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The map label for this gene is glmU [H]

Identifier: 84622330

GI number: 84622330

Start: 723506

End: 724870

Strand: Direct

Name: glmU [H]

Synonym: XOO_0673

Alternate gene names: 84622330

Gene position: 723506-724870 (Clockwise)

Preceding gene: 84622328

Following gene: 84622332

Centisome position: 14.65

GC content: 66.59

Gene sequence:

>1365_bases
ATGACTCTGCCCCTGCACGTTGTGATCCTGGCCGCGGGCGAGGGCAAGCGCATGCGCTCGTCCCTGCCCAAAGTGCTGCA
GCCGCTGGCGGGCCAGCCGATGCTGGCGCACGTGATCGCCACCGCGCGGCAGCTGCAGCCGGCGGCGATCCATATCGTGT
ACGGGCACGGCAGCGATCAGGTGCAGGCCGCCTTTGCCGATCAAAGCGATCTGCAGTGGGCCGCGCAGCGCGAGCAGCTG
GGCACCGGACATGCCGTGCAGCAAGCGATGCCTGCGATTCCCGACGCGGCGAGGGTGCTCGTGTTGTACGGCGATGTGCC
GCTGATCCGCAGCGAAAGCCTGTTGCAGTTGCTGCATGCACCGGGCCGCATGGCGGTGTTGGTGGCCGAACTGGCCAATC
CCACCGGCTATGGACGCATCCTGCGCGATGCGGAAGGCAAGGTGGCCGCCATCGTCGAGCAGAAGGACGCCAACGACGAA
CAGCGCCGCATCCGCACCATCAATACCGGCATCCTCACCGCCGAATCCACCGCACTGCGCCGCTGGTTGGGTGGCTTGTC
CAACGACAATGCGCAGGGCGAGTTCTATCTCACCGATGTGTTCGCCAGCGCCGCTGCCGATTTCACACCGGCCGACATGG
TGCATGTGGCCGACCCGCAGGACGTGGAGGGTGCCAACGACCCGTGGCAACTCGCCCAGCTCGAACGCGCATGGCAGCTG
CGCGCTGCGCGCGCGCTGTCCCTGCAGGGCGTGCGCATGGCCGACCCGGCGCGTGTGGAGCAGCGTGGCAGCGTGCAGGT
GGGTCGCGATGTGCAGCTGGATATCGATGTGATCCTGGAAGGCGAGGTGACGCTGGGCGATGACGTGGTGATCGGCCCGT
TCGTGCGGCTGCGCGATGTCACGCTCGGTGCCGGCACGCAGGTGCGTGCGCACAGCGACCTGGAAGGCGTGATTACCGAA
GGCGCGGTGCAGATCGGCCCGTTCGCGCGGCTGCGCCCGGGCACCGTGTTGGCCGATGGCGTGCATATCGGCAATTTCGT
GGAGACCAAGAAGGTCACCATGGGCGTCGACAGCAAGGCCAACCATCTGACCTACTTGGGCGATGCGGTGATCGGCAGCA
AGGTCAACATCGGTGCCGGCACCATCACCTGCAACTACGACGGAGTGAACAAGTCGCAGACCACCATCGGCGATGGCGCG
TTTGTCGGCTCCAACAGCGCGTTGGTGGCGCCGATCGAAATTGGCGCCAACTCCACCATCGGTGCCGGGTCGGTGGTCAC
GCGCGATGCACCGGCGGGCCAGCTCACGGTGACGCGTGCGCGGCAGACCGTGATCGAAGGCTGGGAACGGCCGACCAAGA
AATAG

Upstream 100 bases:

>100_bases
GGCGCAAACGCCGTTATCGCAGACCAACACTGCATCCGGGCAACGACGCGACGGGGTGCAGCGACTAGAATTTAGCCATC
TATATGCCTGGAATGTCTTG

Downstream 100 bases:

>100_bases
GCTGCACGCTGCATCGCAGAGAACAGCGCCGCTCTGGCGCTGATGGCGCTTGGCGGCGCGACCCATCCAAGCGCGCGACA
GTTCCGCCGTTCTCGGCGCG

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTLPLHVVILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGSDQVQAAFADQSDLQWAAQREQL
GTGHAVQQAMPAIPDAARVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDE
QRRIRTINTGILTAESTALRRWLGGLSNDNAQGEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQL
RAARALSLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGEVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVITE
GAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVDSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGA
FVGSNSALVAPIEIGANSTIGAGSVVTRDAPAGQLTVTRARQTVIEGWERPTKK

Sequences:

>Translated_454_residues
MTLPLHVVILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGSDQVQAAFADQSDLQWAAQREQL
GTGHAVQQAMPAIPDAARVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDE
QRRIRTINTGILTAESTALRRWLGGLSNDNAQGEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQL
RAARALSLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGEVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVITE
GAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVDSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGA
FVGSNSALVAPIEIGANSTIGAGSVVTRDAPAGQLTVTRARQTVIEGWERPTKK
>Mature_453_residues
TLPLHVVILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGSDQVQAAFADQSDLQWAAQREQLG
TGHAVQQAMPAIPDAARVLVLYGDVPLIRSESLLQLLHAPGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDEQ
RRIRTINTGILTAESTALRRWLGGLSNDNAQGEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQLR
AARALSLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGEVTLGDDVVIGPFVRLRDVTLGAGTQVRAHSDLEGVITEG
AVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVDSKANHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGAF
VGSNSALVAPIEIGANSTIGAGSVVTRDAPAGQLTVTRARQTVIEGWERPTKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=51.7699115044248, Blast_Score=447, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48175; Mature: 48044

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPLHVVILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGSDQ
CCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCC
VQAAFADQSDLQWAAQREQLGTGHAVQQAMPAIPDAARVLVLYGDVPLIRSESLLQLLHA
EEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHC
PGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDEQRRIRTINTGILTAESTALR
CCCEEEEEEECCCCCCCCHHEECCCCCEEEEEECCCCCHHHHHEEEEECCEEEECHHHHH
RWLGGLSNDNAQGEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQL
HHHCCCCCCCCCCEEEEEEEHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHH
RAARALSLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGEVTLGDDVVIGPFVRLRDV
HHHHHHEECCCCCCCCHHHHCCCCEEECCEEEEEEEEEEECCEEECCCEEECCCEEEEEE
TLGAGTQVRAHSDLEGVITEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVDSKA
EECCCCEEEECCCCHHHHHCCCEEECCCCCCCCCCEEECCEEECCEEECCEEEECCCCCC
NHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGAFVGSNSALVAPIEIGANSTI
CEEEEECCHHCCCEEECCCEEEEEECCCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCC
GAGSVVTRDAPAGQLTVTRARQTVIEGWERPTKK
CCCCEEECCCCCCCEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLPLHVVILAAGEGKRMRSSLPKVLQPLAGQPMLAHVIATARQLQPAAIHIVYGHGSDQ
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCC
VQAAFADQSDLQWAAQREQLGTGHAVQQAMPAIPDAARVLVLYGDVPLIRSESLLQLLHA
EEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHC
PGRMAVLVAELANPTGYGRILRDAEGKVAAIVEQKDANDEQRRIRTINTGILTAESTALR
CCCEEEEEEECCCCCCCCHHEECCCCCEEEEEECCCCCHHHHHEEEEECCEEEECHHHHH
RWLGGLSNDNAQGEFYLTDVFASAAADFTPADMVHVADPQDVEGANDPWQLAQLERAWQL
HHHCCCCCCCCCCEEEEEEEHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHH
RAARALSLQGVRMADPARVEQRGSVQVGRDVQLDIDVILEGEVTLGDDVVIGPFVRLRDV
HHHHHHEECCCCCCCCHHHHCCCCEEECCEEEEEEEEEEECCEEECCCEEECCCEEEEEE
TLGAGTQVRAHSDLEGVITEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVTMGVDSKA
EECCCCEEEECCCCHHHHHCCCEEECCCCCCCCCCEEECCEEECCEEECCEEEECCCCCC
NHLTYLGDAVIGSKVNIGAGTITCNYDGVNKSQTTIGDGAFVGSNSALVAPIEIGANSTI
CEEEEECCHHCCCEEECCCEEEEEECCCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCC
GAGSVVTRDAPAGQLTVTRARQTVIEGWERPTKK
CCCCEEECCCCCCCEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]