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The map label for this gene is cobY [H]

Identifier: 84489131

GI number: 84489131

Start: 368294

End: 368893

Strand: Direct

Name: cobY [H]

Synonym: Msp_0310

Alternate gene names: 84489131

Gene position: 368294-368893 (Clockwise)

Preceding gene: 84489129

Following gene: 84489132

Centisome position: 20.84

GC content: 29.5

Gene sequence:

>600_bases
ATGACAACTGCATTGATTATGGCTGGTGGAAAAGGTACTAGATTAGACTTAGATTATGAAAAGCCAATGGTTAAAGTCAA
TACAAAACCAATGATAAGTTATGTAATAGAAGCATTATCCTTTTCAACATATATTGATAAGATATTGGTGGCTGTAAGTC
CAAATACTCCATGTACTGCAGATTATGTGAAAAAATATCCTGTTATTGTAGTAAAAACTAAGGGTCTAGGTTATATTGAG
GACTTATCAGATATTCTTTCAAACAGAAAATATGTTGATGAGGATGAAGTAGTTATGACAATAGTTTCTGATTTACCATT
TATCACATCAACTCAAATTGATGATGTGTTAGATAATTATTATGAAAGAAAAAAACCTGCTATGTGTGTATCAGTTCCAG
CATATTTATTTGAGAAATATGGAATAACACCAACAATGGTTTATGAAGGATTGGTTCCAACAGGTGTTAATTTACTACTG
GCAAATAACAAAGAACAAGATCAAACAATTTATGTATCAAAAAATATAGAACTGGCTTTTAACATCAATACACTTGATGA
TTTAGATTTATCTGAACATTATATTAAAAAAAGATGGTAG

Upstream 100 bases:

>100_bases
ATTATTTATATAGATTATGTTTTAAATACTATTTATTTTATGTTTATATTAATTAATAGATAGAGATAAATATATACATT
ATAATAAATGGAGCTTTAAT

Downstream 100 bases:

>100_bases
TTTAAATAAATTATATATACTTTTGAAAATAAATATACTATTTAATAATGTTTATCAATTAGGTAATATAAGATACGTTT
AGGTGGACACATATGACAAA

Product: GTP:adenosylcobinamide-phosphate guanylyltransferase

Products: NA

Alternate protein names: AdoCbi-P guanylyltransferase [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTTALIMAGGKGTRLDLDYEKPMVKVNTKPMISYVIEALSFSTYIDKILVAVSPNTPCTADYVKKYPVIVVKTKGLGYIE
DLSDILSNRKYVDEDEVVMTIVSDLPFITSTQIDDVLDNYYERKKPAMCVSVPAYLFEKYGITPTMVYEGLVPTGVNLLL
ANNKEQDQTIYVSKNIELAFNINTLDDLDLSEHYIKKRW

Sequences:

>Translated_199_residues
MTTALIMAGGKGTRLDLDYEKPMVKVNTKPMISYVIEALSFSTYIDKILVAVSPNTPCTADYVKKYPVIVVKTKGLGYIE
DLSDILSNRKYVDEDEVVMTIVSDLPFITSTQIDDVLDNYYERKKPAMCVSVPAYLFEKYGITPTMVYEGLVPTGVNLLL
ANNKEQDQTIYVSKNIELAFNINTLDDLDLSEHYIKKRW
>Mature_198_residues
TTALIMAGGKGTRLDLDYEKPMVKVNTKPMISYVIEALSFSTYIDKILVAVSPNTPCTADYVKKYPVIVVKTKGLGYIED
LSDILSNRKYVDEDEVVMTIVSDLPFITSTQIDDVLDNYYERKKPAMCVSVPAYLFEKYGITPTMVYEGLVPTGVNLLLA
NNKEQDQTIYVSKNIELAFNINTLDDLDLSEHYIKKRW

Specific function: Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide- phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Can not use other NTPs or GDP. Does not

COG id: COG2266

COG function: function code H; GTP:adenosylcobinamide-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005245
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.62 [H]

Molecular weight: Translated: 22516; Mature: 22385

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTALIMAGGKGTRLDLDYEKPMVKVNTKPMISYVIEALSFSTYIDKILVAVSPNTPCTA
CCEEEEEECCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCH
DYVKKYPVIVVKTKGLGYIEDLSDILSNRKYVDEDEVVMTIVSDLPFITSTQIDDVLDNY
HHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHH
YERKKPAMCVSVPAYLFEKYGITPTMVYEGLVPTGVNLLLANNKEQDQTIYVSKNIELAF
HHHCCCCEEEEHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEE
NINTLDDLDLSEHYIKKRW
ECCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
TTALIMAGGKGTRLDLDYEKPMVKVNTKPMISYVIEALSFSTYIDKILVAVSPNTPCTA
CEEEEEECCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCH
DYVKKYPVIVVKTKGLGYIEDLSDILSNRKYVDEDEVVMTIVSDLPFITSTQIDDVLDNY
HHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHH
YERKKPAMCVSVPAYLFEKYGITPTMVYEGLVPTGVNLLLANNKEQDQTIYVSKNIELAF
HHHCCCCEEEEHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEE
NINTLDDLDLSEHYIKKRW
ECCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]