Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 83720753

GI number: 83720753

Start: 1867817

End: 1868305

Strand: Direct

Name: lrp [H]

Synonym: BTH_I1657

Alternate gene names: 83720753

Gene position: 1867817-1868305 (Clockwise)

Preceding gene: 83718689

Following gene: 83719746

Centisome position: 49.03

GC content: 61.15

Gene sequence:

>489_bases
ATGAGAACTCAACGTCAGCCGGTACGCGCGCTCGACAAGCTCGATCGGCGCATTCTGAAGTTGCTGCAAGAGGACGGGCG
CATGGCGATGAAGGACCTCGCCGAGCGCGTCGGCCTGACGGTCACGCCGTGCATCGAACGGGTGCGGCGGATGGAGCGCG
ACGGCGTGATCACCGGCTACCACGCGCGTGTCGATCCTTCGCAGCTTGGCGCCTCGCTGCTCGTGTTCGTCGAGATCACG
CTCGATCACAAGAACGGCAACATGTTCGAGCAGTTTCGCCGCGAGGTGATGAAGATCGACGAAGTGCTCGAATGCCATTT
GGTGTCGGGCGACTTCGACTACCTGATCAAGGCGCGGATCGGCGAGATGGCCGATTACCGGAAGCTGCTCGGCGACATCC
TGCTTCAGTTGCCGGGCGCCGTACAATCGAAGAGCTATGTCGTGATGGAGGAGATCAAGGAGACGCTGATGATCGCGGTC
GACGAGTGA

Upstream 100 bases:

>100_bases
ATGCGCTCTGCGATTTCCGTTCGACCTAGTTTTTTGCGCTATGTTATGGTTGATCAACCAGGTTTTGTTATTGTATTTTT
TTGATTTTCAGTAAAAAGAG

Downstream 100 bases:

>100_bases
GCGCGCGAACGCCTGCCCGAAGCGCTTGGCACAAACCGCCAATTACTGTATGTTTATACAGTAATTGGCGGTTTTGTCAT
TGGCGGCCCGGGCCGCGTAC

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRTQRQPVRALDKLDRRILKLLQEDGRMAMKDLAERVGLTVTPCIERVRRMERDGVITGYHARVDPSQLGASLLVFVEIT
LDHKNGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLMIAV
DE

Sequences:

>Translated_162_residues
MRTQRQPVRALDKLDRRILKLLQEDGRMAMKDLAERVGLTVTPCIERVRRMERDGVITGYHARVDPSQLGASLLVFVEIT
LDHKNGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLMIAV
DE
>Mature_162_residues
MRTQRQPVRALDKLDRRILKLLQEDGRMAMKDLAERVGLTVTPCIERVRRMERDGVITGYHARVDPSQLGASLLVFVEIT
LDHKNGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLMIAV
DE

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=55.5555555555556, Blast_Score=184, Evalue=3e-48,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=35.0993377483444, Blast_Score=109, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18662; Mature: 18662

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTQRQPVRALDKLDRRILKLLQEDGRMAMKDLAERVGLTVTPCIERVRRMERDGVITGY
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECC
HARVDPSQLGASLLVFVEITLDHKNGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARI
CCCCCHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLMIAVDE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRTQRQPVRALDKLDRRILKLLQEDGRMAMKDLAERVGLTVTPCIERVRRMERDGVITGY
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEECC
HARVDPSQLGASLLVFVEITLDHKNGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARI
CCCCCHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLMIAVDE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]