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The map label for this gene is clcA [H]

Identifier: 83590428

GI number: 83590428

Start: 1621898

End: 1623517

Strand: Reverse

Name: clcA [H]

Synonym: Moth_1588

Alternate gene names: 83590428

Gene position: 1623517-1621898 (Counterclockwise)

Preceding gene: 83590429

Following gene: 83590425

Centisome position: 61.76

GC content: 57.41

Gene sequence:

>1620_bases
ATGGCACGTGTGGAAACTGTACTGCAGGAGCATTCGGTACCAGAGGGTATACTATTAAGAAGATATAGTTACCTTCTTCG
CTTTTTATGTACGGGAGCCCTGGCGGGAGCGGGCGCCGGACTGGTGGGCGCGGCCTTCAGGCTGGCCCTGACGGAAGGGG
ACTTATGGCGTAATAGCCTCTTGACATGGGCCAAGGGAATACCGCTGTGGGGCTGGCTGGCACTGCCGTTCCTGGGTGCC
CTGGCGGGAGGCCTGGCCGGCTGGTTGACCAGCCTGGCGCCGGAAACAGCCGGGAGCGGTATCCCCCATGTGGAAGCAGT
TTTAATTAACCTGCGCCGGTTGGTATGGTGGCGGGTCATACCTGTAAAATTTATAGCCGGGGCCCTGGCCATCGGGGCCG
GGTTATCCCTGGGACCGGAAGGCCCGGCGGTCCAGATGGGGGCGGCCGCCGGCAAGGCGGTAAGTGACGGTTTTGGCCGC
TCGAAAACCGAGGAACTGCACCTTATCGCCTGTGGTGCCGGGGCCGGCCTGGCAGCGGCCTTTAATGCCCCCCTGGCGGG
AGTAGTCTTTGTTCTGGAAGAACTAAGACGCAACTTCTCTCCCTATGCCCTGGGTGGAGCCCTGGTAGCCTCCGTTGTGG
CGGACATGGTATCCCGGCATATCCTGGGACCTTTACCTACTTTCCGGTTAATTGAAGCCTGGCCGGTATTACCATTAACT
ACCCTGCCGGTATTCCTGGTTTTAGGGGTGCTGGCGGGTATCCTGGGGGCCGTCTTTAACTGGTCCCTCTTAGCCAGTCT
CGAACTGGGGGATAGATTAAACAGGTTCCCTCGCTGGTTGCGGGCCCTGCTGATCCTTTTTCTAGCAGGTATCCTGGGCT
ATTTTTTACCAGAGGTTCTGGGGGGCGGGCACCTGCTGGCGGAAGAAGCCCTGGCCGGAAAGGTCGCCTGGACCCTCATC
CCCCTTCTCTTTGTGGTCAAGTTTCTCTTGACTATGATTAGTAACAGCGCCGGCGTTCCTGGGGGCATCTTTTTGCCCCT
GCTGGTACTGGGGGCTCTATTGGGTTCCCTCGTGGGACAGGTAAGCGGGTTGCTAATCCCCGCCTTTCAAGGCATGGTCC
CGGCTTTTGCCATGATCGGTATGGCTGCCTATTTTGTCGCCATTCTGCGCTTACCCCTCACTGGGGTAGTTTTAATAATC
GAGATGACTGGCAGCTACCGGCATATAGTGTTGCTCCTCTTTACCTGTATGATTGCTTACCTGGTGGTAGAGACCCTGGG
GAGCAGACCAGCCTATGAAATGCTGTTGGAGCGTGACCTGGCCAGGGCCAGGGTAGAGGCTGAACCATCTCCGGTTGGCA
AGATGTTAATGCTGGACTTTGCCGTTGAGGCTGGCTCTGATGCCTGCGGTCGCCTGGTAAGGGACCTGGAACTGCCTCCG
GATTGCCTGCTGGTTACTATCCGCCGCAAGGGCAGGGAAATAATTCCGCGTGGTAATACCAGCATTCAGGAAGGAGATCA
CCTGGCGGTGATTACCCCTGAAGAACGGGCGGCAGAAATCTGCCATGAATTATCAGGGGTAACCCGTTGTAAGTTCCAGC
AGAAATTGCAACGATTCTGA

Upstream 100 bases:

>100_bases
AACGGAAATGGGGAAAAACTAGAAAAGCTTAACAAAAAGGTAGGGAGAGTGGTACAATGGAAAAGCGGGATTAAAAAAGG
AGCATGTTGGGGTTACAGAA

Downstream 100 bases:

