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The map label for this gene is acdA [H]

Identifier: 85374667

GI number: 85374667

Start: 1870387

End: 1871562

Strand: Direct

Name: acdA [H]

Synonym: ELI_09200

Alternate gene names: 85374667

Gene position: 1870387-1871562 (Clockwise)

Preceding gene: 85374666

Following gene: 85374668

Centisome position: 61.28

GC content: 62.59

Gene sequence:

>1176_bases
ATGGTGCCTTTCGCGTGGGACGATCCGTTCCGCCTCGACGAGCAATTGACCGAAGACGAGCGGATGATCCGCGACGCGGC
GCATGGATTCGCACAAAGCGAGCTTCAGCCGCGCGTGATCGAGGCCTTTTCCAACGAAGTCGATGCGCCGGAATTGTTCC
CGCTGATGGGCCAAGCCGGACTGCTGGGCGCGACGATCCCCGAAGAGTATGGCGGCGCAGGTGCGGGCTACGTGGCCTAT
GGCCTGATTGCTCGCGAGATCGAGCGCGTCGACAGCGGCTATCGCTCGATGGCCTCGGTGCAATCCTCGCTCGTCATGTA
TCCGATCCACGCTTTCGGTTCGGAGGAGCAGAAGCGCAAATACCTGCCCGGCCTGGCGTCGGGCGAATTGATCGGCTGCT
TCGGGCTGACCGAGCCCGACGCGGGGTCCGACCCTGCCGGCATGAAGACTGTCGCGAAAAAGAACGGCGACGGATACATC
ATTTCCGGTTCCAAGACCTGGATTTCCAACTCACCCTTCGCCGATGTTTTCGTGGTCTGGGCCAAGAGCGAAGAGCACGG
CGGCGGTATCCGCGGCTTCGTGCTGGAAAAGGGGATGGACGGTCTGTCCGCCCCCAAGATCGAAGGCAAGATCTCGCTGC
GCGCCAGCACAACCGGCATGATCGTGATGGACGAGGTCAAGGTCGGTGCGGATGCGCTGCTGCCCGATGTGCAGGGTCTC
AAGGGGCCTTTCTCGTGCCTCAACCGCGCGCGCTACGGCATCAGCTGGGGCAGCATGGGCGCAGCGGAATTCTGTATGCA
CGCAGCGCGGCAATACGGCCTGGATCGCCAGCAGTTCGGCGTCCCGCTGGCGAGTAAGCAGCTCTACCAGCTCAAACTTT
CCAACATGATGAGCGAGATCGCGCTGGGCCTGCAGGCCTCCCTGCGCGTCGGCCGCCTGATGGACGAAGGCAAGTTCGCG
CCCGAGATGATCTCGATCGTCAAGCGCAACAATGTCGGTAAGGCGCTCGATATCGCGCGGGCCGCGCGCGATATGCACGG
CGGCAACGGTATCAGCGAGGAATACCAGGTCATCCGCCACATGGTGAATCTCGAGACGGTCAATACCTATGAAGGCACGC
ATGATGTCCACGCGCTGATCCTGGGCCGCGCAATCACCGGGTTGGCGGCGTTCTGA

Upstream 100 bases:

>100_bases
CCTGATCGCTGCCCTCCGTAAGACTTGATGCAGGGCTCCACTCCTGCGAAAGCGCAGCCACAGAAGTGACCGCCTGACCG
CAGGAGTTTTCATGACTGGT

Downstream 100 bases:

>100_bases
TCTCGCACTTGCTGGCACGGCTGTCCTACACGGACAGGCCATGGCACAAGCGACAGATGGCTCGGTCTGGTGCATTTTCG
CGGGGTTACACGTTGGACTC

Product: putative glutaryl-CoA dehydrogenase protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MVPFAWDDPFRLDEQLTEDERMIRDAAHGFAQSELQPRVIEAFSNEVDAPELFPLMGQAGLLGATIPEEYGGAGAGYVAY
GLIAREIERVDSGYRSMASVQSSLVMYPIHAFGSEEQKRKYLPGLASGELIGCFGLTEPDAGSDPAGMKTVAKKNGDGYI
ISGSKTWISNSPFADVFVVWAKSEEHGGGIRGFVLEKGMDGLSAPKIEGKISLRASTTGMIVMDEVKVGADALLPDVQGL
KGPFSCLNRARYGISWGSMGAAEFCMHAARQYGLDRQQFGVPLASKQLYQLKLSNMMSEIALGLQASLRVGRLMDEGKFA
PEMISIVKRNNVGKALDIARAARDMHGGNGISEEYQVIRHMVNLETVNTYEGTHDVHALILGRAITGLAAF

Sequences:

>Translated_391_residues
MVPFAWDDPFRLDEQLTEDERMIRDAAHGFAQSELQPRVIEAFSNEVDAPELFPLMGQAGLLGATIPEEYGGAGAGYVAY
GLIAREIERVDSGYRSMASVQSSLVMYPIHAFGSEEQKRKYLPGLASGELIGCFGLTEPDAGSDPAGMKTVAKKNGDGYI
ISGSKTWISNSPFADVFVVWAKSEEHGGGIRGFVLEKGMDGLSAPKIEGKISLRASTTGMIVMDEVKVGADALLPDVQGL
KGPFSCLNRARYGISWGSMGAAEFCMHAARQYGLDRQQFGVPLASKQLYQLKLSNMMSEIALGLQASLRVGRLMDEGKFA
PEMISIVKRNNVGKALDIARAARDMHGGNGISEEYQVIRHMVNLETVNTYEGTHDVHALILGRAITGLAAF
>Mature_391_residues
MVPFAWDDPFRLDEQLTEDERMIRDAAHGFAQSELQPRVIEAFSNEVDAPELFPLMGQAGLLGATIPEEYGGAGAGYVAY
GLIAREIERVDSGYRSMASVQSSLVMYPIHAFGSEEQKRKYLPGLASGELIGCFGLTEPDAGSDPAGMKTVAKKNGDGYI
ISGSKTWISNSPFADVFVVWAKSEEHGGGIRGFVLEKGMDGLSAPKIEGKISLRASTTGMIVMDEVKVGADALLPDVQGL
KGPFSCLNRARYGISWGSMGAAEFCMHAARQYGLDRQQFGVPLASKQLYQLKLSNMMSEIALGLQASLRVGRLMDEGKFA
PEMISIVKRNNVGKALDIARAARDMHGGNGISEEYQVIRHMVNLETVNTYEGTHDVHALILGRAITGLAAF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=64.6153846153846, Blast_Score=520, Evalue=1e-148,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=63.5135135135135, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI4557233, Length=392, Percent_Identity=31.3775510204082, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=32.2751322751323, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=32.258064516129, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=30.4, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=31.4814814814815, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=31.4814814814815, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=31.3157894736842, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=27.8947368421053, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI76496475, Length=354, Percent_Identity=29.9435028248588, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=29.1553133514986, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4557235, Length=354, Percent_Identity=29.9435028248588, Blast_Score=139, Evalue=7e-33,
Organism=Escherichia coli, GI1786223, Length=362, Percent_Identity=24.8618784530387, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=24.1469816272966, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=63.1443298969072, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=32.1989528795811, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=30.8310991957105, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17508101, Length=375, Percent_Identity=31.2, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=30.7894736842105, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=272, Percent_Identity=36.3970588235294, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=29.5039164490862, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=37.8260869565217, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=29.1338582677165, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=270, Percent_Identity=31.4814814814815, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71985184, Length=341, Percent_Identity=29.3255131964809, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=380, Percent_Identity=26.5789473684211, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=254, Percent_Identity=31.1023622047244, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17551932, Length=291, Percent_Identity=25.4295532646048, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=293, Percent_Identity=24.2320819112628, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=62.2448979591837, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=32.0855614973262, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=28.8359788359788, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=30.4232804232804, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=31.413612565445, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=30.7486631016043, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281363737, Length=392, Percent_Identity=27.5510204081633, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 42262; Mature: 42262

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPFAWDDPFRLDEQLTEDERMIRDAAHGFAQSELQPRVIEAFSNEVDAPELFPLMGQAG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCC
LLGATIPEEYGGAGAGYVAYGLIAREIERVDSGYRSMASVQSSLVMYPIHAFGSEEQKRK
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCHHHHHH
YLPGLASGELIGCFGLTEPDAGSDPAGMKTVAKKNGDGYIISGSKTWISNSPFADVFVVW
HCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEE
AKSEEHGGGIRGFVLEKGMDGLSAPKIEGKISLRASTTGMIVMDEVKVGADALLPDVQGL
ECCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHCCCHHCC
KGPFSCLNRARYGISWGSMGAAEFCMHAARQYGLDRQQFGVPLASKQLYQLKLSNMMSEI
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHH
ALGLQASLRVGRLMDEGKFAPEMISIVKRNNVGKALDIARAARDMHGGNGISEEYQVIRH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
MVNLETVNTYEGTHDVHALILGRAITGLAAF
HHHHCEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVPFAWDDPFRLDEQLTEDERMIRDAAHGFAQSELQPRVIEAFSNEVDAPELFPLMGQAG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCC
LLGATIPEEYGGAGAGYVAYGLIAREIERVDSGYRSMASVQSSLVMYPIHAFGSEEQKRK
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCHHHHHH
YLPGLASGELIGCFGLTEPDAGSDPAGMKTVAKKNGDGYIISGSKTWISNSPFADVFVVW
HCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEE
AKSEEHGGGIRGFVLEKGMDGLSAPKIEGKISLRASTTGMIVMDEVKVGADALLPDVQGL
ECCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHCCCHHCC
KGPFSCLNRARYGISWGSMGAAEFCMHAARQYGLDRQQFGVPLASKQLYQLKLSNMMSEI
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHH
ALGLQASLRVGRLMDEGKFAPEMISIVKRNNVGKALDIARAARDMHGGNGISEEYQVIRH
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
MVNLETVNTYEGTHDVHALILGRAITGLAAF
HHHHCEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]