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The map label for this gene is bioA [C]

Identifier: 161723149

GI number: 161723149

Start: 1704909

End: 1706237

Strand: Direct

Name: bioA [C]

Synonym: BTH_I1505

Alternate gene names: 161723149

Gene position: 1704909-1706237 (Clockwise)

Preceding gene: 83719173

Following gene: 83721191

Centisome position: 44.76

GC content: 68.1

Gene sequence:

>1329_bases
ATGACCGAGCACGTTTCGCAGACCCCCGACCTCTCCGCGTTCTGGATGCCGTTCACCGCGAACCGGCAGTTCAAGGAAGC
GCCGCGCCTGCTCGTCGCGGCGAAGGGGATGTACTACACGTCGCACGACGGCCGCCGCATCCTCGACGGCACCGCGGGCC
TCTGGTGCGTGAACGCGGGGCATGGACGCGACGAGATCGTCGCCGCGGTGCAGGCGCAGGCCCGGGAGATGGATTTCGCG
CCGACGTTTCAGATGGGACACCCGAAGGCGTTCGAGGCGGCGACGAAGATCGCGCGCCACACGCCGGGCGACCTGAAGCA
TATCTTCTTCACGAACTCCGGCTCGGAGGCGGTCGACACCGCGCTGAAGATCGCGCTTGCGTATCACCGCGCGCGCGGCG
AAGGGCAGCGCACGCGCTTCATCGGCCGCGAGCGCGGCTATCACGGCGTCGGCTTCGGCGGCATCTCGGTGGGCGGCATC
GCACCGAACCGCAAGGCGTATTCGGGGGCGCTGCTGCCGTCGGTCGATCATCTGCCGCACACGCTGAACCTGAAGGAGGC
CGCGTTCTCGAAAGGGCAGCCCGCTTGGGGCGCGCATCTCGCGGACGAACTGGAGCGGCTCGTCGCGCTGCACGACGCAT
CGACGATCGCCGCAGTGATCGTCGAGCCCGTCGCGGGCTCGACGGGCGTGCTGATTCCGCCGCAAGGCTATCTCGAGCGC
TTGCGCGAATTGTGCGACAAGCACGGCATCCTGCTGATCTTCGACGAGGTGATCACCGGCTGGGGGCGGCTCGGCGCGCC
GTTCGCGTCGCAGTTCTTCGGCGTGACGCCCGATCTGCTGACGATGGCGAAAGGCACGAACAACGCGGCGGTGCCGATGG
GCGCGGTGGCGGCGAGCGGCGCGATCCACGACGCGATCGTGGACGGCGCGCCGGCCGGCATCGAGCTTTTTCACGGCTAT
ACGTATTCGGGGCACCCGCTCGCGGCGGCGGCGGCCGTCGCGACGATCGACTTGTACGAGCGCGAAGGGCTCTTGACGCG
CGCCGCGCAGATCGCGCCGATCTTCGAGCGCGAGATCCACAAGCTGAAGGACGCGCGTCACGTGATCGACGTGCGCAATC
TCGGCCTCGTCGGCGGCGTCGAGCTGAAGCCGCGCGACGGCAAGCCGGGCGCGCGTGCGTACGAAGTGTTCGTCAAGTGC
TTCGCGAACGGCGCGATGATTCGCTACACGGGCGACATCCTCGCTTTCTCGCCGCCCCTCATCGTCGAGGAGGCGCAGAT
CGTCGAGTTGTTCTCGATCGTCGCGCAGGCGCTGAAGGAAACGGAGTAG

Upstream 100 bases:

>100_bases
AAGGCGAATTTCCATCGATGCGGCGCTCGCGCGCCGCCCCCGTCAGCGCGCATCGCGACATCTTCCAGATATCGTTCGAT
CGATTTCCGAGGAGCTTTCC

Downstream 100 bases:

>100_bases
GCGGGAGCGGGCGCACGGGCGCGGTGCTCAGACGAAGCGGCGCGCATCGCGTGCGCCGCTTCGATGCGTGCTCAATAGCG
GGGCACCGAAGGATCGACGT

Product: omega amino acid--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVQAQAREMDFA
PTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGI
APNRKAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAHLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPQGYLER
LRELCDKHGILLIFDEVITGWGRLGAPFASQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVDGAPAGIELFHGY
TYSGHPLAAAAAVATIDLYEREGLLTRAAQIAPIFEREIHKLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKC
FANGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE

Sequences:

>Translated_442_residues
MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVQAQAREMDFA
PTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGI
APNRKAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAHLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPQGYLER
LRELCDKHGILLIFDEVITGWGRLGAPFASQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVDGAPAGIELFHGY
TYSGHPLAAAAAVATIDLYEREGLLTRAAQIAPIFEREIHKLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKC
FANGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE
>Mature_441_residues
TEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVQAQAREMDFAP
TFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIA
PNRKAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAHLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPQGYLERL
RELCDKHGILLIFDEVITGWGRLGAPFASQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVDGAPAGIELFHGYT
YSGHPLAAAAAVATIDLYEREGLLTRAAQIAPIFEREIHKLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKCF
ANGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=421, Percent_Identity=28.0285035629454, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=30, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI226442705, Length=437, Percent_Identity=27.0022883295195, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=26.879271070615, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI13994255, Length=376, Percent_Identity=29.2553191489362, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=27.0676691729323, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI24119277, Length=411, Percent_Identity=27.007299270073, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1786991, Length=433, Percent_Identity=32.3325635103926, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI145693181, Length=309, Percent_Identity=34.3042071197411, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=30.9692671394799, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.7506053268765, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1787560, Length=411, Percent_Identity=31.8734793187348, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=29.7297297297297, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786349, Length=326, Percent_Identity=28.2208588957055, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=440, Percent_Identity=29.3181818181818, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=427, Percent_Identity=26.2295081967213, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=27.2311212814645, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=241, Percent_Identity=30.7053941908714, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=433, Percent_Identity=25.635103926097, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6324386, Length=493, Percent_Identity=26.7748478701826, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=25.2475247524752, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357415, Length=415, Percent_Identity=26.2650602409639, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574759, Length=444, Percent_Identity=27.9279279279279, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=27.6018099547511, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21356575, Length=370, Percent_Identity=29.4594594594595, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47481; Mature: 47350

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAG
CCCCCCCCCCCCEEEECCCCCCCHHHCCCEEEEECCEEEECCCCCEEECCCCCEEEEECC
HGRDEIVAAVQAQAREMDFAPTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIAPNRKAYSGALLPSVDHLPH
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHCCCC
TLNLKEAAFSKGQPAWGAHLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPQGYLER
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHEEEHEEECCCCCCCEEECCHHHHHH
LRELCDKHGILLIFDEVITGWGRLGAPFASQFFGVTPDLLTMAKGTNNAAVPMGAVAASG
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHCC
AIHDAIVDGAPAGIELFHGYTYSGHPLAAAAAVATIDLYEREGLLTRAAQIAPIFEREIH
CHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKCFANGAMIRYTGDILAFSPPL
HHHHHHHHHHHHCCCEECCEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCEEEECCCC
IVEEAQIVELFSIVAQALKETE
EECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAG
CCCCCCCCCCCEEEECCCCCCCHHHCCCEEEEECCEEEECCCCCEEECCCCCEEEEECC
HGRDEIVAAVQAQAREMDFAPTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIAPNRKAYSGALLPSVDHLPH
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHCCCC
TLNLKEAAFSKGQPAWGAHLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPQGYLER
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHEEEHEEECCCCCCCEEECCHHHHHH
LRELCDKHGILLIFDEVITGWGRLGAPFASQFFGVTPDLLTMAKGTNNAAVPMGAVAASG
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHCC
AIHDAIVDGAPAGIELFHGYTYSGHPLAAAAAVATIDLYEREGLLTRAAQIAPIFEREIH
CHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKCFANGAMIRYTGDILAFSPPL
HHHHHHHHHHHHCCCEECCEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCEEEECCCC
IVEEAQIVELFSIVAQALKETE
EECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]