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The map label for this gene is moaB [H]

Identifier: 85374216

GI number: 85374216

Start: 1440775

End: 1441302

Strand: Direct

Name: moaB [H]

Synonym: ELI_06945

Alternate gene names: 85374216

Gene position: 1440775-1441302 (Clockwise)

Preceding gene: 85374215

Following gene: 85374217

Centisome position: 47.2

GC content: 63.07

Gene sequence:

>528_bases
ATGGGAATCGACAAAAGTCTCGACTTCAAATCGGTGCGCATTGCACTGCTGACGATCTCCGACACGCGCACTTTCGACGA
TGACACATCGGGCGACATCCTTGCCGGGAGGATCGAGAAGAAGGGCCACGAACTGGTCGCCCGCGAAATCAGCCGCGACA
GTGTCGAGGAAATCGCCGCACACCTGCATCGCTGGATCGACGATCCGGAGATCGACGCGATCGTCACCACCGGCGGCACC
GGGCTGACGGGCCGCGATGTGACGCCAGAAGCGCTCGACCGCGTGAAGAGCAAGGACATCCCGGGTTTCGGCGAGCTGTT
CCGGTGGCTCAGCTACGAGAAGATCGGCACCAGCACGCTGCAATCGCGCGCCTGCGCCGTCGTCGCACGCGGCACCTATA
TCTTCGCCTTGCCCGGCTCCAATGGCGCGGTGAAAGACGGCTGGGACGGCATCCTCGATGCCCAGCTCGACAGCCGCCAC
AGACCCTGCAACTTCGTCGAACTCATGCCGCGCCTGAGAGAACGCTAG

Upstream 100 bases:

>100_bases
ATGCCGACAGCTCCAGCCGCAAGGCGTTGGCAGAGGGCAAGTGGCCGACTTTCCCCGAGGTCAGCGGCGCAACCGGTGTG
CGGATGGCCTCCGCCAACTG

Downstream 100 bases:

>100_bases
GCCTTTCGGAACCGGCGCCAGCGCTCTGCGCTTTAGCCATGTGCCCGAATTCGCGAGCCTTACCACCACCACGCTTGCCC
TGCTGTTCGCCGGATCGGCA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MGIDKSLDFKSVRIALLTISDTRTFDDDTSGDILAGRIEKKGHELVAREISRDSVEEIAAHLHRWIDDPEIDAIVTTGGT
GLTGRDVTPEALDRVKSKDIPGFGELFRWLSYEKIGTSTLQSRACAVVARGTYIFALPGSNGAVKDGWDGILDAQLDSRH
RPCNFVELMPRLRER

Sequences:

>Translated_175_residues
MGIDKSLDFKSVRIALLTISDTRTFDDDTSGDILAGRIEKKGHELVAREISRDSVEEIAAHLHRWIDDPEIDAIVTTGGT
GLTGRDVTPEALDRVKSKDIPGFGELFRWLSYEKIGTSTLQSRACAVVARGTYIFALPGSNGAVKDGWDGILDAQLDSRH
RPCNFVELMPRLRER
>Mature_174_residues
GIDKSLDFKSVRIALLTISDTRTFDDDTSGDILAGRIEKKGHELVAREISRDSVEEIAAHLHRWIDDPEIDAIVTTGGTG
LTGRDVTPEALDRVKSKDIPGFGELFRWLSYEKIGTSTLQSRACAVVARGTYIFALPGSNGAVKDGWDGILDAQLDSRHR
PCNFVELMPRLRER

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=149, Percent_Identity=33.5570469798658, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI66932975, Length=149, Percent_Identity=33.5570469798658, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1787000, Length=160, Percent_Identity=47.5, Blast_Score=151, Evalue=2e-38,
Organism=Escherichia coli, GI1786190, Length=98, Percent_Identity=36.734693877551, Blast_Score=67, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136978, Length=147, Percent_Identity=38.0952380952381, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24638841, Length=147, Percent_Identity=38.0952380952381, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19368; Mature: 19237

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIDKSLDFKSVRIALLTISDTRTFDDDTSGDILAGRIEKKGHELVAREISRDSVEEIAA
CCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHH
HLHRWIDDPEIDAIVTTGGTGLTGRDVTPEALDRVKSKDIPGFGELFRWLSYEKIGTSTL
HHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHH
QSRACAVVARGTYIFALPGSNGAVKDGWDGILDAQLDSRHRPCNFVELMPRLRER
HHHHEEEEECCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
GIDKSLDFKSVRIALLTISDTRTFDDDTSGDILAGRIEKKGHELVAREISRDSVEEIAA
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCHHHHHHHHH
HLHRWIDDPEIDAIVTTGGTGLTGRDVTPEALDRVKSKDIPGFGELFRWLSYEKIGTSTL
HHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHH
QSRACAVVARGTYIFALPGSNGAVKDGWDGILDAQLDSRHRPCNFVELMPRLRER
HHHHEEEEECCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]