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The map label for this gene is dsbC [H]

Identifier: 84622422

GI number: 84622422

Start: 824337

End: 825134

Strand: Direct

Name: dsbC [H]

Synonym: XOO_0765

Alternate gene names: 84622422

Gene position: 824337-825134 (Clockwise)

Preceding gene: 84622421

Following gene: 84622423

Centisome position: 16.69

GC content: 66.54

Gene sequence:

>798_bases
ATGTATCGTCTTGCCATCGCCGCGCTGCTGGGCGCGATCAGCCTTACCGCCTGCGCACAATCGTCGCAGCCTGCGGCAAG
CACTGTCGGCGCCAAGCCCGCCGCCGCGCCCGCCGCCGCCGGCAACGTGGATCAGCGCGTGAGCACGGCGCTCAAGGCGC
TGGACCCGGATTTCAAGCCTGACTACCTCGGTGCTGCACCATTCCCCGGCTTCCGCGAAGTGGTCGTCGGTGGGCAGGTG
CTGTACGTCAGCGATGACGGCCGTTACCTGATCCAGGCGCAGCCGTTCGACATCCAGAACAAGCAATTCGCCGCCAGCCC
GGGCCTGCTGGCCTACCGCCGCAAGCAGCTGGACACTGTGCCCAAAGCCGACCGCATCGTCTTTGCGCCGGCAAACCCGA
AGTACACCGTCACCGTCTTTACCGACGTGGAATGTGGCTACTGCCGCAAGCTGCACAGCGAGATCGGCGAGCTCAACAAG
CAGGGCATCGCGGTGGAATACCTCGCGTTCCCGCGCATGGGCCTGGGCAGCCAGGACCACAAGGAAATGATCGCGGTGTG
GTGCGCTGCCGATCGCAAGCAAGCGCTGACGGCCGCCAAGTCCGGTCAGCCGGTGGCTTCCAAGGACTGCAAGAACCCGG
TGTCGATGGAATACACCCTGGGCCAGCGCCTGGGTGTCAACGGTACGCCGGCGATCTTTGCGCCAGACGGCACGCAGCTT
GGTGGCTACCTGCCGCCAGCGCAGCTGCGTGAGGCGCTGGAAAAGCGCGCCGTCGCCACGGCCGGCGGCAGCCGCTGA

Upstream 100 bases:

>100_bases
GCAGTTGTTCGCTTGCCGTGTTGCCAAATGTCGCGGCCGCTGCCGGGCTTCATCTGCGCTGTGCAAGAATGCCGGCACCT
CATTCCATCTGGATGCGTGA

Downstream 100 bases:

>100_bases
TCCACGGCGGAGCGGCGGTGTGATGCCGCTTGGCGGGTCACATCGGTGGCCGGCGCGATCGAACGGAAGGCTGGAATGCA
GATGCATTCCGGCCTTCTGC

Product: disulfide isomerase

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MYRLAIAALLGAISLTACAQSSQPAASTVGAKPAAAPAAAGNVDQRVSTALKALDPDFKPDYLGAAPFPGFREVVVGGQV
LYVSDDGRYLIQAQPFDIQNKQFAASPGLLAYRRKQLDTVPKADRIVFAPANPKYTVTVFTDVECGYCRKLHSEIGELNK
QGIAVEYLAFPRMGLGSQDHKEMIAVWCAADRKQALTAAKSGQPVASKDCKNPVSMEYTLGQRLGVNGTPAIFAPDGTQL
GGYLPPAQLREALEKRAVATAGGSR

Sequences:

>Translated_265_residues
MYRLAIAALLGAISLTACAQSSQPAASTVGAKPAAAPAAAGNVDQRVSTALKALDPDFKPDYLGAAPFPGFREVVVGGQV
LYVSDDGRYLIQAQPFDIQNKQFAASPGLLAYRRKQLDTVPKADRIVFAPANPKYTVTVFTDVECGYCRKLHSEIGELNK
QGIAVEYLAFPRMGLGSQDHKEMIAVWCAADRKQALTAAKSGQPVASKDCKNPVSMEYTLGQRLGVNGTPAIFAPDGTQL
GGYLPPAQLREALEKRAVATAGGSR
>Mature_265_residues
MYRLAIAALLGAISLTACAQSSQPAASTVGAKPAAAPAAAGNVDQRVSTALKALDPDFKPDYLGAAPFPGFREVVVGGQV
LYVSDDGRYLIQAQPFDIQNKQFAASPGLLAYRRKQLDTVPKADRIVFAPANPKYTVTVFTDVECGYCRKLHSEIGELNK
QGIAVEYLAFPRMGLGSQDHKEMIAVWCAADRKQALTAAKSGQPVASKDCKNPVSMEYTLGQRLGVNGTPAIFAPDGTQL
GGYLPPAQLREALEKRAVATAGGSR

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=199, Percent_Identity=39.6984924623116, Blast_Score=162, Evalue=2e-41,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 28085; Mature: 28085

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRLAIAALLGAISLTACAQSSQPAASTVGAKPAAAPAAAGNVDQRVSTALKALDPDFKP
CHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
DYLGAAPFPGFREVVVGGQVLYVSDDGRYLIQAQPFDIQNKQFAASPGLLAYRRKQLDTV
CCCCCCCCCCHHHHEECCEEEEEECCCCEEEEECCCCCCCCEECCCCCHHHHHHHHHCCC
PKADRIVFAPANPKYTVTVFTDVECGYCRKLHSEIGELNKQGIAVEYLAFPRMGLGSQDH
CCCCEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHH
KEMIAVWCAADRKQALTAAKSGQPVASKDCKNPVSMEYTLGQRLGVNGTPAIFAPDGTQL
HHHHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCCC
GGYLPPAQLREALEKRAVATAGGSR
CCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYRLAIAALLGAISLTACAQSSQPAASTVGAKPAAAPAAAGNVDQRVSTALKALDPDFKP
CHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
DYLGAAPFPGFREVVVGGQVLYVSDDGRYLIQAQPFDIQNKQFAASPGLLAYRRKQLDTV
CCCCCCCCCCHHHHEECCEEEEEECCCCEEEEECCCCCCCCEECCCCCHHHHHHHHHCCC
PKADRIVFAPANPKYTVTVFTDVECGYCRKLHSEIGELNKQGIAVEYLAFPRMGLGSQDH
CCCCEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHH
KEMIAVWCAADRKQALTAAKSGQPVASKDCKNPVSMEYTLGQRLGVNGTPAIFAPDGTQL
HHHHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCCC
GGYLPPAQLREALEKRAVATAGGSR
CCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]