>100_bases
TGAATAATGTAAAAGGCCGGTAACATAGAGGGCAGGTACCGGCTTTTTCTAATGCCCCAGGAGCCGGCGAATTTTGGGTA
GCTGTTTCCGGGTCTCTTCC

Product: Cl- channel, voltage gated

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MARVETVLQEHSVPEGILLRRYSYLLRFLCTGALAGAGAGLVGAAFRLALTEGDLWRNSLLTWAKGIPLWGWLALPFLGA
LAGGLAGWLTSLAPETAGSGIPHVEAVLINLRRLVWWRVIPVKFIAGALAIGAGLSLGPEGPAVQMGAAAGKAVSDGFGR
SKTEELHLIACGAGAGLAAAFNAPLAGVVFVLEELRRNFSPYALGGALVASVVADMVSRHILGPLPTFRLIEAWPVLPLT
TLPVFLVLGVLAGILGAVFNWSLLASLELGDRLNRFPRWLRALLILFLAGILGYFLPEVLGGGHLLAEEALAGKVAWTLI
PLLFVVKFLLTMISNSAGVPGGIFLPLLVLGALLGSLVGQVSGLLIPAFQGMVPAFAMIGMAAYFVAILRLPLTGVVLII
EMTGSYRHIVLLLFTCMIAYLVVETLGSRPAYEMLLERDLARARVEAEPSPVGKMLMLDFAVEAGSDACGRLVRDLELPP
DCLLVTIRRKGREIIPRGNTSIQEGDHLAVITPEERAAEICHELSGVTRCKFQQKLQRF

Sequences:

>Translated_539_residues
MARVETVLQEHSVPEGILLRRYSYLLRFLCTGALAGAGAGLVGAAFRLALTEGDLWRNSLLTWAKGIPLWGWLALPFLGA
LAGGLAGWLTSLAPETAGSGIPHVEAVLINLRRLVWWRVIPVKFIAGALAIGAGLSLGPEGPAVQMGAAAGKAVSDGFGR
SKTEELHLIACGAGAGLAAAFNAPLAGVVFVLEELRRNFSPYALGGALVASVVADMVSRHILGPLPTFRLIEAWPVLPLT
TLPVFLVLGVLAGILGAVFNWSLLASLELGDRLNRFPRWLRALLILFLAGILGYFLPEVLGGGHLLAEEALAGKVAWTLI
PLLFVVKFLLTMISNSAGVPGGIFLPLLVLGALLGSLVGQVSGLLIPAFQGMVPAFAMIGMAAYFVAILRLPLTGVVLII
EMTGSYRHIVLLLFTCMIAYLVVETLGSRPAYEMLLERDLARARVEAEPSPVGKMLMLDFAVEAGSDACGRLVRDLELPP
DCLLVTIRRKGREIIPRGNTSIQEGDHLAVITPEERAAEICHELSGVTRCKFQQKLQRF
>Mature_538_residues
ARVETVLQEHSVPEGILLRRYSYLLRFLCTGALAGAGAGLVGAAFRLALTEGDLWRNSLLTWAKGIPLWGWLALPFLGAL
AGGLAGWLTSLAPETAGSGIPHVEAVLINLRRLVWWRVIPVKFIAGALAIGAGLSLGPEGPAVQMGAAAGKAVSDGFGRS
KTEELHLIACGAGAGLAAAFNAPLAGVVFVLEELRRNFSPYALGGALVASVVADMVSRHILGPLPTFRLIEAWPVLPLTT
LPVFLVLGVLAGILGAVFNWSLLASLELGDRLNRFPRWLRALLILFLAGILGYFLPEVLGGGHLLAEEALAGKVAWTLIP
LLFVVKFLLTMISNSAGVPGGIFLPLLVLGALLGSLVGQVSGLLIPAFQGMVPAFAMIGMAAYFVAILRLPLTGVVLIIE
MTGSYRHIVLLLFTCMIAYLVVETLGSRPAYEMLLERDLARARVEAEPSPVGKMLMLDFAVEAGSDACGRLVRDLELPPD
CLLVTIRRKGREIIPRGNTSIQEGDHLAVITPEERAAEICHELSGVTRCKFQQKLQRF

