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The map label for this gene is ubiA [H]

Identifier: 84622074

GI number: 84622074

Start: 448977

End: 449876

Strand: Direct

Name: ubiA [H]

Synonym: XOO_0417

Alternate gene names: 84622074

Gene position: 448977-449876 (Clockwise)

Preceding gene: 84622073

Following gene: 84622076

Centisome position: 9.09

GC content: 66.89

Gene sequence:

>900_bases
ATGAGCAAGCATGATGTCGAACGACTGCCCGCAGCGTGCGGGCTGACGTGCCCGCAGCGACTGGGCCAGTACTGGCAGCT
GGTCCGTGGCGACCGCCCGATCGGGAGTCTGCTGCTGCTCTGGCCTACCTGGTGGGCGTTGTGGCTGGCCGCCGATGGCC
TGCCGCCGCTTTGGACGCTGTTCGTGTTCACCGCCGGGGTGTGGCTGACCCGCTCGGCCGGCTGCGTGATCAACGATTAC
GCCGACCGCTGGCTGGATCCGCACGTGGAGCGCACCAAATCGCGTCCGCTGGCCACCGGCGCGGTCTCCGGGCGCGAGGC
GCTCTGGGTATTCGTGGTACTGATGTTGGTGGCCTTCGCGCTGGTGTTCACGCTCAACTGGCTGACCGTGCTGCTGAGCG
TGCCCGGCGTCTTCCTGGCCGCCAGCTACCCCTATCTCAAGCGCCACACCCACCTGCCCCAGGTCTATCTGGGCATGGCG
TTCGGCTGGGGCATCCCGATGGCCTTCGCCGCCGTGCAAGGCAGCGTGCCGGTTCTGGGCTGGCTGCTGTACGCCGCCAA
CATCCTGTGGGCAACTGCCTACGACACCTGGTACGCCATGGTCGACCGCGACGACGACATCCGCATGGGCAGCAAATCCA
CCGCCATCCTGTTCGGCAGATTCGATCTGGTCGCGCAAGGCATCTTGTATGCGCTGATGTTCGCAGTCCTGGCCTTGGTC
GACCTGCGCGCTGATCTTGGTGCGGCGTACTGGGCCGGTCTGGGCGTTGCGGCCCTGCTGGTGGCCTACGAATTCCGCAT
CGCCCGCCACCGCGAGCGCGGCCCCTGCTTCCGTGCCTTCCTGCACAACAACTGGGTTGGCCTGGCGATCTTCGTTGGCA
TCGCGGTGGCGGGGCGTTAG

Upstream 100 bases:

>100_bases
GGCCAGCCGTATCCCATCGCGGAGGCAGGGCATTGCCAGGATTGCCGCCCGCACAGCGCCCACATGACCACGGCCGAGCC
GCGCTGCTACCCTTTGCCGC

Downstream 100 bases:

>100_bases
ATTCGGGAATCGGGATGGAGATGGAGATGGGAAATTCGTCGATTGAAGATCAGACATTGAAGTAGCGAGCAAGGATTCAC
AACTTGCCAGCCTCTACTGT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSKHDVERLPAACGLTCPQRLGQYWQLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVFTLNWLTVLLSVPGVFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMAFAAVQGSVPVLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLVAQGILYALMFAVLALV
DLRADLGAAYWAGLGVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAGR

Sequences:

>Translated_299_residues
MSKHDVERLPAACGLTCPQRLGQYWQLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVFTLNWLTVLLSVPGVFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMAFAAVQGSVPVLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLVAQGILYALMFAVLALV
DLRADLGAAYWAGLGVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAGR
>Mature_298_residues
SKHDVERLPAACGLTCPQRLGQYWQLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDYA
DRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVFTLNWLTVLLSVPGVFLAASYPYLKRHTHLPQVYLGMAF
GWGIPMAFAAVQGSVPVLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLVAQGILYALMFAVLALVD
LRADLGAAYWAGLGVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAGR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=286, Percent_Identity=34.965034965035, Blast_Score=157, Evalue=8e-39,
Organism=Escherichia coli, GI1790473, Length=279, Percent_Identity=56.2724014336918, Blast_Score=303, Evalue=9e-84,
Organism=Caenorhabditis elegans, GI17553718, Length=301, Percent_Identity=34.21926910299, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI32565247, Length=302, Percent_Identity=34.1059602649007, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17553720, Length=204, Percent_Identity=39.2156862745098, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32565245, Length=161, Percent_Identity=40.9937888198758, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32565243, Length=160, Percent_Identity=40.625, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324370, Length=293, Percent_Identity=33.7883959044369, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355567, Length=274, Percent_Identity=37.956204379562, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33271; Mature: 33140

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHDVERLPAACGLTCPQRLGQYWQLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTL
CCCCHHHHCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFA
HHHHHHHHHHCCCCCEEEHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVFTLNWLTVLLSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGSVPVLG
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLVAQGILYALMFAVLALV
HHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
DLRADLGAAYWAGLGVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKHDVERLPAACGLTCPQRLGQYWQLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTL
CCCHHHHCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFA
HHHHHHHHHHCCCCCEEEHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVFTLNWLTVLLSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGSVPVLG
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLVAQGILYALMFAVLALV
HHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
DLRADLGAAYWAGLGVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]