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The map label for this gene is rfbB1 [H]

Identifier: 83719612

GI number: 83719612

Start: 1498282

End: 1499175

Strand: Direct

Name: rfbB1 [H]

Synonym: BTH_I1332

Alternate gene names: 83719612

Gene position: 1498282-1499175 (Clockwise)

Preceding gene: 83720344

Following gene: 83718930

Centisome position: 39.33

GC content: 65.77

Gene sequence:

>894_bases
ATGGCAAAAGTTCTGATTACCGGGATCGGCGGCTTCACCGGGCGGTATCTCGCCCGGCGGCTGACGCAGAGCGGGCACGA
CGTGTGCGGCATCGTCCATCGGACGGGCGTCGAGCTCGAATGGCGCGCGCACGTCGCGGATCTGCTCGATCGCGGCCAGC
TCGCGGAAGTCTTCGAGCGAGAACGGCCCGATGCGCTCGTGCATCTGGCCGCGATCGCATTCGTCGCGCACGACGACGCG
AGCGCGATCTATCAAACCAACGTCGTCGGTACACGGAACCTGCTCGATGCGCTGGCGTCGTCGTCTCACGCGCCGCGCTC
GGTGCTGCTCGCGAGCAGCGCCAACGTTTACGGCAACACCGATCGCGAATGGATCGACGAGTCGGTGCCGCCCGCGCCCG
CGAACGATTACGCGGTCAGCAAGCTGTCGATGGAGTTCGTCGCGAAGCTCTGGTGCGACCGGTTGCCGATCGTCGTCGCG
CGGCCGTTCAACTACACGGGCGTCGGTCAGGCGGCCAATTTCCTGCTGCCGAAGATCGTGTCGCACTTTCGCTCGCGCGC
GCCCGTGCTCGAACTCGGCAATCTCGACGTGATTCGCGATTTCTCGGACGTGCGCGCGGTGGCCGCCGCCTATGAGAAGC
TCATCGGCGGCGCGTTCGCCGGCGAGACGTTCAATGTGTGCTCGGGCGTCGGTTATTCGCTGCAGGACGTGCTCGCGATG
GCCGAGGAACTGACGGGCTACCGGCCTGAAATTCGCGTCAATCCGAATTTCGTGCGCGCGAACGAAGTTCGCAAGCTGAT
CGGCAACGGCGCGAAGCTGCGTGACGCGATCGGCGAGCCGCTGGCGATCCCGCTGCGCGACACGCTCGCCTGGATGCTGG
AGCGTACCGCTTGA

Upstream 100 bases:

>100_bases
CGAGCTCGGGTGGGCGCCGGCCACGACACTGGAGCAGTTGTGCCAGATGATGGTCGAGGCCGACATCCGGCGCAATGAAA
CAGGGTTTTCCTTCTGATTT

Downstream 100 bases:

>100_bases
AGCTGATTCTCGCGGTGGACGCGATCGTGCCGCCGCTGACCGGAATCGGGCGCTATACGTGGGAGCTCGCGAAGCACTAT
TCGATGCCGGACAGCGGGCT

Product: GDP-6-deoxy-D-lyxo-4-hexulose reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAKVLITGIGGFTGRYLARRLTQSGHDVCGIVHRTGVELEWRAHVADLLDRGQLAEVFERERPDALVHLAAIAFVAHDDA
SAIYQTNVVGTRNLLDALASSSHAPRSVLLASSANVYGNTDREWIDESVPPAPANDYAVSKLSMEFVAKLWCDRLPIVVA
RPFNYTGVGQAANFLLPKIVSHFRSRAPVLELGNLDVIRDFSDVRAVAAAYEKLIGGAFAGETFNVCSGVGYSLQDVLAM
AEELTGYRPEIRVNPNFVRANEVRKLIGNGAKLRDAIGEPLAIPLRDTLAWMLERTA

Sequences:

>Translated_297_residues
MAKVLITGIGGFTGRYLARRLTQSGHDVCGIVHRTGVELEWRAHVADLLDRGQLAEVFERERPDALVHLAAIAFVAHDDA
SAIYQTNVVGTRNLLDALASSSHAPRSVLLASSANVYGNTDREWIDESVPPAPANDYAVSKLSMEFVAKLWCDRLPIVVA
RPFNYTGVGQAANFLLPKIVSHFRSRAPVLELGNLDVIRDFSDVRAVAAAYEKLIGGAFAGETFNVCSGVGYSLQDVLAM
AEELTGYRPEIRVNPNFVRANEVRKLIGNGAKLRDAIGEPLAIPLRDTLAWMLERTA
>Mature_296_residues
AKVLITGIGGFTGRYLARRLTQSGHDVCGIVHRTGVELEWRAHVADLLDRGQLAEVFERERPDALVHLAAIAFVAHDDAS
AIYQTNVVGTRNLLDALASSSHAPRSVLLASSANVYGNTDREWIDESVPPAPANDYAVSKLSMEFVAKLWCDRLPIVVAR
PFNYTGVGQAANFLLPKIVSHFRSRAPVLELGNLDVIRDFSDVRAVAAAYEKLIGGAFAGETFNVCSGVGYSLQDVLAMA
EELTGYRPEIRVNPNFVRANEVRKLIGNGAKLRDAIGEPLAIPLRDTLAWMLERTA

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=261, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788366, Length=348, Percent_Identity=25, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994969, Length=251, Percent_Identity=29.0836653386454, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788353, Length=337, Percent_Identity=25.8160237388724, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=326, Percent_Identity=25.7668711656442, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=326, Percent_Identity=25.7668711656442, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=326, Percent_Identity=25.7668711656442, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=326, Percent_Identity=25.7668711656442, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=326, Percent_Identity=25.7668711656442, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=334, Percent_Identity=26.3473053892216, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24158427, Length=314, Percent_Identity=23.2484076433121, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 32379; Mature: 32248

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVLITGIGGFTGRYLARRLTQSGHDVCGIVHRTGVELEWRAHVADLLDRGQLAEVFER
CCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHH
ERPDALVHLAAIAFVAHDDASAIYQTNVVGTRNLLDALASSSHAPRSVLLASSANVYGNT
CCCHHHHHHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
DREWIDESVPPAPANDYAVSKLSMEFVAKLWCDRLPIVVARPFNYTGVGQAANFLLPKIV
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHH
SHFRSRAPVLELGNLDVIRDFSDVRAVAAAYEKLIGGAFAGETFNVCSGVGYSLQDVLAM
HHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHCCCCCHHHHHHH
AEELTGYRPEIRVNPNFVRANEVRKLIGNGAKLRDAIGEPLAIPLRDTLAWMLERTA
HHHHCCCCCEEEECCCEECHHHHHHHHCCCHHHHHHCCCCCEECHHHHHHHHHHHCC
>Mature Secondary Structure 
AKVLITGIGGFTGRYLARRLTQSGHDVCGIVHRTGVELEWRAHVADLLDRGQLAEVFER
CEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHH
ERPDALVHLAAIAFVAHDDASAIYQTNVVGTRNLLDALASSSHAPRSVLLASSANVYGNT
CCCHHHHHHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCC
DREWIDESVPPAPANDYAVSKLSMEFVAKLWCDRLPIVVARPFNYTGVGQAANFLLPKIV
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHH
SHFRSRAPVLELGNLDVIRDFSDVRAVAAAYEKLIGGAFAGETFNVCSGVGYSLQDVLAM
HHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHCCCCCHHHHHHH
AEELTGYRPEIRVNPNFVRANEVRKLIGNGAKLRDAIGEPLAIPLRDTLAWMLERTA
HHHHCCCCCEEEECCCEECHHHHHHHHCCCHHHHHHCCCCCEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8022265; 10710307 [H]