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The map label for this gene is sppA [H]

Identifier: 84622191

GI number: 84622191

Start: 583268

End: 585169

Strand: Direct

Name: sppA [H]

Synonym: XOO_0534

Alternate gene names: 84622191

Gene position: 583268-585169 (Clockwise)

Preceding gene: 84622190

Following gene: 84622193

Centisome position: 11.81

GC content: 65.35

Gene sequence:

>1902_bases
ATGAACCATCCCGTGCGTCGCAGTCCCATCGCCAGCTTCTTCGTCGGCCTGTGGGATGTGATGAATTTCACCCGGCGCCT
CATTTTCAACCTGGTGTTCTTCGGTTTCCTGTTTATGCTGCTGCTGGTGTTCGTGGTGGCGCTCGCGCGTGGCGACGGCA
CTAAGCCGCTGGCTGAGCGCACCACCCTGGTGATCAACCCGGAAGGCACGCTGGTCGAGCAGTTCAGCGCCGACCCGGTA
AGCCGTTCGCTGGCCAAGGCAGTGGGCGACAAGAGCGCTCAAGAAGTGCAGCTGCGCGACCTGGTGCGGGTGATCGAGGC
GGCCGGCAAAGATCGCAAGATCGAGCGCGTGCTGTTGAATCTGGACAAGTTCCAACCGTCCGGTTTCGCTTCGCAGCGCG
AAGTGGCCGCTGCGCTGCAGAAGCTGCGTGCCTCCGGCAAGCAGATCGTGGCCTTCAGCGAGAGCATGAGCCAGGGCCAG
TACCTGCTTGCCGCGCAGGCTAACGAGGTGTATCTGGATCCGATGGGCAGCGTGCTGCTGGAAGGCCTCGGCCGCTATCG
CCAGTACTTCCGCGAAGGCCTGCAGGACAAGCTCGGCGTGGACGTGCATCTGTTCCGCGTGGGCGAGTACAAATCCGCCG
CCGAGCCGTACATCCTCGACGCGGCCTCTGCCGATGCCAAGGAAGCGGATCTGTTCTGGATGAACGATGTGTGGCAGCGC
TATCTGGCCGACGTGGTCACTGCGCGCAAGCTGAGCCCGGCGCAGCTGACCGCCGGTATCGACACGCTGCCTGAGGGCGT
GGCCGCCGCCGGTGGCGACCTGGCCAAGTTCGCGCTGCAGCAGAAGCTGGTGGACGGGCTTAAGACCCGCGAGGAAGTCG
ATGCGTTGCTGGTCAAGCGCGGCGTGGCCGATAGCGATGCCGACAGCGGTTTCCGCAACATCGGTTTCAACGATTATCTG
AGCCAGTTGCAGGCGCAGGATTCGCCGATGGACAGCCGCCCGCAGGTGGCGGTGGTGGTGGCGACCGGCGAAATCAGCGG
CGGTGAACAGCCGGCCGGTCGCATCGGTGGCGAGTCCACCGCGGCGCTGCTGCGCCAGGCGCGTGACGACGAGAAAGTGA
AGGCGGTGGTGCTGCGCGTGGATTCGCCCGGCGGCGAAGTGTTCGCCTCCGAGCAGATCCGCCGCGAAGTGGTCGCACTC
AAGCAGGCCGGCAAGCCGGTGGTGGTCTCGATGGGCGATCTGGCCGCTTCCGGCGGTTATTGGATCAGCATGAATGCCGA
TCGCATCTACGCCGACCCGTCGACCATCAGCGGTTCCATCGGCATCTTCGGCATGGTGCCGAACCTGACCCGCGCGCTGG
ACAAGATTGGCGTGCATACCGACGGCGTGGGCACCACGCGGTTCGCTGGTGCGTTCGACATCACCCGGCCGCTGGATCCG
GCCGCCGGCCAGGTTATCCAGGCGGTGATCAACAAGGGTTACGCCGATTTCACCGGCAAGGTGGCGCAGGCGCGCCACCA
GTCGGTGGACGCGATCGACAAGGTTGCGCGTGGCCGTGTGTGGAGCGGCGCGCAGGCCAAGGAGCGTGGGTTGGTGGATG
CGTTCGGCGGCATGTCCGAAGCGGTGGCCGATGCGGCCGACCGCGCCAAGCTGAGCCGTGGCAAGTTCCGCGTGCGCTAT
GTGGAAAAGCCGGCCACGCCGTTCTCGCAGTTCATGAACGGGTTCGCCGGCAGCCGCATGGGCGCATGGATGCTGAGCGA
CTCGGGCATGGCACGCGCACTTGTGGCCCGCGCGTTGCCGGAAGTGGACACGCAGCTGCGCTTTGTCGAAAGCGCCGTGC
ACGACAGCAAGGCGGGTGGCACGCCGGTGAAATCGCTGGCGTATTGCTTCTGCGGATTCTGA

Upstream 100 bases:

>100_bases
CACCGCGACACCCTGACTTCCAGCGCATGCCGCGCGCGCTGCGCAGCCGGTATGCTGGGCACCATCGATTTGTATGCAGC
GTCTTTCGACGGAGTTTTCC

Downstream 100 bases:

>100_bases
TGCGGCGCGTTTGAGCAGCACCTGATGCGTCGCAACGCCGGCCATGTGCCGGCCTTGCTGTGTTGCAGGCGGATGATGCG
GTGTGCGACGGCCGAACGAA

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MNHPVRRSPIASFFVGLWDVMNFTRRLIFNLVFFGFLFMLLLVFVVALARGDGTKPLAERTTLVINPEGTLVEQFSADPV
SRSLAKAVGDKSAQEVQLRDLVRVIEAAGKDRKIERVLLNLDKFQPSGFASQREVAAALQKLRASGKQIVAFSESMSQGQ
YLLAAQANEVYLDPMGSVLLEGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWQR
YLADVVTARKLSPAQLTAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVKRGVADSDADSGFRNIGFNDYL
SQLQAQDSPMDSRPQVAVVVATGEISGGEQPAGRIGGESTAALLRQARDDEKVKAVVLRVDSPGGEVFASEQIRREVVAL
KQAGKPVVVSMGDLAASGGYWISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVGTTRFAGAFDITRPLDP
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMSEAVADAADRAKLSRGKFRVRY
VEKPATPFSQFMNGFAGSRMGAWMLSDSGMARALVARALPEVDTQLRFVESAVHDSKAGGTPVKSLAYCFCGF

Sequences:

>Translated_633_residues
MNHPVRRSPIASFFVGLWDVMNFTRRLIFNLVFFGFLFMLLLVFVVALARGDGTKPLAERTTLVINPEGTLVEQFSADPV
SRSLAKAVGDKSAQEVQLRDLVRVIEAAGKDRKIERVLLNLDKFQPSGFASQREVAAALQKLRASGKQIVAFSESMSQGQ
YLLAAQANEVYLDPMGSVLLEGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWQR
YLADVVTARKLSPAQLTAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVKRGVADSDADSGFRNIGFNDYL
SQLQAQDSPMDSRPQVAVVVATGEISGGEQPAGRIGGESTAALLRQARDDEKVKAVVLRVDSPGGEVFASEQIRREVVAL
KQAGKPVVVSMGDLAASGGYWISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVGTTRFAGAFDITRPLDP
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMSEAVADAADRAKLSRGKFRVRY
VEKPATPFSQFMNGFAGSRMGAWMLSDSGMARALVARALPEVDTQLRFVESAVHDSKAGGTPVKSLAYCFCGF
>Mature_633_residues
MNHPVRRSPIASFFVGLWDVMNFTRRLIFNLVFFGFLFMLLLVFVVALARGDGTKPLAERTTLVINPEGTLVEQFSADPV
SRSLAKAVGDKSAQEVQLRDLVRVIEAAGKDRKIERVLLNLDKFQPSGFASQREVAAALQKLRASGKQIVAFSESMSQGQ
YLLAAQANEVYLDPMGSVLLEGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWQR
YLADVVTARKLSPAQLTAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVKRGVADSDADSGFRNIGFNDYL
SQLQAQDSPMDSRPQVAVVVATGEISGGEQPAGRIGGESTAALLRQARDDEKVKAVVLRVDSPGGEVFASEQIRREVVAL
KQAGKPVVVSMGDLAASGGYWISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVGTTRFAGAFDITRPLDP
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMSEAVADAADRAKLSRGKFRVRY
VEKPATPFSQFMNGFAGSRMGAWMLSDSGMARALVARALPEVDTQLRFVESAVHDSKAGGTPVKSLAYCFCGF

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=626, Percent_Identity=41.85303514377, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1787527, Length=256, Percent_Identity=30.46875, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 68259; Mature: 68259

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPVRRSPIASFFVGLWDVMNFTRRLIFNLVFFGFLFMLLLVFVVALARGDGTKPLAER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
TTLVINPEGTLVEQFSADPVSRSLAKAVGDKSAQEVQLRDLVRVIEAAGKDRKIERVLLN
EEEEECCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LDKFQPSGFASQREVAAALQKLRASGKQIVAFSESMSQGQYLLAAQANEVYLDPMGSVLL
HHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCEEEEECCCEEEECHHHHHHH
EGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWQR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
YLADVVTARKLSPAQLTAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVKR
HHHHHHHHHCCCHHHHHCCHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVADSDADSGFRNIGFNDYLSQLQAQDSPMDSRPQVAVVVATGEISGGEQPAGRIGGEST
CCCCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
AALLRQARDDEKVKAVVLRVDSPGGEVFASEQIRREVVALKQAGKPVVVSMGDLAASGGY
HHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
WISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVGTTRFAGAFDITRPLDP
EEEECCCEEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMSE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHCCHHH
AVADAADRAKLSRGKFRVRYVEKPATPFSQFMNGFAGSRMGAWMLSDSGMARALVARALP
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
EVDTQLRFVESAVHDSKAGGTPVKSLAYCFCGF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNHPVRRSPIASFFVGLWDVMNFTRRLIFNLVFFGFLFMLLLVFVVALARGDGTKPLAER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
TTLVINPEGTLVEQFSADPVSRSLAKAVGDKSAQEVQLRDLVRVIEAAGKDRKIERVLLN
EEEEECCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LDKFQPSGFASQREVAAALQKLRASGKQIVAFSESMSQGQYLLAAQANEVYLDPMGSVLL
HHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCEEEEECCCEEEECHHHHHHH
EGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWQR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
YLADVVTARKLSPAQLTAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVKR
HHHHHHHHHCCCHHHHHCCHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVADSDADSGFRNIGFNDYLSQLQAQDSPMDSRPQVAVVVATGEISGGEQPAGRIGGEST
CCCCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
AALLRQARDDEKVKAVVLRVDSPGGEVFASEQIRREVVALKQAGKPVVVSMGDLAASGGY
HHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
WISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVGTTRFAGAFDITRPLDP
EEEECCCEEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMSE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHCCHHH
AVADAADRAKLSRGKFRVRYVEKPATPFSQFMNGFAGSRMGAWMLSDSGMARALVARALP
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
EVDTQLRFVESAVHDSKAGGTPVKSLAYCFCGF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3522590; 9097039; 9278503; 7973728 [H]