Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 85373274

GI number: 85373274

Start: 485671

End: 487980

Strand: Direct

Name: parC [H]

Synonym: ELI_02235

Alternate gene names: 85373274

Gene position: 485671-487980 (Clockwise)

Preceding gene: 85373273

Following gene: 85373281

Centisome position: 15.91

GC content: 63.85

Gene sequence:

>2310_bases
ATGTCCGACCCGACCGAAATCACTGAACCCGATCCCTTCGATGCCATCGTCGATGCGCCATTCGATTCTGCGCTGGAAGA
GCGCTATCTTGTCTATGCGCTCTCGACCATCACGGCGCGCTCGCTGCCCGATCTGCGCGACGGGTTGAAGCCGGTCCATC
GCCGCTTGCTGTGGACCATGCGGCAGTTGAAGCTGGACCCGACCAACACCTTCAAGAAAAGCGCCCGCGTCGTCGGCGAG
GTGATCGGTAAGTACCACCCGCATGGCGATACCGCGGCCTATGATGCCATGGTCCGCCTCGCGCAGGATTTCGCGCTGCG
TTATCCGCTGGTCGAGGGGCAGGGGAATTTCGGCAATATCGATGGCGATAACGCCGCTGCCTATCGCTACACCGAAGCGC
GGCTGACCCGCACCGCCATGGCGCTGATGGCCGGTCTGGACGAAGGCACGGTCGATTTCATCCCGACCTATAATGGCGAG
GAGGAGGAGCCGGAACTGATGCCGGGCCTGTTCCCCAACCTGCTGGCCAATGGCGCAAGCGGGATCGCGGTGGGGATGGC
GACCAATATCCCCAGCCACAATGTCCATGAAATCATCGACGCAACGCTGGAGCTGATCGACAACCCTCATGTCGAGCACG
CGCGGCTGATGGAGCTATTCCAGGGGCCGGACCTGCCGACCGGCGGCTTGATTGTCGATAGCCCGGAGGTAATCTCCAAC
GCCTATGAAACCGGGCGCGGGTCTTTCCGCATCCGTGGGCGGTTCCATGCGGCGGAGGCGGAGAAACAGGCGGACCAAGG
CGCCGGGATCGAGCGGCTCGGCGGCGGGCAATGGCAGCTCGTCATCTCCGAAATCCCCTACCAGGTGCAGAAGGGCAAGC
TGATCGAGCAGATCGCGCAGGCGATCGCCGACAAGAAGCTGCCGATCCTCGACGATGTCCGCGACGAAAGCGACGAGCAG
ATCCGCATCGTGCTGGTGCCGCGCAGTCGCAATATCGATCCCGAACTGCTCAAGGAATCAATCTACAAGCTGACCGACAT
GGAAACCCGTTTCGGGCTCAACTTGAACGTGCTCGATGCCACCCGCACGCCGATGGTGATGGGGCTGAAGGAGCTGCTGG
AAAACTGGGTCCGCAGCCAGATCGAGATCCTGCAGCGGCGCACGCAGCACCGGCTCGACCAGATCGCGCGGCGGCTGGAG
CTGGTCGAAGGCTATATCATCGCCTTCCTCAATCTCGACCGGGTGATCGAGATCATCCGCTACGAGGACGAGCCGAAGCA
GGTGATGATGGCGGAATTCAGCCTCACCGACCGGCAGGCCGAAGCGATCCTCAACATGCGGCTGCGCAGCTTGCGCAAGC
TGGAGGAGATGGAGCTCAAGCAGGAGAAGACCGACCTGCTGGCCGAGCAGGAAGAGCTGGAGAAGCTGCTCGGCTCGCCT
GCGCGCCAGCGCACGCGACTGAAGCGCGACCTGAAGGCGCTGCAGAAGGAATACGGGCTCGACACAGAATTGGGCGCACG
CCGCACGACCATCGCCGAGGCCGAGCCGACCGTAGAATTCAGCATGGACGCGATGATCGAGAAGGAGCCGGTCACCGTAG
TGCTGAGCCAGAAAGGCTGGGTCCGCGCCGCCAAGGGCCATGTCGACCTGGAAGGCAGCAAGGACGGGTGCGGCGATTTC
AAGTACAAGGAAGGCGATGGCCCGGCCTTTGCCGTCCATTGCCAGACCACCGACAAGGTGCTGCTCGCCGCCGACAACGG
GCGCTTCTTCACGCTGGGCGCGGACAAGCTCCCCGGTGCGCGCGGCTTCGGCGAGCCGGTGCGCAACACGCTCGACATCG
ATGCCGAAGCGCAGATCGTGGCCATGCTGGTGAGCAATCCCAGGGGCCGGCTGCTGCTGGCAGCGGATACTGGCAAGGGT
TTCGCGGCGGAGATGGGCGAACTGGTCGCCGAGACCCGCAAGGGCAAGCAGGTCGTCAACCTCAAGGGCGATGCGAAGCT
GCGCGTCGTCCGCCCGATTGCAGATTGCGACGATCACGTCGCCGTGGTGGGCGAAAACCGCAAGCTGGTCGTGTTCAATC
TCGAGGAGCTACCGGTGCTCGCCCGCGGGCAGGGCGTGCAATTACAGCGCTATCGCGACGGCGGATTGTCCGATGCCAAG
ACCTTCGTGCTCGACCAGGGCCTGAGCTGGCAGATGGGCGGCAAGGGCGACCGGACCCGGACCGAGACCGATATCTGGCA
ATGGAAGGTCGCGCGCGGCGGAGCCGGGCGCTTGCCGCCGCAGGGCTTCCCCAGAGACAACCGGTTCTGA

