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The map label for this gene is metC [H]

Identifier: 84622365

GI number: 84622365

Start: 760713

End: 761906

Strand: Direct

Name: metC [H]

Synonym: XOO_0708

Alternate gene names: 84622365

Gene position: 760713-761906 (Clockwise)

Preceding gene: 84622364

Following gene: 84622366

Centisome position: 15.4

GC content: 65.16

Gene sequence:

>1194_bases
ATGTCCAACCGCACCACTCATAGCCATGACGGCGATCGCGCGCTGTCGCTTGCAACGCTGGCGATCCATGGAGGGCAGTC
GCCGGATCCCAGCACCGGCGCAGTGATGCCGCCGATCTACGCCACGTCCACGTATGCGCAATCCAGCCCCGGCGAACACC
AGGGCTTCGAATATTCCCGCACCCACAACCCCACGCGCTTCGCCTACGAGCGCTGCGTGGCGGCGCTGGAAGGCGGCACG
CGCGCGTTCGCGTTCGCCTCCGGCATGGCTGCCACTTCCACCGTGATGGAGTTGCTGGATGCCGGCAGCCACGTGGTGGC
GATGGACGATCTGTACGGCGGCACCTTCCGCCTGTTCGAGCGCGTGCGCCGTCGCACCGCCGGCCTGGATTTCAGTTTCG
TCGACCTGACCGACCCGGCCGCGTTTAAGGCGGCGATCCGCGCAGACACCAAGATGGTGTGGATCGAAACGCCGACCAAC
CCGATGCTCAAGCTGGTCGACATCGCCGCCATTGCGGTGATCGCGCGCAAGCATGGCCTGTTGACCGTGGTCGACAACAC
CTTTGCCTCGCCGATGCTGCAGCGCCCGCTCAGCCTGGGCGCCGACCTCGTCGTGCACTCGGCCACCAAGTACCTCAACG
GCCACTCGGACATGGTGGGCGGCATTGCGGTGGTGGGCGACAACGCCGAGCTCGCCGAGCAGATGGCGTTCCTGCAGAAC
TCCATCGGTGGCGTGCAAGGCCCGTTCGACAGCTTCCTCGCGCTACGCGGATTGAAGACCTTGCCGCTGCGCATGCGCGC
GCACTGCGAAAATGCCCTGGCGCTGGCGCAATGGCTGGAAACGCACCCCGCCATCGAAAAGGTGATCTACCCCGGCCTGG
CCTCGCACCCGCAGCATGTGCTCGCGAAACGCCAGATGTCCGGCTTCGGCGGCATCGTCTCCATCGTCCTCAAGGGCGGC
TTCGACGCAGCCAAGCGTTTCTGCGAGAAGACCGAGCTGTTCACCCTGGCCGAATCGCTCGGTGGTGTTGAAAGCCTGGT
GAACCATCCCGCCGTCATGACGCACGCCTCCATCCCCGTTGCCCGCCGCGAGCAGCTCGGCATCAGCGATGCGCTGGTGC
GGTTGAGCGTGGGAATCGAGGATCTTGGGGATTTGCGTGGGGATTTGGAGCGGGCGTTGGTGAATCAAAATTGA

Upstream 100 bases:

>100_bases
CGTGCAGTGAATCCCGTGCAGCCGCGCGTTTCGATGAGACGCGCGGCACGGGCCATTCAGACCCGCTTGTTACAATCGCC
CACTTTTTCCGGGAACCTCC

Downstream 100 bases:

>100_bases
GGCGTTTATTGTTATATGGTGCTGTATCTGTTGCTGGAGGTAGTTTGTGCTAAAGAATTTTTCAAATACAAGGCCTACTA
CGATACCGCGGGGAACCAGT

Product: cystathionine gamma-lyase-like protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSNRTTHSHDGDRALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGT
RAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTN
PMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGG
FDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN

Sequences:

>Translated_397_residues
MSNRTTHSHDGDRALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGT
RAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTN
PMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGG
FDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN
>Mature_396_residues
SNRTTHSHDGDRALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTR
AFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNP
MLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNS
IGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHVLAKRQMSGFGGIVSIVLKGGF
DAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=54.7945205479452, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=49.5890410958904, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=47.8021978021978, Blast_Score=315, Evalue=7e-86,
Organism=Escherichia coli, GI1790375, Length=381, Percent_Identity=45.4068241469816, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=29.156010230179, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=52.0435967302452, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=50.1362397820163, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71980708, Length=379, Percent_Identity=37.467018469657, Blast_Score=242, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=48.062015503876, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6321254, Length=405, Percent_Identity=34.8148148148148, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=33.5648148148148, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=324, Percent_Identity=31.7901234567901, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=29.6482412060301, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19922554, Length=381, Percent_Identity=49.3438320209974, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42586; Mature: 42455

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRTTHSHDGDRALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSR
CCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
THNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFE
CCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHH
RVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGL
HHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCE
LTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
EEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHH
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHV
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPV
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCH
ARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNRTTHSHDGDRALSLATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSR
CCCCCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
THNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLYGGTFRLFE
CCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHH
RVRRRTAGLDFSFVDLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGL
HHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCE
LTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN
EEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHH
SIGGVQGPFDSFLALRGLKTLPLRMRAHCENALALAQWLETHPAIEKVIYPGLASHPQHV
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LAKRQMSGFGGIVSIVLKGGFDAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPV
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCH
ARREQLGISDALVRLSVGIEDLGDLRGDLERALVNQN
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]