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The map label for this gene is cdr [H]

Identifier: 83593644

GI number: 83593644

Start: 2672193

End: 2673857

Strand: Direct

Name: cdr [H]

Synonym: Rru_A2309

Alternate gene names: 83593644

Gene position: 2672193-2673857 (Clockwise)

Preceding gene: 83593640

Following gene: 83593645

Centisome position: 61.39

GC content: 67.63

Gene sequence:

>1665_bases
GTGGAGCAGATGAGCATTCTCGTCATTGGCGGCGTGGCCGCCGGCGCGTCCTTTGCCGCGCGGGCCCGGCGCCTGTCGGA
AACGGCGCGGATCACCGTCCTTGAACGCGGCCCGGACGTGTCGTTCGCCAATTGCGGCCTCCCCTATCACATCGGCGGCG
AAATCCCCGATCGCGGCGCGCTGGCGGTGCAATCGGCCGCCTCGCTGAAGGGTCTGCTCAATCTCGACGTCCGCGTCCAG
ACCGAAGCGGTGGCGATCGATCCCAAGGGCAAGCGGGTCGAGGTGCGCGACCTCGCCAGCGGACAAAGCGCCTGGCTGCC
TTACGATAAGCTGATGCTGGCCCCCGGCGCCTCGCCCCTGCGCCCGCCCCTGCCCGGCATCGACGATCCCCGCATCTTCA
CCTTGCGCAATTTGCAAGACATGGACCGCATCATCGCCGCCACCGCCCCGGGCCAGCGCGCCGTGGTCATCGGCGCCGGG
TTCATCGGGCTGGAGATGGCCGAGCAGTTGCACCGCAAGGGGCTTGGCGTCGATCTCGTCGAACTGCAAAGCCAAGTCCT
GCCGCCCCTCGACCCGCCGATGGCCGCCCTGGTCGAAAGCGAACTGCGGCGCCATGACATCGGGCTGCATCTGGGCGACG
CCATCGCCCGCTTCGAAAGCCTGGGCGCCCGACTGCGCTGCCATCTCGCCTCCGACAAGACCTTGGATGCCGACATCGTC
ATCTTGTCGATCGGCGTCAAACCCGAAAGCGATCTCGCCCGCGCCGCCGGTCTGGAGCTTGGCGCCAAGGGCCATATCGT
CGTCGATTCCTTCCAGCGCACCTCCGACCCCGACATCTATGCCGCCGGCGACGGGGTGGAAACGGTCGACCGGATCTTGG
GGGGCAAAACCGCGGTGCCGATGGGCGGCCCGGCCAATCGCCAGGGACGGGTGGCCGCCGATCATATCTTCCTCGCCGAC
AAGGCCCGCCCCTATCCCGGTTCGGTCGGAACGGGGATCGTCCGCGCCTTCGACGCGGTGGTCGGCATCACCGGCTGGAG
CGAGAAGCGCCTTGCCGCCGCCGGCCACCCTTATGAAACGGTGACGGTCAACGACAGCCATCACGCCTCCTATTACCCCG
GCGCCAAGCCGATGACCCTGAAAATCCTCTGGGAGCCCGACAGCGGCCGCCTGCTTGGCGCCCAGGTCAGCGGCAGCGAG
GGGGTCGACAAACGGCTCGACATCTTGTCGACGGCGATCATCGCCGGCATGACCGTCGAGGATCTGTGCCACCTTGAACT
GGCCTATGCGCCGCCCTTCGGTTCGGCCAAGGATCTGGTCAATCTCGCCGGCTTCGCCGCCTGCAACCGCCGCGACGGAC
TGGTCTCCCACACCACCGAGCTGCCGACGGACCCGCAGGTGCAGGTGATCGACGTGCGGGGCAAGCCGCTTGCCGAGGCC
TATCCGGCGCCGGGGACGACGATCAACATTCCCTTCCCGACCCTGCGCGCCCACCTCGACACCCTGGACAAGACACGGCC
GGTGGTGACCCTCTGCGCCTTTGGCAAGATGAGCTATTTCGCCGCCCGGGTCCTTAGCCAGCATGGCTTCACGGTGAAAA
GTTTCAGCGGCGGCCTCAAGGCCAATGTCGATCCGCGCACCCCGGGCAAGTTGCCCGGCGCCTGA

Upstream 100 bases:

>100_bases
ATATCATCATTATATTGACTAATATAACTTACCGCAATAGGGTCGGTGCCACGGTCGTCGTCGTGACCGCCGATCGCCCC
TTCAAAGCGGAGCATTGCCT

Downstream 100 bases:

>100_bases
GGGCGGGCGGTTCCGGGAAAACCGCCTAGCCGACTGTTCTGTAAGGGACGGTTCCATCGAACCGTCCCGCCGATGGAGAT
CGCCGATGGCTCGTTTCGCC

Product: NADH peroxidase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MEQMSILVIGGVAAGASFAARARRLSETARITVLERGPDVSFANCGLPYHIGGEIPDRGALAVQSAASLKGLLNLDVRVQ
TEAVAIDPKGKRVEVRDLASGQSAWLPYDKLMLAPGASPLRPPLPGIDDPRIFTLRNLQDMDRIIAATAPGQRAVVIGAG
FIGLEMAEQLHRKGLGVDLVELQSQVLPPLDPPMAALVESELRRHDIGLHLGDAIARFESLGARLRCHLASDKTLDADIV
ILSIGVKPESDLARAAGLELGAKGHIVVDSFQRTSDPDIYAAGDGVETVDRILGGKTAVPMGGPANRQGRVAADHIFLAD
KARPYPGSVGTGIVRAFDAVVGITGWSEKRLAAAGHPYETVTVNDSHHASYYPGAKPMTLKILWEPDSGRLLGAQVSGSE
GVDKRLDILSTAIIAGMTVEDLCHLELAYAPPFGSAKDLVNLAGFAACNRRDGLVSHTTELPTDPQVQVIDVRGKPLAEA
YPAPGTTINIPFPTLRAHLDTLDKTRPVVTLCAFGKMSYFAARVLSQHGFTVKSFSGGLKANVDPRTPGKLPGA

Sequences:

>Translated_554_residues
MEQMSILVIGGVAAGASFAARARRLSETARITVLERGPDVSFANCGLPYHIGGEIPDRGALAVQSAASLKGLLNLDVRVQ
TEAVAIDPKGKRVEVRDLASGQSAWLPYDKLMLAPGASPLRPPLPGIDDPRIFTLRNLQDMDRIIAATAPGQRAVVIGAG
FIGLEMAEQLHRKGLGVDLVELQSQVLPPLDPPMAALVESELRRHDIGLHLGDAIARFESLGARLRCHLASDKTLDADIV
ILSIGVKPESDLARAAGLELGAKGHIVVDSFQRTSDPDIYAAGDGVETVDRILGGKTAVPMGGPANRQGRVAADHIFLAD
KARPYPGSVGTGIVRAFDAVVGITGWSEKRLAAAGHPYETVTVNDSHHASYYPGAKPMTLKILWEPDSGRLLGAQVSGSE
GVDKRLDILSTAIIAGMTVEDLCHLELAYAPPFGSAKDLVNLAGFAACNRRDGLVSHTTELPTDPQVQVIDVRGKPLAEA
YPAPGTTINIPFPTLRAHLDTLDKTRPVVTLCAFGKMSYFAARVLSQHGFTVKSFSGGLKANVDPRTPGKLPGA
>Mature_554_residues
MEQMSILVIGGVAAGASFAARARRLSETARITVLERGPDVSFANCGLPYHIGGEIPDRGALAVQSAASLKGLLNLDVRVQ
TEAVAIDPKGKRVEVRDLASGQSAWLPYDKLMLAPGASPLRPPLPGIDDPRIFTLRNLQDMDRIIAATAPGQRAVVIGAG
FIGLEMAEQLHRKGLGVDLVELQSQVLPPLDPPMAALVESELRRHDIGLHLGDAIARFESLGARLRCHLASDKTLDADIV
ILSIGVKPESDLARAAGLELGAKGHIVVDSFQRTSDPDIYAAGDGVETVDRILGGKTAVPMGGPANRQGRVAADHIFLAD
KARPYPGSVGTGIVRAFDAVVGITGWSEKRLAAAGHPYETVTVNDSHHASYYPGAKPMTLKILWEPDSGRLLGAQVSGSE
GVDKRLDILSTAIIAGMTVEDLCHLELAYAPPFGSAKDLVNLAGFAACNRRDGLVSHTTELPTDPQVQVIDVRGKPLAEA
YPAPGTTINIPFPTLRAHLDTLDKTRPVVTLCAFGKMSYFAARVLSQHGFTVKSFSGGLKANVDPRTPGKLPGA

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=321, Percent_Identity=27.4143302180685, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI21389617, Length=321, Percent_Identity=27.4143302180685, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI226437568, Length=321, Percent_Identity=27.4143302180685, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1789065, Length=291, Percent_Identity=30.5841924398625, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789765, Length=327, Percent_Identity=25.3822629969419, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788892, Length=206, Percent_Identity=35.9223300970874, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87082354, Length=356, Percent_Identity=25.2808988764045, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786307, Length=325, Percent_Identity=27.0769230769231, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789915, Length=261, Percent_Identity=27.2030651340996, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787352, Length=235, Percent_Identity=24.6808510638298, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=286, Percent_Identity=26.5734265734266, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6325166, Length=352, Percent_Identity=24.7159090909091, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281359715, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281359713, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639250, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18543267, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639252, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24639257, Length=199, Percent_Identity=28.643216080402, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585130, Length=217, Percent_Identity=24.8847926267281, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 58619; Mature: 58619

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQMSILVIGGVAAGASFAARARRLSETARITVLERGPDVSFANCGLPYHIGGEIPDRGA
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCEEECCCCCCCCC
LAVQSAASLKGLLNLDVRVQTEAVAIDPKGKRVEVRDLASGQSAWLPYDKLMLAPGASPL
EEHHHHHHHHHEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHEEECCCCCCC
RPPLPGIDDPRIFTLRNLQDMDRIIAATAPGQRAVVIGAGFIGLEMAEQLHRKGLGVDLV
CCCCCCCCCCCEEEECCHHHHHHHHEECCCCCEEEEEECCHHHHHHHHHHHHCCCCEEHH
ELQSQVLPPLDPPMAALVESELRRHDIGLHLGDAIARFESLGARLRCHLASDKTLDADIV
HHHHHHCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHCCCEEEEEECCCCCCCCEEE
ILSIGVKPESDLARAAGLELGAKGHIVVDSFQRTSDPDIYAAGDGVETVDRILGGKTAVP
EEEECCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEECCCCHHHHHHHHCCCEECC
MGGPANRQGRVAADHIFLADKARPYPGSVGTGIVRAFDAVVGITGWSEKRLAAAGHPYET
CCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEE
VTVNDSHHASYYPGAKPMTLKILWEPDSGRLLGAQVSGSEGVDKRLDILSTAIIAGMTVE
EEECCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHH
DLCHLELAYAPPFGSAKDLVNLAGFAACNRRDGLVSHTTELPTDPQVQVIDVRGKPLAEA
HHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHC
YPAPGTTINIPFPTLRAHLDTLDKTRPVVTLCAFGKMSYFAARVLSQHGFTVKSFSGGLK
CCCCCCEEECCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCC
ANVDPRTPGKLPGA
CCCCCCCCCCCCCC
>Mature Secondary Structure
MEQMSILVIGGVAAGASFAARARRLSETARITVLERGPDVSFANCGLPYHIGGEIPDRGA
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCEEECCCCCCCCC
LAVQSAASLKGLLNLDVRVQTEAVAIDPKGKRVEVRDLASGQSAWLPYDKLMLAPGASPL
EEHHHHHHHHHEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHEEECCCCCCC
RPPLPGIDDPRIFTLRNLQDMDRIIAATAPGQRAVVIGAGFIGLEMAEQLHRKGLGVDLV
CCCCCCCCCCCEEEECCHHHHHHHHEECCCCCEEEEEECCHHHHHHHHHHHHCCCCEEHH
ELQSQVLPPLDPPMAALVESELRRHDIGLHLGDAIARFESLGARLRCHLASDKTLDADIV
HHHHHHCCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHCCCEEEEEECCCCCCCCEEE
ILSIGVKPESDLARAAGLELGAKGHIVVDSFQRTSDPDIYAAGDGVETVDRILGGKTAVP
EEEECCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEECCCCHHHHHHHHCCCEECC
MGGPANRQGRVAADHIFLADKARPYPGSVGTGIVRAFDAVVGITGWSEKRLAAAGHPYET
CCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEE
VTVNDSHHASYYPGAKPMTLKILWEPDSGRLLGAQVSGSEGVDKRLDILSTAIIAGMTVE
EEECCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHH
DLCHLELAYAPPFGSAKDLVNLAGFAACNRRDGLVSHTTELPTDPQVQVIDVRGKPLAEA
HHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHC
YPAPGTTINIPFPTLRAHLDTLDKTRPVVTLCAFGKMSYFAARVLSQHGFTVKSFSGGLK
CCCCCCEEECCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCC
ANVDPRTPGKLPGA
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA