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The map label for this gene is clpX

Identifier: 85373055

GI number: 85373055

Start: 266760

End: 268031

Strand: Direct

Name: clpX

Synonym: ELI_01140

Alternate gene names: 85373055

Gene position: 266760-268031 (Clockwise)

Preceding gene: 85373054

Following gene: 85373056

Centisome position: 8.74

GC content: 60.93

Gene sequence:

>1272_bases
ATGACGAAATTGAGCGGAACCGATAGCAAATCGACGCTGTATTGCAGCTTCTGCGGCAAGTCGCAGCACGAAGTGCGCAA
GCTGATCGCCGGTCCGACCGTGTTCATCTGCGATGAATGCGTCGAGCTGTGCAACGACATCATTCGCGAAGAAACCAAGG
CCGGCCTGACCGGTCGCAAGGAAGGCGATGTTCCCGCGCCGTCAGAAATCTGCGCGACGCTCAACGATTACGTCATCGGC
CAGGACCGTGCCAAGCGCGTGCTCTCGGTTGCGGTCCACAACCATTACAAGCGCCTGAAGCACAGCGGCAAGGCGGATGG
GGTGGAACTGGCCAAGTCGAACATCCTGCTGGTCGGGCCGACCGGTTCGGGCAAGACGCTGCTGGCGCAAACGCTGGCGC
GCACGTTCGACGTGCCTTTCACCATGGCCGATGCCACCACACTGACCGAGGCGGGTTACGTGGGTGAAGACGTCGAGAAC
ATCATCCTCAAGCTGCTGCAGGCGAGCGACTACAATGTCGACAAGGCGCAGCACGGCATCGTCTATATCGACGAGATCGA
CAAGATCACCCGCAAGGCGGAAAACCCCTCGATCACCCGCGACGTGTCGGGCGAGGGCGTGCAGCAGGCGTTGCTCAAGC
TGATGGAAGGCACGACCGCTTCGGTCCCGCCGCAGGGTGGCCGCAAGCATCCGCAGCAGGAGTTCCTGCAGGTCGATACG
ACCAACATCCTGTTCATCTGCGGCGGCGCGTTCGCCGGTCTCGACAAGATCATCGCCGACCGCTTGCAGAAGCGCTCGAT
CGGCTTCGGCGCACATGTTGCCGACCCCGATAAGCGCAAAGTTGGTGAACTTCTGGAAAAGAGCGAACCGGAAGATCTGC
TCAAGTTCGGCCTGATCCCGGAATTCGTCGGCCGTCTGCCGGTCATCGCCACGCTGCACGATCTCGATGTCGATGCGCTG
GTCACGATCCTGCAGGAACCGAAGAACGCCATCGTCAAGCAATACAGCAAGCTGTTCGAGCTCGAAGATGTCGAACTGAC
CTTCACCGACGAGGCGCTGCAGGCGATCGCCGAACGCGCGATCCTGCGCAAGACCGGCGCGCGCGGCCTCCGCTCGATCG
TCGAAGGTATCCTGCTCGACACGATGTTCGACCTGCCCGATCTGGACGATATCAGCGAAGTCGTGATCGACGCCGACGTG
GTGGAAGGCAAGAAAGAGCCGATCCGCGTCGTGTCCAACGATGATGACGGCAAGAAGGAAGAGGCGGCGTAG

Upstream 100 bases:

>100_bases
AGGTGGCCGTGCTATAGGCGGTGGTTGTAATCGCCGCTATGAACGATACATTCCGGCGAATCCCCTGAGCCCTCCGGCCC
GGGGCCGGAAAGCTTAGGAT

Downstream 100 bases:

>100_bases
GCCTCGGTGCTCGAGATTGTCACTGTTGCCGCAGTGACGATCGCCCTCCTCGTCGGTTCTGGTGTCTGGACGAACGCCAG
ATACGCGCGGTTTGACCAAG

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTKLSGTDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREETKAGLTGRKEGDVPAPSEICATLNDYVIG
QDRAKRVLSVAVHNHYKRLKHSGKADGVELAKSNILLVGPTGSGKTLLAQTLARTFDVPFTMADATTLTEAGYVGEDVEN
IILKLLQASDYNVDKAQHGIVYIDEIDKITRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
TNILFICGGAFAGLDKIIADRLQKRSIGFGAHVADPDKRKVGELLEKSEPEDLLKFGLIPEFVGRLPVIATLHDLDVDAL
VTILQEPKNAIVKQYSKLFELEDVELTFTDEALQAIAERAILRKTGARGLRSIVEGILLDTMFDLPDLDDISEVVIDADV
VEGKKEPIRVVSNDDDGKKEEAA

Sequences:

