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The map label for this gene is pyrC [H]

Identifier: 85373034

GI number: 85373034

Start: 244611

End: 245852

Strand: Direct

Name: pyrC [H]

Synonym: ELI_01035

Alternate gene names: 85373034

Gene position: 244611-245852 (Clockwise)

Preceding gene: 85373033

Following gene: 85373035

Centisome position: 8.01

GC content: 66.18

Gene sequence:

>1242_bases
ATGGGCATGAAGCAGCAGCGCCCCCTTCTGATTACGAACGGCAAGGTCGTCACCCCCGACGGGGTCCGCGAGCAGCCGAT
AGTTTGCATCGATGGCCGCATCGCCGCCGTCGACGCCTCAGAGGCACAGGGAGACGTCGACACGCTCGATGCGAGAGGAC
GCATCGTCGCTCCTGGTATCGTCGATCTCGGCGTCTTCGCCATCGACAAGCCGGCCTTCCATTTCGGCGGAATCACCCGC
GCGGCGCTGATGCCCGACCAGTCGCCGCCGCTCGACCTGCCGAGCCGGGTCAACTACATCGCCAAAAGCGGCAAGCCGGA
TTTGTGGGTGCACCCGCTCGCGGCGGCTACGCAGGAACTCAGCGGTGAAGATCTGGCGGAATTCGCCTTGATGCGCGAAG
CCGGTGCCCGCGGTATTGCGACAGGGCGACGCTGGATTGCCGACAGCGGAGTGATGCTCCGCGTGCTGCGCTATGCCGCG
ATGCTCGATCTCGTCGTGGTCAGCCATGCCGAGGACGGCGGGATCGCCGGGGAAGCTGTGGCGACGGCCGGCGAGATGGC
GACGCGCCTCGGATTGCCGAGCGCGCCTGTCGAGGCCGAAGCGCTGGCGGTTGCACGAGACATCGCGCTCGCCGAGATGA
GCGGGGCGCGGCTGCATTTCCGGCAGGTCACGACGAGGGCAGCGCTCGATCTGGTGCGCGCGGCCAAGGCGAGAGGCGTG
GCGGTAACGGCCGGGGTCACGCCGGCGCATTTCATGCTATCCGATCTCGCGACCGGCGATTTCCGGACCTTCGCGCGGCT
CTCGCCACCTCTGCGCGAAGACAGCGACCGGCTCGCGGTGGTCGAAGCGATCGGCGACGGCACGATCGACGTCATTTCGA
GCGGACACGATCCGCGCGGACCCGAAGACAAGCGCCTGCCGTTCAGCGATGCGGAGCCCGGCATGGCCGGCGCCGAGACG
CTGCTGGCGATGACCCTTTCCCTGGTGCGTGACAACGTACTTTCACTGGAACGCGCATTCGAGCTTCTGTCGGCCAATCC
GGCGCGCCTATTGGGTGTCGAAGCTGGCACACTCGAAGCGGGTCGCGAAGCGGACATCTTGCTGGTGGATACGGATAAAC
CCTGGGTTGTCTCGACCGCCAGGATGACGGCAAGTGCAGGCAATACGCCCTTCGACGGGCAGCCTGTGCAGGGTCGCGCC
ATTGCTGTGGTCAAGGGCGGTGTGCAGGTAATCGCAAATTAG

Upstream 100 bases:

>100_bases
AGGTCGAGATGGGCGTCGCCGTACGCATGGCTTGCCTGGACATCTTGACGCGCAAGGGGCGCGGGCTGCCCGGCTGGCAG
GGCGACCTCGGCAAGGGGCA

Downstream 100 bases:

>100_bases
GCAACAGCGCCCAACATAGGTTAAGGCGCTTGGTATACGGGATCGCTACACGGCAACACAGGGATCTCCACTGTGGACGA
AGACGACGACATGATCGGCA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MGMKQQRPLLITNGKVVTPDGVREQPIVCIDGRIAAVDASEAQGDVDTLDARGRIVAPGIVDLGVFAIDKPAFHFGGITR
AALMPDQSPPLDLPSRVNYIAKSGKPDLWVHPLAAATQELSGEDLAEFALMREAGARGIATGRRWIADSGVMLRVLRYAA
MLDLVVVSHAEDGGIAGEAVATAGEMATRLGLPSAPVEAEALAVARDIALAEMSGARLHFRQVTTRAALDLVRAAKARGV
AVTAGVTPAHFMLSDLATGDFRTFARLSPPLREDSDRLAVVEAIGDGTIDVISSGHDPRGPEDKRLPFSDAEPGMAGAET
LLAMTLSLVRDNVLSLERAFELLSANPARLLGVEAGTLEAGREADILLVDTDKPWVVSTARMTASAGNTPFDGQPVQGRA
IAVVKGGVQVIAN

Sequences:

>Translated_413_residues
MGMKQQRPLLITNGKVVTPDGVREQPIVCIDGRIAAVDASEAQGDVDTLDARGRIVAPGIVDLGVFAIDKPAFHFGGITR
AALMPDQSPPLDLPSRVNYIAKSGKPDLWVHPLAAATQELSGEDLAEFALMREAGARGIATGRRWIADSGVMLRVLRYAA
MLDLVVVSHAEDGGIAGEAVATAGEMATRLGLPSAPVEAEALAVARDIALAEMSGARLHFRQVTTRAALDLVRAAKARGV
AVTAGVTPAHFMLSDLATGDFRTFARLSPPLREDSDRLAVVEAIGDGTIDVISSGHDPRGPEDKRLPFSDAEPGMAGAET
LLAMTLSLVRDNVLSLERAFELLSANPARLLGVEAGTLEAGREADILLVDTDKPWVVSTARMTASAGNTPFDGQPVQGRA
IAVVKGGVQVIAN
>Mature_412_residues
GMKQQRPLLITNGKVVTPDGVREQPIVCIDGRIAAVDASEAQGDVDTLDARGRIVAPGIVDLGVFAIDKPAFHFGGITRA
ALMPDQSPPLDLPSRVNYIAKSGKPDLWVHPLAAATQELSGEDLAEFALMREAGARGIATGRRWIADSGVMLRVLRYAAM
LDLVVVSHAEDGGIAGEAVATAGEMATRLGLPSAPVEAEALAVARDIALAEMSGARLHFRQVTTRAALDLVRAAKARGVA
VTAGVTPAHFMLSDLATGDFRTFARLSPPLREDSDRLAVVEAIGDGTIDVISSGHDPRGPEDKRLPFSDAEPGMAGAETL
LAMTLSLVRDNVLSLERAFELLSANPARLLGVEAGTLEAGREADILLVDTDKPWVVSTARMTASAGNTPFDGQPVQGRAI
AVVKGGVQVIAN

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=392, Percent_Identity=26.7857142857143, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786722, Length=426, Percent_Identity=25.5868544600939, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87082175, Length=440, Percent_Identity=26.8181818181818, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=217, Percent_Identity=27.1889400921659, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=201, Percent_Identity=25.3731343283582, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642586, Length=215, Percent_Identity=29.7674418604651, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 43289; Mature: 43158

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMKQQRPLLITNGKVVTPDGVREQPIVCIDGRIAAVDASEAQGDVDTLDARGRIVAPGI
CCCCCCCCEEEECCEEECCCCCCCCCEEEECCEEEEEECCCCCCCCHHHCCCCEEECCCH
VDLGVFAIDKPAFHFGGITRAALMPDQSPPLDLPSRVNYIAKSGKPDLWVHPLAAATQEL
HHCCEEEECCCCHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHC
SGEDLAEFALMREAGARGIATGRRWIADSGVMLRVLRYAAMLDLVVVSHAEDGGIAGEAV
CCHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHH
ATAGEMATRLGLPSAPVEAEALAVARDIALAEMSGARLHFRQVTTRAALDLVRAAKARGV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCE
AVTAGVTPAHFMLSDLATGDFRTFARLSPPLREDSDRLAVVEAIGDGTIDVISSGHDPRG
EEECCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCC
PEDKRLPFSDAEPGMAGAETLLAMTLSLVRDNVLSLERAFELLSANPARLLGVEAGTLEA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
GREADILLVDTDKPWVVSTARMTASAGNTPFDGQPVQGRAIAVVKGGVQVIAN
CCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCEEEECC
>Mature Secondary Structure 
GMKQQRPLLITNGKVVTPDGVREQPIVCIDGRIAAVDASEAQGDVDTLDARGRIVAPGI
CCCCCCCEEEECCEEECCCCCCCCCEEEECCEEEEEECCCCCCCCHHHCCCCEEECCCH
VDLGVFAIDKPAFHFGGITRAALMPDQSPPLDLPSRVNYIAKSGKPDLWVHPLAAATQEL
HHCCEEEECCCCHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHC
SGEDLAEFALMREAGARGIATGRRWIADSGVMLRVLRYAAMLDLVVVSHAEDGGIAGEAV
CCHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHH
ATAGEMATRLGLPSAPVEAEALAVARDIALAEMSGARLHFRQVTTRAALDLVRAAKARGV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCE
AVTAGVTPAHFMLSDLATGDFRTFARLSPPLREDSDRLAVVEAIGDGTIDVISSGHDPRG
EEECCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCC
PEDKRLPFSDAEPGMAGAETLLAMTLSLVRDNVLSLERAFELLSANPARLLGVEAGTLEA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
GREADILLVDTDKPWVVSTARMTASAGNTPFDGQPVQGRAIAVVKGGVQVIAN
CCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA