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The map label for this gene is gyrA [H]

Identifier: 85374095

GI number: 85374095

Start: 1317152

End: 1319947

Strand: Direct

Name: gyrA [H]

Synonym: ELI_06340

Alternate gene names: 85374095

Gene position: 1317152-1319947 (Clockwise)

Preceding gene: 85374093

Following gene: 85374096

Centisome position: 43.15

GC content: 63.13

Gene sequence:

>2796_bases
ATGGGAGACTACGAACGCATCGACATCGTCGATGAGATGAAGACGAGCTACCTCGATTACGCGATGAGCGTGATCGTGAG
CCGCGCGCTGCCCGATGTGCGCGACGGGCTGAAGCCGGTCCACCGCCGTATCCTGTTTGCCTCCAAGGAAGGCGGCTTCG
TCGCCGGGCGTCCCTATCGCAAGAGCGCCAAGATCGTTGGCGACGTGATGGGCAATTATCACCCGCATGGCGACAGCGCG
ATTTACGATGCGCTGGCGCGCATGACGCAGGACTGGTCGCTGCGGGTGCCGCTGATCGATGGTCAGGGCAATTTCGGCTC
GATGGACCCCGATCCGCCGGCGAGCATGCGCTATACCGAAGCGCGGTTGGCCAAGGTTGCCAACGCTCTGCTCGACGATC
TCGACAAGGATACGGTCGACTTTTCCGACAATTACGACGGCTCGCTCAAGGAGCCGCAGGTCCTCCCCGCCCGCTTCCCC
AACCTGCTCGTCAACGGTGCAGGCGGGATCGCGGTCGGCATGGCGACCAATGTCCCGCCGCACAATCTCGGCGAAGTGAT
CGACGGCTGCCTCGCCTTCATCGCAAATCCGGCGATCACCAGCGAAGAGCTGATGCAGTACATACCGGGGCCGGACTTCC
CGACCGCGCCGCTGATCCTCGGCCAGGCCGGTGCCCGCGCGGCCTACACCACCGGGCGAGGCTCGGTACTGATGCGTGCG
CGGCACGAGATCGAAGAGAAGCGCGGCGACCGCAAATCGATCGTCTTCACATCGATCCCCTACCAGGTCGGCAAGTCCGG
GCTGGTCGAAAAGATCGCCGACGCCGCCAAGGAAAAGCGCATCGAAGGCATTTCCGACATTCGCGACGAAAGCTCGCGCG
AAGGTGTGCGGGTCGTCGTCGATCTGAAGCGCGATGCTTCGCCCGAAGTCGTGCTCAACCAGATCTGGCGCTACACGCCT
GCGCAGGCGAGCTTCCCCGCCAACATGCTGGCGATCAAGGGCGGCAGGCCCGAAGTCCTCACCTTGCGCGACATCGTGCA
AGCCTTCGTCAGCTTCCGCGAAGAAGTCATTACTCGTCGCACCAAATTTGAGCTGAATAAGGCCCGCGAACGCGCGCATG
TCTTGCTCGGCCTCGTGGTGGCCGTCTCCAACCTCGACGAAGTCGTGGCGATGATCCGTGGGTCGTCCAATCCACAGATC
GCTCGCGAGAAACTGCGCGCGAAACTATGGCCGATCGGCGATATCGCGCAGTATATCCAGCTGATCGAAGCCATCGAGCC
GACTGCGGACCAGGAAGGCGGCACTTACCAGCTCAGCGAGCGGCAGGTGAAAGCGATCCTCGACCTACGCCTGCACCGTC
TGACCGCGCTCGGGCGCGATGAGATTGGTGACGAGCTCAAGGAATTGGCCAGCGAGATCGAGGAATATCTCTCGATTCTT
GCCGATCGCGGGAAGCTTTTCGGTGTGCTTCAGGACGAGCTGGTCGAGATCAAGGACGAATACGCCACCCCGCGCGTGTC
CGAGATCGCACCGGCCTGGGACGGTCTCGAAGACGAGGACCTGATCGCGCGCGAGGACATGGTCGTGACCGTCACCCATG
GGGGTTACATCAAGCGCACCCCGCTTGCGACCTTCCGCGCACAGGCGCGTGGCGGCAAGGGCCGCAGCGGCATGGCGACC
AAGGACGAAGACGCGGTCGTCGAGCTGTTCGTCACCAGCACGCACAATCCGGTGCTGTTTTTCACCAATCTCGGCCGGGT
CTATCGTATGAAGGTGTGGAAGCTGCCCGAGGGCAGCCCGACCACCAAGGGCCGCCCGATGGTCAACCTGCTGCCGCTGG
GCGACGACGAGCGTGTGACCAACGTCCTGTCCTTGCCCGAGGACGAGGAAAGCTGGGCCGCGCTCAATATCGTGTTCGCG
ACCGAGCAGGGCATGGTGCGCCGCAATTCGATGGATGCCTTCACCAACGTGCCCACGGGCGGCAAATACGCCATGGGCTT
CGTCGAAGGCACCGGTGACCGGTTGATCGGCGTCGAATTGCTGAGCGAAGACCAGGAAATCTTCCTCGCCTCCGATGCCG
GCAAGGCCATCCGTTTCGCCGCCACCGATGCGCGCGAGACCAAGAGCCGCACCGGGATCGGCGTGCGCGGGATGACGCTC
AAGGACGATGCCAAGGTCGTTTCCATGGCGGTGTTGGACCGTCTGGAGCAGGACATGGAGACCCGCGAGGCGTATCTGCG
CGCTGCGATCTGGAAGAACAACGATGCCGAGCATACACTCGATAGCGACAAGGTCGCGCAGATGGAGGAAGGCGAGGAAT
TCATCCTGACGCTGACCGCCAATGGCTATGGCAAGATCTCCTCCGCCTACGAATACCGCACCATCGGTCGCGGGGGCCAG
GGTCTCGCCAATATCGGCACTCCGGACAGCAATCCCGAGCGGAATGGCCCGGTCGTGGCCAGCTTCCCGGTCAAGCACGG
CTCGCAGTTGATGCTGGTGACCGATCAGGCCAAGCTGATCCGCATGCCGATCGAATTCCGCCATATGGTCGAGGGCGGAT
TCGAAGAACACAAGGGCTGGTCCGTTTACGGCCGCACTTCCTCGGGCGTGCGCGTGTTCGATGTCGCCAAGGGCGAGCAT
ATCGTCGGCGCAGCGATCATCGACGAGACCGAGGAACCGGAGAACGAGGCCGAAGAGGCCGTCGTCGAAGGTATGGTCGG
TCGCGGGGCCGAAGAGACAGCGCCCGACCCCACCATGGATCGCGACAGCAACGAGGGCGAGGCACCGCCCGAATGA

Upstream 100 bases:

>100_bases
TGCATCCCCTAATCTCCAGCGCAGCAGATTTGGCCGCAATCATGAGCGGAATGAACACGTTTTGAGCGACGATACAGACA
CCCTTCCCCCGCCGTCTCCC

Downstream 100 bases:

>100_bases
GCATGATCGTCGAGCCGTCCGGACAGGCCTGCGGCGCCACGATACGCGGCGTCGATCTGTCCGGAAAGCTCGATGACGCG
CTGATTACCGATGTCCGATC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 931; Mature: 930

Protein sequence:

>931_residues
MGDYERIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILFASKEGGFVAGRPYRKSAKIVGDVMGNYHPHGDSA
IYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKVANALLDDLDKDTVDFSDNYDGSLKEPQVLPARFP
NLLVNGAGGIAVGMATNVPPHNLGEVIDGCLAFIANPAITSEELMQYIPGPDFPTAPLILGQAGARAAYTTGRGSVLMRA
RHEIEEKRGDRKSIVFTSIPYQVGKSGLVEKIADAAKEKRIEGISDIRDESSREGVRVVVDLKRDASPEVVLNQIWRYTP
AQASFPANMLAIKGGRPEVLTLRDIVQAFVSFREEVITRRTKFELNKARERAHVLLGLVVAVSNLDEVVAMIRGSSNPQI
AREKLRAKLWPIGDIAQYIQLIEAIEPTADQEGGTYQLSERQVKAILDLRLHRLTALGRDEIGDELKELASEIEEYLSIL
ADRGKLFGVLQDELVEIKDEYATPRVSEIAPAWDGLEDEDLIAREDMVVTVTHGGYIKRTPLATFRAQARGGKGRSGMAT
KDEDAVVELFVTSTHNPVLFFTNLGRVYRMKVWKLPEGSPTTKGRPMVNLLPLGDDERVTNVLSLPEDEESWAALNIVFA
TEQGMVRRNSMDAFTNVPTGGKYAMGFVEGTGDRLIGVELLSEDQEIFLASDAGKAIRFAATDARETKSRTGIGVRGMTL
KDDAKVVSMAVLDRLEQDMETREAYLRAAIWKNNDAEHTLDSDKVAQMEEGEEFILTLTANGYGKISSAYEYRTIGRGGQ
GLANIGTPDSNPERNGPVVASFPVKHGSQLMLVTDQAKLIRMPIEFRHMVEGGFEEHKGWSVYGRTSSGVRVFDVAKGEH
IVGAAIIDETEEPENEAEEAVVEGMVGRGAEETAPDPTMDRDSNEGEAPPE

Sequences:

>Translated_931_residues
MGDYERIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILFASKEGGFVAGRPYRKSAKIVGDVMGNYHPHGDSA
IYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKVANALLDDLDKDTVDFSDNYDGSLKEPQVLPARFP
NLLVNGAGGIAVGMATNVPPHNLGEVIDGCLAFIANPAITSEELMQYIPGPDFPTAPLILGQAGARAAYTTGRGSVLMRA
RHEIEEKRGDRKSIVFTSIPYQVGKSGLVEKIADAAKEKRIEGISDIRDESSREGVRVVVDLKRDASPEVVLNQIWRYTP
AQASFPANMLAIKGGRPEVLTLRDIVQAFVSFREEVITRRTKFELNKARERAHVLLGLVVAVSNLDEVVAMIRGSSNPQI
AREKLRAKLWPIGDIAQYIQLIEAIEPTADQEGGTYQLSERQVKAILDLRLHRLTALGRDEIGDELKELASEIEEYLSIL
ADRGKLFGVLQDELVEIKDEYATPRVSEIAPAWDGLEDEDLIAREDMVVTVTHGGYIKRTPLATFRAQARGGKGRSGMAT
KDEDAVVELFVTSTHNPVLFFTNLGRVYRMKVWKLPEGSPTTKGRPMVNLLPLGDDERVTNVLSLPEDEESWAALNIVFA
TEQGMVRRNSMDAFTNVPTGGKYAMGFVEGTGDRLIGVELLSEDQEIFLASDAGKAIRFAATDARETKSRTGIGVRGMTL
KDDAKVVSMAVLDRLEQDMETREAYLRAAIWKNNDAEHTLDSDKVAQMEEGEEFILTLTANGYGKISSAYEYRTIGRGGQ
GLANIGTPDSNPERNGPVVASFPVKHGSQLMLVTDQAKLIRMPIEFRHMVEGGFEEHKGWSVYGRTSSGVRVFDVAKGEH
IVGAAIIDETEEPENEAEEAVVEGMVGRGAEETAPDPTMDRDSNEGEAPPE
>Mature_930_residues
GDYERIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILFASKEGGFVAGRPYRKSAKIVGDVMGNYHPHGDSAI
YDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKVANALLDDLDKDTVDFSDNYDGSLKEPQVLPARFPN
LLVNGAGGIAVGMATNVPPHNLGEVIDGCLAFIANPAITSEELMQYIPGPDFPTAPLILGQAGARAAYTTGRGSVLMRAR
HEIEEKRGDRKSIVFTSIPYQVGKSGLVEKIADAAKEKRIEGISDIRDESSREGVRVVVDLKRDASPEVVLNQIWRYTPA
QASFPANMLAIKGGRPEVLTLRDIVQAFVSFREEVITRRTKFELNKARERAHVLLGLVVAVSNLDEVVAMIRGSSNPQIA
REKLRAKLWPIGDIAQYIQLIEAIEPTADQEGGTYQLSERQVKAILDLRLHRLTALGRDEIGDELKELASEIEEYLSILA
DRGKLFGVLQDELVEIKDEYATPRVSEIAPAWDGLEDEDLIAREDMVVTVTHGGYIKRTPLATFRAQARGGKGRSGMATK
DEDAVVELFVTSTHNPVLFFTNLGRVYRMKVWKLPEGSPTTKGRPMVNLLPLGDDERVTNVLSLPEDEESWAALNIVFAT
EQGMVRRNSMDAFTNVPTGGKYAMGFVEGTGDRLIGVELLSEDQEIFLASDAGKAIRFAATDARETKSRTGIGVRGMTLK
DDAKVVSMAVLDRLEQDMETREAYLRAAIWKNNDAEHTLDSDKVAQMEEGEEFILTLTANGYGKISSAYEYRTIGRGGQG
LANIGTPDSNPERNGPVVASFPVKHGSQLMLVTDQAKLIRMPIEFRHMVEGGFEEHKGWSVYGRTSSGVRVFDVAKGEHI
VGAAIIDETEEPENEAEEAVVEGMVGRGAEETAPDPTMDRDSNEGEAPPE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1788562, Length=927, Percent_Identity=44.8759439050701, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=715, Percent_Identity=33.4265734265734, Blast_Score=362, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 102333; Mature: 102202

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDYERIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILFASKEGGFVAGRPYR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCEEECCCCC
KSAKIVGDVMGNYHPHGDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHH
ARLAKVANALLDDLDKDTVDFSDNYDGSLKEPQVLPARFPNLLVNGAGGIAVGMATNVPP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCEEEEEECCCCC
HNLGEVIDGCLAFIANPAITSEELMQYIPGPDFPTAPLILGQAGARAAYTTGRGSVLMRA
CHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHH
RHEIEEKRGDRKSIVFTSIPYQVGKSGLVEKIADAAKEKRIEGISDIRDESSREGVRVVV
HHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEE
DLKRDASPEVVLNQIWRYTPAQASFPANMLAIKGGRPEVLTLRDIVQAFVSFREEVITRR
EECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHH
TKFELNKARERAHVLLGLVVAVSNLDEVVAMIRGSSNPQIAREKLRAKLWPIGDIAQYIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
LIEAIEPTADQEGGTYQLSERQVKAILDLRLHRLTALGRDEIGDELKELASEIEEYLSIL
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ADRGKLFGVLQDELVEIKDEYATPRVSEIAPAWDGLEDEDLIAREDMVVTVTHGGYIKRT
HCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEECCCEEEEEECCCEEEEC
PLATFRAQARGGKGRSGMATKDEDAVVELFVTSTHNPVLFFTNLGRVYRMKVWKLPEGSP
CHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEEEEECCCCCC
TTKGRPMVNLLPLGDDERVTNVLSLPEDEESWAALNIVFATEQGMVRRNSMDAFTNVPTG
CCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHCCCHHHHCCCCC
GKYAMGFVEGTGDRLIGVELLSEDQEIFLASDAGKAIRFAATDARETKSRTGIGVRGMTL
CCEEEEEEECCCCCEEEEEEECCCCEEEEECCCCCEEEEEECCCHHHHHHCCCCEECCEE
KDDAKVVSMAVLDRLEQDMETREAYLRAAIWKNNDAEHTLDSDKVAQMEEGEEFILTLTA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEEC
NGYGKISSAYEYRTIGRGGQGLANIGTPDSNPERNGPVVASFPVKHGSQLMLVTDQAKLI
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCHHEE
RMPIEFRHMVEGGFEEHKGWSVYGRTSSGVRVFDVAKGEHIVGAAIIDETEEPENEAEEA
ECCHHHHHHHHCCHHHCCCEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHHH
VVEGMVGRGAEETAPDPTMDRDSNEGEAPPE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GDYERIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILFASKEGGFVAGRPYR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCEEECCCCC
KSAKIVGDVMGNYHPHGDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHH
ARLAKVANALLDDLDKDTVDFSDNYDGSLKEPQVLPARFPNLLVNGAGGIAVGMATNVPP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCEEEEEECCCCC
HNLGEVIDGCLAFIANPAITSEELMQYIPGPDFPTAPLILGQAGARAAYTTGRGSVLMRA
CHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHH
RHEIEEKRGDRKSIVFTSIPYQVGKSGLVEKIADAAKEKRIEGISDIRDESSREGVRVVV
HHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEE
DLKRDASPEVVLNQIWRYTPAQASFPANMLAIKGGRPEVLTLRDIVQAFVSFREEVITRR
EECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHH
TKFELNKARERAHVLLGLVVAVSNLDEVVAMIRGSSNPQIAREKLRAKLWPIGDIAQYIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
LIEAIEPTADQEGGTYQLSERQVKAILDLRLHRLTALGRDEIGDELKELASEIEEYLSIL
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ADRGKLFGVLQDELVEIKDEYATPRVSEIAPAWDGLEDEDLIAREDMVVTVTHGGYIKRT
HCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEECCCEEEEEECCCEEEEC
PLATFRAQARGGKGRSGMATKDEDAVVELFVTSTHNPVLFFTNLGRVYRMKVWKLPEGSP
CHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEEEEECCCCCC
TTKGRPMVNLLPLGDDERVTNVLSLPEDEESWAALNIVFATEQGMVRRNSMDAFTNVPTG
CCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHCCCHHHHCCCCC
GKYAMGFVEGTGDRLIGVELLSEDQEIFLASDAGKAIRFAATDARETKSRTGIGVRGMTL
CCEEEEEEECCCCCEEEEEEECCCCEEEEECCCCCEEEEEECCCHHHHHHCCCCEECCEE
KDDAKVVSMAVLDRLEQDMETREAYLRAAIWKNNDAEHTLDSDKVAQMEEGEEFILTLTA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEEC
NGYGKISSAYEYRTIGRGGQGLANIGTPDSNPERNGPVVASFPVKHGSQLMLVTDQAKLI
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCHHEE
RMPIEFRHMVEGGFEEHKGWSVYGRTSSGVRVFDVAKGEHIVGAAIIDETEEPENEAEEA
ECCHHHHHHHHCCHHHCCCEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHHH
VVEGMVGRGAEETAPDPTMDRDSNEGEAPPE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA