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The map label for this gene is dcuS [H]

Identifier: 83590419

GI number: 83590419

Start: 1613395

End: 1614228

Strand: Reverse

Name: dcuS [H]

Synonym: Moth_1579

Alternate gene names: 83590419

Gene position: 1614228-1613395 (Counterclockwise)

Preceding gene: 83590420

Following gene: 83590418

Centisome position: 61.41

GC content: 37.65

Gene sequence:

>834_bases
ATGGAAAAAAGATGGTTGCTTTTTGTAAACCTTCTTTTGTTACAGCTTTTTTTGTTCCTCTTATTGGCTTACAATTATGT
TTTTACGAGCTTCAGAATACCCGTTACTATTGTTTTGTTTGCTATTATTGCTGTGATGATTTCAAGTTTATGGGTGGTCC
GGGAGATGCTTAGACTGGTTGAAAGGGAAAGTGAAGCCGAGAAAGTAATGGTAAGGTTAGAGGAAGCCGAAAAATTAATT
ACCACCTTGAGGTCTAAACATCATGATTTTGTGAACCATTTACAGGTAATCCTGGGACTTATTCAATTGAAGATGGATAA
TGATGCTGCCGATTATATTAAAAGTCTATCAAAAGATCTAATTCAAATTGAAAAACTTGTTTCCTTAAAAAGGCCGGAAG
TTGCCGCCCTTATTAGCAGCAAGCTGGCAAGTCTGAGTTATTTGCAGGCGTCGTTAGATGTGAATACTTCTTTGGCCGAG
TTGTCTATCTCTCCAGATAAGCTGGTAAGTATTCTTGGCAATTTGCTTGATAATGCTATTTACGAGACGAGCTTCTATAA
AGATAAATGGATTAAGATGAGAATCGATCAGGAAGATGAGTGGTTTATTTTTGAAATAACAAACCCGGGTACTATTGCAC
CTGAGATCCGAGAAAGGATTTTTGAACCGGGATTTACAACCAAGGGACAGGAAGGATCGGGGATGGGTTTATTTATTGTT
AAAAATCTGGTGAGGGAATGCGGTGGAACTATTTCCTTTGATTCACGTGATGATGATATAATGACAGTATTTACGGTCAG
ATTGCCAAAAATTCCTATGGAGTATGGAAACTGA

Upstream 100 bases:

>100_bases
ATATACAGAAATTGTGTTTTTGGCATTAATGTTGATTATTAATAAAGTGTTTGGGTTTACCTTAACTAGATCGCAGGAGA
TACATAAGTAGGGATTATTC

Downstream 100 bases:

>100_bases
TCATCGGAACTCTGCTGTCTCTTCTGACCCTCATGGTGGCTATCACCATGCTGCGGAAGTAATTGAAAACCCTTGAAGCT
GCTGCAACAGCTTCAAGGGT

Product: signal transduction histidine kinase regulating citrate/malate metabolism

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEKRWLLFVNLLLLQLFLFLLLAYNYVFTSFRIPVTIVLFAIIAVMISSLWVVREMLRLVERESEAEKVMVRLEEAEKLI
TTLRSKHHDFVNHLQVILGLIQLKMDNDAADYIKSLSKDLIQIEKLVSLKRPEVAALISSKLASLSYLQASLDVNTSLAE
LSISPDKLVSILGNLLDNAIYETSFYKDKWIKMRIDQEDEWFIFEITNPGTIAPEIRERIFEPGFTTKGQEGSGMGLFIV
KNLVRECGGTISFDSRDDDIMTVFTVRLPKIPMEYGN

Sequences:

>Translated_277_residues
MEKRWLLFVNLLLLQLFLFLLLAYNYVFTSFRIPVTIVLFAIIAVMISSLWVVREMLRLVERESEAEKVMVRLEEAEKLI
TTLRSKHHDFVNHLQVILGLIQLKMDNDAADYIKSLSKDLIQIEKLVSLKRPEVAALISSKLASLSYLQASLDVNTSLAE
LSISPDKLVSILGNLLDNAIYETSFYKDKWIKMRIDQEDEWFIFEITNPGTIAPEIRERIFEPGFTTKGQEGSGMGLFIV
KNLVRECGGTISFDSRDDDIMTVFTVRLPKIPMEYGN
>Mature_277_residues
MEKRWLLFVNLLLLQLFLFLLLAYNYVFTSFRIPVTIVLFAIIAVMISSLWVVREMLRLVERESEAEKVMVRLEEAEKLI
TTLRSKHHDFVNHLQVILGLIQLKMDNDAADYIKSLSKDLIQIEKLVSLKRPEVAALISSKLASLSYLQASLDVNTSLAE
LSISPDKLVSILGNLLDNAIYETSFYKDKWIKMRIDQEDEWFIFEITNPGTIAPEIRERIFEPGFTTKGQEGSGMGLFIV
KNLVRECGGTISFDSRDDDIMTVFTVRLPKIPMEYGN

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790567, Length=238, Percent_Identity=32.3529411764706, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786837, Length=223, Percent_Identity=26.457399103139, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=257, Percent_Identity=27.2373540856031, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 31773; Mature: 31773

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRWLLFVNLLLLQLFLFLLLAYNYVFTSFRIPVTIVLFAIIAVMISSLWVVREMLRLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERESEAEKVMVRLEEAEKLITTLRSKHHDFVNHLQVILGLIQLKMDNDAADYIKSLSKDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IQIEKLVSLKRPEVAALISSKLASLSYLQASLDVNTSLAELSISPDKLVSILGNLLDNAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
YETSFYKDKWIKMRIDQEDEWFIFEITNPGTIAPEIRERIFEPGFTTKGQEGSGMGLFIV
HHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHH
KNLVRECGGTISFDSRDDDIMTVFTVRLPKIPMEYGN
HHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MEKRWLLFVNLLLLQLFLFLLLAYNYVFTSFRIPVTIVLFAIIAVMISSLWVVREMLRLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERESEAEKVMVRLEEAEKLITTLRSKHHDFVNHLQVILGLIQLKMDNDAADYIKSLSKDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IQIEKLVSLKRPEVAALISSKLASLSYLQASLDVNTSLAELSISPDKLVSILGNLLDNAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
YETSFYKDKWIKMRIDQEDEWFIFEITNPGTIAPEIRERIFEPGFTTKGQEGSGMGLFIV
HHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHH
KNLVRECGGTISFDSRDDDIMTVFTVRLPKIPMEYGN
HHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]