>Translated_423_residues
MTKLSGTDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREETKAGLTGRKEGDVPAPSEICATLNDYVIG
QDRAKRVLSVAVHNHYKRLKHSGKADGVELAKSNILLVGPTGSGKTLLAQTLARTFDVPFTMADATTLTEAGYVGEDVEN
IILKLLQASDYNVDKAQHGIVYIDEIDKITRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
TNILFICGGAFAGLDKIIADRLQKRSIGFGAHVADPDKRKVGELLEKSEPEDLLKFGLIPEFVGRLPVIATLHDLDVDAL
VTILQEPKNAIVKQYSKLFELEDVELTFTDEALQAIAERAILRKTGARGLRSIVEGILLDTMFDLPDLDDISEVVIDADV
VEGKKEPIRVVSNDDDGKKEEAA
>Mature_422_residues
TKLSGTDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREETKAGLTGRKEGDVPAPSEICATLNDYVIGQ
DRAKRVLSVAVHNHYKRLKHSGKADGVELAKSNILLVGPTGSGKTLLAQTLARTFDVPFTMADATTLTEAGYVGEDVENI
ILKLLQASDYNVDKAQHGIVYIDEIDKITRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDTT
NILFICGGAFAGLDKIIADRLQKRSIGFGAHVADPDKRKVGELLEKSEPEDLLKFGLIPEFVGRLPVIATLHDLDVDALV
TILQEPKNAIVKQYSKLFELEDVELTFTDEALQAIAERAILRKTGARGLRSIVEGILLDTMFDLPDLDDISEVVIDADVV
EGKKEPIRVVSNDDDGKKEEAA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=340, Percent_Identity=52.0588235294118, Blast_Score=325, Evalue=7e-89,
Organism=Escherichia coli, GI1786642, Length=412, Percent_Identity=70.3883495145631, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI1790366, Length=230, Percent_Identity=35.2173913043478, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71982905, Length=316, Percent_Identity=49.0506329113924, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71982908, Length=316, Percent_Identity=49.0506329113924, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71988663, Length=424, Percent_Identity=37.7358490566038, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71988660, Length=282, Percent_Identity=37.2340425531915, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319704, Length=430, Percent_Identity=37.2093023255814, Blast_Score=253, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24648289, Length=317, Percent_Identity=51.7350157728707, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24648291, Length=317, Percent_Identity=51.7350157728707, Blast_Score=314, Evalue=6e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_ERYLH (Q2NDC1)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457117.1
- ProteinModelPortal:   Q2NDC1
- STRING:   Q2NDC1
- GeneID:   3871612
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_01140
- NMPDR:   fig|314225.3.peg.2861
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q2NDC1
- ProtClustDB:   PRK05342
- BioCyc:   ELIT314225:ELI_01140-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: 3.4.21.92

Molecular weight: Translated: 46136; Mature: 46005

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLSGTDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREETKAGLTGRK
CCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EGDVPAPSEICATLNDYVIGQDRAKRVLSVAVHNHYKRLKHSGKADGVELAKSNILLVGP
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEC
TGSGKTLLAQTLARTFDVPFTMADATTLTEAGYVGEDVENIILKLLQASDYNVDKAQHGI
CCCCHHHHHHHHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCCE
VYIDEIDKITRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
EEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
TNILFICGGAFAGLDKIIADRLQKRSIGFGAHVADPDKRKVGELLEKSEPEDLLKFGLIP
CCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCH
EFVGRLPVIATLHDLDVDALVTILQEPKNAIVKQYSKLFELEDVELTFTDEALQAIAERA
HHHCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
ILRKTGARGLRSIVEGILLDTMFDLPDLDDISEVVIDADVVEGKKEPIRVVSNDDDGKKE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
EAA
CCC
>Mature Secondary Structure 
TKLSGTDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCNDIIREETKAGLTGRK
CCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EGDVPAPSEICATLNDYVIGQDRAKRVLSVAVHNHYKRLKHSGKADGVELAKSNILLVGP
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEC
TGSGKTLLAQTLARTFDVPFTMADATTLTEAGYVGEDVENIILKLLQASDYNVDKAQHGI
CCCCHHHHHHHHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCCE
VYIDEIDKITRKAENPSITRDVSGEGVQQALLKLMEGTTASVPPQGGRKHPQQEFLQVDT
EEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
TNILFICGGAFAGLDKIIADRLQKRSIGFGAHVADPDKRKVGELLEKSEPEDLLKFGLIP
CCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCH
EFVGRLPVIATLHDLDVDALVTILQEPKNAIVKQYSKLFELEDVELTFTDEALQAIAERA
HHHCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
ILRKTGARGLRSIVEGILLDTMFDLPDLDDISEVVIDADVVEGKKEPIRVVSNDDDGKKE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
EAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA