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The map label for this gene is iolS [H]

Identifier: 82750307

GI number: 82750307

Start: 616390

End: 617328

Strand: Direct

Name: iolS [H]

Synonym: SAB0552

Alternate gene names: 82750307

Gene position: 616390-617328 (Clockwise)

Preceding gene: 82750306

Following gene: 82750308

Centisome position: 22.48

GC content: 34.61

Gene sequence:

>939_bases
ATGAAGCAATTTGTAAACTTAGGTAAATCTGATGTTGAAGTGTTTCCAATCGCACTTGGGACAAACGCAGTAGGTGGGCA
TAATTTATATCCGAACTTAGATGAAGAACAAGGAAAAGATGTTGTTCGTCAAGCCATTAATCATGGTATTAATTTATTAG
ATACGGCATATATTTATGGGCCAGAACGATCAGAAGAATTGGTTGGAGAAGTTGTTAAAGAATATCCGCGAGAGCAAATT
AAAATTGCTACGAAAGGGTCTCATGAATTTGATGAAAATCAAGAAGTACATCAGAACAATCAACCGGAATATTTAAAACA
ACAAGTTGAGAATAGTTTGAAACGTCTACAAACTGATTATATCGATTTATATTATATTCATTTTCCGGATGACAACACTC
CGAAAGATCAAGCAGTTGCAGCATTACAAGAGCTTAAGGAACAAGGAAAGATTAAAGCTATTGGTGTATCAAATTTCACA
TTAGATCAACTTAAAGAAGCAAATAAAGATGGTTACATTGATGTTGTACAGTTGGAATATAATTTATTGCATCGCGAAAA
TGAGGCAGTATTACAATATTGTGTTGATCACCAAATCACATTTATTCCATATTTCCCATTAGTATCCGGTATTTTAGCTG
GAAAATATGATGAGAACACTAAATTTAGTGACCATCGTACTACACGTCGTGATTTTATACCTGGTGTTTTTGAAGAGAAT
GTGCGTCGCGTAAAAGCTTTGGAAAGCCTAGCTGCAGCACATCAAACTTCAATTGCGAACATTGTATTAGCATTTTATTT
AACAAGACCAGCTATCGATGTGATTATTCCTGGCGCAAAACGTGCAGAACAAGTCGTTGAAAATATTAAAGCTGCAGATA
TCGTTTTATCAGATGATGAGATTCAATATATCGATGAACTGTTTCCGATTGAAGACTAA

Upstream 100 bases:

>100_bases
ACAACGCCTAAATTCAAACCCTAATTCTAACATTTGGAAGTTGTATTAAATCATGGTAGTGTGATAGTGGAAAAGTTATA
AAGATAAGGAGCTGGGTCTA

Downstream 100 bases:

>100_bases
ATGAATTGTATTTAATGATGACATATGTAGCTAATTCATTATGAATTAGCCTCGTATCACAAACGACGTTATATATGGCA
TGACGAAATTTCGTCAAATT

Product: oxidoreductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQI
KIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFT
LDQLKEANKDGYIDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLVSGILAGKYDENTKFSDHRTTRRDFIPGVFEEN
VRRVKALESLAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED

Sequences:

>Translated_312_residues
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQI
KIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFT
LDQLKEANKDGYIDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLVSGILAGKYDENTKFSDHRTTRRDFIPGVFEEN
VRRVKALESLAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED
>Mature_312_residues
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQI
KIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFT
LDQLKEANKDGYIDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLVSGILAGKYDENTKFSDHRTTRRDFIPGVFEEN
VRRVKALESLAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=324, Percent_Identity=27.1604938271605, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4504825, Length=324, Percent_Identity=27.1604938271605, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI27436964, Length=326, Percent_Identity=25.4601226993865, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI27436962, Length=310, Percent_Identity=26.1290322580645, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI27436966, Length=308, Percent_Identity=26.2987012987013, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI27436971, Length=329, Percent_Identity=26.7477203647416, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI223718702, Length=296, Percent_Identity=27.7027027027027, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI41152114, Length=298, Percent_Identity=27.1812080536913, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI41327764, Length=276, Percent_Identity=28.6231884057971, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=29.5918367346939, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI291291012, Length=294, Percent_Identity=28.2312925170068, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI223718708, Length=177, Percent_Identity=27.683615819209, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=27.8571428571429, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI5453543, Length=294, Percent_Identity=27.5510204081633, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI45446745, Length=299, Percent_Identity=27.0903010033445, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4503285, Length=299, Percent_Identity=27.0903010033445, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI24497585, Length=305, Percent_Identity=25.5737704918033, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24497583, Length=306, Percent_Identity=26.1437908496732, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI310109920, Length=299, Percent_Identity=26.7558528428094, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI300116273, Length=282, Percent_Identity=27.3049645390071, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1788070, Length=334, Percent_Identity=34.4311377245509, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87081735, Length=311, Percent_Identity=29.903536977492, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789375, Length=323, Percent_Identity=28.4829721362229, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787674, Length=283, Percent_Identity=26.1484098939929, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789199, Length=345, Percent_Identity=29.8550724637681, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788081, Length=297, Percent_Identity=26.9360269360269, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082198, Length=274, Percent_Identity=28.8321167883212, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994888, Length=273, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786400, Length=272, Percent_Identity=25.7352941176471, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=299, Percent_Identity=27.7591973244147, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17564128, Length=303, Percent_Identity=27.0627062706271, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561298, Length=309, Percent_Identity=27.1844660194175, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=27.8169014084507, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538386, Length=311, Percent_Identity=24.7588424437299, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17566692, Length=310, Percent_Identity=27.741935483871, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561300, Length=310, Percent_Identity=26.7741935483871, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=283, Percent_Identity=24.3816254416961, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=330, Percent_Identity=27.5757575757576, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323998, Length=325, Percent_Identity=25.5384615384615, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319958, Length=298, Percent_Identity=25.1677852348993, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319951, Length=325, Percent_Identity=26.1538461538462, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322615, Length=256, Percent_Identity=25.78125, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323684, Length=173, Percent_Identity=32.9479768786127, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24646155, Length=198, Percent_Identity=33.8383838383838, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646159, Length=174, Percent_Identity=33.9080459770115, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=24.8322147651007, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366140, Length=281, Percent_Identity=24.9110320284698, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35488; Mature: 35488

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYG
CCHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEEC
PERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDY
CCCHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
IDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYIDVVQLEY
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEEEEEEHH
NLLHRENEAVLQYCVDHQITFIPYFPLVSGILAGKYDENTKFSDHRTTRRDFIPGVFEEN
HHHHCCCHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHH
VRRVKALESLAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHEEECCCH
IQYIDELFPIED
HHHHHHHCCCCC
>Mature Secondary Structure
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYG
CCHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEEEC
PERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDY
CCCHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCC
IDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYIDVVQLEY
EEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCEEEEEEHH
NLLHRENEAVLQYCVDHQITFIPYFPLVSGILAGKYDENTKFSDHRTTRRDFIPGVFEEN
HHHHCCCHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHH
VRRVKALESLAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHEEECCCH
IQYIDELFPIED
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]