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The map label for this gene is pyrC [H]

Identifier: 83718396

GI number: 83718396

Start: 1378910

End: 1379968

Strand: Direct

Name: pyrC [H]

Synonym: BTH_I1230

Alternate gene names: 83718396

Gene position: 1378910-1379968 (Clockwise)

Preceding gene: 83721273

Following gene: 83718815

Centisome position: 36.2

GC content: 70.54

Gene sequence:

>1059_bases
ATGAATGCTTCCGCTCCCGCCTCGCTGACCCTCGCGCGCCCCGACGACTGGCACCTGCACGTGCGCGACGGCGCGATGCT
CGCGGCCGTCCTGCCGCACACCGCCCGCCAATTCGGCCGCGCGATCATCATGCCGAACCTGAAGCCGCCCGTCACGACGA
CCGCGCAGGCGCAGGCGTACCGCGAGCGCATCCTGGCCGCGCTGCCGGCCGGCATGACGTTCGAGCCGCTGATGACGCTG
TACCTGACCGACAACACCCCCGCCGACGAGATCCGCCGTGCGCGCGAAAGCGGCTTCGTGCACGGCGTGAAGCTGTATCC
GGCGGGCGCGACGACGAACTCGGACGCTGGCGTGACCGATCTGCTCGGCAAATGCGCGAAGACGCTCGAGGCGATGCAGG
AAGTCGGAATGCCGCTCCTCGTGCACGGCGAGGTGACGGACCCGTCGATCGATCTGTTCGATCGCGAGAAGGCGTTCATC
GATCGCGTGATGGAGCCGCTGCGCCGCGCGCTGCCGGGGCTCAAGGTGGTGTTCGAGCACATCACGACGAAGGACGCTGC
CGACTACGTGCGCGACGTCGACGCGGCGCCCGGCCAGATCGGCGCGACGATCACCGCGCACCATCTGCTGTACAACCGCA
ACGCGATGTTCGTGGGCGGCATTCGCCCGCATTACTACTGCCTGCCGGTGCTCAAGCGCGAGACGCACCGGGTCGCGCTC
GTCGCGGCGGCGAGCTCGGGCAATCCGCGCTTCTTCCTCGGCACCGACAGCGCGCCGCACCCGAAGGGCGCGAAGGAGGC
CGCGTGCGGCTGCGCGGGCTGCTACACCGCGCTGCACGCGCTCGAGCTGTACGCGGAGGCGTTCGATCAGGCGGGCGCGC
TCGACAAGCTCGAAGGCTTCGCGAGCTTCTTCGGCGCGGACTTCTACGGTTTGCCGCGCAGCGCCGAGACGGTGACGCTG
CGCCGCGAGACGTGGGAGCTGCCGCGCGAGATCGACGCGGGCGCGGGCCCCGTCGTGCCGCTGCGCGGCGGCGAGCCGAT
CGGCTGGCGGCTCGTTTGA

Upstream 100 bases:

>100_bases
AAGGCGAAAACCGCGCGCGCGCGGTTCCGTGTTGCGGTTTGCCGTCAGTCAGGCGCCGCCGCGCGCATCGCTTCTCGCCG
CGCGCCATTCCCACGACACC

Downstream 100 bases:

>100_bases
CGCTCGTGGCGCGGCGGCCGGCCGGGTTGCCGCGCGCGGCGGATCGGGTGTCGACGAGATGAGCGAGCCGGACGACGCGA
GCCCCCGGGGCCGCATGAGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNASAPASLTLARPDDWHLHVRDGAMLAAVLPHTARQFGRAIIMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPLMTL
YLTDNTPADEIRRARESGFVHGVKLYPAGATTNSDAGVTDLLGKCAKTLEAMQEVGMPLLVHGEVTDPSIDLFDREKAFI
DRVMEPLRRALPGLKVVFEHITTKDAADYVRDVDAAPGQIGATITAHHLLYNRNAMFVGGIRPHYYCLPVLKRETHRVAL
VAAASSGNPRFFLGTDSAPHPKGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGFASFFGADFYGLPRSAETVTL
RRETWELPREIDAGAGPVVPLRGGEPIGWRLV

Sequences:

>Translated_352_residues
MNASAPASLTLARPDDWHLHVRDGAMLAAVLPHTARQFGRAIIMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPLMTL
YLTDNTPADEIRRARESGFVHGVKLYPAGATTNSDAGVTDLLGKCAKTLEAMQEVGMPLLVHGEVTDPSIDLFDREKAFI
DRVMEPLRRALPGLKVVFEHITTKDAADYVRDVDAAPGQIGATITAHHLLYNRNAMFVGGIRPHYYCLPVLKRETHRVAL
VAAASSGNPRFFLGTDSAPHPKGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGFASFFGADFYGLPRSAETVTL
RRETWELPREIDAGAGPVVPLRGGEPIGWRLV
>Mature_352_residues
MNASAPASLTLARPDDWHLHVRDGAMLAAVLPHTARQFGRAIIMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPLMTL
YLTDNTPADEIRRARESGFVHGVKLYPAGATTNSDAGVTDLLGKCAKTLEAMQEVGMPLLVHGEVTDPSIDLFDREKAFI
DRVMEPLRRALPGLKVVFEHITTKDAADYVRDVDAAPGQIGATITAHHLLYNRNAMFVGGIRPHYYCLPVLKRETHRVAL
VAAASSGNPRFFLGTDSAPHPKGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGFASFFGADFYGLPRSAETVTL
RRETWELPREIDAGAGPVVPLRGGEPIGWRLV

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=349, Percent_Identity=53.8681948424069, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323452, Length=358, Percent_Identity=36.0335195530726, Blast_Score=192, Evalue=8e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38108; Mature: 38108

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASAPASLTLARPDDWHLHVRDGAMLAAVLPHTARQFGRAIIMPNLKPPVTTTAQAQAY
CCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHH
RERILAALPAGMTFEPLMTLYLTDNTPADEIRRARESGFVHGVKLYPAGATTNSDAGVTD
HHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHH
LLGKCAKTLEAMQEVGMPLLVHGEVTDPSIDLFDREKAFIDRVMEPLRRALPGLKVVFEH
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ITTKDAADYVRDVDAAPGQIGATITAHHLLYNRNAMFVGGIRPHYYCLPVLKRETHRVAL
HHCHHHHHHHHHCCCCCCCCCCCEEEHHHEEECCEEEECCCCCCEEEEHHHHCCCCEEEE
VAAASSGNPRFFLGTDSAPHPKGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGF
EEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ASFFGADFYGLPRSAETVTLRRETWELPREIDAGAGPVVPLRGGEPIGWRLV
HHHHCCCCCCCCCCCCEEEEEHHHHCCCHHHCCCCCCEEECCCCCCCCCEEC
>Mature Secondary Structure
MNASAPASLTLARPDDWHLHVRDGAMLAAVLPHTARQFGRAIIMPNLKPPVTTTAQAQAY
CCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHH
RERILAALPAGMTFEPLMTLYLTDNTPADEIRRARESGFVHGVKLYPAGATTNSDAGVTD
HHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHH
LLGKCAKTLEAMQEVGMPLLVHGEVTDPSIDLFDREKAFIDRVMEPLRRALPGLKVVFEH
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ITTKDAADYVRDVDAAPGQIGATITAHHLLYNRNAMFVGGIRPHYYCLPVLKRETHRVAL
HHCHHHHHHHHHCCCCCCCCCCCEEEHHHEEECCEEEECCCCCCEEEEHHHHCCCCEEEE
VAAASSGNPRFFLGTDSAPHPKGAKEAACGCAGCYTALHALELYAEAFDQAGALDKLEGF
EEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ASFFGADFYGLPRSAETVTLRRETWELPREIDAGAGPVVPLRGGEPIGWRLV
HHHHCCCCCCCCCCCCEEEEEHHHHCCCHHHCCCCCCEEECCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA