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The map label for this gene is rir1

Identifier: 82750435

GI number: 82750435

Start: 748283

End: 750379

Strand: Direct

Name: rir1

Synonym: SAB0682

Alternate gene names: 82750435

Gene position: 748283-750379 (Clockwise)

Preceding gene: 82750434

Following gene: 82750436

Centisome position: 27.28

GC content: 32.9

Gene sequence:

>2097_bases
ATGGAAGAGAAAAAGTACAATCATATTGAATTAAATAATGAGGTCACTAAACGAAGAGAAGATGGATTCTTTAGTTTAGA
AAAAGACCAAGAAGCTTTAGTAGCTTATTTAGAAGAAGTAAAAGACAAAACAATCTTCTTCGACACTGAAATCGAGCGTT
TACGTTATTTAGTAGACAACGATTTTTATTTCAATGTGTTTGATATTTATAGTGAAGCGGATCTAATTGAAATCACTGAT
TATGCAAAATCAATCCCGTTTAATTTTGCAAGTTATATGTCAGCTAGTAAATTTTTCAAAGATTACGCTTTGAAAACAAA
TGATAAAAGTCAATACTTAGAAGACTATAATCAACACGTTGCCATTGTTGCTTTATACCTAGCAAATGGTAATAAAGCAC
AAGCTAAACAATTTATTTCTGCTATGGTTGAACAAAGATATCAACCAGCGACACCAACATTTTTAAACGCAGGCCGTGCG
CGTCGTGGTGAGCTAGTGTCATGTTTCTTATTAGAAGTGGATGACAGCTTAAATTCAATTAACTTTATTGATTCAACTGC
AAAACAATTAAGTAAAATTGGGGGCGGCGTTGCAATTAACTTATCTAAATTGCGTGCACGTGGTGAAGCAATTAAAGGAA
TTAAAGGCGTAGCGAAAGGCGTTTTACCTATTGCTAAGTCACTTGAAGGTGGCTTTAGCTATGCAGATCAACTTGGTCAA
CGCCCTGGTGCTGGTGCAGTGTACTTAAATATCTTCCATTATGATGTAGAAGAATTTTTAGATACTAAAAAAGTAAATGC
GGATGAAGATTTACGTTTATCTACAATATCAACTGGTTTAATTGTTCCATCTAAATTCTTCGATTTAGCTAAAGAAGGTA
AGGACTTTTATATGTTTGCACCTCATACAGTTAAAGAAGAATATGGTGTGACATTAGACGATATCGATTTAGAAAAATAT
TATGATGACATGGTTGCAAACCCAAATGTTGAGAAAAAGAAAAAGAATGCGCGTGAAATGTTGAATTTAATTGCGCAAAC
ACAATTACAATCAGGTTATCCTTATTTAATGTTTAAAGATAATGCTAACAGAGTGCATCCGAATTCAAACATTGGACAAA
TTAAAATGAGTAACTTATGTACGGAAATTTTCCAACTACAAGAAACTTCAATTATTAATGACTATGGTATTGAAGACGAA
ATTCAACGTGATATTTCTTGTAACTTGGGCTCATTAAATATTGTTAATGTGATGGAAAGCGGAAAATTCAGAGATTCAGT
TCACTCTGGTATGGACGCATTAACTGTTGTGAGTGATGTAGCAAATATTCAAAATGCACCAGGAGTTAGAAAAGCTAACA
GTGAATTACATTCAGTTGGTCTTGGTGTCATGAATTTACACGGTTACCTTGCAAAAAATAAAATTGGTTATGAGTCAGAA
GAAGCAAAAGATTTTGCAAATATCTTCTTTATGATGATGAATTTCTACTCAATCGAACGTTCAATGGAAATCGCTAAAGA
GCGTGGTATCAAATATCAAGACTTTGAAAAGTCTGATTATGCTAATGGTAAATATTTCGAGTTCTATACAACTCAAGAAT
TTGAACCTCAATTCGAAAAAGTACGTGAATTATTCGACGGTATGGCTATTCCTACTTCTGAGGATTGGAAGAAACTACAA
CAAGATGTTGAACAATATGGTTTATATCATGCATATAGATTAGCAATTGCTCCAACACAAAGTATTTCTTATGTTCAAAA
TGCTACAAGTTCTGTAATGCCAATCGTTGACCAAATTGAACGTCGTACTTATGGTAATGCGGAAACATTTTACCCTATGC
CATTCTTATCACCACAAACAATGTGGTACTACAAATCAGCATTCAATACTGATCAGATGAAATTAATCGATTTAATAGCG
ACAATTCAAACGCATATTGACCAAGGTATCTCAACGATACTTTATGTTAATTCTGAAATTTCTACACGTGAGTTAGCAAG
ATTATATGTATATGCGCACTATAAAGGATTAAAATCACTTTACTATACTAGAAATAAATTATTAAGTGTAGAAGAATGTA
CAAGTTGTTCTATCTAA

Upstream 100 bases:

>100_bases
GAAGAGTATAATGTCCCTTTATTAATGAAGTTTGAGTTACATGGAAAAAACAAAGACGTTATTGAATTTAAGAACAAGGT
GGGTAATTTTAATGAAAACC

Downstream 100 bases:

>100_bases
CAATTAAATGTTGAAAATGACAAACAGCTAATCATCTGGTCTGAATTAGCAGATGATTAGACTGCTATGTCTGTATTTGT
CAATTATTGAGTAACATTAC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase large subunit [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITD
YAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRA
RRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQ
RPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKY
YDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDE
IQRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESE
EAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQ
QDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIA
TIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI

Sequences:

>Translated_698_residues
MEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITD
YAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRA
RRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQ
RPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKY
YDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDE
IQRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESE
EAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQ
QDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIA
TIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
>Mature_698_residues
MEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDNDFYFNVFDIYSEADLIEITD
YAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHVAIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRA
RRGELVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQ
RPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKEEYGVTLDDIDLEKY
YDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKDNANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDE
IQRDISCNLGSLNIVNVMESGKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESE
EAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEKVRELFDGMAIPTSEDWKKLQ
QDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIA
TIQTHIDQGISTILYVNSEISTRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=636, Percent_Identity=26.8867924528302, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1789030, Length=687, Percent_Identity=41.6302765647744, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI2367133, Length=572, Percent_Identity=23.9510489510489, Blast_Score=152, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17555242, Length=642, Percent_Identity=26.01246105919, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322123, Length=649, Percent_Identity=25.7318952234206, Blast_Score=187, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6320914, Length=646, Percent_Identity=24.3034055727554, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17352481, Length=631, Percent_Identity=27.2583201267829, Blast_Score=188, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926
- InterPro:   IPR013554 [H]

Pfam domain/function: PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; PF08343 RNR_N [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 79766; Mature: 79766

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDN
CCCCCCCCEECCCHHHHHHCCCCEEECCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCC
DFYFNVFDIYSEADLIEITDYAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHV
CCEEEEEECCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCE
AIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRARRGELVSCFLLEVDDSLNSI
EEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCEEEEEEEEECCCCCCC
NFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQ
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
RPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFA
CCCCCEEEEEEEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEC
PHTVKEEYGVTLDDIDLEKYYDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKD
CCHHHHHHCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
NANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDEIQRDISCNLGSLNIVNVMES
CCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEHHHC
GKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESE
CCHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHCCHHHHHCCHHHHHHHHHHHCCCCCCCH
EAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
VRELFDGMAIPTSEDWKKLQQDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIE
HHHHHCCCCCCCCHHHHHHHHHHHHHCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
RRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIATIQTHIDQGISTILYVNSEI
HHCCCCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
STRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
>Mature Secondary Structure
MEEKKYNHIELNNEVTKRREDGFFSLEKDQEALVAYLEEVKDKTIFFDTEIERLRYLVDN
CCCCCCCCEECCCHHHHHHCCCCEEECCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCC
DFYFNVFDIYSEADLIEITDYAKSIPFNFASYMSASKFFKDYALKTNDKSQYLEDYNQHV
CCEEEEEECCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCE
AIVALYLANGNKAQAKQFISAMVEQRYQPATPTFLNAGRARRGELVSCFLLEVDDSLNSI
EEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCEEEEEEEEECCCCCCC
NFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPIAKSLEGGFSYADQLGQ
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
RPGAGAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFA
CCCCCEEEEEEEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEC
PHTVKEEYGVTLDDIDLEKYYDDMVANPNVEKKKKNAREMLNLIAQTQLQSGYPYLMFKD
CCHHHHHHCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
NANRVHPNSNIGQIKMSNLCTEIFQLQETSIINDYGIEDEIQRDISCNLGSLNIVNVMES
CCCEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEHHHC
GKFRDSVHSGMDALTVVSDVANIQNAPGVRKANSELHSVGLGVMNLHGYLAKNKIGYESE
CCHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHCCHHHHHCCHHHHHHHHHHHCCCCCCCH
EAKDFANIFFMMMNFYSIERSMEIAKERGIKYQDFEKSDYANGKYFEFYTTQEFEPQFEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHH
VRELFDGMAIPTSEDWKKLQQDVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIE
HHHHHCCCCCCCCHHHHHHHHHHHHHCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
RRTYGNAETFYPMPFLSPQTMWYYKSAFNTDQMKLIDLIATIQTHIDQGISTILYVNSEI
HHCCCCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
STRELARLYVYAHYKGLKSLYYTRNKLLSVEECTSCSI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969495; 9384377 [H]