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The map label for this gene is srrB

Identifier: 82751086

GI number: 82751086

Start: 1481447

End: 1483198

Strand: Reverse

Name: srrB

Synonym: SAB1352c

Alternate gene names: 82751086

Gene position: 1483198-1481447 (Counterclockwise)

Preceding gene: 82751087

Following gene: 82751085

Centisome position: 54.08

GC content: 32.71

Gene sequence:

>1752_bases
ATGATGAGCCGGCTAAATAGTGTCGTAATTAAACTGTGGTTAACTATTATTTTAATAGTGACGACAGTTTTAATTTTATT
AAGTATTGCTTTAATTACCTTTATGCAATACTATTTCACACAAGAAACTGAAAATGCCATAAGAGAAGATGCTAGACGTA
TAAGTTCACTGGTCGAACAATCACATAATAAAGAAGAAGCAATAAAATATAGTCAAACATTAATTGAAAATCCTGGTGGG
TTGATGATTATAAATAATAAACATCGTCAATCAACGGCTTCACTTTCTAATATTAAAAAGCAAATGTTGAATGAAGTAGT
CAACAACGACCATTTTGACGATGTGTTTGATAAAGGTAAATCTGTTACTCGAAATGTAACGATTAAAGAAAAGGGTTCAT
CTCAAACATATATTTTGTTAGGCTATCCAACAAAAGCACAGAAGAATAGTCATAGCAAATATAGTGGAGTCTTTATATAT
AAAGACTTGAAATCAATCGAAGATACAAATAATGCTATTACGATTATCACTATAATTACGGCTGTTATTTTCTTAACAAT
TACAACAGTCTTTGCGTTTTTCTTATCGTCAAGAATTACAAAACCTTTAAGACGTTTAAGAGATCAAGCTACACGTGTAT
CTGAAGGGGATTACTCTTATAAACCTTCTGTCACAACGAAAGATGAAATTGGTCAATTATCACAGGCATTTAATCAGATG
AGTACAGAAATCGAAGAGCATGTCGACGCATTATCCACATCTAAAAATATTAGAGACAGCTTAATTAACTCTATGGTAGA
AGGTGTCCTAGGTATTAATGAGAGTCGACAAATTATCTTATCAAATAAGATGGCGAATGATATTATGGACAATATTGATG
AAGATGCTAAAGCTTTCTTATTAAGACAAATTGAAGATACTTTTAAATCAAAACAAACTGAAATGCGTGATTTAGAAATA
AATGCACGATTCTTTGTTGTGACTACAAGCTATATCGACAAGATTGAACAGGGAGGTAAAAGTGGTGTTGTTGTGACAGT
TCGTGATATGACTAATGAGCACAATCTAGATCAAATGAAGAAAGATTTCATTGCTAATGTATCACATGAATTACGTACAC
CGATCTCATTACTTCAAGGTTATACTGAATCAATTGTAGATGGTATTGTTACAGAACCGGATGAAATAAAAGAATCGCTT
GCCATTGTCCTTGATGAATCGAAACGTTTAAATCGTTTAGTTAATGAATTGTTAAATGTCGCACGCATGGATGCTGAAGG
GTTATCCGTAAATAAAGAAATTCAACCTATTGCAGCGTTACTAGATAAGATGAAAATTAAGTATCGTCAACAAGCTGATG
ATTTAGGTCTAAATATGACTTTTAATTATTGTAAGAAGCGTGTTTGGAGATATGATATGGATCGCATGGACCAAGTACTA
ACGAACTTAATTGATAATGCATCACGTTATACGAAACCTGGTGATGAAATTGCAATTACTTGTGCTGAAAATGAAAGCGA
AGATATTTTATACATTAAAGATACAGGCACAGGCATTGCACCAGAACATTTACAACAAGTATTTGATCGTTTTTATAAAG
TTGATGCAGCGAGAACGAGAGGTAAACAAGGTACCGGTTTAGGTTTGTTCATTTGTAAAATGATTATCGAAGAGCATGGT
GGTTCCATTGATGTTAAAAGCGAATTAGGAAAAGGCACAACGTTTATTATCAAATTACCAAAGCCGGAATAA

Upstream 100 bases:

>100_bases
GTTAAACGACTTAGAGAAAAGTTAAATCGTGTGTCTAGCGAAGCTGCGCATATGATTCAAACAGTCTGGGGCGTTGGGTA
TAAATTTGAGGTTAAATCTA

Downstream 100 bases:

>100_bases
AACTGAATATAGTTATTTAAGAACGCATGTTATTGATTAGAGACTCTAATTTATAGCATGCGTTTTTTAAATTGATGTGG
GGAGTTTTGTATGTGGATTA

Product: respiratory response protein B

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG
LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY
KDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEI
NARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL
AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEIQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWRYDMDRMDQVL
TNLIDNASRYTKPGDEIAITCAENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHG
GSIDVKSELGKGTTFIIKLPKPE

Sequences:

>Translated_583_residues
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG
LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY
KDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEI
NARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL
AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEIQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWRYDMDRMDQVL
TNLIDNASRYTKPGDEIAITCAENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHG
GSIDVKSELGKGTTFIIKLPKPE
>Mature_583_residues
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG
LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY
KDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEI
NARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL
AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEIQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWRYDMDRMDQVL
TNLIDNASRYTKPGDEIAITCAENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHG
GSIDVKSELGKGTTFIIKLPKPE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=32.2869955156951, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786600, Length=346, Percent_Identity=28.0346820809249, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=34.3891402714932, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=30.1724137931034, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=29.7071129707113, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994928, Length=466, Percent_Identity=23.8197424892704, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1789149, Length=227, Percent_Identity=30.3964757709251, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=30, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=27.6119402985075, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788549, Length=422, Percent_Identity=23.9336492890995, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=32.3404255319149, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=27.8481012658228, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=25.5411255411255, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=200, Percent_Identity=23.5, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1788279, Length=228, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789403, Length=215, Percent_Identity=28.8372093023256, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=23.6714975845411, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790567, Length=356, Percent_Identity=25.8426966292135, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66098; Mature: 66098

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGK
CCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
SVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIIT
CCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHH
AVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHH
LRQIEDTFKSKQTEMRDLEINARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMK
HHHHHHHHHHHHHHHHHEEECCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
KDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ARMDAEGLSVNKEIQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWRYDMDRMDQVL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHH
TNLIDNASRYTKPGDEIAITCAENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTR
HHHHHCHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
CCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCEEEEECCCCC
>Mature Secondary Structure
MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGK
CCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
SVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIIT
CCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHH
AVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHH
LRQIEDTFKSKQTEMRDLEINARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMK
HHHHHHHHHHHHHHHHHEEECCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
KDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ARMDAEGLSVNKEIQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWRYDMDRMDQVL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHH
TNLIDNASRYTKPGDEIAITCAENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTR
HHHHHCHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHC
GKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
CCCCCCHHHHHHHHHHHHCCCCEEEHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA