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The map label for this gene is rfbB [H]

Identifier: 83719152

GI number: 83719152

Start: 1664571

End: 1665764

Strand: Direct

Name: rfbB [H]

Synonym: BTH_I1469

Alternate gene names: 83719152

Gene position: 1664571-1665764 (Clockwise)

Preceding gene: 83719567

Following gene: 83718471

Centisome position: 43.7

GC content: 64.91

Gene sequence:

>1194_bases
ATGGTTCGATCGAGCCACGCGGCCGCAACCGGCGGTGACATTCGAGCGACCAACGGCATTCTCCCGACCATGCCGGCCAT
GCCGCATCACGCCGGTTGTTTGACCGACTCCCAATTTCAGCAAAGGAATTCCATGATCTTGGTAACGGGCGGCGCCGGTT
TCATCGGCGCCAACTTCGTGCTTGACTGGCTGGCTCAATCCGACGAGGCGGTGCTGAACGTCGACAAGCTGACGTACGCG
GGCAACCTCGGCACGTTGAAGTCGTTGCAGGGGAATCCGAAGCACGTGTTCGCGCGCGTAGACATCTGCGACCGCGCCGC
AATCGACGCGCTGTTGGCGCAGTACAAGCCGCGCGCGATCCTGCACTTTGCCGCCGAGAGCCATGTGGACCGGTCGATTC
ACGGTCCGGCCGATTTCGTGCAGACGAACGTCGTCGGCACCTTCACGCTGCTCGAAGCCGCGCGCCAATACTGGAGCGCG
CTCGACGCCGACGCGAAGGCGGCGTTCCGCTTCCTGCACGTGTCGACGGACGAGGTGTTCGGCTCGCTGTCGCCCGCCGA
TCCGCAGTTCTCCGAGACCACGCCGTACGCGCCGAACAGCCCGTACTCGGCGACGAAGGCGGGCTCCGACCATCTCGTGC
GCGCGTATCACCACACGTACGGGCTGCCCACGCTCACGACGAACTGCTCGAACAACTACGGCCCGTATCAGTTCCCCGAG
AAGCTGATTCCGCTGATGATTGCAAACGCGCTCGGCGGCAAGCCGCTGCCCGTTTACGGCGACGGCCAGAACGTGCGCGA
CTGGCTGTACGTCGGCGATCACTGCAGCGCGATTCGCGAGGTGCTCGCGCGCGGCGTGCCGGGCGAGACGTACAACGTCG
GCGGCTGGAACGAGAAGAAGAACCTCGACGTCGTGCACACGCTGTGCGATCTGCTCGACGAAGCGCGGCCGAAGGCGGCC
GGCTCGTACCGCGATCAGATCACGTATGTGACCGATCGTCCCGGCCACGATCGCCGCTATGCGATCGACGCGCGCAAGCT
CGAGCGCGAGCTCGGCTGGAAGCCGGCCGAGACGTTCGAGACCGGCCTCGCGAAGACCGTGCGCTGGTATCTCGACAGCC
AGGAGTGGGTCGACGAGGTGGCATCGGGCGATTATCGCAAGTGGGTCGAAACGAACTACGCGCAACGCGCGTAA

Upstream 100 bases:

>100_bases
CACGAGCTGTTTCAAGATGTTAGAGGGATGTTTTTTCACTTCCTTGCCCGTATAATTGCGGCCTTGTGGGGCAGTCGCTG
TGCACTGCCGACTTGGGCGC

Downstream 100 bases:

>100_bases
AGGCTGAATCGATGGCGCGCAAGGGCATTATTCTCGCCGGCGGCTCCGGCACGCGGCTGTATCCGATCACGCATGCCGTG
TCGAAGCAATTGCTGCCGGT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MVRSSHAAATGGDIRATNGILPTMPAMPHHAGCLTDSQFQQRNSMILVTGGAGFIGANFVLDWLAQSDEAVLNVDKLTYA
GNLGTLKSLQGNPKHVFARVDICDRAAIDALLAQYKPRAILHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSA
LDADAKAAFRFLHVSTDEVFGSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPE
KLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLARGVPGETYNVGGWNEKKNLDVVHTLCDLLDEARPKAA
GSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLAKTVRWYLDSQEWVDEVASGDYRKWVETNYAQRA

Sequences:

>Translated_397_residues
MVRSSHAAATGGDIRATNGILPTMPAMPHHAGCLTDSQFQQRNSMILVTGGAGFIGANFVLDWLAQSDEAVLNVDKLTYA
GNLGTLKSLQGNPKHVFARVDICDRAAIDALLAQYKPRAILHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSA
LDADAKAAFRFLHVSTDEVFGSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPE
KLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLARGVPGETYNVGGWNEKKNLDVVHTLCDLLDEARPKAA
GSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLAKTVRWYLDSQEWVDEVASGDYRKWVETNYAQRA
>Mature_397_residues
MVRSSHAAATGGDIRATNGILPTMPAMPHHAGCLTDSQFQQRNSMILVTGGAGFIGANFVLDWLAQSDEAVLNVDKLTYA
GNLGTLKSLQGNPKHVFARVDICDRAAIDALLAQYKPRAILHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSA
LDADAKAAFRFLHVSTDEVFGSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPE
KLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLARGVPGETYNVGGWNEKKNLDVVHTLCDLLDEARPKAA
GSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLAKTVRWYLDSQEWVDEVASGDYRKWVETNYAQRA

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=34.3465045592705, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI42516563, Length=336, Percent_Identity=23.8095238095238, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI56237023, Length=359, Percent_Identity=26.7409470752089, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI56118217, Length=359, Percent_Identity=26.7409470752089, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI189083684, Length=359, Percent_Identity=26.7409470752089, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4504031, Length=353, Percent_Identity=24.0793201133144, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788353, Length=359, Percent_Identity=62.3955431754875, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI48994969, Length=344, Percent_Identity=61.6279069767442, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1786974, Length=351, Percent_Identity=26.7806267806268, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788366, Length=301, Percent_Identity=26.578073089701, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=343, Percent_Identity=34.1107871720117, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI115532424, Length=339, Percent_Identity=32.4483775811209, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71982035, Length=366, Percent_Identity=27.5956284153005, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=368, Percent_Identity=27.445652173913, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539532, Length=369, Percent_Identity=22.7642276422764, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=341, Percent_Identity=23.7536656891496, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=336, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=336, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133901790, Length=336, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=344, Percent_Identity=23.8372093023256, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539424, Length=344, Percent_Identity=23.8372093023256, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=367, Percent_Identity=25.6130790190736, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19923002, Length=360, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356223, Length=332, Percent_Identity=24.6987951807229, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24158427, Length=352, Percent_Identity=26.7045454545455, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 43759; Mature: 43759

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRSSHAAATGGDIRATNGILPTMPAMPHHAGCLTDSQFQQRNSMILVTGGAGFIGANFV
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCHHHHHHH
LDWLAQSDEAVLNVDKLTYAGNLGTLKSLQGNPKHVFARVDICDRAAIDALLAQYKPRAI
HHHHHCCCCCEEEEHHEEECCCCCCHHHCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCE
LHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSALDADAKAAFRFLHVSTDEVF
EEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECHHHHH
GSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCHH
KLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLARGVPGETYNVGGWNEKK
HHHHHHHHHHCCCCCCEEECCCCCCCHHEEECHHHHHHHHHHHCCCCCCEEECCCCCCCC
NLDVVHTLCDLLDEARPKAAGSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFE
CHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCCCHHHHH
TGLAKTVRWYLDSQEWVDEVASGDYRKWVETNYAQRA
HHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCHHCCC
>Mature Secondary Structure
MVRSSHAAATGGDIRATNGILPTMPAMPHHAGCLTDSQFQQRNSMILVTGGAGFIGANFV
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCHHHHHHH
LDWLAQSDEAVLNVDKLTYAGNLGTLKSLQGNPKHVFARVDICDRAAIDALLAQYKPRAI
HHHHHCCCCCEEEEHHEEECCCCCCHHHCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCE
LHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSALDADAKAAFRFLHVSTDEVF
EEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECHHHHH
GSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCHH
KLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLARGVPGETYNVGGWNEKK
HHHHHHHHHHCCCCCCEEECCCCCCCHHEEECHHHHHHHHHHHCCCCCCEEECCCCCCCC
NLDVVHTLCDLLDEARPKAAGSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFE
CHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCCCHHHHH
TGLAKTVRWYLDSQEWVDEVASGDYRKWVETNYAQRA
HHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609; 11796113 [H]