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The map label for this gene is rnc [H]

Identifier: 161723174

GI number: 161723174

Start: 1938726

End: 1940135

Strand: Direct

Name: rnc [H]

Synonym: BTH_I1730

Alternate gene names: 161723174

Gene position: 1938726-1940135 (Clockwise)

Preceding gene: 83718479

Following gene: 83719946

Centisome position: 50.9

GC content: 68.65

Gene sequence:

>1410_bases
ATGCCCCTATCCCAGTTGGAAAGCCGGCTGCGCTACGAATTTCGCAATGCGGAATTGCTGCGCCAGGCTTTGACCCATCG
CAGTCACAGTGCCACGCATAACGAACGGCTCGAGTTTCTCGGCGATTCCGTTCTGAATTGCGCGGTGGCCGCCCTTTTGT
TTCAGCGCTTCAGCAAGCTGGACGAAGGCGATTTGTCGCGCGTGCGGGCGAATCTCGTCAAGCAGCAGTCACTGTACGAG
ATTGCTCAGGCCCTCAATATCTCGGACGGCCTGCGGCTTGGCGAAGGCGAGTTGCGCAGCGGCGGATTCCGAAGACCGTC
GATCCTCGCGGACGCATTCGAAGCCATCATCGGGGCGGTGTTCCTCGATGGCGGCTTCGAAGCCGCCCAAGGGGTCATCA
AGCGGCTGTACGTGCCGATTCTCGACCACATCGATCCGCGCACGCTCGGCAAGGATGCGAAGACGCTGCTGCAGGAGTAC
TTGCAGGGCCATAAGATCGCGCTGCCGACCTATACCGTCGTCGCGACGCATGGCGCGGCGCACAATCAGCAGTTCGAAGT
CGAGTGCACGGTGCCGAAGCTGGACATCAAGGTGTCGGGTTCGGGCGCGAGCCGTCGCGCGGCCGAGCAGGCCGCCGCGA
AGAAGGCGCTCGACGAGGTGATGGCGGTTGCGCCGATGCTTGCCGCGAAGCCGAAGCGCTCGAAGAGCGCGCGCGGCGCG
AAGCACATGGAGCCCGAGATCGTGCCGGGCGTGAAGGGCGTGCAGGAGGCGCTCGACCTGCGTTCGCCGGACCGCAAGGA
GCGCGGCGCGGGCCGCACGGCGGGCGGCGAAGCGAAAGGCGTCGAGCCGAAGGCGGCCGATGTGAGGGCCACGGTCGACG
CGAAGTCGGGCGACGCGAAGCAGGGCGAGCCGAAGGTTGCGGAGTCGCGCGTGGACGATTCGAGGGCGACCGAGGCAAGG
GCCTCGGCGGACGCGAAGGCTGGCGCGCAAACTCACGCGGCCGTTTCGCCCGTCGTGCCCGCGCACGCCGACGATTCGGC
CGCCCGTTCCCCCGGGACCGCGCCCGTCGCGATGATCCGCGCGGCACACGTCGAGCACGGCGCCGACAAGGGCGAGCCGC
GTGCGGCGAAGCCGGCCGAGAAGCCCGCGCCGGCGACGGACAGGTTGCAGGAGAAATCGGCGGAAAAGGCGCCGGACAAG
GGCCACGAGAAGCCGCAGGACAAATCGCCCGACCCGGCTCCGGAAAAGACGCCCGACAAGACGGCGGAGCCGCTGACGGA
AAAGCCGGACGCCGCCGCGCGCGTTTGCGCGGGGGCCGCCGATCGGCCGCCGCGCGCGCGCGACGCGTCATCGGCCGCCG
AGCCCGATCTGGCCGCCGCGCCCGTGCGCGTGGCCGATGCGGGTCATTGA

Upstream 100 bases:

>100_bases
CGAACTGCTCGCAGAACCGGCGGCAACACCGCCTCGTCACGCCTTTTTGCGCCAGGTCGCGTTTCCCGACCGACGCGGCG
CCCGCGTTATACTCCTGTCC

Downstream 100 bases:

>100_bases
CATCGTTCCAATCGACACCGCGGTCGCGCACGGTCGCGCGGCCGCTTCCGAACCCAGCAGCAGCCTGATATGAACGCACC
CGCTCCCACCGGTTTTCGTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVMAVAPMLAAKPKRSKSARGA
KHMEPEIVPGVKGVQEALDLRSPDRKERGAGRTAGGEAKGVEPKAADVRATVDAKSGDAKQGEPKVAESRVDDSRATEAR
ASADAKAGAQTHAAVSPVVPAHADDSAARSPGTAPVAMIRAAHVEHGADKGEPRAAKPAEKPAPATDRLQEKSAEKAPDK
GHEKPQDKSPDPAPEKTPDKTAEPLTEKPDAAARVCAGAADRPPRARDASSAAEPDLAAAPVRVADAGH

Sequences:

>Translated_469_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVMAVAPMLAAKPKRSKSARGA
KHMEPEIVPGVKGVQEALDLRSPDRKERGAGRTAGGEAKGVEPKAADVRATVDAKSGDAKQGEPKVAESRVDDSRATEAR
ASADAKAGAQTHAAVSPVVPAHADDSAARSPGTAPVAMIRAAHVEHGADKGEPRAAKPAEKPAPATDRLQEKSAEKAPDK
GHEKPQDKSPDPAPEKTPDKTAEPLTEKPDAAARVCAGAADRPPRARDASSAAEPDLAAAPVRVADAGH
>Mature_468_residues
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKLDEGDLSRVRANLVKQQSLYEI
AQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYL
QGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVMAVAPMLAAKPKRSKSARGAK
HMEPEIVPGVKGVQEALDLRSPDRKERGAGRTAGGEAKGVEPKAADVRATVDAKSGDAKQGEPKVAESRVDDSRATEARA
SADAKAGAQTHAAVSPVVPAHADDSAARSPGTAPVAMIRAAHVEHGADKGEPRAAKPAEKPAPATDRLQEKSAEKAPDKG
HEKPQDKSPDPAPEKTPDKTAEPLTEKPDAAARVCAGAADRPPRARDASSAAEPDLAAAPVRVADAGH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=27.1929824561404, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=27.1929824561404, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=51.9417475728155, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=32.48730964467, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=32.48730964467, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323895, Length=97, Percent_Identity=38.1443298969072, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137682, Length=242, Percent_Identity=28.9256198347107, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 49653; Mature: 49522

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVMAVAPMLAAKPKRSKSARGA
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
KHMEPEIVPGVKGVQEALDLRSPDRKERGAGRTAGGEAKGVEPKAADVRATVDAKSGDAK
CCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
QGEPKVAESRVDDSRATEARASADAKAGAQTHAAVSPVVPAHADDSAARSPGTAPVAMIR
CCCCHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHCCCCCCCHHHHHH
AAHVEHGADKGEPRAAKPAEKPAPATDRLQEKSAEKAPDKGHEKPQDKSPDPAPEKTPDK
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
TAEPLTEKPDAAARVCAGAADRPPRARDASSAAEPDLAAAPVRVADAGH
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
>Mature Secondary Structure 
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLDIKVSGSGASRRAAEQAAAKKALDEVMAVAPMLAAKPKRSKSARGA
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
KHMEPEIVPGVKGVQEALDLRSPDRKERGAGRTAGGEAKGVEPKAADVRATVDAKSGDAK
CCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
QGEPKVAESRVDDSRATEARASADAKAGAQTHAAVSPVVPAHADDSAARSPGTAPVAMIR
CCCCHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHCCCCCCCHHHHHH
AAHVEHGADKGEPRAAKPAEKPAPATDRLQEKSAEKAPDKGHEKPQDKSPDPAPEKTPDK
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
TAEPLTEKPDAAARVCAGAADRPPRARDASSAAEPDLAAAPVRVADAGH
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]