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The map label for this gene is fahA

Identifier: 83721225

GI number: 83721225

Start: 1572550

End: 1573857

Strand: Direct

Name: fahA

Synonym: BTH_I1398

Alternate gene names: NA

Gene position: 1572550-1573857 (Clockwise)

Preceding gene: 83719016

Following gene: 83720823

Centisome position: 41.28

GC content: 68.96

Gene sequence:

>1308_bases
ATGAGCGCTATTTCCGACGCGCTGCGCGCGAGCCTCGATCCTTCCCGCAAGAGCTGGCTCGATGCGGCGAACGACGCCGC
GTGCGACTTCCCGATCCAGAACCTGCCGTTCGGCGTCTTCAGCGATGCGCGCAACCCGTCGCGCCGCGCGGGCGTCGCGC
TCGGCGACCAGATCGTCGACCTCGCCGAGCTTGCGCGCGCGGGGCTGTTGACGGTCGAGGGCGGGGCGGCCGTGTTCGAG
CGGCCCGCACTGAACGATTTCATCTCGCTCGGCCGCGACGCGTGGCGCAGCGTGCGCATTCAGCTGAGCACGCTTTTCGA
GCGAGGCTGCGCGCGGCTGCGCGACGACACGGCGCTGCGTGCACGGGTGCTCGTCGCGCAGCGCGACGCGACGCTTCATC
TGCCCGTCGACATTCCCGGCTACACCGATTTCTACTCGTCGAAGGAGCACGCGACGAACGTCGGCTCGATGTTTCGCGAT
CCGAAGAACGCGCTGCTGCCGAACTGGTCGGAGATGCCGATCGGCTACAACGGCCGCGCGTCGTCGGTCGTCGTGAGTGG
CACGCCGGTGCGCCGCCCGAACGGTCAACTGAAGCTGCCCGACAGCGAGCGCCCGGTGTTCGGCGCGTGCCGCAAGCTCG
ACATCGAGCTCGAGACGGGCTTCATCGTCGGGCGCGGCAATGCGCTCGGCGAGCCGATCGCGTGCGAGGACGCGGAGTCG
CACATCTTCGGGATGGTGCTGCTCAACGACTGGAGCGCGCGCGATATCCAGCAATGGGAGTACGTGCCGCTCGGGCCGTT
CAACGCGAAGACGTTCGCGACGTCGATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAGCCGTTCCGCACCGCGCAGC
CGAAGCAGGCGCCGGAGCCGCTCGCGTATCTGCGCCACGGCGGCGAGCATGCGTTCGACGTCGAGCTCGAGGTGCGGCTG
AAGCCGCAAGGCGCGGCCGGCGCGACGACGATCGCGCGCACGAACTTTCGGTATATGTACTGGACGATGGCGCAGCAGCT
CGCGCATCACACGGTGTCGGGCTGCAACACGCGGGTCGGCGACCTGATGGGCTCGGGCACGATCAGCGGGCCGACGAAGG
ATTCGTTCGGCAGCCTGCTCGAGTTGACGTGGAACGGCAAGGAGCCCGTCGCGCTCGCGGGCGGCGGCACGCGCGCGTTC
ATCGAGGACGGCGACGAGCTGACGCTTGCCGGCTGGTGTCAGGGCGACGGGTATCGCGTCGGCTTCGGCACGTGCGTCGG
GAAGATTCTGCCGGCGTTGAGCCGGTGA

Upstream 100 bases:

>100_bases
TGATCCGGCCGACGCGCTTCGCGCTCGATACCGCGCAACTGCAGGCGAACTACTTCGAATGCTGGCAAGGCCTCAAGAAA
CATTTCAATCCGGAGCAACG

Downstream 100 bases:

>100_bases
CGCGGTAGGGCGCGCGGCGGGCCGCGCCGCCTTGTGCGATCGACGTCGCGAAAGGGTGGCGCGGAAAGCTGCGCGCGGTC
ATCGAATCGGGCGCTTGCGG

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSAISDALRASLDPSRKSWLDAANDAACDFPIQNLPFGVFSDARNPSRRAGVALGDQIVDLAELARAGLLTVEGGAAVFE
RPALNDFISLGRDAWRSVRIQLSTLFERGCARLRDDTALRARVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRD
PKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPKQAPEPLAYLRHGGEHAFDVELEVRL
KPQGAAGATTIARTNFRYMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALAGGGTRAF
IEDGDELTLAGWCQGDGYRVGFGTCVGKILPALSR

