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The map label for this gene is adhC [C]

Identifier: 85374752

GI number: 85374752

Start: 1961788

End: 1962876

Strand: Direct

Name: adhC [C]

Synonym: ELI_09625

Alternate gene names: 85374752

Gene position: 1961788-1962876 (Clockwise)

Preceding gene: 85374751

Following gene: 85374753

Centisome position: 64.27

GC content: 65.66

Gene sequence:

>1089_bases
ATGGCCAAGGCCGCAATTTTAGAGAAACCCGGCGAAGGGCTGGTCATCGGCGATGTCGAAATTGCCGATCCGGCACCGCA
TGAGGTCCTGATCGACACCAAGGCGTGCGGGCTGTGTCATTCGGACCTGCACTTCATCGACGGGGCTTATCCGCACCCGC
TGCCCGCCATCCCGGGGCACGAGGCGGCTGGTGTGGTGCGCGCGGTCGGCAGCGAAGTGAAGACGGTGCGGCCGGGCGAC
CATGTGGTGTCCTGCCTCAGCGCCTTCTGCGGCCATTGCGAGTTTTGCGTCACCGGCCGGATGGCGCTGTGCATGGGCGC
GGACACGCGCCGTGGACCGGACGGCCCGCCCCGCATCACCCGGGCCGATGGCTCTCCCATCAACCAGATGCTGAACCTGT
CGGCATTCTCCGAGCAGATGCTGATCCACGAACACGCCTGCGTCGCTATCGACAAGGACATGCCGCTGGACCGCGCTGCC
GTGATCGGCTGCGCCGTCACGACTGGTGCCGGCACGATCTTCAACGCCGCCAATGTCACGCCGGGCGAGACAGTGCTGGT
GGTCGGCTGCGGCGGTGTCGGTCTCGCAGCCATCAATGCCGCCAAGATTGCCGGGGCTGGCAAGGTCATCGCAGCCGATC
CGCTCGAGGAAAAGCGCGAACTCGCGAAAGTTCTCGGCGCGACCCACACGGTCAACGCCCTCGACGAGGACGCAGCGCAG
CAGATCCTGACGATTTCGGCCGGGGGCGTGCATTATGGGATCGAGGCGGTGGGCCGCCAGGCCTCCGCCGACCTCGCGGT
CGCTTCGCTGCGGCGCGGCGGGACGGCGATCATCCTCGGCATGATGCCGCTCGACTGCAAGGTCGGCCTCGGCGCGATGG
ACCTGCTGTCGGGCAAGAAGCTGCAAGGCGCGATCATGGGCGAGAACCACTTTCCCGTCGATCTCCCGCGACTGGTCGAC
TTCTACATGCGCGGTTTGCTCGATCTCGACACGATCATCGCCGAACGCATCTCGCTCGACGAGATCAATGCCGGGTTCGA
CAAGATGCGAGAGGGTCATTCCGCTCGCAGCGTAGTGGTGTTCGACTGA

Upstream 100 bases:

>100_bases
TTCGTGCTGAGCCTGTCGAAGCACTGCTCTTCTCTGTGAGCGCGGCGCCAGAATTAAGGACGGCCCTTGGACAAGCTCAG
GGCGAACGGAGTTATTGCGT

Downstream 100 bases:

>100_bases
TGGCCGAAGAAAACACGATCGATTTCGACAAGGAGATGGTCGGCACGATCGACGTGCCCGAAGCCGACCAGATCGATCTC
GAAAAGCTCACGGCATGGTT

Product: Zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MAKAAILEKPGEGLVIGDVEIADPAPHEVLIDTKACGLCHSDLHFIDGAYPHPLPAIPGHEAAGVVRAVGSEVKTVRPGD
HVVSCLSAFCGHCEFCVTGRMALCMGADTRRGPDGPPRITRADGSPINQMLNLSAFSEQMLIHEHACVAIDKDMPLDRAA
VIGCAVTTGAGTIFNAANVTPGETVLVVGCGGVGLAAINAAKIAGAGKVIAADPLEEKRELAKVLGATHTVNALDEDAAQ
QILTISAGGVHYGIEAVGRQASADLAVASLRRGGTAIILGMMPLDCKVGLGAMDLLSGKKLQGAIMGENHFPVDLPRLVD
FYMRGLLDLDTIIAERISLDEINAGFDKMREGHSARSVVVFD

Sequences:

>Translated_362_residues
MAKAAILEKPGEGLVIGDVEIADPAPHEVLIDTKACGLCHSDLHFIDGAYPHPLPAIPGHEAAGVVRAVGSEVKTVRPGD
HVVSCLSAFCGHCEFCVTGRMALCMGADTRRGPDGPPRITRADGSPINQMLNLSAFSEQMLIHEHACVAIDKDMPLDRAA
VIGCAVTTGAGTIFNAANVTPGETVLVVGCGGVGLAAINAAKIAGAGKVIAADPLEEKRELAKVLGATHTVNALDEDAAQ
QILTISAGGVHYGIEAVGRQASADLAVASLRRGGTAIILGMMPLDCKVGLGAMDLLSGKKLQGAIMGENHFPVDLPRLVD
FYMRGLLDLDTIIAERISLDEINAGFDKMREGHSARSVVVFD
>Mature_361_residues
AKAAILEKPGEGLVIGDVEIADPAPHEVLIDTKACGLCHSDLHFIDGAYPHPLPAIPGHEAAGVVRAVGSEVKTVRPGDH
VVSCLSAFCGHCEFCVTGRMALCMGADTRRGPDGPPRITRADGSPINQMLNLSAFSEQMLIHEHACVAIDKDMPLDRAAV
IGCAVTTGAGTIFNAANVTPGETVLVVGCGGVGLAAINAAKIAGAGKVIAADPLEEKRELAKVLGATHTVNALDEDAAQQ
ILTISAGGVHYGIEAVGRQASADLAVASLRRGGTAIILGMMPLDCKVGLGAMDLLSGKKLQGAIMGENHFPVDLPRLVDF
YMRGLLDLDTIIAERISLDEINAGFDKMREGHSARSVVVFD

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=38.7533875338753, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=38.4823848238482, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=37.940379403794, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=34.4262295081967, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=34.9162011173184, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI71565152, Length=371, Percent_Identity=32.8840970350404, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=33.1506849315069, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=32.8767123287671, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=32.8767123287671, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=35.3260869565217, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=28.4530386740331, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=26.9121813031161, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=29.1666666666667, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788075, Length=352, Percent_Identity=26.9886363636364, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=29.1066282420749, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082125, Length=282, Percent_Identity=29.0780141843972, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788407, Length=214, Percent_Identity=32.7102803738318, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=28.2857142857143, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082401, Length=371, Percent_Identity=24.2587601078167, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=372, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=33.1550802139037, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17565904, Length=336, Percent_Identity=33.6309523809524, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17562584, Length=368, Percent_Identity=29.0760869565217, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562876, Length=351, Percent_Identity=26.4957264957265, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=363, Percent_Identity=27.5482093663912, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=260, Percent_Identity=28.4615384615385, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562582, Length=366, Percent_Identity=27.3224043715847, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=370, Percent_Identity=33.5135135135135, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319621, Length=370, Percent_Identity=28.9189189189189, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323729, Length=356, Percent_Identity=28.6516853932584, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=364, Percent_Identity=28.021978021978, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=360, Percent_Identity=27.2222222222222, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=331, Percent_Identity=29.607250755287, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.0718232044199, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=26.7955801104972, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=228, Percent_Identity=32.0175438596491, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=26.647564469914, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=352, Percent_Identity=26.1363636363636, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37600; Mature: 37469

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAAILEKPGEGLVIGDVEIADPAPHEVLIDTKACGLCHSDLHFIDGAYPHPLPAIPGH
CCCCCCCCCCCCEEEEEEEEECCCCCCEEEEECHHCCCCCCCHHHHCCCCCCCCCCCCCC
EAAGVVRAVGSEVKTVRPGDHVVSCLSAFCGHCEFCVTGRMALCMGADTRRGPDGPPRIT
HHHHHHHHHCCHHCCCCCHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCCCCEE
RADGSPINQMLNLSAFSEQMLIHEHACVAIDKDMPLDRAAVIGCAVTTGAGTIFNAANVT
ECCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHEEEEEEECCCCCEEECCCCC
PGETVLVVGCGGVGLAAINAAKIAGAGKVIAADPLEEKRELAKVLGATHTVNALDEDAAQ
CCCEEEEEECCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHH
QILTISAGGVHYGIEAVGRQASADLAVASLRRGGTAIILGMMPLDCKVGLGAMDLLSGKK
HEEEEECCCEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCC
LQGAIMGENHFPVDLPRLVDFYMRGLLDLDTIIAERISLDEINAGFDKMREGHSARSVVV
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHCCCCCCEEEE
FD
EC
>Mature Secondary Structure 
AKAAILEKPGEGLVIGDVEIADPAPHEVLIDTKACGLCHSDLHFIDGAYPHPLPAIPGH
CCCCCCCCCCCEEEEEEEEECCCCCCEEEEECHHCCCCCCCHHHHCCCCCCCCCCCCCC
EAAGVVRAVGSEVKTVRPGDHVVSCLSAFCGHCEFCVTGRMALCMGADTRRGPDGPPRIT
HHHHHHHHHCCHHCCCCCHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCCCCEE
RADGSPINQMLNLSAFSEQMLIHEHACVAIDKDMPLDRAAVIGCAVTTGAGTIFNAANVT
ECCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHEEEEEEECCCCCEEECCCCC
PGETVLVVGCGGVGLAAINAAKIAGAGKVIAADPLEEKRELAKVLGATHTVNALDEDAAQ
CCCEEEEEECCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHH
QILTISAGGVHYGIEAVGRQASADLAVASLRRGGTAIILGMMPLDCKVGLGAMDLLSGKK
HEEEEECCCEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCC
LQGAIMGENHFPVDLPRLVDFYMRGLLDLDTIIAERISLDEINAGFDKMREGHSARSVVV
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHCCCCCCEEEE
FD
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]