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The map label for this gene is fabG [C]

Identifier: 85374592

GI number: 85374592

Start: 1797722

End: 1798651

Strand: Direct

Name: fabG [C]

Synonym: ELI_08825

Alternate gene names: 85374592

Gene position: 1797722-1798651 (Clockwise)

Preceding gene: 85374591

Following gene: 85374597

Centisome position: 58.9

GC content: 63.33

Gene sequence:

>930_bases
ATGAGCATCTCATTCAAGGACAAGGTCGCCATCGTCACCGGTGCGGGCGGCGGTCTGGGTCGCGAATATGCGCTCGAACT
CGCCCGCCGCGGCGCAAAGGTTGTGGTCAACGATCTCGGCGGATCGCGTGACGGCACCGGCCATTCGGACATGGCGCTGC
AGGTGGTCGAGGAAATCGAGAAGGCCGGCGGCGAAGCGATGTCGAACGGCGGCAGTGTCACCGAATACGAGCAGATGGAA
AAGATGGTTGCCGACGCGAAGCAGAAGTGGGGCGGCGTGCACGTCGTCATCAACAATGCCGGCGTCCTGCGCGACAAGAC
CTTCGCCAAGATGACGATGGACGACTTCCGCTTCGTCGTGGACGTCCACCTCAACGGTTCGGCCAATGTCAGCAAGGCGG
CGTGGGAAACCATGCGCGAGCAAGCTTATGGCCGCATCCTTATGACCGCCAGCTCGACCGGCCTGTTCGGCAACTTCGGC
CAGGCCAATTATGGCGCGGCCAAGCTGGGCCTTGCCGGTCTCACCAAGACGCTCCAACTCGAAGGCGCGAAGTACAACAT
CAAGGTCAACACGATCTCGCCGGTCGCTGGCACGCGCATGACCGAAGACCTGTTTCCCGAAGAAGCCTTCAAGCTGTTCG
ACCCGGTCAACGTGGTTCCCGCGGCCCTTTTCCTCGTCAGCGAAGATGCCCCGACCAACGCCATCGTCGGCGCCGGCGCG
GGTGGCTTCCACTCGGCATGGACGGTGATGAACGACGCCGTCTGGCTGAAGGACGAAGACCGCACAGTCGAAGGCTTCGC
CGCCAACTGGGACAAGATCAGCGAGTTCGCCAACCTCAAGGCGCCGCAGAGCGGCTCCGAACAGTCGGGCGCGATCCTGA
CCGCCATGCAGAAGGTCACGGGCACCGGGCCAAGCAGCGCGCGCGGCTAA

Upstream 100 bases:

>100_bases
CAGCAGGGAAAATGCCACCCAGCCGCCACGTTGACGGGCGCGTAAAGCTCGCGAAACCAGAAAATCACATTCCCCAATTC
GTCTTCAGGAGGACATCCCC

Downstream 100 bases:

>100_bases
CGCCCATTTCTGCGGATGAGAACGGGGCCTCGCATTCCGGTGCGGGGCCTCTTTCCGTGGAAGTCAGTCCCCGATCGACT
TGAGCAGCCGCCGCTCCATC

Product: 3-oxo-(acyl) acyl carrier protein reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSISFKDKVAIVTGAGGGLGREYALELARRGAKVVVNDLGGSRDGTGHSDMALQVVEEIEKAGGEAMSNGGSVTEYEQME
KMVADAKQKWGGVHVVINNAGVLRDKTFAKMTMDDFRFVVDVHLNGSANVSKAAWETMREQAYGRILMTASSTGLFGNFG
QANYGAAKLGLAGLTKTLQLEGAKYNIKVNTISPVAGTRMTEDLFPEEAFKLFDPVNVVPAALFLVSEDAPTNAIVGAGA
GGFHSAWTVMNDAVWLKDEDRTVEGFAANWDKISEFANLKAPQSGSEQSGAILTAMQKVTGTGPSSARG

Sequences:

>Translated_309_residues
MSISFKDKVAIVTGAGGGLGREYALELARRGAKVVVNDLGGSRDGTGHSDMALQVVEEIEKAGGEAMSNGGSVTEYEQME
KMVADAKQKWGGVHVVINNAGVLRDKTFAKMTMDDFRFVVDVHLNGSANVSKAAWETMREQAYGRILMTASSTGLFGNFG
QANYGAAKLGLAGLTKTLQLEGAKYNIKVNTISPVAGTRMTEDLFPEEAFKLFDPVNVVPAALFLVSEDAPTNAIVGAGA
GGFHSAWTVMNDAVWLKDEDRTVEGFAANWDKISEFANLKAPQSGSEQSGAILTAMQKVTGTGPSSARG
>Mature_308_residues
SISFKDKVAIVTGAGGGLGREYALELARRGAKVVVNDLGGSRDGTGHSDMALQVVEEIEKAGGEAMSNGGSVTEYEQMEK
MVADAKQKWGGVHVVINNAGVLRDKTFAKMTMDDFRFVVDVHLNGSANVSKAAWETMREQAYGRILMTASSTGLFGNFGQ
ANYGAAKLGLAGLTKTLQLEGAKYNIKVNTISPVAGTRMTEDLFPEEAFKLFDPVNVVPAALFLVSEDAPTNAIVGAGAG
GFHSAWTVMNDAVWLKDEDRTVEGFAANWDKISEFANLKAPQSGSEQSGAILTAMQKVTGTGPSSARG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=309, Percent_Identity=46.6019417475728, Blast_Score=261, Evalue=6e-70,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=30.4166666666667, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=29.3172690763052, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503817, Length=190, Percent_Identity=29.4736842105263, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4758504, Length=223, Percent_Identity=31.8385650224215, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI25282469, Length=227, Percent_Identity=25.9911894273128, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI83715985, Length=184, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=238, Percent_Identity=32.7731092436975, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=30.9236947791165, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790717, Length=237, Percent_Identity=27.8481012658228, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787905, Length=236, Percent_Identity=30.9322033898305, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=31.25, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788459, Length=188, Percent_Identity=30.3191489361702, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=25.4826254826255, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789057, Length=211, Percent_Identity=28.9099526066351, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=305, Percent_Identity=43.9344262295082, Blast_Score=237, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=31.6, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=209, Percent_Identity=31.5789473684211, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=194, Percent_Identity=28.3505154639175, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=178, Percent_Identity=28.6516853932584, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=207, Percent_Identity=30.9178743961353, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=190, Percent_Identity=26.8421052631579, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=192, Percent_Identity=26.5625, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=198, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=213, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=30.5418719211823, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=279, Percent_Identity=50.5376344086022, Blast_Score=258, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6324126, Length=190, Percent_Identity=30.5263157894737, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859837, Length=302, Percent_Identity=41.0596026490066, Blast_Score=224, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24640492, Length=191, Percent_Identity=28.2722513089005, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24639444, Length=190, Percent_Identity=34.7368421052632, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24649181, Length=194, Percent_Identity=30.4123711340206, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364892, Length=175, Percent_Identity=27.4285714285714, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355631, Length=174, Percent_Identity=28.1609195402299, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357673, Length=192, Percent_Identity=28.125, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356301, Length=190, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737361, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=26.4248704663212, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32665; Mature: 32534

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISFKDKVAIVTGAGGGLGREYALELARRGAKVVVNDLGGSRDGTGHSDMALQVVEEIE
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
KAGGEAMSNGGSVTEYEQMEKMVADAKQKWGGVHVVINNAGVLRDKTFAKMTMDDFRFVV
HCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCEEEEE
DVHLNGSANVSKAAWETMREQAYGRILMTASSTGLFGNFGQANYGAAKLGLAGLTKTLQL
EEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
EGAKYNIKVNTISPVAGTRMTEDLFPEEAFKLFDPVNVVPAALFLVSEDAPTNAIVGAGA
CCCEEEEEEEEECCCCCCCCHHHHCHHHHHHHHCCHHHHHHEEEEEECCCCCCEEEECCC
GGFHSAWTVMNDAVWLKDEDRTVEGFAANWDKISEFANLKAPQSGSEQSGAILTAMQKVT
CCCHHHHHHHCCEEEEECCCCCCCCHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
GTGPSSARG
CCCCCCCCC
>Mature Secondary Structure 
SISFKDKVAIVTGAGGGLGREYALELARRGAKVVVNDLGGSRDGTGHSDMALQVVEEIE
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
KAGGEAMSNGGSVTEYEQMEKMVADAKQKWGGVHVVINNAGVLRDKTFAKMTMDDFRFVV
HCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCEEEEE
DVHLNGSANVSKAAWETMREQAYGRILMTASSTGLFGNFGQANYGAAKLGLAGLTKTLQL
EEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
EGAKYNIKVNTISPVAGTRMTEDLFPEEAFKLFDPVNVVPAALFLVSEDAPTNAIVGAGA
CCCEEEEEEEEECCCCCCCCHHHHCHHHHHHHHCCHHHHHHEEEEEECCCCCCEEEECCC
GGFHSAWTVMNDAVWLKDEDRTVEGFAANWDKISEFANLKAPQSGSEQSGAILTAMQKVT
CCCHHHHHHHCCEEEEECCCCCCCCHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
GTGPSSARG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]