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The map label for this gene is cbs [H]

Identifier: 84622364

GI number: 84622364

Start: 759252

End: 760622

Strand: Direct

Name: cbs [H]

Synonym: XOO_0707

Alternate gene names: 84622364

Gene position: 759252-760622 (Clockwise)

Preceding gene: 84622363

Following gene: 84622365

Centisome position: 15.37

GC content: 63.68

Gene sequence:

>1371_bases
ATGGCGATTCATTCCTCCGTACTCGAACTGATTGGCAACACGCCGATCGTCAAGGCCCAGCGCCTGGACACCGGCGTCTG
CGAGCTGTTCCTCAAGCTGGAGGCGAGTAATCCTGGCGGATCGATCAAGGACCGCATCGGTCTGTCGATGATCGAAGCGG
CCGAGCAGCGCGGCGATCTCACGCCCGGCGCCACCCTGGTGGAGGGCACCGCCGGCAACACCGGTCTGGGCTTGGCCCTG
GTGGCGCAGCAGAAGGGCTACCAGTTGATCCTGGTGGTGCCGGACAAGATGAGCCGCGAGAAGATCTTCAATCTCAAGGC
CATGGGCGCCAACGTGGTGCTGACCCGCTCGGATGTGGCCAAGGGCCACCCGGAGTACTACCAGGACCTGGCCGCCAAGA
TCGCTGCCGAAACGCCGGGGGCCTACTTCATCAACCAGTTCGGCAACCCGGACAACCCGGCCGCGCACGAATTCGGCACC
GGCCCGGAGATCCTGGCGCAGATGGACGGCCAGCTGGACGCCATCGTGTTCGGCTGCGGCAGCTCCGGCACCATGACTGG
CCTGTCGCGCGCCTTCGCCAGCGCCTCGCCGCACACCGAACTGGTGCTGGCCGACCCGGTCGGCTCGATCCTGACCCAGT
ACATCGAAGAAGGCACGGTCAGCGAAAAGTCGGGCAGCTGGCTGGTCGAAGGCATCGGCGAAGACTTCTTGCCGGACATC
TCCGACTTTTCGCGCGTCAAGAAGGCCTATTCCATCAGCGATGCGGAAAGCTTCCACACCGCGCGCGAATTGCTGGCCAA
AGAGGGCGTCCTCGGCGGCTCGTCCACCGGCACCTTGCTGGCCGCGGCGCTGAAGTATTGCCGCGAGCAGACCACGCCCA
AGCGCGTGCTGGTGTTCGTCTGCGATACCGGCAACAAGTATCTGTCGAAGATGTACAACGACTACTGGATGCTCGACAAC
GGCTTTTTGGAGCGCCCGCAATACGGCGATCTGCGCGACCTGATCCTTCGCCCGTACAACAAGCGCGACACCGTGGTGGT
GGGCCCGAAGGATCTGCTGACCACCGCCTACCAGCGCATGAAACTGTACGATGTGTCGCAGCTGCCGGTGATCGACGATG
GCGAATTGGTCGGCATCGTCGACGAGAGCGACGTGCTGCTGCATGTCTATGGCGACGAGGCGCGCTTCCGCGACCCGATC
TCCACCGCCATGGTGAGCAAGCTGGATCGTCTGGACGTCGCATCGCCCATCGAAGCGCTGTTGCCGGTGTTCGACCGCGG
CCAGGTCGCCATCGTCATGAACGGCAAGCAGTTTCTTGGCCTGATCACCCGCATCGACCTGCTCAACTACCTGCGCCGTC
GCGTGCAGTGA

Upstream 100 bases:

>100_bases
TCATCGGCCTGCATGATCGTTTCAAGGCTGAATGCGCATTCCCCAGCTGTTCGTCGGATAATGACCGGCCCAGCCCGTGT
GGCGCAGCGACGATATGCCG

Downstream 100 bases:

>100_bases
ATCCCGTGCAGCCGCGCGTTTCGATGAGACGCGCGGCACGGGCCATTCAGACCCGCTTGTTACAATCGCCCACTTTTTCC
GGGAACCTCCATGTCCAACC

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEASNPGGSIKDRIGLSMIEAAEQRGDLTPGATLVEGTAGNTGLGLAL
VAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAAKIAAETPGAYFINQFGNPDNPAAHEFGT
GPEILAQMDGQLDAIVFGCGSSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
SDFSRVKKAYSISDAESFHTARELLAKEGVLGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDN
GFLERPQYGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRMKLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPI
STAMVSKLDRLDVASPIEALLPVFDRGQVAIVMNGKQFLGLITRIDLLNYLRRRVQ

Sequences:

>Translated_456_residues
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEASNPGGSIKDRIGLSMIEAAEQRGDLTPGATLVEGTAGNTGLGLAL
VAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAAKIAAETPGAYFINQFGNPDNPAAHEFGT
GPEILAQMDGQLDAIVFGCGSSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
SDFSRVKKAYSISDAESFHTARELLAKEGVLGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDN
GFLERPQYGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRMKLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPI
STAMVSKLDRLDVASPIEALLPVFDRGQVAIVMNGKQFLGLITRIDLLNYLRRRVQ
>Mature_455_residues
AIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEASNPGGSIKDRIGLSMIEAAEQRGDLTPGATLVEGTAGNTGLGLALV
AQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVAKGHPEYYQDLAAKIAAETPGAYFINQFGNPDNPAAHEFGTG
PEILAQMDGQLDAIVFGCGSSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDIS
DFSRVKKAYSISDAESFHTARELLAKEGVLGGSSTGTLLAAALKYCREQTTPKRVLVFVCDTGNKYLSKMYNDYWMLDNG
FLERPQYGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRMKLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPIS
TAMVSKLDRLDVASPIEALLPVFDRGQVAIVMNGKQFLGLITRIDLLNYLRRRVQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=472, Percent_Identity=35.3813559322034, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI295821200, Length=472, Percent_Identity=35.3813559322034, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI4557415, Length=472, Percent_Identity=35.3813559322034, Blast_Score=265, Evalue=5e-71,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=39.6103896103896, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=42.1052631578947, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=41.7682926829268, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=38.109756097561, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=36.6883116883117, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=37.2549019607843, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=37.2093023255814, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI115535073, Length=345, Percent_Identity=36.5217391304348, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=34.640522875817, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=33.0357142857143, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71996324, Length=343, Percent_Identity=26.8221574344023, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=24.1279069767442, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=503, Percent_Identity=33.5984095427435, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6321449, Length=337, Percent_Identity=33.5311572700297, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24643623, Length=468, Percent_Identity=33.974358974359, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI20129101, Length=468, Percent_Identity=33.974358974359, Blast_Score=241, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49617; Mature: 49486

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEASNPGGSIKDRIGLSMIEAAEQRGDL
CCCHHHHHHHHCCCCCEEHHHCCHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
TPGATLVEGTAGNTGLGLALVAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVA
CCCCEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHEECCCEEEEEECHHC
KGHPEYYQDLAAKIAAETPGAYFINQFGNPDNPAAHEFGTGPEILAQMDGQLDAIVFGCG
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECC
SSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCH
SDFSRVKKAYSISDAESFHTARELLAKEGVLGGSSTGTLLAAALKYCREQTTPKRVLVFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
CDTGNKYLSKMYNDYWMLDNGFLERPQYGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRM
ECCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPISTAMVSKLDRLDVASPIEAL
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
LPVFDRGQVAIVMNGKQFLGLITRIDLLNYLRRRVQ
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIHSSVLELIGNTPIVKAQRLDTGVCELFLKLEASNPGGSIKDRIGLSMIEAAEQRGDL
CCHHHHHHHHCCCCCEEHHHCCHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
TPGATLVEGTAGNTGLGLALVAQQKGYQLILVVPDKMSREKIFNLKAMGANVVLTRSDVA
CCCCEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHEECCCEEEEEECHHC
KGHPEYYQDLAAKIAAETPGAYFINQFGNPDNPAAHEFGTGPEILAQMDGQLDAIVFGCG
CCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECC
SSGTMTGLSRAFASASPHTELVLADPVGSILTQYIEEGTVSEKSGSWLVEGIGEDFLPDI
CCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCH
SDFSRVKKAYSISDAESFHTARELLAKEGVLGGSSTGTLLAAALKYCREQTTPKRVLVFV
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
CDTGNKYLSKMYNDYWMLDNGFLERPQYGDLRDLILRPYNKRDTVVVGPKDLLTTAYQRM
ECCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KLYDVSQLPVIDDGELVGIVDESDVLLHVYGDEARFRDPISTAMVSKLDRLDVASPIEAL
HHCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
LPVFDRGQVAIVMNGKQFLGLITRIDLLNYLRRRVQ
HHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]