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The map label for this gene is gyrA [H]

Identifier: 83720946

GI number: 83720946

Start: 1837999

End: 1840599

Strand: Direct

Name: gyrA [H]

Synonym: BTH_I1632

Alternate gene names: 83720946

Gene position: 1837999-1840599 (Clockwise)

Preceding gene: 83720780

Following gene: 83721229

Centisome position: 48.25

GC content: 65.05

Gene sequence:

>2601_bases
ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTCGAGGAGGAAATGCGCAAGTCGTATCTCGATTACGCCATGAG
CGTGATCGTCGGACGTGCCCTTCCGGATGTCCGCGATGGCTTGAAGCCCGTGCACCGGCGCGTGCTGTTCGCGATGCACG
AGTTGAACAACGACTGGAACCGGCCCTACAAGAAGTCCGCGCGTATCGTCGGCGACGTGATCGGTAAATACCATCCGCAC
GGCGACACTGCGGTCTACGACACGATCGTCCGGATGGCCCAGGATTTCTCGCTGCGCTACATGCTCGTCGACGGCCAGGG
CAACTTCGGCTCGGTCGACGGCGACAACGCGGCCGCGATGCGCTACACCGAAATCCGGATGGCCAAGATCGGCCACGAAC
TGCTTGCGGACATCGACAAGGAAACCGTCGACTTCGGCCCGAACTACGACGGCAGCGAGATGCAGCCGCTCATCCTGCCG
TCGCGGATTCCGAACCTCCTCATCAACGGTTCGTCGGGGATCGCGGTCGGCATGGCGACCAACATTCCGCCGCACAACCT
GAACGAGGTCGTCGACGCATGCCTGTACCTGCTGAACAATCCGCAGGCGAGCGTCGACGAGCTGATCGAGATCATCCCCG
CGCCCGATTTCCCGACGGCGGGCATCATCTACGGCGTTGCCGGCGTGCGCGATGGCTACCGCACCGGCCGCGGGCGCGTC
GTGATGCGCGCGGCCACGCACTTCGAGGAGATCGACCGCGGCCAGCGGATGGCGATCATCGTCGACGAGCTGCCGTACCA
GGTCAACAAGCGCTCGCTGCTCGAGCGGATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAGGGCATCTCCGACATTCGCG
ACGAGTCGGACAAGAGCGGCATGCGGGTCGTGATCGAGCTCAAGCGCGGCGAGGTGCCCGAGGTCGTGCTGAACAACCTG
TACAAGGCGACTCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACAACCAGCCGAAGCTCCTGAATCT
GAGGGAGATCCTGCAGTGCTTCCTGTCGCATCGGCGCGAAGTGCTGACGCGGCGCACAGTCTACGAACTGCGCAAGGCGC
GCGAGCGCGGCCACGTGCTCGAAGGTCTCGCCGTCGCGCTCGCGAACATCGACGAGTTCATCGCGATCATCAAGGCCGCG
CCGACGCCGCCGATCGCGAAGCAGGAGCTGATGGCGAAGTCGTGGGATTCGTCGCTCGTGCGCGAGATGCTCACGCGCGC
GGAGGCGGAGAACGCGGCGGCGGGCGGGCGCGCGGCGTACCGCCCGGAAGGGCTGAGCCCGGCGTTCGGCATGCAGGGCG
ACGGCCTGTACCGTTTGTCCGACACGCAGGCGCAGGAAATCCTCCAGATGCGCCTGCAACGCCTGACGGGCCTCGAGCAG
GACAAGATCATCGGCGAATATCGCGACGTGATGGCGCAGATCGCGGATTTGCTGGATATCCTGGCCCGCCCCGAGCGGAT
CACGGTGATGATCGGCGAAGAACTGGCTGCGGTGAAGGCCGAGTTCGGCGATGCGCGCCGCTCGAAGATCGAGCTGAACG
CGACCGAGCTGAACACCGAAGACCTGATTACTCCGCAGGACATGGTGGTCACGATGTCGCACGCGGGCTATGTGAAGTCG
CAGCCGCTGTCCGAGTACCGCGCGCAGAAGCGCGGTGGCCGCGGCAAGCAGGCGACGCAGATGAAAGAAGACGACTGGAT
CGAGACGCTCTTCATCGCGAACACGCACGACTACATCCTGTGCTTCTCGAACCGCGGCCGCGTGTACTGGGTCAAGGTCT
ACGAGGTGCCGCAGGGCTCGCGCAACTCGCGCGGCCGTCCGATCGTCAACATGTTCCCGCTGCAGGACGGCGAGAAGATC
AACGTCGTGCTGCCCGTGAAGGAATTCTCGGCCGACAAGTACGTGTTCATGACGACGGCTTTGGGCACGGTCAAGAAGAC
GCCGCTCGAAGCGTTCAGCCGCCCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGACGGCGACTATCTGATCGGCG
CGGCGATCACCGACGGTGCGCACGACGTGATGCTGTTCTCCGACGCCGGCAAGGCGGTGCGCTTCGACGAGAACGACGTG
CGTCCGATGGGCCGCGAGGCGCGCGGCGTGCGCGGGATGCAGCTCGACGACGGGCAGCAGGTGATCGCGATGCTCGTCGC
GGGCAGCGAGGAGCAGTCGGTGCTGACCGCGACCGAGAACGGCTACGGCAAGCGCACGCCGATCACCGAGTACACGCGCC
ACGGGCGCGGCACGAAGGGGATGATCGCGATCCAGACGTCCGAGCGCAACGGCCGCGTCGTTGCGGCGACGCTCGTCGAC
ACCGAGGATCAGATCATGCTGATCACGACGGCGGGCGTGCTGATCCGCACGCGCGTATCGGAGATCCGCGAGATGGGGCG
GGCGACGCAAGGTGTTACACTCATCAGTCTCGATGAAGGCACCAAGCTTTCGGGTCTGCAGCAGATCGCCGAGGCGGACG
CCGATGCCGACGACGACGCGTCGGAGGCCGGCGACGCCTGA

Upstream 100 bases:

>100_bases
TGGGGCGGGTTGGGGCGCATGTTAGAATCGCACGTTGCGTCGCGCGAGCGGCGCCCACGCGAAAGGCGGCCCCGTCTTCG
CTCCGAAAAGATACGGATAC

Downstream 100 bases:

>100_bases
GTCAGGTTGTGACCGTCGAGCCGCCGCCCGGCGCGCGCGCAAAGATGTGGCGTGAGGGGGGCGGCGTATAAACTGTGCAT
ATTTTCATGAGGGAGTGATG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 866; Mature: 866

Protein sequence:

>866_residues
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKSWDSSLVREMLTRAEAENAAAGGRAAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQIADLLDILARPERITVMIGEELAAVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDDGQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVD
TEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDASEAGDA

Sequences:

>Translated_866_residues
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKSWDSSLVREMLTRAEAENAAAGGRAAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQIADLLDILARPERITVMIGEELAAVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDDGQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVD
TEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDASEAGDA
>Mature_866_residues
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKSWDSSLVREMLTRAEAENAAAGGRAAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQIADLLDILARPERITVMIGEELAAVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKYVFMTTALGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDDGQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGRVVAATLVD
TEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEADADADDDASEAGDA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=378, Percent_Identity=25.6613756613757, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=25.5451713395639, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1788562, Length=869, Percent_Identity=59.6087456846951, Blast_Score=1043, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=718, Percent_Identity=34.8189415041783, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=490, Percent_Identity=25.5102040816327, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=409, Percent_Identity=25.4278728606357, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=187, Percent_Identity=30.4812834224599, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=25.9365994236311, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.9340974212034, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96035; Mature: 96035

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPSRIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKSWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLTRAEAENAAAGGRAAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYRDVMAQIADLLDILARPERITVMIGEELAAVKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKYVFMTTA
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEH
LGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
HHHHHCCHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC
RPMGREARGVRGMQLDDGQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKG
CCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCC
MIAIQTSERNGRVVAATLVDTEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQIAEADADADDDASEAGDA
CCHHHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MDQFAKETLPTSLEEEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPSRIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACLYLLNNPQASVDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDNQPKLLNLREILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKSWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLTRAEAENAAAGGRAAYRPEGLSPAFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYRDVMAQIADLLDILARPERITVMIGEELAAVKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKYVFMTTA
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEH
LGTVKKTPLEAFSRPMKKGIIAVGLDDGDYLIGAAITDGAHDVMLFSDAGKAVRFDENDV
HHHHHCCHHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC
RPMGREARGVRGMQLDDGQQVIAMLVAGSEEQSVLTATENGYGKRTPITEYTRHGRGTKG
CCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCC
MIAIQTSERNGRVVAATLVDTEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQIAEADADADDDASEAGDA
CCHHHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]