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI119433677, Length=424, Percent_Identity=23.5849056603774, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4557473, Length=429, Percent_Identity=25.8741258741259, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI189217923, Length=429, Percent_Identity=25.8741258741259, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI189217921, Length=429, Percent_Identity=25.8741258741259, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI55770840, Length=403, Percent_Identity=26.5508684863524, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI55770838, Length=403, Percent_Identity=26.5508684863524, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI283806618, Length=443, Percent_Identity=23.4762979683973, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI153252026, Length=404, Percent_Identity=25.990099009901, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI283806622, Length=419, Percent_Identity=23.8663484486874, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI156104869, Length=419, Percent_Identity=23.8663484486874, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI283806616, Length=412, Percent_Identity=23.3009708737864, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1786350, Length=443, Percent_Identity=34.7629796839729, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87081943, Length=313, Percent_Identity=30.9904153354633, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980828, Length=468, Percent_Identity=24.7863247863248, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71980824, Length=468, Percent_Identity=24.7863247863248, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980820, Length=473, Percent_Identity=24.7357293868922, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17532615, Length=406, Percent_Identity=25.1231527093596, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996452, Length=528, Percent_Identity=22.3484848484848, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71996455, Length=528, Percent_Identity=22.3484848484848, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17559050, Length=380, Percent_Identity=25.5263157894737, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=378, Percent_Identity=26.7195767195767, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24665008, Length=403, Percent_Identity=27.0471464019851, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161078208, Length=421, Percent_Identity=24.7030878859857, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281361606, Length=421, Percent_Identity=24.7030878859857, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573073, Length=421, Percent_Identity=24.7030878859857, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573071, Length=435, Percent_Identity=24.367816091954, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281361608, Length=435, Percent_Identity=24.367816091954, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573075, Length=435, Percent_Identity=24.367816091954, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922112, Length=409, Percent_Identity=26.4058679706601, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551566, Length=389, Percent_Identity=26.2210796915167, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 57468; Mature: 57337

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVETVLQEHSVPEGILLRRYSYLLRFLCTGALAGAGAGLVGAAFRLALTEGDLWRNSL
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHH
LTWAKGIPLWGWLALPFLGALAGGLAGWLTSLAPETAGSGIPHVEAVLINLRRLVWWRVI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHH
PVKFIAGALAIGAGLSLGPEGPAVQMGAAAGKAVSDGFGRSKTEELHLIACGAGAGLAAA
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHH
FNAPLAGVVFVLEELRRNFSPYALGGALVASVVADMVSRHILGPLPTFRLIEAWPVLPLT
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHH
TLPVFLVLGVLAGILGAVFNWSLLASLELGDRLNRFPRWLRALLILFLAGILGYFLPEVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGHLLAEEALAGKVAWTLIPLLFVVKFLLTMISNSAGVPGGIFLPLLVLGALLGSLVGQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
VSGLLIPAFQGMVPAFAMIGMAAYFVAILRLPLTGVVLIIEMTGSYRHIVLLLFTCMIAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCEEEEEEECCCHHHHHHHHHHHHHHH
LVVETLGSRPAYEMLLERDLARARVEAEPSPVGKMLMLDFAVEAGSDACGRLVRDLELPP
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
DCLLVTIRRKGREIIPRGNTSIQEGDHLAVITPEERAAEICHELSGVTRCKFQQKLQRF
HHEEEHHHHCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARVETVLQEHSVPEGILLRRYSYLLRFLCTGALAGAGAGLVGAAFRLALTEGDLWRNSL
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHH
LTWAKGIPLWGWLALPFLGALAGGLAGWLTSLAPETAGSGIPHVEAVLINLRRLVWWRVI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHH
PVKFIAGALAIGAGLSLGPEGPAVQMGAAAGKAVSDGFGRSKTEELHLIACGAGAGLAAA
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHH
FNAPLAGVVFVLEELRRNFSPYALGGALVASVVADMVSRHILGPLPTFRLIEAWPVLPLT
HCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHH
TLPVFLVLGVLAGILGAVFNWSLLASLELGDRLNRFPRWLRALLILFLAGILGYFLPEVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGHLLAEEALAGKVAWTLIPLLFVVKFLLTMISNSAGVPGGIFLPLLVLGALLGSLVGQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
VSGLLIPAFQGMVPAFAMIGMAAYFVAILRLPLTGVVLIIEMTGSYRHIVLLLFTCMIAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCEEEEEEECCCHHHHHHHHHHHHHHH
LVVETLGSRPAYEMLLERDLARARVEAEPSPVGKMLMLDFAVEAGSDACGRLVRDLELPP
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
DCLLVTIRRKGREIIPRGNTSIQEGDHLAVITPEERAAEICHELSGVTRCKFQQKLQRF
HHEEEHHHHCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA