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The map label for this gene is lpd [H]

Identifier: 84622315

GI number: 84622315

Start: 710544

End: 712367

Strand: Direct

Name: lpd [H]

Synonym: XOO_0658

Alternate gene names: 84622315

Gene position: 710544-712367 (Clockwise)

Preceding gene: 84622314

Following gene: 84622316

Centisome position: 14.38

GC content: 65.95

Gene sequence:

>1824_bases
ATGGCGGTCATTGAAATCAAGGTTCCCGACATCGGCGATTACAGCGATGTCCCCGTCATCGAAGTGCTGGTCGCCGTTGG
CGACAGCGTGGCCAAGGACCAGGGCCTGGTAACGCTGGAATCGGACAAGGCCACGCTGGAAGTGCCGTCCTCGGCCGCGG
GTGTTGTCAAGGAACTCAAGGTCAAGGTCGGCGACATCTTGTCCGAAGGCGCGCTCGTGCTGCTGCTCGAAACCGAAGGC
GAGGCTGCCGCGCCGGCCAAGGCCGAGACCAAGGCCGCACCGGCCGCTGTCGCGCCTGCTGCCGCGCCGGGCAGCAAGCC
GCCGGTGACGCCGTCGCATCGCGCCCCGGCCGAACCGGCGCCGTCCAAGCCCGCACTGGCCAGCGACAAGCCGGCCGATA
TCGCATGCAAGATGGTGGTGCTCGGCGCCGGCCCCGGTGGCTACACGGCCGCATTCCGCGCCGCCGATCTGGGCCTGGAC
ACGGTGCTGATCGAGCGCTACGCCAGCCTCGGCGGCGTCTGCCTCAACGTTGGCTGCATCCCGTCCAAGGCGCTGCTGCA
TGCCGCCGCGGTGATCGATGAAGTGGCCCATGCCGGCGACTTCGGCGTGGACTTCGGTCAGCCCAAGATCACCCTGGGCA
CGCTGCGCGAGTACAAGGAAAAAGTGGTCGGCAAGCTCACCGGCGGCCTGGCCAGCATGGCCAAGCAGCGCAAGGTACGT
ACCGTCACCGGCGTGGCAACGTTCGTTTCGCCCAATGAGCTGGAAATCGTCGGCGACGACGGCAAGACCCAGCTGCTGCG
CTTCGAGCACTGCATCATCGCGGCCGGCTCGCAGGCGGTGAAGCTGCCCAACTTCCCATGGGACGACAAGCGCGTGATGG
ACTCCACCGACGCGCTGGAGCTGCACGACATTCCCAAGACCCTGCTGGTGGTCGGCGGCGGCATCATCGGTCTGGAAATG
GCCACGGTGTACAGCGCGCTCGGCAGCAAGGTCACCGTGGTCGAATTCATGGACCAGCTGATGCCGGGCGCCGACAAGGA
CCTGGTCAAGCCGCTGGCCGACCGCCTGAAGAAGCAGGGCGTCGACGTCCATCTCAAGACCAAGGCCACCGACGTCACCG
CCGGTAAAAAGGGCATCACCGTGTCCTTCGAAGCGGCCGTGGAGGGCGACAAACCCGGCCTGCAGGCCACTGCGTACGAC
CGCGTGCTGGTCGCCGTGGGCCGCTCGCCCAACGGCAAGAAGATCGGTGCCGACAAGGCCGGCGTCACGGTCACCGAGCG
TGGCTTCATTCCGGTCGACCGGCAGATGCGCACCAACGTGCCGCACATCTTCGCCATCGGCGACATCGTCGGTAACCCGA
TGCTGGCGCACAAGGCCACGCACGAAGGCAAGCTGGCCGCCGAAGTGGCTGCCGGCGAGAAGAAGGAATGGGTGGCGCGG
GTGATCCCGTCGGTGGCGTACACCAACCCGGAAATCGCCTGGGTCGGCGTGACCGAGACCGAAGCCAAGGCCAAGGGCCT
GAAGGTCGGCGTGGCCAAGTTCCCGTGGGCTGCCAGTGGCCGCGCGATCGGTATCGGCCGCACCGAGGGCTTCACCAAGC
TGATTTTCGACGAAGAAACCCATCGCGTGATCGGTGGCGCCATCGTCGGTGTGCATGCCGGCGATCTGCTGGCTGAAATT
GGTCTGGCGATCGAAATGGGTGCCGAGGCCGAAGACATCGGCCACACCATCCATGCGCATCCGACCCTGAGCGAATCGGT
CGGCATGGCTGCCGAGGTGTACGACGGCACCATCACCGACCTGTACATCCCCAAGAAAAAGTGA

Upstream 100 bases:

>100_bases
GAAAAGAAGCGCGACAAGCGCTGGACCCAAATCGAATCGTCGCTGGATGAACTCCAGCAGACGCTTGCCGGCACGGCCGG
TTGAGCTACAGGAGAAGCAA

Downstream 100 bases:

>100_bases
CGCCGCTCTGCACGACCGTGCCGCCACGTATGGCACGGTCGCCGCGGTGCTGACTCGACGCATGGAGGTCGCCGTGTGGT
GGGGGGGCAATCTGTGTCCC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MAVIEIKVPDIGDYSDVPVIEVLVAVGDSVAKDQGLVTLESDKATLEVPSSAAGVVKELKVKVGDILSEGALVLLLETEG
EAAAPAKAETKAAPAAVAPAAAPGSKPPVTPSHRAPAEPAPSKPALASDKPADIACKMVVLGAGPGGYTAAFRAADLGLD
TVLIERYASLGGVCLNVGCIPSKALLHAAAVIDEVAHAGDFGVDFGQPKITLGTLREYKEKVVGKLTGGLASMAKQRKVR
TVTGVATFVSPNELEIVGDDGKTQLLRFEHCIIAAGSQAVKLPNFPWDDKRVMDSTDALELHDIPKTLLVVGGGIIGLEM
ATVYSALGSKVTVVEFMDQLMPGADKDLVKPLADRLKKQGVDVHLKTKATDVTAGKKGITVSFEAAVEGDKPGLQATAYD
RVLVAVGRSPNGKKIGADKAGVTVTERGFIPVDRQMRTNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAGEKKEWVAR
VIPSVAYTNPEIAWVGVTETEAKAKGLKVGVAKFPWAASGRAIGIGRTEGFTKLIFDEETHRVIGGAIVGVHAGDLLAEI
GLAIEMGAEAEDIGHTIHAHPTLSESVGMAAEVYDGTITDLYIPKKK

Sequences:

>Translated_607_residues
MAVIEIKVPDIGDYSDVPVIEVLVAVGDSVAKDQGLVTLESDKATLEVPSSAAGVVKELKVKVGDILSEGALVLLLETEG
EAAAPAKAETKAAPAAVAPAAAPGSKPPVTPSHRAPAEPAPSKPALASDKPADIACKMVVLGAGPGGYTAAFRAADLGLD
TVLIERYASLGGVCLNVGCIPSKALLHAAAVIDEVAHAGDFGVDFGQPKITLGTLREYKEKVVGKLTGGLASMAKQRKVR
TVTGVATFVSPNELEIVGDDGKTQLLRFEHCIIAAGSQAVKLPNFPWDDKRVMDSTDALELHDIPKTLLVVGGGIIGLEM
ATVYSALGSKVTVVEFMDQLMPGADKDLVKPLADRLKKQGVDVHLKTKATDVTAGKKGITVSFEAAVEGDKPGLQATAYD
RVLVAVGRSPNGKKIGADKAGVTVTERGFIPVDRQMRTNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAGEKKEWVAR
VIPSVAYTNPEIAWVGVTETEAKAKGLKVGVAKFPWAASGRAIGIGRTEGFTKLIFDEETHRVIGGAIVGVHAGDLLAEI
GLAIEMGAEAEDIGHTIHAHPTLSESVGMAAEVYDGTITDLYIPKKK
>Mature_606_residues
AVIEIKVPDIGDYSDVPVIEVLVAVGDSVAKDQGLVTLESDKATLEVPSSAAGVVKELKVKVGDILSEGALVLLLETEGE
AAAPAKAETKAAPAAVAPAAAPGSKPPVTPSHRAPAEPAPSKPALASDKPADIACKMVVLGAGPGGYTAAFRAADLGLDT
VLIERYASLGGVCLNVGCIPSKALLHAAAVIDEVAHAGDFGVDFGQPKITLGTLREYKEKVVGKLTGGLASMAKQRKVRT
VTGVATFVSPNELEIVGDDGKTQLLRFEHCIIAAGSQAVKLPNFPWDDKRVMDSTDALELHDIPKTLLVVGGGIIGLEMA
TVYSALGSKVTVVEFMDQLMPGADKDLVKPLADRLKKQGVDVHLKTKATDVTAGKKGITVSFEAAVEGDKPGLQATAYDR
VLVAVGRSPNGKKIGADKAGVTVTERGFIPVDRQMRTNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAGEKKEWVARV
IPSVAYTNPEIAWVGVTETEAKAKGLKVGVAKFPWAASGRAIGIGRTEGFTKLIFDEETHRVIGGAIVGVHAGDLLAEIG
LAIEMGAEAEDIGHTIHAHPTLSESVGMAAEVYDGTITDLYIPKKK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=41.1637931034483, Blast_Score=339, Evalue=5e-93,
Organism=Homo sapiens, GI50301238, Length=450, Percent_Identity=27.7777777777778, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=27.1264367816092, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148277065, Length=435, Percent_Identity=27.1264367816092, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI33519430, Length=435, Percent_Identity=27.1264367816092, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI33519428, Length=435, Percent_Identity=27.1264367816092, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI33519426, Length=435, Percent_Identity=27.1264367816092, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=28.110599078341, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI22035672, Length=437, Percent_Identity=28.3752860411899, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI291045268, Length=424, Percent_Identity=26.6509433962264, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1786307, Length=475, Percent_Identity=60.8421052631579, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=28.9130434782609, Blast_Score=185, Evalue=9e-48,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=28.7280701754386, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=27.5626423690205, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1786305, Length=78, Percent_Identity=56.4102564102564, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=41.7218543046358, Blast_Score=344, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=29.6610169491525, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71983429, Length=442, Percent_Identity=27.3755656108597, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=442, Percent_Identity=27.3755656108597, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=443, Percent_Identity=25.2821670428894, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=41.8604651162791, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6325240, Length=481, Percent_Identity=28.8981288981289, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6325166, Length=458, Percent_Identity=28.3842794759825, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=42.3982869379015, Blast_Score=357, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24640551, Length=524, Percent_Identity=26.9083969465649, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640549, Length=431, Percent_Identity=27.3781902552204, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24640553, Length=431, Percent_Identity=27.3781902552204, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=26.0780287474333, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 63104; Mature: 62973

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIEIKVPDIGDYSDVPVIEVLVAVGDSVAKDQGLVTLESDKATLEVPSSAAGVVKELK
CEEEEEECCCCCCCCCCHHHHHHHHHCCCHHCCCCCEEEECCCCEEECCCHHHHHHHHHH
VKVGDILSEGALVLLLETEGEAAAPAKAETKAAPAAVAPAAAPGSKPPVTPSHRAPAEPA
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSKPALASDKPADIACKMVVLGAGPGGYTAAFRAADLGLDTVLIERYASLGGVCLNVGCI
CCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCC
PSKALLHAAAVIDEVAHAGDFGVDFGQPKITLGTLREYKEKVVGKLTGGLASMAKQRKVR
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
TVTGVATFVSPNELEIVGDDGKTQLLRFEHCIIAAGSQAVKLPNFPWDDKRVMDSTDALE
EEEEEEEEECCCEEEEECCCCCEEEEEEEEEEEECCCCEEECCCCCCCCCHHCCCCCCEE
LHDIPKTLLVVGGGIIGLEMATVYSALGSKVTVVEFMDQLMPGADKDLVKPLADRLKKQG
ECCCCCEEEHCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VDVHLKTKATDVTAGKKGITVSFEAAVEGDKPGLQATAYDRVLVAVGRSPNGKKIGADKA
CCEEEEECCCEECCCCCCEEEEEEEEECCCCCCCEEEHHCEEEEEECCCCCCCCCCCCCC
GVTVTERGFIPVDRQMRTNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAGEKKEWVAR
CEEEEECCCCCCCHHHHCCCCEEEEEHHHHCCCHHEECCCCCCCEEEHHHCCCHHHHHHH
VIPSVAYTNPEIAWVGVTETEAKAKGLKVGVAKFPWAASGRAIGIGRTEGFTKLIFDEET
HHHHHHCCCCCEEEEECCCCHHHHCCEEEEHEECCCCCCCCEEEECCCCCCEEEEECCCH
HRVIGGAIVGVHAGDLLAEIGLAIEMGAEAEDIGHTIHAHPTLSESVGMAAEVYDGTITD
HHEECEEEEEEEHHHHHHHHCCEEECCCCHHHHCCEEECCCCCHHHHCCEEEECCCCEEE
LYIPKKK
EEECCCC
>Mature Secondary Structure 
AVIEIKVPDIGDYSDVPVIEVLVAVGDSVAKDQGLVTLESDKATLEVPSSAAGVVKELK
EEEEEECCCCCCCCCCHHHHHHHHHCCCHHCCCCCEEEECCCCEEECCCHHHHHHHHHH
VKVGDILSEGALVLLLETEGEAAAPAKAETKAAPAAVAPAAAPGSKPPVTPSHRAPAEPA
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSKPALASDKPADIACKMVVLGAGPGGYTAAFRAADLGLDTVLIERYASLGGVCLNVGCI
CCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCC
PSKALLHAAAVIDEVAHAGDFGVDFGQPKITLGTLREYKEKVVGKLTGGLASMAKQRKVR
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
TVTGVATFVSPNELEIVGDDGKTQLLRFEHCIIAAGSQAVKLPNFPWDDKRVMDSTDALE
EEEEEEEEECCCEEEEECCCCCEEEEEEEEEEEECCCCEEECCCCCCCCCHHCCCCCCEE
LHDIPKTLLVVGGGIIGLEMATVYSALGSKVTVVEFMDQLMPGADKDLVKPLADRLKKQG
ECCCCCEEEHCCCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VDVHLKTKATDVTAGKKGITVSFEAAVEGDKPGLQATAYDRVLVAVGRSPNGKKIGADKA
CCEEEEECCCEECCCCCCEEEEEEEEECCCCCCCEEEHHCEEEEEECCCCCCCCCCCCCC
GVTVTERGFIPVDRQMRTNVPHIFAIGDIVGNPMLAHKATHEGKLAAEVAAGEKKEWVAR
CEEEEECCCCCCCHHHHCCCCEEEEEHHHHCCCHHEECCCCCCCEEEHHHCCCHHHHHHH
VIPSVAYTNPEIAWVGVTETEAKAKGLKVGVAKFPWAASGRAIGIGRTEGFTKLIFDEET
HHHHHHCCCCCEEEEECCCCHHHHCCEEEEHEECCCCCCCCEEEECCCCCCEEEEECCCH
HRVIGGAIVGVHAGDLLAEIGLAIEMGAEAEDIGHTIHAHPTLSESVGMAAEVYDGTITD
HHEECEEEEEEEHHHHHHHHCCEEECCCCHHHHCCEEECCCCCHHHHCCEEEECCCCEEE
LYIPKKK
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]