Upstream 100 bases:

>100_bases
TAGAGCGTCTGCGAGAAATCGAGGTCAGCAATTCATGCTCTCCCAATCCTGTGGAAACCCCTCTCCCTAGCTGCGCGCCG
CCTTGCTAGACGGGCGGCCA

Downstream 100 bases:

>100_bases
CGACCCCCTCTCCTGACCGAGAATCAAGAAGGGCCGCCGACGCCAGAGGCGCGACGACCCTTCCGATGCGACCCGAGGGC
TAACCCTTGCAGGGAGGCGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MSDPTEITEPDPFDAIVDAPFDSALEERYLVYALSTITARSLPDLRDGLKPVHRRLLWTMRQLKLDPTNTFKKSARVVGE
VIGKYHPHGDTAAYDAMVRLAQDFALRYPLVEGQGNFGNIDGDNAAAYRYTEARLTRTAMALMAGLDEGTVDFIPTYNGE
EEEPELMPGLFPNLLANGASGIAVGMATNIPSHNVHEIIDATLELIDNPHVEHARLMELFQGPDLPTGGLIVDSPEVISN
AYETGRGSFRIRGRFHAAEAEKQADQGAGIERLGGGQWQLVISEIPYQVQKGKLIEQIAQAIADKKLPILDDVRDESDEQ
IRIVLVPRSRNIDPELLKESIYKLTDMETRFGLNLNVLDATRTPMVMGLKELLENWVRSQIEILQRRTQHRLDQIARRLE
LVEGYIIAFLNLDRVIEIIRYEDEPKQVMMAEFSLTDRQAEAILNMRLRSLRKLEEMELKQEKTDLLAEQEELEKLLGSP
ARQRTRLKRDLKALQKEYGLDTELGARRTTIAEAEPTVEFSMDAMIEKEPVTVVLSQKGWVRAAKGHVDLEGSKDGCGDF
KYKEGDGPAFAVHCQTTDKVLLAADNGRFFTLGADKLPGARGFGEPVRNTLDIDAEAQIVAMLVSNPRGRLLLAADTGKG
FAAEMGELVAETRKGKQVVNLKGDAKLRVVRPIADCDDHVAVVGENRKLVVFNLEELPVLARGQGVQLQRYRDGGLSDAK
TFVLDQGLSWQMGGKGDRTRTETDIWQWKVARGGAGRLPPQGFPRDNRF

Sequences:

>Translated_769_residues
MSDPTEITEPDPFDAIVDAPFDSALEERYLVYALSTITARSLPDLRDGLKPVHRRLLWTMRQLKLDPTNTFKKSARVVGE
VIGKYHPHGDTAAYDAMVRLAQDFALRYPLVEGQGNFGNIDGDNAAAYRYTEARLTRTAMALMAGLDEGTVDFIPTYNGE
EEEPELMPGLFPNLLANGASGIAVGMATNIPSHNVHEIIDATLELIDNPHVEHARLMELFQGPDLPTGGLIVDSPEVISN
AYETGRGSFRIRGRFHAAEAEKQADQGAGIERLGGGQWQLVISEIPYQVQKGKLIEQIAQAIADKKLPILDDVRDESDEQ
IRIVLVPRSRNIDPELLKESIYKLTDMETRFGLNLNVLDATRTPMVMGLKELLENWVRSQIEILQRRTQHRLDQIARRLE
LVEGYIIAFLNLDRVIEIIRYEDEPKQVMMAEFSLTDRQAEAILNMRLRSLRKLEEMELKQEKTDLLAEQEELEKLLGSP
ARQRTRLKRDLKALQKEYGLDTELGARRTTIAEAEPTVEFSMDAMIEKEPVTVVLSQKGWVRAAKGHVDLEGSKDGCGDF
KYKEGDGPAFAVHCQTTDKVLLAADNGRFFTLGADKLPGARGFGEPVRNTLDIDAEAQIVAMLVSNPRGRLLLAADTGKG
FAAEMGELVAETRKGKQVVNLKGDAKLRVVRPIADCDDHVAVVGENRKLVVFNLEELPVLARGQGVQLQRYRDGGLSDAK
TFVLDQGLSWQMGGKGDRTRTETDIWQWKVARGGAGRLPPQGFPRDNRF
>Mature_768_residues
SDPTEITEPDPFDAIVDAPFDSALEERYLVYALSTITARSLPDLRDGLKPVHRRLLWTMRQLKLDPTNTFKKSARVVGEV
IGKYHPHGDTAAYDAMVRLAQDFALRYPLVEGQGNFGNIDGDNAAAYRYTEARLTRTAMALMAGLDEGTVDFIPTYNGEE
EEPELMPGLFPNLLANGASGIAVGMATNIPSHNVHEIIDATLELIDNPHVEHARLMELFQGPDLPTGGLIVDSPEVISNA
YETGRGSFRIRGRFHAAEAEKQADQGAGIERLGGGQWQLVISEIPYQVQKGKLIEQIAQAIADKKLPILDDVRDESDEQI
RIVLVPRSRNIDPELLKESIYKLTDMETRFGLNLNVLDATRTPMVMGLKELLENWVRSQIEILQRRTQHRLDQIARRLEL
VEGYIIAFLNLDRVIEIIRYEDEPKQVMMAEFSLTDRQAEAILNMRLRSLRKLEEMELKQEKTDLLAEQEELEKLLGSPA
RQRTRLKRDLKALQKEYGLDTELGARRTTIAEAEPTVEFSMDAMIEKEPVTVVLSQKGWVRAAKGHVDLEGSKDGCGDFK
YKEGDGPAFAVHCQTTDKVLLAADNGRFFTLGADKLPGARGFGEPVRNTLDIDAEAQIVAMLVSNPRGRLLLAADTGKGF
AAEMGELVAETRKGKQVVNLKGDAKLRVVRPIADCDDHVAVVGENRKLVVFNLEELPVLARGQGVQLQRYRDGGLSDAKT
FVLDQGLSWQMGGKGDRTRTETDIWQWKVARGGAGRLPPQGFPRDNRF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=195, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19913406, Length=190, Percent_Identity=30.5263157894737, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1789396, Length=687, Percent_Identity=40.7569141193595, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1788562, Length=652, Percent_Identity=38.1901840490798, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI212645845, Length=183, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=189, Percent_Identity=32.2751322751323, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=178, Percent_Identity=31.4606741573034, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=439, Percent_Identity=23.2346241457859, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136538, Length=188, Percent_Identity=30.8510638297872, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 85776; Mature: 85645

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPTEITEPDPFDAIVDAPFDSALEERYLVYALSTITARSLPDLRDGLKPVHRRLLWTM
CCCCCCCCCCCCCCHHHCCCCHHHHHHHHHEEHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RQLKLDPTNTFKKSARVVGEVIGKYHPHGDTAAYDAMVRLAQDFALRYPLVEGQGNFGNI
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCC
DGDNAAAYRYTEARLTRTAMALMAGLDEGTVDFIPTYNGEEEEPELMPGLFPNLLANGAS
CCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCC
GIAVGMATNIPSHNVHEIIDATLELIDNPHVEHARLMELFQGPDLPTGGLIVDSPEVISN
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECCHHHHHH
AYETGRGSFRIRGRFHAAEAEKQADQGAGIERLGGGQWQLVISEIPYQVQKGKLIEQIAQ
HHHCCCCCEEEEEEEEHHHHHHHHHCCCCCHHCCCCEEEEEEECCCCHHHCCHHHHHHHH
AIADKKLPILDDVRDESDEQIRIVLVPRSRNIDPELLKESIYKLTDMETRFGLNLNVLDA
HHHCCCCCCHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCEEEEECC
TRTPMVMGLKELLENWVRSQIEILQRRTQHRLDQIARRLELVEGYIIAFLNLDRVIEIIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHH
YEDEPKQVMMAEFSLTDRQAEAILNMRLRSLRKLEEMELKQEKTDLLAEQEELEKLLGSP
CCCCCHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARQRTRLKRDLKALQKEYGLDTELGARRTTIAEAEPTVEFSMDAMIEKEPVTVVLSQKGW
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEHHHHCCCCCEEEEECCCCC
VRAAKGHVDLEGSKDGCGDFKYKEGDGPAFAVHCQTTDKVLLAADNGRFFTLGADKLPGA
EEECCCEEEECCCCCCCCCCCEECCCCCEEEEEECCCCCEEEEECCCEEEEECCCCCCCC
RGFGEPVRNTLDIDAEAQIVAMLVSNPRGRLLLAADTGKGFAAEMGELVAETRKGKQVVN
CCCCHHHHCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
LKGDAKLRVVRPIADCDDHVAVVGENRKLVVFNLEELPVLARGQGVQLQRYRDGGLSDAK
ECCCCEEEEECCCCCCCCCEEEEECCCEEEEEEHHHCCEEECCCCCEEEEECCCCCCHHH
TFVLDQGLSWQMGGKGDRTRTETDIWQWKVARGGAGRLPPQGFPRDNRF
HHEECCCCCCCCCCCCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDPTEITEPDPFDAIVDAPFDSALEERYLVYALSTITARSLPDLRDGLKPVHRRLLWTM
CCCCCCCCCCCCCHHHCCCCHHHHHHHHHEEHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RQLKLDPTNTFKKSARVVGEVIGKYHPHGDTAAYDAMVRLAQDFALRYPLVEGQGNFGNI
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCC
DGDNAAAYRYTEARLTRTAMALMAGLDEGTVDFIPTYNGEEEEPELMPGLFPNLLANGAS
CCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCC
GIAVGMATNIPSHNVHEIIDATLELIDNPHVEHARLMELFQGPDLPTGGLIVDSPEVISN
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECCHHHHHH
AYETGRGSFRIRGRFHAAEAEKQADQGAGIERLGGGQWQLVISEIPYQVQKGKLIEQIAQ
HHHCCCCCEEEEEEEEHHHHHHHHHCCCCCHHCCCCEEEEEEECCCCHHHCCHHHHHHHH
AIADKKLPILDDVRDESDEQIRIVLVPRSRNIDPELLKESIYKLTDMETRFGLNLNVLDA
HHHCCCCCCHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHCCEEEEECC
TRTPMVMGLKELLENWVRSQIEILQRRTQHRLDQIARRLELVEGYIIAFLNLDRVIEIIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHH
YEDEPKQVMMAEFSLTDRQAEAILNMRLRSLRKLEEMELKQEKTDLLAEQEELEKLLGSP
CCCCCHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARQRTRLKRDLKALQKEYGLDTELGARRTTIAEAEPTVEFSMDAMIEKEPVTVVLSQKGW
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEHHHHCCCCCEEEEECCCCC
VRAAKGHVDLEGSKDGCGDFKYKEGDGPAFAVHCQTTDKVLLAADNGRFFTLGADKLPGA
EEECCCEEEECCCCCCCCCCCEECCCCCEEEEEECCCCCEEEEECCCEEEEECCCCCCCC
RGFGEPVRNTLDIDAEAQIVAMLVSNPRGRLLLAADTGKGFAAEMGELVAETRKGKQVVN
CCCCHHHHCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
LKGDAKLRVVRPIADCDDHVAVVGENRKLVVFNLEELPVLARGQGVQLQRYRDGGLSDAK
ECCCCEEEEECCCCCCCCCEEEEECCCEEEEEEHHHCCEEECCCCCEEEEECCCCCCHHH
TFVLDQGLSWQMGGKGDRTRTETDIWQWKVARGGAGRLPPQGFPRDNRF
HHEECCCCCCCCCCCCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]