Sequences:

>Translated_435_residues
MSAISDALRASLDPSRKSWLDAANDAACDFPIQNLPFGVFSDARNPSRRAGVALGDQIVDLAELARAGLLTVEGGAAVFE
RPALNDFISLGRDAWRSVRIQLSTLFERGCARLRDDTALRARVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRD
PKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPKQAPEPLAYLRHGGEHAFDVELEVRL
KPQGAAGATTIARTNFRYMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALAGGGTRAF
IEDGDELTLAGWCQGDGYRVGFGTCVGKILPALSR
>Mature_434_residues
SAISDALRASLDPSRKSWLDAANDAACDFPIQNLPFGVFSDARNPSRRAGVALGDQIVDLAELARAGLLTVEGGAAVFER
PALNDFISLGRDAWRSVRIQLSTLFERGCARLRDDTALRARVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAESH
IFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPKQAPEPLAYLRHGGEHAFDVELEVRLK
PQGAAGATTIARTNFRYMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALAGGGTRAFI
EDGDELTLAGWCQGDGYRVGFGTCVGKILPALSR

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=419, Percent_Identity=57.9952267303103, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17568863, Length=406, Percent_Identity=54.1871921182266, Blast_Score=460, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24657182, Length=406, Percent_Identity=52.4630541871921, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47192; Mature: 47061

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAISDALRASLDPSRKSWLDAANDAACDFPIQNLPFGVFSDARNPSRRAGVALGDQIVD
CCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHCCCCHHCCCCCCCHHCCCHHHHHHHH
LAELARAGLLTVEGGAAVFERPALNDFISLGRDAWRSVRIQLSTLFERGCARLRDDTALR
HHHHHHCCEEEEECCCHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ARVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRA
EEEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC
SSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
CEEEEECCCCCCCCCCEECCCCCCCHHHCCEEEEEEEECCEEEECCCCCCCCCCCCCCCC
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPKQAPEP
CEEEEEEECCCCCCCCCCCCEEECCCCCCHHHEECCCCEEEEEECCCCHHCCCCCCCCCH
LAYLRHGGEHAFDVELEVRLKPQGAAGATTIARTNFRYMYWTMAQQLAHHTVSGCNTRVG
HHHHHCCCCEEEEEEEEEEECCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCCCCHHH
DLMGSGTISGPTKDSFGSLLELTWNGKEPVALAGGGTRAFIEDGDELTLAGWCQGDGYRV
HHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCEEEEEECCCEEEEEEEECCCCEEE
GFGTCVGKILPALSR
EHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAISDALRASLDPSRKSWLDAANDAACDFPIQNLPFGVFSDARNPSRRAGVALGDQIVD
CHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHCCCCHHCCCCCCCHHCCCHHHHHHHH
LAELARAGLLTVEGGAAVFERPALNDFISLGRDAWRSVRIQLSTLFERGCARLRDDTALR
HHHHHHCCEEEEECCCHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ARVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRA
EEEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC
SSVVVSGTPVRRPNGQLKLPDSERPVFGACRKLDIELETGFIVGRGNALGEPIACEDAES
CEEEEECCCCCCCCCCEECCCCCCCHHHCCEEEEEEEECCEEEECCCCCCCCCCCCCCCC
HIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATSISPWIVTLDALEPFRTAQPKQAPEP
CEEEEEEECCCCCCCCCCCCEEECCCCCCHHHEECCCCEEEEEECCCCHHCCCCCCCCCH
LAYLRHGGEHAFDVELEVRLKPQGAAGATTIARTNFRYMYWTMAQQLAHHTVSGCNTRVG
HHHHHCCCCEEEEEEEEEEECCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCCCCHHH
DLMGSGTISGPTKDSFGSLLELTWNGKEPVALAGGGTRAFIEDGDELTLAGWCQGDGYRV
HHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCEEEEEECCCEEEEEEEECCCCEEE
GFGTCVGKILPALSR
EHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA