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The map label for this gene is hofD [H]

Identifier: 83590393

GI number: 83590393

Start: 1592651

End: 1593394

Strand: Reverse

Name: hofD [H]

Synonym: Moth_1550

Alternate gene names: 83590393

Gene position: 1593394-1592651 (Counterclockwise)

Preceding gene: 83590394

Following gene: 83590392

Centisome position: 60.61

GC content: 55.78

Gene sequence:

>744_bases
ATGCTGGTATTTTTTTTCTTGGCGGGTCTTTTTATCGGCAGTTTCCTCAACGTGGTCGTATACCGCTTACCGCGCGGAGA
AACGGTGGTCTGGGGCCGTTCGCACTGCCCGACCTGCGGGCGGGAGCTGGCCTGGTACGACCTTATTCCCGTATTGAGCT
ACCTGTTTCTGCGGGGCAGGTGCCGTTACTGCCACCTGCCGATTTCCCCTCGATACCCTATAGTTGAGCTTGTTACTGGC
GTGGTGTTTACCACCCTTTTTTATAATTTCGGCCTCTCCTGGGTCCTGGTAAAATACCTTTTCCTGGGCGCCGTGCTGGT
AGCCGCAAGCTTCATCGACCTGGAGCATTACTTAATCCCCGATAGCCTGGTGGTGACCGGAGCCTGCGGAGGTATTCTTT
TTAGCCTGCTGGCGCGGGATGTGGGGTTCCGGGCTGCTTTAGGGGGATCTGTCGCAGCAGCAGGATTTTTGCTGCTCGTT
GCCGTAATTAGTAATGGTGGCATGGGCGGCGGGGATGTGAAACTTGCAGGTATGGTAGGGCTTTTCCTCGGCTGGCCCCT
GGCATCCCTGGCTCTCTTCCTTTCCCTGGTCACAGGCGGCCTGGCGGGCGTTTGCTTGCTGGTATCTGGCCTAAAAAAAC
GGGAGGACCCCCTTCCCTTCGCGCCCTTTATCGCCATAGGGGGGTTGCTGGCATTGTTTTTTGGCGAGAAAATGTTGCAC
TGGTATCTTGGCAGGTTTATGTAA

Upstream 100 bases:

>100_bases
GGCTGCTAAGGTTTACAGGAGCAAAGCAGGGCTAAATATTTATAAACGGGTGATAACAGGATAGCCAGGCAAATTCTACA
GGAGTAATAAGGAAAAAGTC

Downstream 100 bases:

>100_bases
AATCAGGCCAAGCGAAACGCAGGCTGTTAACATGAGGGTACTCGACATGGCAGGGGGAGCAGGGGCTGGCTCCAGGCGGC
CGTTAAAGGGAAATGGCGGT

Product: type 4 prepilin peptidase 1. Aspartic peptidase. MEROPS family A24A

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MLVFFFLAGLFIGSFLNVVVYRLPRGETVVWGRSHCPTCGRELAWYDLIPVLSYLFLRGRCRYCHLPISPRYPIVELVTG
VVFTTLFYNFGLSWVLVKYLFLGAVLVAASFIDLEHYLIPDSLVVTGACGGILFSLLARDVGFRAALGGSVAAAGFLLLV
AVISNGGMGGGDVKLAGMVGLFLGWPLASLALFLSLVTGGLAGVCLLVSGLKKREDPLPFAPFIAIGGLLALFFGEKMLH
WYLGRFM

Sequences:

>Translated_247_residues
MLVFFFLAGLFIGSFLNVVVYRLPRGETVVWGRSHCPTCGRELAWYDLIPVLSYLFLRGRCRYCHLPISPRYPIVELVTG
VVFTTLFYNFGLSWVLVKYLFLGAVLVAASFIDLEHYLIPDSLVVTGACGGILFSLLARDVGFRAALGGSVAAAGFLLLV
AVISNGGMGGGDVKLAGMVGLFLGWPLASLALFLSLVTGGLAGVCLLVSGLKKREDPLPFAPFIAIGGLLALFFGEKMLH
WYLGRFM
>Mature_247_residues
MLVFFFLAGLFIGSFLNVVVYRLPRGETVVWGRSHCPTCGRELAWYDLIPVLSYLFLRGRCRYCHLPISPRYPIVELVTG
VVFTTLFYNFGLSWVLVKYLFLGAVLVAASFIDLEHYLIPDSLVVTGACGGILFSLLARDVGFRAALGGSVAAAGFLLLV
AVISNGGMGGGDVKLAGMVGLFLGWPLASLALFLSLVTGGLAGVCLLVSGLKKREDPLPFAPFIAIGGLLALFFGEKMLH
WYLGRFM

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=266, Percent_Identity=32.7067669172932, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 26724; Mature: 26724

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVFFFLAGLFIGSFLNVVVYRLPRGETVVWGRSHCPTCGRELAWYDLIPVLSYLFLRGR
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
CRYCHLPISPRYPIVELVTGVVFTTLFYNFGLSWVLVKYLFLGAVLVAASFIDLEHYLIP
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSLVVTGACGGILFSLLARDVGFRAALGGSVAAAGFLLLVAVISNGGMGGGDVKLAGMVG
CHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LFLGWPLASLALFLSLVTGGLAGVCLLVSGLKKREDPLPFAPFIAIGGLLALFFGEKMLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
WYLGRFM
HHHHHCC
>Mature Secondary Structure
MLVFFFLAGLFIGSFLNVVVYRLPRGETVVWGRSHCPTCGRELAWYDLIPVLSYLFLRGR
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
CRYCHLPISPRYPIVELVTGVVFTTLFYNFGLSWVLVKYLFLGAVLVAASFIDLEHYLIP
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSLVVTGACGGILFSLLARDVGFRAALGGSVAAAGFLLLVAVISNGGMGGGDVKLAGMVG
CHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LFLGWPLASLALFLSLVTGGLAGVCLLVSGLKKREDPLPFAPFIAIGGLLALFFGEKMLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
WYLGRFM
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]