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The map label for this gene is gmd-1 [H]

Identifier: 83720344

GI number: 83720344

Start: 1497241

End: 1498278

Strand: Direct

Name: gmd-1 [H]

Synonym: BTH_I1331

Alternate gene names: 83720344

Gene position: 1497241-1498278 (Clockwise)

Preceding gene: 83721153

Following gene: 83719612

Centisome position: 39.31

GC content: 61.85

Gene sequence:

>1038_bases
ATGAGCGTCATTGCAATTATCACCGGCATCACGGGCCAAGACGGGGCTTATCTCGCTCAACTCCTGCTCGACAAGGGCTA
TGTGGTTCACGGCACCTATCGCCGCACCAGCTCGGTCAACTTCTGGCGCATCGAGGAGCTCGGCATCGGCGCTCATCCGA
ATCTCCATCTCGTCGAATACGATCTGACCGACCTGAGCGCGAGCATCCGCCTGCTGCGGACGACGGGCGCGACGGAAGTT
TACAATCTTGCCGCGCAAAGCTTCGTCGGCGTATCGTTCGACCAGCCCGTCACCACCGCGGAGATCACCGGCATCGGCCC
GCTGAACCTGCTCGAGGCGATCCGGATCGTGAATCCGGCGATCCGCTTCTATCAGGCGAGCACGTCGGAGATGTTCGGCA
AGGTGCAGGCGATTCCGCAGACGGAGACGACGCCGTTCTATCCGCGCAGCCCATACGGCGTCGCGAAGCTCTATGCGCAC
TGGATCACGGTCAACTATCGCGAAAGCTACAACATCTTCGGCTGCAGCGGGATTCTGTTCAATCACGAATCGCCGCTGCG
CGGCCGCGAATTCGTCACGCGCAAGATCACCGACAGCATGGCGAAGATCCGCCTCGGCAAGCTCGACGTGCTCGAGCTAG
GCAATCTCGACGCGAAGCGCGACTGGGGCTTCGCGAAGGAATACGTGGAAGGGATGTGGCGGATGCTGCAGGCCGACAAG
CCCGATACCTACGTGCTCGCGACGAACCGGACCGAGAAGGTGCGGGACTTCGTCGGCATGGCGGCGCGCGCGGCGGGCTT
CAAGCTTGCATGGGAAGGCCGCGAAGAAAACGAAGTCGGGATCGACCTGGGCTCGGGCAAGACGATCGTGAGGATCAATC
CGAAGTTCTATCGGCCGGCCGAAGTGGATCTGCTGATCGGCGATCCGAAGAAGGCGCGCGACGAGCTCGGGTGGGCGCCG
GCCACGACACTGGAGCAGTTGTGCCAGATGATGGTCGAGGCCGACATCCGGCGCAATGAAACAGGGTTTTCCTTCTGA

Upstream 100 bases:

>100_bases
TGGAAATAACGAAGCGGTAGAAGGTATCGAGCGCGTCGGCCCGGCGAGTGCTTCGTCCGGCCGCGCCGGGCATGATGGAC
ACCAATCTAGTGAGTCAACA

Downstream 100 bases:

>100_bases
TTTATGGCAAAAGTTCTGATTACCGGGATCGGCGGCTTCACCGGGCGGTATCTCGCCCGGCGGCTGACGCAGAGCGGGCA
CGACGTGTGCGGCATCGTCC

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSVIAIITGITGQDGAYLAQLLLDKGYVVHGTYRRTSSVNFWRIEELGIGAHPNLHLVEYDLTDLSASIRLLRTTGATEV
YNLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAIRFYQASTSEMFGKVQAIPQTETTPFYPRSPYGVAKLYAH
WITVNYRESYNIFGCSGILFNHESPLRGREFVTRKITDSMAKIRLGKLDVLELGNLDAKRDWGFAKEYVEGMWRMLQADK
PDTYVLATNRTEKVRDFVGMAARAAGFKLAWEGREENEVGIDLGSGKTIVRINPKFYRPAEVDLLIGDPKKARDELGWAP
ATTLEQLCQMMVEADIRRNETGFSF

Sequences:

>Translated_345_residues
MSVIAIITGITGQDGAYLAQLLLDKGYVVHGTYRRTSSVNFWRIEELGIGAHPNLHLVEYDLTDLSASIRLLRTTGATEV
YNLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAIRFYQASTSEMFGKVQAIPQTETTPFYPRSPYGVAKLYAH
WITVNYRESYNIFGCSGILFNHESPLRGREFVTRKITDSMAKIRLGKLDVLELGNLDAKRDWGFAKEYVEGMWRMLQADK
PDTYVLATNRTEKVRDFVGMAARAAGFKLAWEGREENEVGIDLGSGKTIVRINPKFYRPAEVDLLIGDPKKARDELGWAP
ATTLEQLCQMMVEADIRRNETGFSF
>Mature_344_residues
SVIAIITGITGQDGAYLAQLLLDKGYVVHGTYRRTSSVNFWRIEELGIGAHPNLHLVEYDLTDLSASIRLLRTTGATEVY
NLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPAIRFYQASTSEMFGKVQAIPQTETTPFYPRSPYGVAKLYAHW
ITVNYRESYNIFGCSGILFNHESPLRGREFVTRKITDSMAKIRLGKLDVLELGNLDAKRDWGFAKEYVEGMWRMLQADKP
DTYVLATNRTEKVRDFVGMAARAAGFKLAWEGREENEVGIDLGSGKTIVRINPKFYRPAEVDLLIGDPKKARDELGWAPA
TTLEQLCQMMVEADIRRNETGFSF

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=340, Percent_Identity=54.7058823529412, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1788366, Length=351, Percent_Identity=52.4216524216524, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17507723, Length=342, Percent_Identity=55.8479532163743, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133901788, Length=340, Percent_Identity=55.5882352941177, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=55.5882352941177, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133901786, Length=340, Percent_Identity=55.5882352941177, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539422, Length=340, Percent_Identity=55.5882352941177, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539424, Length=340, Percent_Identity=55.5882352941177, Blast_Score=373, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24158427, Length=341, Percent_Identity=53.3724340175953, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38632; Mature: 38500

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIAIITGITGQDGAYLAQLLLDKGYVVHGTYRRTSSVNFWRIEELGIGAHPNLHLVEY
CEEEEEEECCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEE
DLTDLSASIRLLRTTGATEVYNLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPA
ECHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
IRFYQASTSEMFGKVQAIPQTETTPFYPRSPYGVAKLYAHWITVNYRESYNIFGCSGILF
HHHEECCHHHHHHHEEECCCCCCCCCCCCCCCHHHHHEEEEEEEEECCCCCEEEEEEEEE
NHESPLRGREFVTRKITDSMAKIRLGKLDVLELGNLDAKRDWGFAKEYVEGMWRMLQADK
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
PDTYVLATNRTEKVRDFVGMAARAAGFKLAWEGREENEVGIDLGSGKTIVRINPKFYRPA
CCEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCEEEEECCCCCCCC
EVDLLIGDPKKARDELGWAPATTLEQLCQMMVEADIRRNETGFSF
EEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SVIAIITGITGQDGAYLAQLLLDKGYVVHGTYRRTSSVNFWRIEELGIGAHPNLHLVEY
EEEEEEECCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEE
DLTDLSASIRLLRTTGATEVYNLAAQSFVGVSFDQPVTTAEITGIGPLNLLEAIRIVNPA
ECHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHH
IRFYQASTSEMFGKVQAIPQTETTPFYPRSPYGVAKLYAHWITVNYRESYNIFGCSGILF
HHHEECCHHHHHHHEEECCCCCCCCCCCCCCCHHHHHEEEEEEEEECCCCCEEEEEEEEE
NHESPLRGREFVTRKITDSMAKIRLGKLDVLELGNLDAKRDWGFAKEYVEGMWRMLQADK
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
PDTYVLATNRTEKVRDFVGMAARAAGFKLAWEGREENEVGIDLGSGKTIVRINPKFYRPA
CCEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCEEEEECCCCCCCC
EVDLLIGDPKKARDELGWAPATTLEQLCQMMVEADIRRNETGFSF
EEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]