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The map label for this gene is cysK [H]

Identifier: 85373173

GI number: 85373173

Start: 390128

End: 391141

Strand: Direct

Name: cysK [H]

Synonym: ELI_01730

Alternate gene names: 85373173

Gene position: 390128-391141 (Clockwise)

Preceding gene: 85373172

Following gene: 85373174

Centisome position: 12.78

GC content: 64.3

Gene sequence:

>1014_bases
ATGAACATTACTGCGCCTCACAGCGACACAATTTCCCTGATCGGCAACACACCGCTCGTCCGCCTGCAAGGGCCGAGCGA
CGCGGCTGGGTGCGAAATCTACGGCAAGTGCGAATATGCCAATCCGGGCGCGTCGGTCAAAGACCGTGCGGCGCTGTGGA
TCATCCGCGACGCGGAAGAGCGCGGCGAACTCAAGCCCGGTGGCACTGTCGTCGAAGGCACTGCGGGCAACACCGGGATC
GGTATCGCGCTGGTCGCCAATGCGCGCGGCTACAAAACGATCATCGTGATGCCGGACAACCAGAGCCAGGAAAAGATGGA
CACGCTGCGCGCGCTGGGCGCGGAGCTGGTGCTCGTGCCGCCAACCAAATTCGCCGACTGCAACCACTTCGTCCACACCT
CGCGACGTCTGGCGGAAGAAACCGAAGGCGCGATCTGGGCCAACCAGTTCGACAACACTGCCAACCGCAAGGCCCATATC
GAAGGCACCGCGCCCGAATTGTGGGAGCAGCTCGAAGGCCGGATCGACGGTTTCACCTGCGCGGCCGGTACCGGCGGCAC
GATCGCGGGCGTGGGCATGGCACTCAAGGAACTGGACGAAAACGTCGTCATCGCGCTGACCGACCCGCATGGCGCGGCGC
TCTACAATTACTACGCCAATGGCGAGCTGAAGGCCGAGGGCTCCTCGGTTGCCGAGGGCATCGGGCAGGGCCGCATCACC
GGCAATCTCGAAGGCGCACCGATCGATACGCAGTTCCGCATTTCGGACGAAGAAGGGCTCGAATGGGTCCGCCGCCTCCT
GCGCGAAGAGGGGCTCTGCCTCGGCCTTTCCAGCGGCATCAATGTCGCGGGTGCGGTGGCGCTGGGCAAGCAACTCGTCG
CCGACGGCCGCAAGGATGCGCGCGTCGCAACCATCCTGTGCGACACCGGGTTTCGCTATCTCTCCAGCCTCTACAACGCC
GACTGGCTGCGCTCGAAAGACCTGCCGGTGTTCGACTGGCTCGGACAGGACTGA

Upstream 100 bases:

>100_bases
GATCCCGTTCACGCCCGATCTCGACGGGCTGAAGGTTACTATCGCCCCTGAAGATTGATCTATCTTGGCGCAAGGTGAGG
GAGTGCCTACCTCGCTCAGC

Downstream 100 bases:

>100_bases
CGCCGCGCCCGCAAACGGTTGTTTGACGTTCAGCGCGGGGCGACTAGACTTGCCGGGATGAACCTGCTGCCTACCCGATT
GCGTCCGGCCGAAGGTGCGG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MNITAPHSDTISLIGNTPLVRLQGPSDAAGCEIYGKCEYANPGASVKDRAALWIIRDAEERGELKPGGTVVEGTAGNTGI
GIALVANARGYKTIIVMPDNQSQEKMDTLRALGAELVLVPPTKFADCNHFVHTSRRLAEETEGAIWANQFDNTANRKAHI
EGTAPELWEQLEGRIDGFTCAAGTGGTIAGVGMALKELDENVVIALTDPHGAALYNYYANGELKAEGSSVAEGIGQGRIT
GNLEGAPIDTQFRISDEEGLEWVRRLLREEGLCLGLSSGINVAGAVALGKQLVADGRKDARVATILCDTGFRYLSSLYNA
DWLRSKDLPVFDWLGQD

Sequences:

>Translated_337_residues
MNITAPHSDTISLIGNTPLVRLQGPSDAAGCEIYGKCEYANPGASVKDRAALWIIRDAEERGELKPGGTVVEGTAGNTGI
GIALVANARGYKTIIVMPDNQSQEKMDTLRALGAELVLVPPTKFADCNHFVHTSRRLAEETEGAIWANQFDNTANRKAHI
EGTAPELWEQLEGRIDGFTCAAGTGGTIAGVGMALKELDENVVIALTDPHGAALYNYYANGELKAEGSSVAEGIGQGRIT
GNLEGAPIDTQFRISDEEGLEWVRRLLREEGLCLGLSSGINVAGAVALGKQLVADGRKDARVATILCDTGFRYLSSLYNA
DWLRSKDLPVFDWLGQD
>Mature_337_residues
MNITAPHSDTISLIGNTPLVRLQGPSDAAGCEIYGKCEYANPGASVKDRAALWIIRDAEERGELKPGGTVVEGTAGNTGI
GIALVANARGYKTIIVMPDNQSQEKMDTLRALGAELVLVPPTKFADCNHFVHTSRRLAEETEGAIWANQFDNTANRKAHI
EGTAPELWEQLEGRIDGFTCAAGTGGTIAGVGMALKELDENVVIALTDPHGAALYNYYANGELKAEGSSVAEGIGQGRIT
GNLEGAPIDTQFRISDEEGLEWVRRLLREEGLCLGLSSGINVAGAVALGKQLVADGRKDARVATILCDTGFRYLSSLYNA
DWLRSKDLPVFDWLGQD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=321, Percent_Identity=39.2523364485981, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI295821200, Length=321, Percent_Identity=39.2523364485981, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI4557415, Length=321, Percent_Identity=39.2523364485981, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=40.1960784313725, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=37.8548895899054, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17562970, Length=318, Percent_Identity=36.1635220125786, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566674, Length=309, Percent_Identity=36.8932038834951, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17535051, Length=311, Percent_Identity=35.6913183279743, Blast_Score=173, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17534315, Length=321, Percent_Identity=37.6947040498442, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=321, Percent_Identity=35.8255451713396, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=36.1904761904762, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=35.7142857142857, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=31.0043668122271, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71996324, Length=356, Percent_Identity=28.3707865168539, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321449, Length=349, Percent_Identity=38.10888252149, Blast_Score=197, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321594, Length=329, Percent_Identity=34.3465045592705, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24643623, Length=323, Percent_Identity=36.8421052631579, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI20129101, Length=323, Percent_Identity=36.8421052631579, Blast_Score=194, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36000; Mature: 36000

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITAPHSDTISLIGNTPLVRLQGPSDAAGCEIYGKCEYANPGASVKDRAALWIIRDAEE
CCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCHH
RGELKPGGTVVEGTAGNTGIGIALVANARGYKTIIVMPDNQSQEKMDTLRALGAELVLVP
CCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEC
PTKFADCNHFVHTSRRLAEETEGAIWANQFDNTANRKAHIEGTAPELWEQLEGRIDGFTC
CCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCCCHHHHHHHCCCCCCEEE
AAGTGGTIAGVGMALKELDENVVIALTDPHGAALYNYYANGELKAEGSSVAEGIGQGRIT
ECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCEEEECCCHHHHHCCCCCEE
GNLEGAPIDTQFRISDEEGLEWVRRLLREEGLCLGLSSGINVAGAVALGKQLVADGRKDA
ECCCCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
RVATILCDTGFRYLSSLYNADWLRSKDLPVFDWLGQD
EEEEEEECCHHHHHHHHHCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MNITAPHSDTISLIGNTPLVRLQGPSDAAGCEIYGKCEYANPGASVKDRAALWIIRDAEE
CCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCHH
RGELKPGGTVVEGTAGNTGIGIALVANARGYKTIIVMPDNQSQEKMDTLRALGAELVLVP
CCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEC
PTKFADCNHFVHTSRRLAEETEGAIWANQFDNTANRKAHIEGTAPELWEQLEGRIDGFTC
CCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCCCHHHHHHHCCCCCCEEE
AAGTGGTIAGVGMALKELDENVVIALTDPHGAALYNYYANGELKAEGSSVAEGIGQGRIT
ECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCEEEECCCHHHHHCCCCCEE
GNLEGAPIDTQFRISDEEGLEWVRRLLREEGLCLGLSSGINVAGAVALGKQLVADGRKDA
ECCCCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
RVATILCDTGFRYLSSLYNADWLRSKDLPVFDWLGQD
EEEEEEECCHHHHHHHHHCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA