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The map label for this gene is trxA [H]

Identifier: 83721362

GI number: 83721362

Start: 2494218

End: 2494658

Strand: Reverse

Name: trxA [H]

Synonym: BTH_I2218

Alternate gene names: 83721362

Gene position: 2494658-2494218 (Counterclockwise)

Preceding gene: 83718560

Following gene: 83718809

Centisome position: 65.49

GC content: 62.36

Gene sequence:

>441_bases
ATGCAGCGCTCACGCCCTTCTTTTCGCAAGAGCGGAGCTTCCTGCCCCGGCGACCGGCAAGGCCCTCCGGCGGCCGGCGC
AGGCAGTCCCCGAACCGAAAGAGGTATTGACCCAATGAGCGAACAGATCAAACACATCAGCGACGCATCGTTCGAGCAGG
ACGTCGTCAAGTCCGACAAGCCGGTCCTGCTGGACTTCTGGGCCGAATGGTGCGGTCCGTGCAAGATGATTGCCCCGATT
CTCGATGAAGTCGCGAAGGACTACGGCGACAAGCTGCAGATCGCGAAGATCAACGTCGACGACAACCAGGCGACGCCCGC
GAAGTTCGGCGTGCGCGGCATCCCGACGCTGATCCTCTTCAAGAACGGCGCGGTCGCCGCGCAAAAGGTGGGCGCGCTGT
CGAAGTCGCAACTCACCGCGTTCCTGGACAGCCATCTCTAA

Upstream 100 bases:

>100_bases
AAGCGCATCACGCCCCTGTTCGCATGACGACTACTATCGCCGTCAACAGCGGATAGCAATTTAGGCTAATATGACGCCCG
AATGACCCGCGAGCCGCGGT

Downstream 100 bases:

>100_bases
ACGGGTGCGCCGCGGCGCACGTGTTGTCAGCCGGCAACACGTGCGCCGCGAAATCCGCCGATCGGTCGCTCAAGCCCGAA
TCGGCCTATGCTAGAATCAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MQRSRPSFRKSGASCPGDRQGPPAAGAGSPRTERGIDPMSEQIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPI
LDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL

Sequences:

>Translated_146_residues
MQRSRPSFRKSGASCPGDRQGPPAAGAGSPRTERGIDPMSEQIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPI
LDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL
>Mature_146_residues
MQRSRPSFRKSGASCPGDRQGPPAAGAGSPRTERGIDPMSEQIKHISDASFEQDVVKSDKPVLLDFWAEWCGPCKMIAPI
LDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=43.010752688172, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=155, Evalue=8e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=40.2173913043478, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=38.0952380952381, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=115, Percent_Identity=33.9130434782609, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=39.0804597701149, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=39.5348837209302, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=39.4736842105263, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=40, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=167, Percent_Identity=23.3532934131737, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=39.3617021276596, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=40, Blast_Score=71, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=39.3617021276596, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=34.7826086956522, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24639068, Length=139, Percent_Identity=29.4964028776978, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=40.5405405405405, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 15722; Mature: 15722

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSRPSFRKSGASCPGDRQGPPAAGAGSPRTERGIDPMSEQIKHISDASFEQDVVKSDK
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCC
PVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLILF
CCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCCCEEEEE
KNGAVAAQKVGALSKSQLTAFLDSHL
CCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQRSRPSFRKSGASCPGDRQGPPAAGAGSPRTERGIDPMSEQIKHISDASFEQDVVKSDK
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCC
PVLLDFWAEWCGPCKMIAPILDEVAKDYGDKLQIAKINVDDNQATPAKFGVRGIPTLILF
CCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCCCEEEEE
KNGAVAAQKVGALSKSQLTAFLDSHL
CCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]