Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 85374823

GI number: 85374823

Start: 2025810

End: 2027141

Strand: Direct

Name: gor [H]

Synonym: ELI_09980

Alternate gene names: 85374823

Gene position: 2025810-2027141 (Clockwise)

Preceding gene: 85374822

Following gene: 85374824

Centisome position: 66.37

GC content: 59.83

Gene sequence:

>1332_bases
ATGGCTGAGGCTTTCGATTTCGTCGCCATCGGATCGGGAACTGCTGCGCAGGTCGCGGTCCACCAGATGGCCAACGCCGG
GAAGCGCTGCGCGGTTATCGATTATCGGCCTTACGGTGGCACATGTGCGCTTCGAGGGTGCGACCCGAAAAAGATGATGG
TGAGCGGAGAGGAAGCGCTCGCGGCATACAGGCGAATGAAGGGGAAGGGCATCAAGGGCTCGGTTTCAATTGATTGGGCC
GACCTCCAGGCATTCAAGCGCAGCTTTACCGACCCCGTCCCTGAAAAGCAGGAAGCTCGCTACGAGCGTAAGGGCGTCGC
GACTTTTCACGGCGCGGCACGCTTTGCTGGCCCCGACAGGATCGTGATAGGCGACCGGGAACTGAGTTTCTCGCACGCTC
TTATCGCAACGGGAGCAGAGCCTCGACCGCTTGGGATCGAAGGTGAGGAATTGCTGATTCACAGCGATGCATTCCTAGAA
CTCAAAACCCTTCCAGATCGGATCGTATTCGTCGGCGGCGGATACATTGCCGCAGAATTTGCCCACCTCGCCGCGCGCGC
CGGTGCAAAGGTCACAATCTTCCAACGAGGCCGCATTCTGAAAGCCTTCGACCCTGACACGGTCGATTGGCTCATGCCAA
GTTTCGATGATCTCGGCATCGAAATTGTGGACGCTGAAGTGGACCGCGTAACGAAGAAAGGCAGCGTGCTGACCGTCCAT
GCTGGCGACCGCAGGATCGAAGGGAGCCTGGTGGTGCACGCTGCCGGAAGAATCCCTGCGATCGGCTCGCTCGATCTGGA
GGCGGGAGACGTCGCCTGTGACGCGGGTCGCTTGGCACTTACCGCCCAGCTACGGAGCCAAAGTAACCCCAAGGTCTTCG
CGGCAGGTGACGCTGCTGCAAATGGCCCGCCACTGACTCCAGTCTCCAGTAACGATGCCAAGGTCGTGGTAGAAAACATA
CTCGATGATACCGGTCGAACTCCGAACTATCGAGGGGTGCCAAGTGCACTTTTCACGGAGCCGCCGGCGGCCAGGGTCGG
AATGCTGGAAAGCGAGGCGCGTGAGGCAGGGCTGGATTTCACGGTGCATGCTGGCTCGCACCCTGGTTGGTTCTCGGCGA
GGCGGCTGAACGAAGAGATCTACGGCCACAAGCTGCTGGTCGAGAACGGAACGGGACGCATCCTTGGAGCCCACTTGGTC
GGCCCTGACGCCGACGAGCTCGTCAATATCTTCGGCTTGGCCATGCGCCATGGGCTAAACGCGGACGACATCAAATCTAC
CATGTTCGCTTATCCGACGGCGGCCTCCGATGCAGGGTATATGTTGGGATGA

Upstream 100 bases:

>100_bases
GGTTGCGGCGTTCGCCTTCAGCCGCTCCAAGGCGATTGCTGCGTGTTTTGCTCGTACGGCACCGTTCCCTGCCCCCCAAT
ACAGGAAGGGGATTGCTGCC

Downstream 100 bases:

>100_bases
GCAACGCGGAAGCCACCAACAAGCGTGACTTGGCCGCCAACCGTCTGCACCGTATCCTAATCTGGGGCGTGCCGTTTGCG
GCGCTAATCGGCCTAAACTT

Product: regulatory protein

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAEAFDFVAIGSGTAAQVAVHQMANAGKRCAVIDYRPYGGTCALRGCDPKKMMVSGEEALAAYRRMKGKGIKGSVSIDWA
DLQAFKRSFTDPVPEKQEARYERKGVATFHGAARFAGPDRIVIGDRELSFSHALIATGAEPRPLGIEGEELLIHSDAFLE
LKTLPDRIVFVGGGYIAAEFAHLAARAGAKVTIFQRGRILKAFDPDTVDWLMPSFDDLGIEIVDAEVDRVTKKGSVLTVH
AGDRRIEGSLVVHAAGRIPAIGSLDLEAGDVACDAGRLALTAQLRSQSNPKVFAAGDAAANGPPLTPVSSNDAKVVVENI
LDDTGRTPNYRGVPSALFTEPPAARVGMLESEAREAGLDFTVHAGSHPGWFSARRLNEEIYGHKLLVENGTGRILGAHLV
GPDADELVNIFGLAMRHGLNADDIKSTMFAYPTAASDAGYMLG

Sequences:

>Translated_443_residues
MAEAFDFVAIGSGTAAQVAVHQMANAGKRCAVIDYRPYGGTCALRGCDPKKMMVSGEEALAAYRRMKGKGIKGSVSIDWA
DLQAFKRSFTDPVPEKQEARYERKGVATFHGAARFAGPDRIVIGDRELSFSHALIATGAEPRPLGIEGEELLIHSDAFLE
LKTLPDRIVFVGGGYIAAEFAHLAARAGAKVTIFQRGRILKAFDPDTVDWLMPSFDDLGIEIVDAEVDRVTKKGSVLTVH
AGDRRIEGSLVVHAAGRIPAIGSLDLEAGDVACDAGRLALTAQLRSQSNPKVFAAGDAAANGPPLTPVSSNDAKVVVENI
LDDTGRTPNYRGVPSALFTEPPAARVGMLESEAREAGLDFTVHAGSHPGWFSARRLNEEIYGHKLLVENGTGRILGAHLV
GPDADELVNIFGLAMRHGLNADDIKSTMFAYPTAASDAGYMLG
>Mature_442_residues
AEAFDFVAIGSGTAAQVAVHQMANAGKRCAVIDYRPYGGTCALRGCDPKKMMVSGEEALAAYRRMKGKGIKGSVSIDWAD
LQAFKRSFTDPVPEKQEARYERKGVATFHGAARFAGPDRIVIGDRELSFSHALIATGAEPRPLGIEGEELLIHSDAFLEL
KTLPDRIVFVGGGYIAAEFAHLAARAGAKVTIFQRGRILKAFDPDTVDWLMPSFDDLGIEIVDAEVDRVTKKGSVLTVHA
GDRRIEGSLVVHAAGRIPAIGSLDLEAGDVACDAGRLALTAQLRSQSNPKVFAAGDAAANGPPLTPVSSNDAKVVVENIL
DDTGRTPNYRGVPSALFTEPPAARVGMLESEAREAGLDFTVHAGSHPGWFSARRLNEEIYGHKLLVENGTGRILGAHLVG
PDADELVNIFGLAMRHGLNADDIKSTMFAYPTAASDAGYMLG

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=23.9740820734341, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI148277065, Length=450, Percent_Identity=26.4444444444444, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=26.4444444444444, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=26.4444444444444, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=26.4444444444444, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI148277071, Length=450, Percent_Identity=26.4444444444444, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI91199540, Length=452, Percent_Identity=26.9911504424779, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=26.865671641791, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI22035672, Length=448, Percent_Identity=26.5625, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI291045268, Length=465, Percent_Identity=25.1612903225806, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789915, Length=447, Percent_Identity=28.4116331096197, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI87081717, Length=445, Percent_Identity=29.2134831460674, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=26.431718061674, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87082354, Length=452, Percent_Identity=22.787610619469, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557007, Length=471, Percent_Identity=27.8131634819533, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=449, Percent_Identity=25.6124721603563, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=474, Percent_Identity=24.4725738396624, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=453, Percent_Identity=25.8278145695364, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=453, Percent_Identity=25.8278145695364, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=28.5097192224622, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=23.0434782608696, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=23.4309623430962, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=28.4140969162996, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17737741, Length=468, Percent_Identity=26.2820512820513, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24640549, Length=466, Percent_Identity=25.1072961373391, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24640553, Length=466, Percent_Identity=25.1072961373391, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24640551, Length=466, Percent_Identity=25.1072961373391, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 47149; Mature: 47018

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAFDFVAIGSGTAAQVAVHQMANAGKRCAVIDYRPYGGTCALRGCDPKKMMVSGEEAL
CCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCHHEEECCHHHH
AAYRRMKGKGIKGSVSIDWADLQAFKRSFTDPVPEKQEARYERKGVATFHGAARFAGPDR
HHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCHHCCCCCE
IVIGDRELSFSHALIATGAEPRPLGIEGEELLIHSDAFLELKTLPDRIVFVGGGYIAAEF
EEECCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCHHHHHH
AHLAARAGAKVTIFQRGRILKAFDPDTVDWLMPSFDDLGIEIVDAEVDRVTKKGSVLTVH
HHHHHHCCCEEEEEECCCEEEECCCCCHHHHCCCCCCCCEEEEECHHHHHHCCCCEEEEE
AGDRRIEGSLVVHAAGRIPAIGSLDLEAGDVACDAGRLALTAQLRSQSNPKVFAAGDAAA
CCCCEECCEEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEEHHCCCCCEEEEECCCCC
NGPPLTPVSSNDAKVVVENILDDTGRTPNYRGVPSALFTEPPAARVGMLESEAREAGLDF
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHCCHHHHHHHCCCEE
TVHAGSHPGWFSARRLNEEIYGHKLLVENGTGRILGAHLVGPDADELVNIFGLAMRHGLN
EEECCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCC
ADDIKSTMFAYPTAASDAGYMLG
HHHHHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure 
AEAFDFVAIGSGTAAQVAVHQMANAGKRCAVIDYRPYGGTCALRGCDPKKMMVSGEEAL
CCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCHHEEECCHHHH
AAYRRMKGKGIKGSVSIDWADLQAFKRSFTDPVPEKQEARYERKGVATFHGAARFAGPDR
HHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCHHCCCCCE
IVIGDRELSFSHALIATGAEPRPLGIEGEELLIHSDAFLELKTLPDRIVFVGGGYIAAEF
EEECCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCHHHHHH
AHLAARAGAKVTIFQRGRILKAFDPDTVDWLMPSFDDLGIEIVDAEVDRVTKKGSVLTVH
HHHHHHCCCEEEEEECCCEEEECCCCCHHHHCCCCCCCCEEEEECHHHHHHCCCCEEEEE
AGDRRIEGSLVVHAAGRIPAIGSLDLEAGDVACDAGRLALTAQLRSQSNPKVFAAGDAAA
CCCCEECCEEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEEHHCCCCCEEEEECCCCC
NGPPLTPVSSNDAKVVVENILDDTGRTPNYRGVPSALFTEPPAARVGMLESEAREAGLDF
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHCCHHHHHHHCCCEE
TVHAGSHPGWFSARRLNEEIYGHKLLVENGTGRILGAHLVGPDADELVNIFGLAMRHGLN
EEECCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCC
ADDIKSTMFAYPTAASDAGYMLG
HHHHHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]