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The map label for this gene is qor [C]

Identifier: 85374330

GI number: 85374330

Start: 1557984

End: 1558958

Strand: Direct

Name: qor [C]

Synonym: ELI_07515

Alternate gene names: 85374330

Gene position: 1557984-1558958 (Clockwise)

Preceding gene: 85374329

Following gene: 85374339

Centisome position: 51.04

GC content: 65.33

Gene sequence:

>975_bases
ATGAAAGCGCTGCGCGTCCAGCACCTGTCGGACGACCTGTCCGGCGTGGAACTGGTCGACCTGCCGCAGCCCGAACGAAA
GCAGGGCGAGGTGCTCGTCCTCGTGCGCGCCGCTTCGCTCAATTACCCCGACCTGCTGATGACGCAGGGCAAATACCAGT
TCAAACCGGAGCCTCCTTTCACCAGCGGGATGGAGCTGGCGGGCAAAGTGCTCGAGGCAGATAGCGATAGCGGCTTCGCG
CCCGGTGATCGGGTCATGGGCGGCGCGAAGACCGGTGGGTTCGCTGAGACGGCCGTAGCCCCGGCGCGCGCACTCCGGCG
TATTCCCGACGGCGTGTCCCTCGCGACCGCTGCGGCGATGGGCGCAGCCTATTCCACTGCCTACACCGGGCTCGTCGAAT
TGGGGGGACTCGAAGCTAGCCAGTCGGTGTTGGTCCATGGAGCGAGCGGAGGCGTTGGCCTTGCCGCATGCGATCTAGCC
AAGGCACTAGGAGCGACCGTGATCGCGGCGACGCATCGCGAAGATAAGCTGGAAGCGCTTGAGGCCGCATCGGGCGCGGA
TCATGTCATCCTCAACCATGGCCGTTTCCGCGAACAGGTGGGCGACCTGACGGGCGGCACGCTGTGCGATCTCGTATTCG
ATCCGGTCGGCGGCGATGTGTTCGACGAGAGCACCCGCTGCGTGGCGTTCGGAGGCAAATTGCTCGTGGTCGGCTTTGTC
GCGGGACGCATCCCGGAAATCGCGGTCAATATACCGCTGATCAAGGGCTTCTCCGTCGTTGGCGTGCGCGCCGGCGAATA
TGCCCGGCGCTTCCCCGATCGCGGGGCGCGGATCATGGGGGAGCTCGACAAACTCGCCGTCAGCGGCGCGATCACCCCGC
ATATCGATCGCACACTACCCCTCGCCTGTTGGCGCGAGGCTTTCGATGCCATGGCGGCGGGGGACCTGATCGGAAAAGTA
GTGCTGGAGCCGTAA

Upstream 100 bases:

>100_bases
CTGCGCGCCGACGACCCGGCGCTGGTAGCAAAATGGGGCGGTGATGCGCCGCATGAAACCTTTGCCGCGTTAAGGGCGGG
CAAGGACAATTTCTGACACC

Downstream 100 bases:

>100_bases
TGTGACCTCAGGCCTGTAGGGCCGATCGCCCTGAGCCTGTCGAAGGGCAGCCCCAGCATTCGCTCCAAGTGGCGGCGCCG
TGGCTGGGCTTCGACAAGCT

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKALRVQHLSDDLSGVELVDLPQPERKQGEVLVLVRAASLNYPDLLMTQGKYQFKPEPPFTSGMELAGKVLEADSDSGFA
PGDRVMGGAKTGGFAETAVAPARALRRIPDGVSLATAAAMGAAYSTAYTGLVELGGLEASQSVLVHGASGGVGLAACDLA
KALGATVIAATHREDKLEALEAASGADHVILNHGRFREQVGDLTGGTLCDLVFDPVGGDVFDESTRCVAFGGKLLVVGFV
AGRIPEIAVNIPLIKGFSVVGVRAGEYARRFPDRGARIMGELDKLAVSGAITPHIDRTLPLACWREAFDAMAAGDLIGKV
VLEP

Sequences:

>Translated_324_residues
MKALRVQHLSDDLSGVELVDLPQPERKQGEVLVLVRAASLNYPDLLMTQGKYQFKPEPPFTSGMELAGKVLEADSDSGFA
PGDRVMGGAKTGGFAETAVAPARALRRIPDGVSLATAAAMGAAYSTAYTGLVELGGLEASQSVLVHGASGGVGLAACDLA
KALGATVIAATHREDKLEALEAASGADHVILNHGRFREQVGDLTGGTLCDLVFDPVGGDVFDESTRCVAFGGKLLVVGFV
AGRIPEIAVNIPLIKGFSVVGVRAGEYARRFPDRGARIMGELDKLAVSGAITPHIDRTLPLACWREAFDAMAAGDLIGKV
VLEP
>Mature_324_residues
MKALRVQHLSDDLSGVELVDLPQPERKQGEVLVLVRAASLNYPDLLMTQGKYQFKPEPPFTSGMELAGKVLEADSDSGFA
PGDRVMGGAKTGGFAETAVAPARALRRIPDGVSLATAAAMGAAYSTAYTGLVELGGLEASQSVLVHGASGGVGLAACDLA
KALGATVIAATHREDKLEALEAASGADHVILNHGRFREQVGDLTGGTLCDLVFDPVGGDVFDESTRCVAFGGKLLVVGFV
AGRIPEIAVNIPLIKGFSVVGVRAGEYARRFPDRGARIMGELDKLAVSGAITPHIDRTLPLACWREAFDAMAAGDLIGKV
VLEP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=333, Percent_Identity=30.6306306306306, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI13236495, Length=333, Percent_Identity=30.6306306306306, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI22538446, Length=317, Percent_Identity=28.7066246056782, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI22538444, Length=317, Percent_Identity=28.7066246056782, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI194239676, Length=200, Percent_Identity=37, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI18379349, Length=314, Percent_Identity=29.6178343949045, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI24308257, Length=209, Percent_Identity=32.5358851674641, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI67078404, Length=329, Percent_Identity=27.6595744680851, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI67078406, Length=293, Percent_Identity=27.6450511945392, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI41872631, Length=310, Percent_Identity=29.0322580645161, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI28557745, Length=351, Percent_Identity=30.1994301994302, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI47519420, Length=332, Percent_Identity=28.0120481927711, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1790485, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789651, Length=200, Percent_Identity=32.5, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556000, Length=301, Percent_Identity=27.906976744186, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=146, Percent_Identity=38.3561643835616, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71987554, Length=358, Percent_Identity=25.6983240223464, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=324, Percent_Identity=26.5432098765432, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=25.8823529411765, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330659, Length=309, Percent_Identity=26.8608414239482, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19920632, Length=309, Percent_Identity=26.8608414239482, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581345, Length=338, Percent_Identity=27.5147928994083, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550423, Length=319, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 33703; Mature: 33703

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALRVQHLSDDLSGVELVDLPQPERKQGEVLVLVRAASLNYPDLLMTQGKYQFKPEPPF
CCCCCHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCHHEEECCCEEECCCCCC
TSGMELAGKVLEADSDSGFAPGDRVMGGAKTGGFAETAVAPARALRRIPDGVSLATAAAM
CCCHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
GAAYSTAYTGLVELGGLEASQSVLVHGASGGVGLAACDLAKALGATVIAATHREDKLEAL
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHH
EAASGADHVILNHGRFREQVGDLTGGTLCDLVFDPVGGDVFDESTRCVAFGGKLLVVGFV
HHCCCCCEEEECCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCEEEEEHH
AGRIPEIAVNIPLIKGFSVVGVRAGEYARRFPDRGARIMGELDKLAVSGAITPHIDRTLP
HCCCCEEEEECEEECCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
LACWREAFDAMAAGDLIGKVVLEP
HHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MKALRVQHLSDDLSGVELVDLPQPERKQGEVLVLVRAASLNYPDLLMTQGKYQFKPEPPF
CCCCCHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCHHEEECCCEEECCCCCC
TSGMELAGKVLEADSDSGFAPGDRVMGGAKTGGFAETAVAPARALRRIPDGVSLATAAAM
CCCHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
GAAYSTAYTGLVELGGLEASQSVLVHGASGGVGLAACDLAKALGATVIAATHREDKLEAL
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHH
EAASGADHVILNHGRFREQVGDLTGGTLCDLVFDPVGGDVFDESTRCVAFGGKLLVVGFV
HHCCCCCEEEECCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCEEEEEHH
AGRIPEIAVNIPLIKGFSVVGVRAGEYARRFPDRGARIMGELDKLAVSGAITPHIDRTLP
HCCCCEEEEECEEECCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
LACWREAFDAMAAGDLIGKVVLEP
HHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]