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The map label for this gene is clpP

Identifier: 85373054

GI number: 85373054

Start: 265852

End: 266556

Strand: Direct

Name: clpP

Synonym: ELI_01135

Alternate gene names: 85373054

Gene position: 265852-266556 (Clockwise)

Preceding gene: 85373049

Following gene: 85373055

Centisome position: 8.71

GC content: 63.55

Gene sequence:

>705_bases
ATGATCGATGTCCGCGAACAGCTTGGCGAAACCCACGGCACACAGGGCCAGTTCACCCGCGACCCGCTCACGGGCGCGCT
GGTGCCGGTGGTCGTCGAGCAGACCAGCCGCGGCGAGCGCAGCTTCGATATTTTCAGCCGCCTGCTGCGCGAACGGATCG
TCTTCGTGACCGGCCAGGTCGAAGACGGCATGGCCTCGTTGATCACTGCGCAGCTGCTGTTCCTGGAAAGCGAGAACCCG
TCCAAGCCGATCAGCATGTATATCAACTCGCCCGGCGGCGTGGTGACGGCCGGCATGGCGATCCACGATACCATGCAGTA
TATCAAACCCAAGGTTTCGACCGTCTGCATGGGCCAGGCCGCCAGCATGGGCAGTTTCCTGCTCGCGGCGGGCGAGCCGG
GGATGCGTGTTGCGCTGCCCAATGCGCGGATCATGGTCCACCAGCCGTCGGGCGGCGCGCGCGGCATGGCCTCCGACATC
GAGATCCAGGCCCGCGAAATCCTGCGCATCCGCAAGCGCATGAACGATCTCTACGTCAAGTATACCGGCCAGAAGCTCGC
CGACATCGAAAAAGCGATGGATCGCGACACCTTCCTCGAAGCGGAAGAGGCGATGAAATTCGGCCTCGTCGACAAGGTTT
TCGAGACCCGTCCGGAGAATGAAGGCGGCGACAAGGAAGAGGGATCGGGCGGCGCGCCCGAGTGA

Upstream 100 bases:

>100_bases
CGGCGGAAGCTGTTCACAGGCGAAGGGTTAAGGGGGTTGAACATCGCCACGCCACGGACAACATAAGTCGCCAACACCAA
ACCTATAGGAAGCCTTCCCG

Downstream 100 bases:

>100_bases
CCCGGCAGGCGCGGGGGCGTTAACCCCTGCCGCCGCGGTCCGCCCCAGCCCGGGACAGGGCATCGCAAGATCGCGGTAAC
TGCGGCCCTACAGGCGAATG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MIDVREQLGETHGTQGQFTRDPLTGALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGQVEDGMASLITAQLLFLESENP
SKPISMYINSPGGVVTAGMAIHDTMQYIKPKVSTVCMGQAASMGSFLLAAGEPGMRVALPNARIMVHQPSGGARGMASDI
EIQAREILRIRKRMNDLYVKYTGQKLADIEKAMDRDTFLEAEEAMKFGLVDKVFETRPENEGGDKEEGSGGAPE

Sequences:

>Translated_234_residues
MIDVREQLGETHGTQGQFTRDPLTGALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGQVEDGMASLITAQLLFLESENP
SKPISMYINSPGGVVTAGMAIHDTMQYIKPKVSTVCMGQAASMGSFLLAAGEPGMRVALPNARIMVHQPSGGARGMASDI
EIQAREILRIRKRMNDLYVKYTGQKLADIEKAMDRDTFLEAEEAMKFGLVDKVFETRPENEGGDKEEGSGGAPE
>Mature_234_residues
MIDVREQLGETHGTQGQFTRDPLTGALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGQVEDGMASLITAQLLFLESENP
SKPISMYINSPGGVVTAGMAIHDTMQYIKPKVSTVCMGQAASMGSFLLAAGEPGMRVALPNARIMVHQPSGGARGMASDI
EIQAREILRIRKRMNDLYVKYTGQKLADIEKAMDRDTFLEAEEAMKFGLVDKVFETRPENEGGDKEEGSGGAPE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=199, Percent_Identity=62.3115577889447, Blast_Score=265, Evalue=2e-71,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=66.1458333333333, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=60.2150537634409, Blast_Score=240, Evalue=5e-64,
Organism=Drosophila melanogaster, GI20129427, Length=204, Percent_Identity=57.3529411764706, Blast_Score=256, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 25584; Mature: 25584

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDVREQLGETHGTQGQFTRDPLTGALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGQV
CCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHEEEEECCC
EDGMASLITAQLLFLESENPSKPISMYINSPGGVVTAGMAIHDTMQYIKPKVSTVCMGQA
CHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCEEEECHHHHHHHHHHCHHHHHHHHCCH
ASMGSFLLAAGEPGMRVALPNARIMVHQPSGGARGMASDIEIQAREILRIRKRMNDLYVK
HCCCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEE
YTGQKLADIEKAMDRDTFLEAEEAMKFGLVDKVFETRPENEGGDKEEGSGGAPE
ECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDVREQLGETHGTQGQFTRDPLTGALVPVVVEQTSRGERSFDIFSRLLRERIVFVTGQV
CCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHEEEEECCC
EDGMASLITAQLLFLESENPSKPISMYINSPGGVVTAGMAIHDTMQYIKPKVSTVCMGQA
CHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCEEEECHHHHHHHHHHCHHHHHHHHCCH
ASMGSFLLAAGEPGMRVALPNARIMVHQPSGGARGMASDIEIQAREILRIRKRMNDLYVK
HCCCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEE
YTGQKLADIEKAMDRDTFLEAEEAMKFGLVDKVFETRPENEGGDKEEGSGGAPE
ECCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA