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The map label for this gene is cysK [H]

Identifier: 82750220

GI number: 82750220

Start: 511167

End: 512099

Strand: Direct

Name: cysK [H]

Synonym: SAB0462

Alternate gene names: 82750220

Gene position: 511167-512099 (Clockwise)

Preceding gene: 82750219

Following gene: 82750221

Centisome position: 18.64

GC content: 37.51

Gene sequence:

>933_bases
ATGGCACAAAAACCAGTAGATAATATTACTCAAATTATTGGCGGTACACCGGTAGTCAAATTGAGAAATGTAGTAGATGA
CAATGCAGCAGATGTTTATGTAAAATTGGAATATCAAAATCCAGGTGGTTCTGTAAAGGATAGAATTGCTTTAGCAATGA
TTGAAAAAGCAGAGCGAGAAGGCAAAATTAAACCTGGCGATACAATTGTAGAACCAACAAGTGGTAATACAGGTATCGGT
TTAGCATTTGTATGTGCTGCTAAAGGATATAAAGCAGTATTTACTATGCCTGAAACAATGAGCCAAGAGCGTCGTAATTT
ATTAAAAGCATACGGTGCGGAATTAGTTTTAACGCCTGGATCAGAAGCGATGAAAGGTGCAATTAAAAAAGCTAAAGAAT
TAAAAGAAGAACATGGTTACTTCGAGCCACAACAATTTGAAAACCCTGCGAACCCTGAAGTTCATGAGTTAACTACAGGT
CCTGAGTTATTACAACAATTTGAAGGGAAAACTATTGATGCGTTCCTAGCTGGTGTTGGTACTGGTGGTACGTTATCTGG
TGTAGGTAAAGTTCTGAAAAAAGAATATCCTAACATCGAAATTGTTGCTATAGAGCCTGAGGCTTCTCCAGTATTGAGTG
GTGGTGAGCCAGGTCCACATAAATTACAAGGTTTAGGTGCTGGATTTATTCCAGGTACTTTGAATACAGAAATCTATGAC
AGTATTATTAAAGTAGGAAATGATACAGCGATGGAAATGTCTCGTCGAGTTGCTAAAGAGGAAGGTATTTTAGCAGGTAT
TTCATCAGGTGCTGCGATTTATGCTGCCATTCAAAAAGCAAAAGAATTAGGAAAAGGTAAAACAGTAATAACAGTATTGC
CGAGTAATGGTGAGCGCTACTTATCAACACCTTTATATTCATTCGATGACTAA

Upstream 100 bases:

>100_bases
TAGTGATTTTGTTTGCTTTCTAGAATTTATTTGATAAAATAATTCTATATCCGATAAATAAACTAAGATTTCAACAACTA
ACTAAAAAGGAGTGTTCTTA

Downstream 100 bases:

>100_bases
TTAATGTCATTTAAAAGAGTGAGTTATCTTTTTGAGATAACTTGCTCTTTTTTTCTACCATGTATAATTTTAAAAATATG
AGCGTTAAATTAAACATTTT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIG
LAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTG
PELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVITVLPSNGERYLSTPLYSFDD

Sequences:

>Translated_310_residues
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIG
LAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTG
PELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVITVLPSNGERYLSTPLYSFDD
>Mature_309_residues
AQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGL
AFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGP
ELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDS
IIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVITVLPSNGERYLSTPLYSFDD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=38.6581469648562, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=38.6581469648562, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=38.6581469648562, Blast_Score=222, Evalue=3e-58,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=52.2875816993464, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=40.531561461794, Blast_Score=230, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=52.3026315789474, Blast_Score=287, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=49.1694352159468, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=49.1694352159468, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=49.1525423728814, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=46.6442953020134, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32566672, Length=217, Percent_Identity=48.3870967741936, Blast_Score=200, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=39.297124600639, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=36.3057324840764, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=43.6974789915966, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=313, Percent_Identity=27.1565495207668, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.5796178343949, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=34.5345345345345, Blast_Score=152, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=39.5498392282958, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=39.5498392282958, Blast_Score=215, Evalue=4e-56,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32990; Mature: 32859

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAERE
CCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHC
GKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPG
CCCCCCCEEECCCCCCCCCHHHEEECCCCCEEEEECHHHHHHHHHHHHHHCCCEEEECCC
SEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVG
HHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHCCCCCHHHHHHHCCCEEEHHHHCCC
TGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHH
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVITVLPSNGERY
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
LSTPLYSFDD
ECCCCCCCCC
>Mature Secondary Structure 
AQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLEYQNPGGSVKDRIALAMIEKAERE
CCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHC
GKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPG
CCCCCCCEEECCCCCCCCCHHHEEECCCCCEEEEECHHHHHHHHHHHHHHCCCEEEECCC
SEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVG
HHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHCCCCCHHHHHHHCCCEEEHHHHCCC
TGGTLSGVGKVLKKEYPNIEIVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYD
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHH
SIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVITVLPSNGERY
HHHHCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
LSTPLYSFDD
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA