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The map label for this gene is ubiE [H]

Identifier: 83590288

GI number: 83590288

Start: 1485531

End: 1486136

Strand: Reverse

Name: ubiE [H]

Synonym: Moth_1443

Alternate gene names: 83590288

Gene position: 1486136-1485531 (Counterclockwise)

Preceding gene: 83590289

Following gene: 83590287

Centisome position: 56.53

GC content: 52.15

Gene sequence:

>606_bases
ATGCTTACCCACCGCGAGTATTTTAACAGCAAGGCTGATATTTGGGACAGCCTGTGTGCGCCGGAAGAAAAAGCCAAGCT
GGAAACAATTATTAGAGGATTGAACATTGCTCCCGGCAGCACGGTGTTAGATGTGGGTTGCGGCACAGGGATATTAATTC
CCTATTTACTGGCTGCCGTAGGCCCTGCTGGCCGGATAGTGGCCCTGGATATAGCCGAGGCCATGCTGGAACGGGCGCAA
AGTAAAGGGTTCCCCGCTAATGTGGAGTTCATTTGCGCCGACGTTGTTTCCGTACCCTATCCGGATGCTACTTTCGACGA
GGTCATCTGCAACTCGGCTTTCCCCCATTTTCCCCATAAACTTAAGGCCTTAAAAGAGATGGCCCGGGTGTTGAAACCAG
GCGGGCGGGTGGTTATCTGCCATACGAAAGCAAGGGAAACCATAAATAATTTGCATAGATCCCTGGGGGGCGTTATAGCC
GGGGACCAGATCCCGCCGGGCAGCGAAATGATGGGTATGCTGGTAGCTGCCGGGTTAACGGGAATCGAGATTGATGAGGC
TCTTGATTATTACCTGGCATCTGGGTTCAAGGCGATGTATGAGTAA

Upstream 100 bases:

>100_bases
GTCCTGGCAACAATTTTCTCCCCGAAACGCAAGGTAAAACAGTGGCAAGAAAATGAGTGATTACGGGTTAAAACAATATG
CGAGCGCAGGAGGGAGTTAT

Downstream 100 bases:

>100_bases
TTGCCAAACTACCAGCAGGATTTTGCTGTACGGTTCAGAGAACTTTTAGAGTTTGTTTAAAAGGTCTCTGAACCATTTTT
TATTTTTAAAGCCCTGTTTT

Product: UbiE/COQ5 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MLTHREYFNSKADIWDSLCAPEEKAKLETIIRGLNIAPGSTVLDVGCGTGILIPYLLAAVGPAGRIVALDIAEAMLERAQ
SKGFPANVEFICADVVSVPYPDATFDEVICNSAFPHFPHKLKALKEMARVLKPGGRVVICHTKARETINNLHRSLGGVIA
GDQIPPGSEMMGMLVAAGLTGIEIDEALDYYLASGFKAMYE

Sequences:

>Translated_201_residues
MLTHREYFNSKADIWDSLCAPEEKAKLETIIRGLNIAPGSTVLDVGCGTGILIPYLLAAVGPAGRIVALDIAEAMLERAQ
SKGFPANVEFICADVVSVPYPDATFDEVICNSAFPHFPHKLKALKEMARVLKPGGRVVICHTKARETINNLHRSLGGVIA
GDQIPPGSEMMGMLVAAGLTGIEIDEALDYYLASGFKAMYE
>Mature_201_residues
MLTHREYFNSKADIWDSLCAPEEKAKLETIIRGLNIAPGSTVLDVGCGTGILIPYLLAAVGPAGRIVALDIAEAMLERAQ
SKGFPANVEFICADVVSVPYPDATFDEVICNSAFPHFPHKLKALKEMARVLKPGGRVVICHTKARETINNLHRSLGGVIA
GDQIPPGSEMMGMLVAAGLTGIEIDEALDYYLASGFKAMYE

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Escherichia coli, GI48994983, Length=108, Percent_Identity=39.8148148148148, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 21603; Mature: 21603

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTHREYFNSKADIWDSLCAPEEKAKLETIIRGLNIAPGSTVLDVGCGTGILIPYLLAAV
CCCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHC
GPAGRIVALDIAEAMLERAQSKGFPANVEFICADVVSVPYPDATFDEVICNSAFPHFPHK
CCCCCEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHH
LKALKEMARVLKPGGRVVICHTKARETINNLHRSLGGVIAGDQIPPGSEMMGMLVAAGLT
HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHCCC
GIEIDEALDYYLASGFKAMYE
CCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTHREYFNSKADIWDSLCAPEEKAKLETIIRGLNIAPGSTVLDVGCGTGILIPYLLAAV
CCCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHC
GPAGRIVALDIAEAMLERAQSKGFPANVEFICADVVSVPYPDATFDEVICNSAFPHFPHK
CCCCCEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHH
LKALKEMARVLKPGGRVVICHTKARETINNLHRSLGGVIAGDQIPPGSEMMGMLVAAGLT
HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHCCC
GIEIDEALDYYLASGFKAMYE
CCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA