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The map label for this gene is nrdA [H]

Identifier: 84622096

GI number: 84622096

Start: 479528

End: 482026

Strand: Direct

Name: nrdA [H]

Synonym: XOO_0439

Alternate gene names: 84622096

Gene position: 479528-482026 (Clockwise)

Preceding gene: 84622095

Following gene: 84622097

Centisome position: 9.71

GC content: 62.87

Gene sequence:

>2499_bases
ATGACCACCAACGACACCCTTGCCGCGATCGCCGCCGGTACCGCAACACCCACCAGCGTTCCTGCCAGCGTTGCCGCGCC
CGCCTGTGGCGCGCCGGAATTGACCGACCCGTCGGACATCGTGCCGCCTCCCCGCCAAGCGATTGCAATGCACGCACAGA
CCATCGAAGAACAAAACGTCTCCACCTGGATCACCAAGGAAGCGGGCAATCGCAAGATTCCGTTCGAGCCGGAGCGCCTG
GAGCGCGCCATCGACCAGATCCACGCCGAGTTCCCGCAGCTGGACGTGGCCGACTACAAGCGCTCGGTGTTCGGGTTTGT
CGAGCGCAAGGACAGCGTCAACGCCGACGACCTGGTCGACCACCTGATCCGCGAGGCCGAAGCCCGCGTCGATCTGACCA
CCCCGGAGTGGGAACACTTCGCGGCGCGCCTGTACCTGCGCCGCCTGTACAAGCGTGCCAGCCGCAACCGCTTCTACGAC
GCCAGCCAGAAGTACGGCTCGTTCGTCGGCCTGCAGGAGAGCCTGGCCGACCGCAATGTCTATTCCAACGACATCCTGCG
CCGTTACTCCAAGGACGAGCTGATCGAAGCCGGCAAGATGATCGAGCCCGAGCGCGACAAGCTGTTCGCCTACAACGGCC
TGTACCTGCTGGCCACGCGTTACCTGGCCACCGACAGCTCGCGCGGCGTGTTCGAACTGCCCCAAGAGCGCTGGCTGACC
ATTGCGCTGTACCTGATGCAGGACGAGATCGGCACCGGCAAGGGCAGCCGCGAGCGCCGCATGCAGCTGGTCGGCGAGGC
CTACTGGGCGCTGTCCAACCTGTACATGACGGTGGCAACCCCGACGCTGGCCAATGCCGGCAAGGTCGGCGGCCAGCTGT
CGAGCTGCTTCATCGACACTGTCGACGACAGCCTGCAGGGCATCTACGACTCCAATACCGACGTGGCGCGCGTGTCCAAG
CACGGCGGCGGCGTGGGCGCGTACCTGGGCTATGTGCGCTCGTCGGGTTCGGCGATCCGTGGCGTGTCCAACTCGTCCGG
TGGCGTGGTGCCGTGGATCAAGCAGCTCAACAACACCGCCGTGTCGGTGGATCAGCTGGGCCAGCGCAAGGGCGCCATCG
CGGTCTATCTGGACATCTTCCACCGCGATATCGAAGCGTTCCTGGATCTGCGCCTGAACAACGGCGACCAGCGCCTGCGC
GCGCACGACGTGTTCACCTCGGTGTGCATCCCCGACCTGTTCATGGAAGCGGTCGAGCGCCGCGGCGACTGGTACCTGTT
CGACCCGCACGAAGTGAAGCGGGTCAAGGGCTGGTACTTGCAGGACTTCTATGACGAGAAGAAGGGCGACGCCAACAGCA
GCTTCCGCCGCAAGTACGAAGAAGTCGTCGCCGACGAGCGCATCACGCGCAAGACCGTCAAGGCGATCGAGATCTTCAAG
CGCATCATGGTCAGCCAGCTGGAAACCGGCAACCCGTTCATGTTCTATCGCGATGAAGTCAATCGCAAGAACCCGAACAA
GCACGAGGGCATGGTCTATTCGTCCAACCTGTGTACCGAGATCCTGCAGAACATGAGCCCGACGCGGATGATGCAGGAGA
TCATCAGCGGCAATCAGATCGTCACCACCAAGAAGGCCGGCGACTTCGTCGTGTGCAACCTGTCCTCGATCAACCTGGGC
CGCGCGATCACCGTGCAGGCCGACCAGGCCGATCTGCTGGGTGCCGACGTGCTGGAGCGCCTGATCCCGATCCAGGTGCG
CATGCTCGACAACGTGATCGATCTGAACCAGTTGCCGGTGCCGCAGGCCACCATCACCAATCAGAAATACCGCGCAATTG
GTCTTGGCACCTTCGGGTGGCACCATCTGCTCGCGCAGAAGGCCATCCACTGGAATGCCAAGGAAGCCGAGGACTACAGC
GATGAGCTGTACGAGCGCATCAACTACCTGACCATCCAGGCGAGCATGGAGCTGGCCAAGGAAAAGGGCACCTACAGCGT
GTTCCGCGGCAGCGACTGGCACAACGGCGAGTACTTCCGTGCGCGCGACTACAACAGCCCGCAATGGCTGGAACTGTCGG
CGCAGGTGGCGGTCAACGGCGTGCGCAATGCCTGGATGCTGGCGGTGGCACCGAACATGAGCACCGCGCAGATCGCCGGT
TCCACTGCGTCGATCGACCCGATCTACAGCGCGTTCTATTACGAAGAAAAGAAGGACTTCCGGCGTCCGGTCGCCGCTCC
TGGTTTGTCGCTGGACACCTGGCCGTACTACGAAAAGGGCGCCTACAAGGTCGACCAGTTCGCCAGCGTGCGCCAGAACG
CGCGTCGCCAGCGTCACGTGGACCAATCGATCAGTTTCAACTTCTACGTGCCCAGCACCATCCGTGCGAGCACGCTGCTG
GACCTGCACATGACCGCCTGGCGGGAAGGTCTGAAGACCACGTACTACGTGCGTTCCAACGATATCGACATCAGTGAGTG
CGAGTGGTGCAGTAGCTAA

Upstream 100 bases:

>100_bases
GGCCTGCGCGCTGCGGCTGTCGTCTTGCCAATACCGCCTGAACGCCGCTCGGCCGTTGCCTGCTCACCGGCAGGTTCGTG
TGCCTAAGTATGGAGGACGC

Downstream 100 bases:

>100_bases
GCGCATTCGCGCTTCGCTTCCACAGTTCGCAAGGCCAACTGTGGACCCTGCTTCACCAGCTCCCACACCTCGCGCCTTCG
GCGCGCCCCCTGACTCAGGG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 832; Mature: 831

Protein sequence:

>832_residues
MTTNDTLAAIAAGTATPTSVPASVAAPACGAPELTDPSDIVPPPRQAIAMHAQTIEEQNVSTWITKEAGNRKIPFEPERL
ERAIDQIHAEFPQLDVADYKRSVFGFVERKDSVNADDLVDHLIREAEARVDLTTPEWEHFAARLYLRRLYKRASRNRFYD
ASQKYGSFVGLQESLADRNVYSNDILRRYSKDELIEAGKMIEPERDKLFAYNGLYLLATRYLATDSSRGVFELPQERWLT
IALYLMQDEIGTGKGSRERRMQLVGEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTDVARVSK
HGGGVGAYLGYVRSSGSAIRGVSNSSGGVVPWIKQLNNTAVSVDQLGQRKGAIAVYLDIFHRDIEAFLDLRLNNGDQRLR
AHDVFTSVCIPDLFMEAVERRGDWYLFDPHEVKRVKGWYLQDFYDEKKGDANSSFRRKYEEVVADERITRKTVKAIEIFK
RIMVSQLETGNPFMFYRDEVNRKNPNKHEGMVYSSNLCTEILQNMSPTRMMQEIISGNQIVTTKKAGDFVVCNLSSINLG
RAITVQADQADLLGADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLAQKAIHWNAKEAEDYS
DELYERINYLTIQASMELAKEKGTYSVFRGSDWHNGEYFRARDYNSPQWLELSAQVAVNGVRNAWMLAVAPNMSTAQIAG
STASIDPIYSAFYYEEKKDFRRPVAAPGLSLDTWPYYEKGAYKVDQFASVRQNARRQRHVDQSISFNFYVPSTIRASTLL
DLHMTAWREGLKTTYYVRSNDIDISECEWCSS

Sequences:

>Translated_832_residues
MTTNDTLAAIAAGTATPTSVPASVAAPACGAPELTDPSDIVPPPRQAIAMHAQTIEEQNVSTWITKEAGNRKIPFEPERL
ERAIDQIHAEFPQLDVADYKRSVFGFVERKDSVNADDLVDHLIREAEARVDLTTPEWEHFAARLYLRRLYKRASRNRFYD
ASQKYGSFVGLQESLADRNVYSNDILRRYSKDELIEAGKMIEPERDKLFAYNGLYLLATRYLATDSSRGVFELPQERWLT
IALYLMQDEIGTGKGSRERRMQLVGEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTDVARVSK
HGGGVGAYLGYVRSSGSAIRGVSNSSGGVVPWIKQLNNTAVSVDQLGQRKGAIAVYLDIFHRDIEAFLDLRLNNGDQRLR
AHDVFTSVCIPDLFMEAVERRGDWYLFDPHEVKRVKGWYLQDFYDEKKGDANSSFRRKYEEVVADERITRKTVKAIEIFK
RIMVSQLETGNPFMFYRDEVNRKNPNKHEGMVYSSNLCTEILQNMSPTRMMQEIISGNQIVTTKKAGDFVVCNLSSINLG
RAITVQADQADLLGADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLAQKAIHWNAKEAEDYS
DELYERINYLTIQASMELAKEKGTYSVFRGSDWHNGEYFRARDYNSPQWLELSAQVAVNGVRNAWMLAVAPNMSTAQIAG
STASIDPIYSAFYYEEKKDFRRPVAAPGLSLDTWPYYEKGAYKVDQFASVRQNARRQRHVDQSISFNFYVPSTIRASTLL
DLHMTAWREGLKTTYYVRSNDIDISECEWCSS
>Mature_831_residues
TTNDTLAAIAAGTATPTSVPASVAAPACGAPELTDPSDIVPPPRQAIAMHAQTIEEQNVSTWITKEAGNRKIPFEPERLE
RAIDQIHAEFPQLDVADYKRSVFGFVERKDSVNADDLVDHLIREAEARVDLTTPEWEHFAARLYLRRLYKRASRNRFYDA
SQKYGSFVGLQESLADRNVYSNDILRRYSKDELIEAGKMIEPERDKLFAYNGLYLLATRYLATDSSRGVFELPQERWLTI
ALYLMQDEIGTGKGSRERRMQLVGEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTDVARVSKH
GGGVGAYLGYVRSSGSAIRGVSNSSGGVVPWIKQLNNTAVSVDQLGQRKGAIAVYLDIFHRDIEAFLDLRLNNGDQRLRA
HDVFTSVCIPDLFMEAVERRGDWYLFDPHEVKRVKGWYLQDFYDEKKGDANSSFRRKYEEVVADERITRKTVKAIEIFKR
IMVSQLETGNPFMFYRDEVNRKNPNKHEGMVYSSNLCTEILQNMSPTRMMQEIISGNQIVTTKKAGDFVVCNLSSINLGR
AITVQADQADLLGADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLAQKAIHWNAKEAEDYSD
ELYERINYLTIQASMELAKEKGTYSVFRGSDWHNGEYFRARDYNSPQWLELSAQVAVNGVRNAWMLAVAPNMSTAQIAGS
TASIDPIYSAFYYEEKKDFRRPVAAPGLSLDTWPYYEKGAYKVDQFASVRQNARRQRHVDQSISFNFYVPSTIRASTLLD
LHMTAWREGLKTTYYVRSNDIDISECEWCSS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=723, Percent_Identity=30.4287690179806, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1789030, Length=687, Percent_Identity=30.5676855895196, Blast_Score=280, Evalue=3e-76,
Organism=Escherichia coli, GI2367133, Length=740, Percent_Identity=26.7567567567568, Blast_Score=230, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17555242, Length=742, Percent_Identity=30.8625336927224, Blast_Score=307, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6320914, Length=746, Percent_Identity=30.9651474530831, Blast_Score=306, Evalue=7e-84,
Organism=Saccharomyces cerevisiae, GI6322123, Length=746, Percent_Identity=31.0991957104558, Blast_Score=304, Evalue=4e-83,
Organism=Drosophila melanogaster, GI17352481, Length=738, Percent_Identity=29.5392953929539, Blast_Score=290, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 94162; Mature: 94031

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNDTLAAIAAGTATPTSVPASVAAPACGAPELTDPSDIVPPPRQAIAMHAQTIEEQNV
CCCCCCCCEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
STWITKEAGNRKIPFEPERLERAIDQIHAEFPQLDVADYKRSVFGFVERKDSVNADDLVD
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
HLIREAEARVDLTTPEWEHFAARLYLRRLYKRASRNRFYDASQKYGSFVGLQESLADRNV
HHHHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
YSNDILRRYSKDELIEAGKMIEPERDKLFAYNGLYLLATRYLATDSSRGVFELPQERWLT
HHHHHHHHCCHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCEECCCHHHEE
IALYLMQDEIGTGKGSRERRMQLVGEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDT
EEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHH
VDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSSGSAIRGVSNSSGGVVPWIKQLNNTA
HHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCE
VSVDQLGQRKGAIAVYLDIFHRDIEAFLDLRLNNGDQRLRAHDVFTSVCIPDLFMEAVER
EEHHHHCCCCCCEEEEHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
RGDWYLFDPHEVKRVKGWYLQDFYDEKKGDANSSFRRKYEEVVADERITRKTVKAIEIFK
CCCEEEECHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIMVSQLETGNPFMFYRDEVNRKNPNKHEGMVYSSNLCTEILQNMSPTRMMQEIISGNQI
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCCEE
VTTKKAGDFVVCNLSSINLGRAITVQADQADLLGADVLERLIPIQVRMLDNVIDLNQLPV
EEEECCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PQATITNQKYRAIGLGTFGWHHLLAQKAIHWNAKEAEDYSDELYERINYLTIQASMELAK
CCHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEHHHHHHH
EKGTYSVFRGSDWHNGEYFRARDYNSPQWLELSAQVAVNGVRNAWMLAVAPNMSTAQIAG
CCCCEEEECCCCCCCCCEEEECCCCCCCEEEEEHHHHHHCCCCEEEEEECCCCCHHHCCC
STASIDPIYSAFYYEEKKDFRRPVAAPGLSLDTWPYYEKGAYKVDQFASVRQNARRQRHV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
DQSISFNFYVPSTIRASTLLDLHMTAWREGLKTTYYVRSNDIDISECEWCSS
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCC
>Mature Secondary Structure 
TTNDTLAAIAAGTATPTSVPASVAAPACGAPELTDPSDIVPPPRQAIAMHAQTIEEQNV
CCCCCCCEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
STWITKEAGNRKIPFEPERLERAIDQIHAEFPQLDVADYKRSVFGFVERKDSVNADDLVD
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
HLIREAEARVDLTTPEWEHFAARLYLRRLYKRASRNRFYDASQKYGSFVGLQESLADRNV
HHHHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
YSNDILRRYSKDELIEAGKMIEPERDKLFAYNGLYLLATRYLATDSSRGVFELPQERWLT
HHHHHHHHCCHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCEECCCHHHEE
IALYLMQDEIGTGKGSRERRMQLVGEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDT
EEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHH
VDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSSGSAIRGVSNSSGGVVPWIKQLNNTA
HHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCE
VSVDQLGQRKGAIAVYLDIFHRDIEAFLDLRLNNGDQRLRAHDVFTSVCIPDLFMEAVER
EEHHHHCCCCCCEEEEHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
RGDWYLFDPHEVKRVKGWYLQDFYDEKKGDANSSFRRKYEEVVADERITRKTVKAIEIFK
CCCEEEECHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIMVSQLETGNPFMFYRDEVNRKNPNKHEGMVYSSNLCTEILQNMSPTRMMQEIISGNQI
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCCEE
VTTKKAGDFVVCNLSSINLGRAITVQADQADLLGADVLERLIPIQVRMLDNVIDLNQLPV
EEEECCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PQATITNQKYRAIGLGTFGWHHLLAQKAIHWNAKEAEDYSDELYERINYLTIQASMELAK
CCHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEHHHHHHH
EKGTYSVFRGSDWHNGEYFRARDYNSPQWLELSAQVAVNGVRNAWMLAVAPNMSTAQIAG
CCCCEEEECCCCCCCCCEEEECCCCCCCEEEEEHHHHHHCCCCEEEEEECCCCCHHHCCC
STASIDPIYSAFYYEEKKDFRRPVAAPGLSLDTWPYYEKGAYKVDQFASVRQNARRQRHV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
DQSISFNFYVPSTIRASTLLDLHMTAWREGLKTTYYVRSNDIDISECEWCSS
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]