCCTCCGCCGACCGTCTCTGTCGAAAGCGCCGCCTTCGCCAATGTCGTTCGCGGCC
CCAGCGTAGGCGCACTGCCGATTACCACCACGGATGCCAATTTCGCGCTCTCCGCCTTTCGCGAAAGTTGCGACTGGGCG
ACGCGCAAGGAGGACCGTAGCGGTCTGACCTTCCCTGCCGACTGGGCACCGGCCTGCGCGGCGGCGCGCACTTGGTCCGC
CACGCGCGGGCGCGAGTTCTTCATCGAACACTTCGAAACCGCGCGGGTCGGCGACGGCTCGGCATTCGCGACCGGCTATT
TCGAGCCCGAAATCGAAGGCAGCCGGACCAGGCGGCCCGGATACGATGTGCCGGTCTATCGCGTGCCGGACGATCTCGTG
CGCGCCTGGCCGCGCGACATGCCGGCCAGCGAGCGCACCGGCCGCGCCCCGCTCGGGCGCACCGATGCCAATGGCGATCA
CGTGCCGTACTACACCCGCGCAGAGATCGAGGAGGGCGCGCTCGCGGGGCGCGGCCTGGAAATCGCCTGGGCCAAGGATC
CGATCGAGATGTTCTTCCTGCAGATCCAGGGTTCGGGCCTGCTGCGACTGCCCGACGGTTCGCTGATGCGGATCGGCTAT
GCCGGACAGAACGGACACGGCTATACCGCGATCGGCCGCCCGATGCGCGAACAGGGGCTGATCGGCGACGGCACGCCATA
CGCGGTCAGCATGCAGGGCATCGTCGACTGGCTCCGCGCCAATCCCGACCGCGCGTCGGAGCTCATGCGGCTCAACGAAA
GCTGGATATTTTTCCGCGAACTCACCACCGACGGTCCGCTCGGCTCGATCGGCGTCCCGGTGCGGCGCGAGAGCAGCGTC
GCGGTCGATCCGCGTTTCGTGCCCTACGGCGCGCCCGTTTTCCTCGACATGGATCGCAATGTCGCCGACGGCCTGTGGAT
TGCGCAGGATACCGGCGGCGCGATCAAGGGCGCGAACCGGTTCGACACCTTCTGGGGTAACGGCGGCGACGCGCGCGAGA
TTGCCGGCAGCATGTCCAGCAGCGGAACCGCGCTGGTGTTGCTACCAAAAGGGGTGGTCGACCGCCTCAAGCGCGCCCAG
CCGGGGCAGTGA

Upstream 100 bases:

>100_bases
ATCTGGACCTTCAGCCGCAATGTCGATGCCGCCGGGCCCGATTGGGTGCTCGACGAAACCGACGAAGGCTAAGCGCCGGA
TCGATATGAGGGAGCGGGGC

Downstream 100 bases:

>100_bases
ACCATCCGCGAGGTCTGAGCGATGCGGAAGCCGCCGCGTGGGAGAAACTCGCCGCGACGGTCGAGCCGCTGTCCGGCTCG
ACAGCCAAAGCGGGGGCGGA

Product: MltA:3D

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MRRGIVVAALASALAVLAGCSVIPESKPPSPVIEQPPPTVSVESAAFANVVRGPSVGALPITTTDANFALSAFRESCDWA
TRKEDRSGLTFPADWAPACAAARTWSATRGREFFIEHFETARVGDGSAFATGYFEPEIEGSRTRRPGYDVPVYRVPDDLV
RAWPRDMPASERTGRAPLGRTDANGDHVPYYTRAEIEEGALAGRGLEIAWAKDPIEMFFLQIQGSGLLRLPDGSLMRIGY
AGQNGHGYTAIGRPMREQGLIGDGTPYAVSMQGIVDWLRANPDRASELMRLNESWIFFRELTTDGPLGSIGVPVRRESSV
AVDPRFVPYGAPVFLDMDRNVADGLWIAQDTGGAIKGANRFDTFWGNGGDAREIAGSMSSSGTALVLLPKGVVDRLKRAQ
PGQ

Sequences:

>Translated_403_residues
MRRGIVVAALASALAVLAGCSVIPESKPPSPVIEQPPPTVSVESAAFANVVRGPSVGALPITTTDANFALSAFRESCDWA
TRKEDRSGLTFPADWAPACAAARTWSATRGREFFIEHFETARVGDGSAFATGYFEPEIEGSRTRRPGYDVPVYRVPDDLV
RAWPRDMPASERTGRAPLGRTDANGDHVPYYTRAEIEEGALAGRGLEIAWAKDPIEMFFLQIQGSGLLRLPDGSLMRIGY
AGQNGHGYTAIGRPMREQGLIGDGTPYAVSMQGIVDWLRANPDRASELMRLNESWIFFRELTTDGPLGSIGVPVRRESSV
AVDPRFVPYGAPVFLDMDRNVADGLWIAQDTGGAIKGANRFDTFWGNGGDAREIAGSMSSSGTALVLLPKGVVDRLKRAQ
PGQ
>Mature_403_residues
MRRGIVVAALASALAVLAGCSVIPESKPPSPVIEQPPPTVSVESAAFANVVRGPSVGALPITTTDANFALSAFRESCDWA
TRKEDRSGLTFPADWAPACAAARTWSATRGREFFIEHFETARVGDGSAFATGYFEPEIEGSRTRRPGYDVPVYRVPDDLV
RAWPRDMPASERTGRAPLGRTDANGDHVPYYTRAEIEEGALAGRGLEIAWAKDPIEMFFLQIQGSGLLRLPDGSLMRIGY
AGQNGHGYTAIGRPMREQGLIGDGTPYAVSMQGIVDWLRANPDRASELMRLNESWIFFRELTTDGPLGSIGVPVRRESSV
AVDPRFVPYGAPVFLDMDRNVADGLWIAQDTGGAIKGANRFDTFWGNGGDAREIAGSMSSSGTALVLLPKGVVDRLKRAQ
PGQ

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=402, Percent_Identity=27.363184079602, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43442; Mature: 43442

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGIVVAALASALAVLAGCSVIPESKPPSPVIEQPPPTVSVESAAFANVVRGPSVGALP
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCEEE
ITTTDANFALSAFRESCDWATRKEDRSGLTFPADWAPACAAARTWSATRGREFFIEHFET
EEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
ARVGDGSAFATGYFEPEIEGSRTRRPGYDVPVYRVPDDLVRAWPRDMPASERTGRAPLGR
HCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCC
TDANGDHVPYYTRAEIEEGALAGRGLEIAWAKDPIEMFFLQIQGSGLLRLPDGSLMRIGY
CCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCEEEEEE
AGQNGHGYTAIGRPMREQGLIGDGTPYAVSMQGIVDWLRANPDRASELMRLNESWIFFRE
CCCCCCCCHHCCCCHHHCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHCCCCEEEEEE
LTTDGPLGSIGVPVRRESSVAVDPRFVPYGAPVFLDMDRNVADGLWIAQDTGGAIKGANR
ECCCCCCCCCCCCEECCCCEEECCEECCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCC
FDTFWGNGGDAREIAGSMSSSGTALVLLPKGVVDRLKRAQPGQ
CCCCCCCCCCHHHHHCCCCCCCCEEEEECHHHHHHHHHCCCCC
>Mature Secondary Structure
MRRGIVVAALASALAVLAGCSVIPESKPPSPVIEQPPPTVSVESAAFANVVRGPSVGALP
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCEEE
ITTTDANFALSAFRESCDWATRKEDRSGLTFPADWAPACAAARTWSATRGREFFIEHFET
EEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
ARVGDGSAFATGYFEPEIEGSRTRRPGYDVPVYRVPDDLVRAWPRDMPASERTGRAPLGR
HCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCC
TDANGDHVPYYTRAEIEEGALAGRGLEIAWAKDPIEMFFLQIQGSGLLRLPDGSLMRIGY
CCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCEEEEEE
AGQNGHGYTAIGRPMREQGLIGDGTPYAVSMQGIVDWLRANPDRASELMRLNESWIFFRE
CCCCCCCCHHCCCCHHHCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHCCCCEEEEEE
LTTDGPLGSIGVPVRRESSVAVDPRFVPYGAPVFLDMDRNVADGLWIAQDTGGAIKGANR
ECCCCCCCCCCCCEECCCCEEECCEECCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCC
FDTFWGNGGDAREIAGSMSSSGTALVLLPKGVVDRLKRAQPGQ
CCCCCCCCCCHHHHHCCCCCCCCEEEEECHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]