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The map label for this gene is proC [H]

Identifier: 85373195

GI number: 85373195

Start: 414191

End: 415000

Strand: Direct

Name: proC [H]

Synonym: ELI_01840

Alternate gene names: 85373195

Gene position: 414191-415000 (Clockwise)

Preceding gene: 85373194

Following gene: 85373196

Centisome position: 13.57

GC content: 66.54

Gene sequence:

>810_bases
ATGACTGATATTCGCAACATGTTGATAGTGGGCTTTGGCACGATGACCGGGGCCATGGTCGAAGGGTGGCTGAAGGCGGG
CATCGCGCCCGAGGTCTTCACCGTCTATCATCCGCGCGGCAAGGATGTGCCGGAAGGGGTGCGGCTCGTGACCGACTGGC
CGACCGAGCGCTTCGACGCGGTGCTGCTCGGCGTAAAACCCTATATGCTCGACGATGTCGCGCCCGGTCTTGCCCGGGCC
GTGTCCGACAAGACGGTCGTCCTGTCGGTCTTGGCCGGGATCGAGCTGGCTAGCCTGCGCGCACGCTTCCCGCAGGCCGA
GGGCGTGGTGCGCTTCATGCCCAATCTCGCCTGCGCGCTCGGCAAGGCGCCCAACGGGCTGATCGGGGAGGGGCTCTCCG
ACACGCAACGCGGCATGGTCACCGATCTGGCTGAAAAACTCGGCTCGGCAGAATGGCTCGAAGACGAAAGCCGGTTCGAC
CTTGTGACCGCGCTCGCCGGATCGGGTCCGGGCTTCGTCTATCGTTTCATCGATGCGCTGGCGGTTGCCGGGACCAGGCT
CGGTCTGGACGAGGGCCAGGCGGGCAGGCTCGCGATCCAGATGGTCGAAGGCGCGGCGGCGCTGGCCGCGCAGAGCGAAC
ACAGCCCGGGCGAGTTGGCCCGGCGAGTCGCCAGCCCCGGCGGGATGACGCAGAAAGGGCTCGACGTGCTCGATGAAAAC
GATGCGCTGGTCGACCTGTTGACGCAAACGCTGCGCGCGGCTCGCGATCGGGGCGCGGAAATGGCCGCAGAGGCGCGTGA
AAAAGGTTAA

Upstream 100 bases:

>100_bases
ATCGCCCGAGGCGGCGCTGGAGGCATCGATGGTGGACGCTGCCGGCGAAGCCTGAAGCGCGGGCCTGACAGTCCGGCGCA
GTCCCGCTACAGCGCCACGC

Downstream 100 bases:

>100_bases
TTGAAGCTCATTTGCATTCTGCGGAACAGTGCCCGGTTTCCCTTGAAATCGAGCCGTCTTGCCCTGATATTACACCCACA
CCGGCGCGATAGTGCGTCCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTDIRNMLIVGFGTMTGAMVEGWLKAGIAPEVFTVYHPRGKDVPEGVRLVTDWPTERFDAVLLGVKPYMLDDVAPGLARA
VSDKTVVLSVLAGIELASLRARFPQAEGVVRFMPNLACALGKAPNGLIGEGLSDTQRGMVTDLAEKLGSAEWLEDESRFD
LVTALAGSGPGFVYRFIDALAVAGTRLGLDEGQAGRLAIQMVEGAAALAAQSEHSPGELARRVASPGGMTQKGLDVLDEN
DALVDLLTQTLRAARDRGAEMAAEAREKG

Sequences:

>Translated_269_residues
MTDIRNMLIVGFGTMTGAMVEGWLKAGIAPEVFTVYHPRGKDVPEGVRLVTDWPTERFDAVLLGVKPYMLDDVAPGLARA
VSDKTVVLSVLAGIELASLRARFPQAEGVVRFMPNLACALGKAPNGLIGEGLSDTQRGMVTDLAEKLGSAEWLEDESRFD
LVTALAGSGPGFVYRFIDALAVAGTRLGLDEGQAGRLAIQMVEGAAALAAQSEHSPGELARRVASPGGMTQKGLDVLDEN
DALVDLLTQTLRAARDRGAEMAAEAREKG
>Mature_268_residues
TDIRNMLIVGFGTMTGAMVEGWLKAGIAPEVFTVYHPRGKDVPEGVRLVTDWPTERFDAVLLGVKPYMLDDVAPGLARAV
SDKTVVLSVLAGIELASLRARFPQAEGVVRFMPNLACALGKAPNGLIGEGLSDTQRGMVTDLAEKLGSAEWLEDESRFDL
VTALAGSGPGFVYRFIDALAVAGTRLGLDEGQAGRLAIQMVEGAAALAAQSEHSPGELARRVASPGGMTQKGLDVLDEND
ALVDLLTQTLRAARDRGAEMAAEAREKG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=247, Percent_Identity=29.5546558704453, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI24797095, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI24797097, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI21361454, Length=279, Percent_Identity=26.8817204301075, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=26.5151515151515, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=27.7580071174377, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17569021, Length=259, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=221, Percent_Identity=27.1493212669683, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358587, Length=249, Percent_Identity=31.7269076305221, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648116, Length=223, Percent_Identity=32.2869955156951, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647700, Length=148, Percent_Identity=36.4864864864865, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28447; Mature: 28316

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIRNMLIVGFGTMTGAMVEGWLKAGIAPEVFTVYHPRGKDVPEGVRLVTDWPTERFDA
CCCHHHHHEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCCCHHHHE
VLLGVKPYMLDDVAPGLARAVSDKTVVLSVLAGIELASLRARFPQAEGVVRFMPNLACAL
EHCCCCCHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GKAPNGLIGEGLSDTQRGMVTDLAEKLGSAEWLEDESRFDLVTALAGSGPGFVYRFIDAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHHH
AVAGTRLGLDEGQAGRLAIQMVEGAAALAAQSEHSPGELARRVASPGGMTQKGLDVLDEN
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHCCHHHCCC
DALVDLLTQTLRAARDRGAEMAAEAREKG
HHHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
TDIRNMLIVGFGTMTGAMVEGWLKAGIAPEVFTVYHPRGKDVPEGVRLVTDWPTERFDA
CCHHHHHEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCCCHHHHE
VLLGVKPYMLDDVAPGLARAVSDKTVVLSVLAGIELASLRARFPQAEGVVRFMPNLACAL
EHCCCCCHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GKAPNGLIGEGLSDTQRGMVTDLAEKLGSAEWLEDESRFDLVTALAGSGPGFVYRFIDAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHHH
AVAGTRLGLDEGQAGRLAIQMVEGAAALAAQSEHSPGELARRVASPGGMTQKGLDVLDEN
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHCCHHHCCC
DALVDLLTQTLRAARDRGAEMAAEAREKG
HHHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]