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The map label for this gene is purM

Identifier: 85374597

GI number: 85374597

Start: 1801804

End: 1802910

Strand: Direct

Name: purM

Synonym: ELI_08850

Alternate gene names: 85374597

Gene position: 1801804-1802910 (Clockwise)

Preceding gene: 85374592

Following gene: 85374598

Centisome position: 59.03

GC content: 65.94

Gene sequence:

>1107_bases
ATGTCTGCGGATAGTTCTGGAAAAACCGGCTATACCTATGCCGATGCCGGGGTCGATATCGATGCCGGCAACGCGCTCGT
CAAAGCGATCGGACCGCTGGTGAAAGCCACGATGCGCCCCGGCGCGGACGGCGAGATCGGCGGCTTCGGCGGATTCTTCG
ACCCCGGGGCGGCCGGGTACAAGGACCCGCTGCTGGTCGCAGGCAATGACGGCGTCGGCACCAAGCTCAAGCTCGCGATC
GACACCCAGCGCCATGATACGGTGGGTATCGATCTCGTCGCCATGTGCGTGAACGATTTGATCGTGCAGGGTGCCGAGCC
GCTGTTCTTCCTCGACTATTTCGCCACCGGCAAGCTGCAAAACGGCGTCGCCGAGCGCGTGATCGCGGGCATTGCCGAGG
GCTGCAAACTGGCCGGATGCGCGCTGATCGGCGGGGAAACGGCGGAGATGCCCGGCATGTATGCCGAAGGCGACTACGAC
CTCGCCGGCTTCTGCGTCGGCGCGGTCGAACGTGGCGAGCAGCTGACCGGCACGAAGGTTGCGCCCGGCCATGTCCTGCT
TGGCCTCGCCTCATCGGGCATCCACTCCAACGGCTATTCGCTGGTCCGGCGGCTGGCGGCGGACAAGGGCTGGAAGCTCG
ACCGCCCCGCCCTGTTCGACAACGAGCGCCTGCTGATCGAGCATTTGCTCGAACCGACGCGGATTTATGTCGCCAGCCTG
CTGCCCGCAGTGCGCGCAGGCGAAATCGACGCGCTGGCGCATATCACCGGTGGCGGGCTGCTGGAGAATATTCCGCGCGT
GCTGCCGCAAGGCGCGCATGCGGTGATCGATGCCGATGCGTGGGAACAGCCGCGCCTGATGGCTTTCCTCCAGGCGCAGG
GCGGCATCGAACCGGGCGAGATGGCGCGCACTTTTAACTGCGGGATCGGAATGGTCCTGGCGGTCACGCCGGACAAGGTA
GAGGCGGTGACGGCGCGCCTGAACGAGGCGGGCGAAACCGTCCACCGCATCGGAACGATCGAGGCGGGTGAGAAAGGCTG
CACCGTGCGCGGCTCGACAGGCACATGGTCCGCCACCGCCGATTGGGAAACCCGGCATCTTGGCTGA

Upstream 100 bases:

>100_bases
TGCGGGTGGGGAGGTGTGCGATCAGTGCCATGGGGAAAACCGCGAGCCTTTTGCCGAAAGCCACGTGCGATTCCAAGCGC
GAAAGACTAAAGGTCGTGGC

Downstream 100 bases:

>100_bases
GACGCCGCTCGCCAAGGTGGCCGTGCTGGTTTCGGGCAGCGGGACCAATATGGCGGCGCTCCTCTATGCCAGCCGCCTCC
CGGACAGCCCCTACGAAATC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSADSSGKTGYTYADAGVDIDAGNALVKAIGPLVKATMRPGADGEIGGFGGFFDPGAAGYKDPLLVAGNDGVGTKLKLAI
DTQRHDTVGIDLVAMCVNDLIVQGAEPLFFLDYFATGKLQNGVAERVIAGIAEGCKLAGCALIGGETAEMPGMYAEGDYD
LAGFCVGAVERGEQLTGTKVAPGHVLLGLASSGIHSNGYSLVRRLAADKGWKLDRPALFDNERLLIEHLLEPTRIYVASL
LPAVRAGEIDALAHITGGGLLENIPRVLPQGAHAVIDADAWEQPRLMAFLQAQGGIEPGEMARTFNCGIGMVLAVTPDKV
EAVTARLNEAGETVHRIGTIEAGEKGCTVRGSTGTWSATADWETRHLG

Sequences:

>Translated_368_residues
MSADSSGKTGYTYADAGVDIDAGNALVKAIGPLVKATMRPGADGEIGGFGGFFDPGAAGYKDPLLVAGNDGVGTKLKLAI
DTQRHDTVGIDLVAMCVNDLIVQGAEPLFFLDYFATGKLQNGVAERVIAGIAEGCKLAGCALIGGETAEMPGMYAEGDYD
LAGFCVGAVERGEQLTGTKVAPGHVLLGLASSGIHSNGYSLVRRLAADKGWKLDRPALFDNERLLIEHLLEPTRIYVASL
LPAVRAGEIDALAHITGGGLLENIPRVLPQGAHAVIDADAWEQPRLMAFLQAQGGIEPGEMARTFNCGIGMVLAVTPDKV
EAVTARLNEAGETVHRIGTIEAGEKGCTVRGSTGTWSATADWETRHLG
>Mature_367_residues
SADSSGKTGYTYADAGVDIDAGNALVKAIGPLVKATMRPGADGEIGGFGGFFDPGAAGYKDPLLVAGNDGVGTKLKLAID
TQRHDTVGIDLVAMCVNDLIVQGAEPLFFLDYFATGKLQNGVAERVIAGIAEGCKLAGCALIGGETAEMPGMYAEGDYDL
AGFCVGAVERGEQLTGTKVAPGHVLLGLASSGIHSNGYSLVRRLAADKGWKLDRPALFDNERLLIEHLLEPTRIYVASLL
PAVRAGEIDALAHITGGGLLENIPRVLPQGAHAVIDADAWEQPRLMAFLQAQGGIEPGEMARTFNCGIGMVLAVTPDKVE
AVTARLNEAGETVHRIGTIEAGEKGCTVRGSTGTWSATADWETRHLG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=54.8961424332344, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=54.8961424332344, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=54.8961424332344, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI1788845, Length=339, Percent_Identity=55.7522123893805, Blast_Score=370, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=43.8395415472779, Blast_Score=281, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6321203, Length=358, Percent_Identity=51.3966480446927, Blast_Score=351, Evalue=9e-98,
Organism=Drosophila melanogaster, GI24582400, Length=272, Percent_Identity=47.7941176470588, Blast_Score=234, Evalue=6e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_ERYLH (Q2N8X9)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458659.1
- ProteinModelPortal:   Q2N8X9
- SMR:   Q2N8X9
- STRING:   Q2N8X9
- GeneID:   3870172
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_08850
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q2N8X9
- ProtClustDB:   PRK05385
- BioCyc:   ELIT314225:ELI_08850-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38311; Mature: 38180

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADSSGKTGYTYADAGVDIDAGNALVKAIGPLVKATMRPGADGEIGGFGGFFDPGAAGY
CCCCCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
KDPLLVAGNDGVGTKLKLAIDTQRHDTVGIDLVAMCVNDLIVQGAEPLFFLDYFATGKLQ
CCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCHH
NGVAERVIAGIAEGCKLAGCALIGGETAEMPGMYAEGDYDLAGFCVGAVERGEQLTGTKV
HHHHHHHHHHHHHCCCEECEEEECCCCHHCCCEECCCCCCHHHHHHHHHHCCCCCCCCCC
APGHVLLGLASSGIHSNGYSLVRRLAADKGWKLDRPALFDNERLLIEHLLEPTRIYVASL
CCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
LPAVRAGEIDALAHITGGGLLENIPRVLPQGAHAVIDADAWEQPRLMAFLQAQGGIEPGE
HHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHH
MARTFNCGIGMVLAVTPDKVEAVTARLNEAGETVHRIGTIEAGEKGCTVRGSTGTWSATA
HHEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEC
DWETRHLG
CCCCCCCC
>Mature Secondary Structure 
SADSSGKTGYTYADAGVDIDAGNALVKAIGPLVKATMRPGADGEIGGFGGFFDPGAAGY
CCCCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
KDPLLVAGNDGVGTKLKLAIDTQRHDTVGIDLVAMCVNDLIVQGAEPLFFLDYFATGKLQ
CCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCHH
NGVAERVIAGIAEGCKLAGCALIGGETAEMPGMYAEGDYDLAGFCVGAVERGEQLTGTKV
HHHHHHHHHHHHHCCCEECEEEECCCCHHCCCEECCCCCCHHHHHHHHHHCCCCCCCCCC
APGHVLLGLASSGIHSNGYSLVRRLAADKGWKLDRPALFDNERLLIEHLLEPTRIYVASL
CCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
LPAVRAGEIDALAHITGGGLLENIPRVLPQGAHAVIDADAWEQPRLMAFLQAQGGIEPGE
HHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHH
MARTFNCGIGMVLAVTPDKVEAVTARLNEAGETVHRIGTIEAGEKGCTVRGSTGTWSATA
HHEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEC
DWETRHLG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA