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The map label for this gene is mtaD

Identifier: 84489028

GI number: 84489028

Start: 246296

End: 247573

Strand: Direct

Name: mtaD

Synonym: Msp_0200

Alternate gene names: 84489028

Gene position: 246296-247573 (Clockwise)

Preceding gene: 84489025

Following gene: 84489031

Centisome position: 13.94

GC content: 30.2

Gene sequence:

>1278_bases
ATGAGTGAAACAACAAGTATATTAATTAAAGATACCACTATTTTATCAGATAAAATAAAAAAAGCATCCATATTAATTGT
AGATAATACTATTGAAGAGATAAGTAATGATTTATCAGTGACTGATGCAAGTAAAGTTATTGATGGAACAAATAAGATAA
CAATGCCTGGCCTTGTTAACACACACTCTCATGTGGCAATGACACTGCTTAGAGGAGTAGGTGATGATGAAGAATTACAA
ACATGGCTTAATGATTATATATGGCCTAAAGAAGCAAAACTGGATGAAAAATTAGTATATGCTGGTTCAAAGTTGGCAAT
GGCTGAAATGATAAAAACAGGTACAACAACTTTTAATGATATGTATTTCTATATGGAAGAAACTGCAAAGGCAGTTGAAG
AATCAGGAATAAGGGGAGTTTTAGGTTATGGTATGATTGATCTTTTTGATGATGAAAAAAGAAAACAAGAAATTAAAGCA
ACAAAAAATCTTATAAAAAACTCACACAATACTGCTAATGGTAGAGTACAAGTAGCAGTAGCACCGCATGCTCCATATAC
TTGTTCTAAGGAATTATTAAGTGAATCTAAAAAATTAGCTAATAAACATAATCTAAAATTACATATACATGTTTCAGAAA
CACAACAAGAAGTAAATGATTTAGAAAAACAGAGAAATCAAACACCATTTGAATATTTGGATAGTATAGATTTGCTTGAT
GAAAATACTATTGCAGCACATGGAGTATGGACAACAGATAATGAAATGAAACTTCTTAAAGAAAAACAAGTATCCATATC
ACATAATCCATCAAGTAATATGAAATTAGCATCAGGTATTGCACCAGTTAGTAAATATATTAAAAATGATATTAATGTAG
CAATAGGTACTGATGGAGTATCTTCAAATAACAATCTAGACATGTTTAGTGAAATGAAACTAACAGCACTTCTACAGAAA
GTAAATACTATGAATGCAAAAACACTACCAGCACAAGCAACATTCAATATGGCAACAGAGAATGGTGCTAGAGCATTAGG
TATAAATACAGGTTCTATAAAAGAAGGTAAACTAGCAGATATTGTACTTGTTAATATGAATGTTCCACATATGATACCTG
TTAGAAATCCATTAAGTAACATAATATACTCAGCATTAGGTAGTGATGTTGATACAGTAATATGTGATGGACAACTACTT
CTAGAAGATAAGAAATTATTAACAATCAATGAAGAAGATGCTATTTATGATGCAAAATTAGCAGCACAACAGCTATAA

Upstream 100 bases:

>100_bases
TTTAATATAATAACTCATATTTTTCTATTAGAAAAATAACTATAAAAATAATTAGATTGTATTATATAACTATTTTATAA
CAATAAAATGAGGATTATGT

Downstream 100 bases:

>100_bases
AAAAAAGTATATGCTGGAAGCATATCTATTTAGCATATTCTCCAATACTTGAGAACTTCTCAATAATATCTTCTTTTTTT
AATTCTTTTTGTGGTATGGA

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSETTSILIKDTTILSDKIKKASILIVDNTIEEISNDLSVTDASKVIDGTNKITMPGLVNTHSHVAMTLLRGVGDDEELQ
TWLNDYIWPKEAKLDEKLVYAGSKLAMAEMIKTGTTTFNDMYFYMEETAKAVEESGIRGVLGYGMIDLFDDEKRKQEIKA
TKNLIKNSHNTANGRVQVAVAPHAPYTCSKELLSESKKLANKHNLKLHIHVSETQQEVNDLEKQRNQTPFEYLDSIDLLD
ENTIAAHGVWTTDNEMKLLKEKQVSISHNPSSNMKLASGIAPVSKYIKNDINVAIGTDGVSSNNNLDMFSEMKLTALLQK
VNTMNAKTLPAQATFNMATENGARALGINTGSIKEGKLADIVLVNMNVPHMIPVRNPLSNIIYSALGSDVDTVICDGQLL
LEDKKLLTINEEDAIYDAKLAAQQL

Sequences:

>Translated_425_residues
MSETTSILIKDTTILSDKIKKASILIVDNTIEEISNDLSVTDASKVIDGTNKITMPGLVNTHSHVAMTLLRGVGDDEELQ
TWLNDYIWPKEAKLDEKLVYAGSKLAMAEMIKTGTTTFNDMYFYMEETAKAVEESGIRGVLGYGMIDLFDDEKRKQEIKA
TKNLIKNSHNTANGRVQVAVAPHAPYTCSKELLSESKKLANKHNLKLHIHVSETQQEVNDLEKQRNQTPFEYLDSIDLLD
ENTIAAHGVWTTDNEMKLLKEKQVSISHNPSSNMKLASGIAPVSKYIKNDINVAIGTDGVSSNNNLDMFSEMKLTALLQK
VNTMNAKTLPAQATFNMATENGARALGINTGSIKEGKLADIVLVNMNVPHMIPVRNPLSNIIYSALGSDVDTVICDGQLL
LEDKKLLTINEEDAIYDAKLAAQQL
>Mature_424_residues
SETTSILIKDTTILSDKIKKASILIVDNTIEEISNDLSVTDASKVIDGTNKITMPGLVNTHSHVAMTLLRGVGDDEELQT
WLNDYIWPKEAKLDEKLVYAGSKLAMAEMIKTGTTTFNDMYFYMEETAKAVEESGIRGVLGYGMIDLFDDEKRKQEIKAT
KNLIKNSHNTANGRVQVAVAPHAPYTCSKELLSESKKLANKHNLKLHIHVSETQQEVNDLEKQRNQTPFEYLDSIDLLDE
NTIAAHGVWTTDNEMKLLKEKQVSISHNPSSNMKLASGIAPVSKYIKNDINVAIGTDGVSSNNNLDMFSEMKLTALLQKV
NTMNAKTLPAQATFNMATENGARALGINTGSIKEGKLADIVLVNMNVPHMIPVRNPLSNIIYSALGSDVDTVICDGQLLL
EDKKLLTINEEDAIYDAKLAAQQL

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=338, Percent_Identity=29.2899408284024, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082177, Length=380, Percent_Identity=25, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789249, Length=410, Percent_Identity=26.5853658536585, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17540282, Length=384, Percent_Identity=26.0416666666667, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319963, Length=341, Percent_Identity=28.1524926686217, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24643849, Length=363, Percent_Identity=28.099173553719, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_METST (Q2NHL6)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447260.1
- ProteinModelPortal:   Q2NHL6
- SMR:   Q2NHL6
- STRING:   Q2NHL6
- GeneID:   3855574
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0200
- NMPDR:   fig|339860.6.peg.197
- eggNOG:   arNOG04550
- HOGENOM:   HBG668170
- OMA:   KENIESH
- PhylomeDB:   Q2NHL6
- ProtClustDB:   PRK06038
- BioCyc:   MSTA339860:MSP_0200-MONOMER
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 46882; Mature: 46751

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: BINDING 91-91 BINDING 183-183 BINDING 213-213 BINDING 298-298

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETTSILIKDTTILSDKIKKASILIVDNTIEEISNDLSVTDASKVIDGTNKITMPGLVN
CCCCEEEEEECCCHHHHCCCEEEEEEEECHHHHHCCCCCCCCHHHHHCCCCCEECCCCCC
THSHVAMTLLRGVGDDEELQTWLNDYIWPKEAKLDEKLVYAGSKLAMAEMIKTGTTTFND
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCHHH
MYFYMEETAKAVEESGIRGVLGYGMIDLFDDEKRKQEIKATKNLIKNSHNTANGRVQVAV
HEEHHHHHHHHHHHCCCCEEHHCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
APHAPYTCSKELLSESKKLANKHNLKLHIHVSETQQEVNDLEKQRNQTPFEYLDSIDLLD
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCCHHHHCCHHHCC
ENTIAAHGVWTTDNEMKLLKEKQVSISHNPSSNMKLASGIAPVSKYIKNDINVAIGTDGV
CCCEEECEEEECCCHHHHHHHHCCEECCCCCCCCCHHHCHHHHHHHHHCCCEEEEECCCC
SSNNNLDMFSEMKLTALLQKVNTMNAKTLPAQATFNMATENGARALGINTGSIKEGKLAD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCEEE
IVLVNMNVPHMIPVRNPLSNIIYSALGSDVDTVICDGQLLLEDKKLLTINEEDAIYDAKL
EEEEECCCCCEEECCCHHHHHHHHHHCCCCCEEEECCEEEEECCEEEEECCCCCHHHHHH
AAQQL
HHHCC
>Mature Secondary Structure 
SETTSILIKDTTILSDKIKKASILIVDNTIEEISNDLSVTDASKVIDGTNKITMPGLVN
CCCEEEEEECCCHHHHCCCEEEEEEEECHHHHHCCCCCCCCHHHHHCCCCCEECCCCCC
THSHVAMTLLRGVGDDEELQTWLNDYIWPKEAKLDEKLVYAGSKLAMAEMIKTGTTTFND
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCHHH
MYFYMEETAKAVEESGIRGVLGYGMIDLFDDEKRKQEIKATKNLIKNSHNTANGRVQVAV
HEEHHHHHHHHHHHCCCCEEHHCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
APHAPYTCSKELLSESKKLANKHNLKLHIHVSETQQEVNDLEKQRNQTPFEYLDSIDLLD
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCCHHHHCCHHHCC
ENTIAAHGVWTTDNEMKLLKEKQVSISHNPSSNMKLASGIAPVSKYIKNDINVAIGTDGV
CCCEEECEEEECCCHHHHHHHHCCEECCCCCCCCCHHHCHHHHHHHHHCCCEEEEECCCC
SSNNNLDMFSEMKLTALLQKVNTMNAKTLPAQATFNMATENGARALGINTGSIKEGKLAD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCEEE
IVLVNMNVPHMIPVRNPLSNIIYSALGSDVDTVICDGQLLLEDKKLLTINEEDAIYDAKL
EEEEECCCCCEEECCCHHHHHHHHHHCCCCCEEEECCEEEEECCEEEEECCCCCHHHHHH
AAQQL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA