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The map label for this gene is glyA [H]

Identifier: 161723137

GI number: 161723137

Start: 1555703

End: 1556950

Strand: Direct

Name: glyA [H]

Synonym: BTH_I1379

Alternate gene names: 161723137

Gene position: 1555703-1556950 (Clockwise)

Preceding gene: 83720366

Following gene: 83718876

Centisome position: 40.84

GC content: 64.18

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATTGCGAACGTCGATCCCGAGATCTGGCAAGCGATCCAGCAGGAAAACGTCCGCCA
GGAAGAGCACATCGAGCTGATCGCGTCGGAGAACTACACGAGCCCGGCCGTGATGGCGGCGCAAGGCTCGCAGCTCACGA
ACAAGTACGCGGAAGGCTACCCGGGCAAGCGCTATTACGGCGGCTGCGAATACGTCGACATCGTCGAGCAGCTTGCGATC
GACCGCGTGAAGGCGCTGTTCGGCTCCGAAGCCGCGAACGTGCAGCCGAACTCCGGCTCGCAGGCGAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGATACGATCATGGGCATGAGCCTCGCGCATGGCGGCCACCTGACGCACGGCTCGCCCG
TCAACATGTCGGGCAAATGGTTCAACGTCGTGAGCTACGGCTTGAACGAGAACGAAGACATCGACTACGAAGCCGCCGAT
AAGCTTGCGCACGAGCACAAGCCGAAGCTGATCGTCGCCGGCGCTTCGGCGTTTGCGCTGAAGATCGATTTCGAGCGTCT
CGCGAAGATCGCGAAGGCGGTCGGCGCGTACCTGATGGTCGACATGGCGCACTACGCGGGCCTCATCGCCGCTGGCGTCT
ACCCGAACCCGGTGCCGCACGCCGATTTCGTCACGACGACGACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAGTACGAGAAGCAGATCAACTCGGCGATCTTCCCGGGCATCCAGGGCGGTCCGCTGATGCACGTGAT
TGCGGCGAAGGCCGTCGCGTTCAAGGAAGCGCTGTCGCCGGAATTCAAGGAATACCAGCAGAAGGTGATCGAGAACGCGC
GCGTGCTGGCCGAGACGCTCGTCAAGCGCGGCCTGCGCATCGTGTCGGGCCGCACCGAAAGCCACGTGATGCTCGTTGAC
CTGCGCGCGAAGAACATTACCGGCAAGGCCGCGGAAGCGGCGCTCGGCAATGCGCACATCACGGTCAACAAGAACGCGAT
CCCGAACGATCCGGAGAAGCCGTTCGTGACGAGCGGCGTGCGTCTCGGCTCGCCCGCGATGACGACGCGCGGCTTCGGTC
CGCAGGAAGCCGAACTGGTCGGCAACCTGATCGCCGACGTGCTCGAGCATCCGGAAGACGCGGCGACGATCGAGCGCGTG
CGCGCGCAGGTCGCCGACCTGACCAAGCGTTTCCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
TTCCTCGGAATTCCTCCGCCGCGTCGAGCCGGTTGCGCTGCCGGCTGCGCGACGTTACTTGGCCACTTCGGTCAACCTGT
ACACACTTAACGGAAACCGT

Downstream 100 bases:

>100_bases
TCGGCCATGCGCTGCCCGTTCTGCCGGCACGACGATACGCAAGTGGTGGATTCGCGCGTGTCGGAAGACGGCGCCGCGAT
CCGCCGGCGTCGGCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI
DRVKALFGSEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAD
KLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVIENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERV
RAQVADLTKRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI
DRVKALFGSEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAD
KLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVIENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERV
RAQVADLTKRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI
DRVKALFGSEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAD
KLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVIENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERV
RAQVADLTKRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=404, Percent_Identity=45.049504950495, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI261862350, Length=404, Percent_Identity=45.049504950495, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI261862348, Length=404, Percent_Identity=45.049504950495, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI19923315, Length=404, Percent_Identity=45.049504950495, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=44.4168734491315, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=41.8224299065421, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=40.1937046004843, Blast_Score=275, Evalue=4e-74,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=64.0096618357488, Blast_Score=546, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25144732, Length=441, Percent_Identity=43.3106575963719, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25144729, Length=441, Percent_Identity=43.3106575963719, Blast_Score=345, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=45.5421686746988, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=431, Percent_Identity=43.6194895591647, Blast_Score=334, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=41.978021978022, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=41.978021978022, Blast_Score=353, Evalue=1e-97,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45032; Mature: 45032

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDIVEQLAIDRVKALFGSEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAADKLAHEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVIENARVLAETL
EEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVADLTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDIVEQLAIDRVKALFGSEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAADKLAHEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVIENARVLAETL
EEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVADLTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA