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The map label for this gene is pth [H]

Identifier: 82750209

GI number: 82750209

Start: 497304

End: 497876

Strand: Direct

Name: pth [H]

Synonym: SAB0451

Alternate gene names: 82750209

Gene position: 497304-497876 (Clockwise)

Preceding gene: 82750208

Following gene: 82750210

Centisome position: 18.13

GC content: 32.98

Gene sequence:

>573_bases
ATGAAATGTATTGTAGGTCTAGGTAATATAGGTAAACGTTTTGAACTTACAAGACATAATATCGGCTTTGAAGTCGTTGA
TTATATTTTAGAGAAAAATAATTTTTCATTAGATAAACAAAAGTTTAAAGGTGCATATACAATTGAACGAATGAACGGAG
ATAAAGTGTTATTTATCGAACCAATGACAATGATGAATTTGTCAGGTGAAGCAGTTGCACCGATTATGGATTATTACAAT
GTTAATCCAGAAGATTTAATTGTCTTATATGATGATTTAGATTTAGAACAAGGACAAGTTCGCTTAAGACAAAAAGGAAG
TGCGGGCGGTCACAATGGTATGAAATCAATTATTAAAATGCTTGGTACAGACCAATTTAAACGTATTCGTATTGGCGTGG
GAAGACCAACGAATGGTATGACGGTACCTGATTATGTTTTACAACGCTTTTCAAATGATGAAATGGTAACGATGGAAAAA
GTTATCGAACACGCAGGACGCGCAATTGAAAAGTTTGTTGAAACATCACGATTTGACCATGTTATGAATGAATTTAATGG
TGAAGTGAAATAA

Upstream 100 bases:

>100_bases
CTTACTAAGCTAAAGAATAATGATAATTGATGGCAATGGCGGAAAATAGATGTTGTCATTATAATAATAAATGAAATAAT
TATGTTGGAGGTAAACACGC

Downstream 100 bases:

>100_bases
TGACAATATTGACAACGCTTATAAAAGAAGATAATCATTTTCAAGACCTTAATCAGGTATTTGGACAAGCAAACACACTA
GTAACTGGTCTTTCCCCATC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYN
VNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEK
VIEHAGRAIEKFVETSRFDHVMNEFNGEVK

Sequences:

>Translated_190_residues
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYN
VNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEK
VIEHAGRAIEKFVETSRFDHVMNEFNGEVK
>Mature_190_residues
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYN
VNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEK
VIEHAGRAIEKFVETSRFDHVMNEFNGEVK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=166, Percent_Identity=27.710843373494, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1787455, Length=174, Percent_Identity=37.3563218390805, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21689; Mature: 21689

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
CEEEEECCCCCCCEEEHHHCCCHHHHHHHHHCCCCCCCHHHCCCEEEEEEECCCEEEEEC
PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
CHHHCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHH
LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAGRAIEKFVETSRFDH
HCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VMNEFNGEVK
HHHHCCCCCC
>Mature Secondary Structure
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIE
CEEEEECCCCCCCEEEHHHCCCHHHHHHHHHCCCCCCCHHHCCCEEEEEEECCCEEEEEC
PMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKM
CHHHCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHH
LGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAGRAIEKFVETSRFDH
HCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VMNEFNGEVK
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA