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The map label for this gene is nudF [H]

Identifier: 85374619

GI number: 85374619

Start: 1824541

End: 1825092

Strand: Direct

Name: nudF [H]

Synonym: ELI_08960

Alternate gene names: 85374619

Gene position: 1824541-1825092 (Clockwise)

Preceding gene: 85374618

Following gene: 85374620

Centisome position: 59.77

GC content: 63.95

Gene sequence:

>552_bases
ATGACAGACCCCGATGCCAACCTGCCCGAAGAGATCATGTGGCAGGGCAAGTTCGTTACCGCCAAACGCCGCGGACGCTG
GGAATATGCCAGCCGCTCGCGCGGCATCCGCGCCGCCGCCATCGTCGCCATCGACGACGAAGGGCATGTCCTGCTGGTCG
AGCAATGTCGCGTGCCGCTGGGCCGCGTCTGCCTGGAAATCCCCGCTGGCCTGATCGGCGATCACGAGGGGCAGGAAGAC
GAAGACGCGGTCGAAGCGGCGATCCGCGAGCTGGAGGAAGAAACCGGCTACCGCGCCGGCCGCATGGAAGTGATCGGCGA
ATTCTATTCCAGCCCTGGCATGGTCAGCGAGGCTTTCACACTCATCCGCGCACACGACCTCGTGAAGGTCGGCGAAGGCG
GCGGGACCGATAGCGAGGACATCACCATCCACCGGGTCAGACTGCGCGACCTGCCGCAATTCGTTGCGGACTGGCGCAAA
CGCGGCCACGGTGTCGATGTTCGGATCGCCATGCTGATGGCGCCGCATTTTCTGGGAGAGGATTTTAGATGA

Upstream 100 bases:

>100_bases
GGCGCGGAGCCACCAAGGTTGGCATGGCCCACCCCGCTGCGACTAGGTCGCTAGCGCGACCAAATCTCGCTGCCCCTCCC
GCGAGCGGGAGGGGAACACC

Downstream 100 bases:

>100_bases
CTGGACGTGTAGCGGGCAAGATGGCGCTGGTTACCGGGGCTGCGCAGGGACTGGGAGCGCAGCATTGCAAGACGCTCGCT
GCCGAAGGCGCCAAGGTGCT

Product: NTP pyrophosphohydrolase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTDPDANLPEEIMWQGKFVTAKRRGRWEYASRSRGIRAAAIVAIDDEGHVLLVEQCRVPLGRVCLEIPAGLIGDHEGQED
EDAVEAAIRELEEETGYRAGRMEVIGEFYSSPGMVSEAFTLIRAHDLVKVGEGGGTDSEDITIHRVRLRDLPQFVADWRK
RGHGVDVRIAMLMAPHFLGEDFR

Sequences:

>Translated_183_residues
MTDPDANLPEEIMWQGKFVTAKRRGRWEYASRSRGIRAAAIVAIDDEGHVLLVEQCRVPLGRVCLEIPAGLIGDHEGQED
EDAVEAAIRELEEETGYRAGRMEVIGEFYSSPGMVSEAFTLIRAHDLVKVGEGGGTDSEDITIHRVRLRDLPQFVADWRK
RGHGVDVRIAMLMAPHFLGEDFR
>Mature_182_residues
TDPDANLPEEIMWQGKFVTAKRRGRWEYASRSRGIRAAAIVAIDDEGHVLLVEQCRVPLGRVCLEIPAGLIGDHEGQEDE
DAVEAAIRELEEETGYRAGRMEVIGEFYSSPGMVSEAFTLIRAHDLVKVGEGGGTDSEDITIHRVRLRDLPQFVADWRKR
GHGVDVRIAMLMAPHFLGEDFR

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17564994, Length=145, Percent_Identity=31.7241379310345, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 20483; Mature: 20352

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPDANLPEEIMWQGKFVTAKRRGRWEYASRSRGIRAAAIVAIDDEGHVLLVEQCRVPL
CCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHCCCCEEEEEEEECCCCCEEEHHHHCCCH
GRVCLEIPAGLIGDHEGQEDEDAVEAAIRELEEETGYRAGRMEVIGEFYSSPGMVSEAFT
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
LIRAHDLVKVGEGGGTDSEDITIHRVRLRDLPQFVADWRKRGHGVDVRIAMLMAPHFLGE
HHHHHHHEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCC
DFR
CCC
>Mature Secondary Structure 
TDPDANLPEEIMWQGKFVTAKRRGRWEYASRSRGIRAAAIVAIDDEGHVLLVEQCRVPL
CCCCCCCCHHHHHCCCEEEECCCCCCCHHHHCCCCEEEEEEEECCCCCEEEHHHHCCCH
GRVCLEIPAGLIGDHEGQEDEDAVEAAIRELEEETGYRAGRMEVIGEFYSSPGMVSEAFT
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
LIRAHDLVKVGEGGGTDSEDITIHRVRLRDLPQFVADWRKRGHGVDVRIAMLMAPHFLGE
HHHHHHHEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCC
DFR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]