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The map label for this gene is patB [H]

Identifier: 82703374

GI number: 82703374

Start: 2565427

End: 2566656

Strand: Reverse

Name: patB [H]

Synonym: Nmul_A2256

Alternate gene names: 82703374

Gene position: 2566656-2565427 (Counterclockwise)

Preceding gene: 82703375

Following gene: 82703373

Centisome position: 80.6

GC content: 54.96

Gene sequence:

>1230_bases
TTGAACAGAAGTGCTCCCATTGCGGACCAGGATTTTGATAAGGAAATCGACCGGACCGGGACAGCCAGCCTGAAATACGA
TGGGCGCCAAAGCATGTTCGGCGCAGCGGGAGTGATTCCCCTATGGGTCGCGGATATGGATTTTGCCGCTCCAGTCGCGG
TCACCCAGGCGCTTTCCCGACGTGCCGCTCATCCGGTGTACGGGTACACTGTCTTTCCCGACAGTTTGTATGAGTCGCTG
ATGGATTGGCTGCGGCGCCGTCATGGCTGGGAGATCGAGCGGGACTGGATTATGATGTGTCCCGGCGTTGTTCCGTCGTT
GCATGCCGTCATCATGACCTTTGCCCCCCCCGGAGCATCGGTTATCGTACAGCCGCCGGTATATTTCCCCTTTTTTTCTG
CTGTCACCGCTACAGGCAGGCAACTCGTACAGAATCCCTTGCGGTTGCGGAATGGTCATTATGAGATCGATTACGATCAT
CTCGAGCAATGCGCGCAAGGCGCACGTCTTCTGCTTCTATGCTCGCCGCATAATCCCGTCGGCAGGGTGTGGAGCAGGGG
AGAGCTCGAGCGCATCCTGCGGATAGCGGATAAACACGATCTCGTGGTATTTTCCGACGAAATCCACGCTGATCTGGTTT
ATTCCGAAGCCAGGCATCATATACTCTCCCGGCTGGCGAAAACATGGGCTGGAAGCAAGGCGAATGTCATAACAGCTGTC
GCTCCCAGCAAGACATTCAATATTCCCGGATTGAATCTTTCCGCACTTGTCGTGCCGGATTCCAGGCATCGGGAGGAGCT
TGCGCGGACGTTCGATATCCTGCATGTCAGCGCATCCAATCCTTTCAGCATTGCTGCTTTCGAGGCAGCCTATCGGGAAG
GGGAGGTCTGGCTGGATGAATTGCTGGTTTATCTACAGGAAACCCGTGATTTTGTCTCAGAATATCTGGCGACTCGCCTT
CCGGAAATCCACCTCATCGAGCCCGAAGGCACGTATCTGCTCTGGTTTGATTGCCACGAATTGATGAACGCACTGGGAAT
GACGGATATCCAGCTCAGGCATTTTTTTGTGCACGAAGCGGGTATCGGCATGAGTCCCGGCACTTTGTTTGGCGCAGAAG
GCAGCGGTTTCATGCGTATGAACATCGGTGCGCCCCGCAGCACCATCGAAGCAGCCCTTGAAAGCATCAGAAAAGCTGTG
CACAAAAAAGCAAAGCAGGGGAGCGCCTGA

Upstream 100 bases:

>100_bases
GGCTCATTCAAGGGCCTACGGAGGTTCCATTTGTCATTCGCGAAACACGCCGTAAATTCCAGCACACGCTCTCGGAAGTA
ACAATCTGGGAGAAAACTGC

Downstream 100 bases:

>100_bases
GCGTATGGAAGCTCCGGCAGGCCTGTTTTCCCGGAAAGGGAAGCTCTGCTCGTACCCATGAAACAGCTGCAACAAAGAAC
AACCAGACAATAAGCTGTTT

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MNRSAPIADQDFDKEIDRTGTASLKYDGRQSMFGAAGVIPLWVADMDFAAPVAVTQALSRRAAHPVYGYTVFPDSLYESL
MDWLRRRHGWEIERDWIMMCPGVVPSLHAVIMTFAPPGASVIVQPPVYFPFFSAVTATGRQLVQNPLRLRNGHYEIDYDH
LEQCAQGARLLLLCSPHNPVGRVWSRGELERILRIADKHDLVVFSDEIHADLVYSEARHHILSRLAKTWAGSKANVITAV
APSKTFNIPGLNLSALVVPDSRHREELARTFDILHVSASNPFSIAAFEAAYREGEVWLDELLVYLQETRDFVSEYLATRL
PEIHLIEPEGTYLLWFDCHELMNALGMTDIQLRHFFVHEAGIGMSPGTLFGAEGSGFMRMNIGAPRSTIEAALESIRKAV
HKKAKQGSA

Sequences:

>Translated_409_residues
MNRSAPIADQDFDKEIDRTGTASLKYDGRQSMFGAAGVIPLWVADMDFAAPVAVTQALSRRAAHPVYGYTVFPDSLYESL
MDWLRRRHGWEIERDWIMMCPGVVPSLHAVIMTFAPPGASVIVQPPVYFPFFSAVTATGRQLVQNPLRLRNGHYEIDYDH
LEQCAQGARLLLLCSPHNPVGRVWSRGELERILRIADKHDLVVFSDEIHADLVYSEARHHILSRLAKTWAGSKANVITAV
APSKTFNIPGLNLSALVVPDSRHREELARTFDILHVSASNPFSIAAFEAAYREGEVWLDELLVYLQETRDFVSEYLATRL
PEIHLIEPEGTYLLWFDCHELMNALGMTDIQLRHFFVHEAGIGMSPGTLFGAEGSGFMRMNIGAPRSTIEAALESIRKAV
HKKAKQGSA
>Mature_409_residues
MNRSAPIADQDFDKEIDRTGTASLKYDGRQSMFGAAGVIPLWVADMDFAAPVAVTQALSRRAAHPVYGYTVFPDSLYESL
MDWLRRRHGWEIERDWIMMCPGVVPSLHAVIMTFAPPGASVIVQPPVYFPFFSAVTATGRQLVQNPLRLRNGHYEIDYDH
LEQCAQGARLLLLCSPHNPVGRVWSRGELERILRIADKHDLVVFSDEIHADLVYSEARHHILSRLAKTWAGSKANVITAV
APSKTFNIPGLNLSALVVPDSRHREELARTFDILHVSASNPFSIAAFEAAYREGEVWLDELLVYLQETRDFVSEYLATRL
PEIHLIEPEGTYLLWFDCHELMNALGMTDIQLRHFFVHEAGIGMSPGTLFGAEGSGFMRMNIGAPRSTIEAALESIRKAV
HKKAKQGSA

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=391, Percent_Identity=23.0179028132992, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI56713254, Length=391, Percent_Identity=23.0179028132992, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787909, Length=395, Percent_Identity=29.873417721519, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786816, Length=358, Percent_Identity=23.1843575418994, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790797, Length=387, Percent_Identity=23.2558139534884, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=398, Percent_Identity=22.8643216080402, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=394, Percent_Identity=23.0964467005076, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=323, Percent_Identity=22.6006191950464, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=352, Percent_Identity=19.8863636363636, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573069, Length=334, Percent_Identity=24.251497005988, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646114, Length=334, Percent_Identity=24.251497005988, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573067, Length=334, Percent_Identity=24.251497005988, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573065, Length=334, Percent_Identity=24.251497005988, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45750; Mature: 45750

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSAPIADQDFDKEIDRTGTASLKYDGRQSMFGAAGVIPLWVADMDFAAPVAVTQALSR
CCCCCCCCCCCHHHHHCCCCCCEEEECCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHH
RAAHPVYGYTVFPDSLYESLMDWLRRRHGWEIERDWIMMCPGVVPSLHAVIMTFAPPGAS
HCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHEEEEECCCCCC
VIVQPPVYFPFFSAVTATGRQLVQNPLRLRNGHYEIDYDHLEQCAQGARLLLLCSPHNPV
EEEECCCCHHHHHHHHHHHHHHHHCHHHHCCCCEEECHHHHHHHHCCCEEEEEECCCCCH
GRVWSRGELERILRIADKHDLVVFSDEIHADLVYSEARHHILSRLAKTWAGSKANVITAV
HHHCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
APSKTFNIPGLNLSALVVPDSRHREELARTFDILHVSASNPFSIAAFEAAYREGEVWLDE
CCCCEECCCCCCEEEEECCCHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHHCCHHHHHH
LLVYLQETRDFVSEYLATRLPEIHLIEPEGTYLLWFDCHELMNALGMTDIQLRHFFVHEA
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEHHHHHHHHCCCHHHHHHEEEECC
GIGMSPGTLFGAEGSGFMRMNIGAPRSTIEAALESIRKAVHKKAKQGSA
CCCCCCCCEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNRSAPIADQDFDKEIDRTGTASLKYDGRQSMFGAAGVIPLWVADMDFAAPVAVTQALSR
CCCCCCCCCCCHHHHHCCCCCCEEEECCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHH
RAAHPVYGYTVFPDSLYESLMDWLRRRHGWEIERDWIMMCPGVVPSLHAVIMTFAPPGAS
HCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHEEEEECCCCCC
VIVQPPVYFPFFSAVTATGRQLVQNPLRLRNGHYEIDYDHLEQCAQGARLLLLCSPHNPV
EEEECCCCHHHHHHHHHHHHHHHHCHHHHCCCCEEECHHHHHHHHCCCEEEEEECCCCCH
GRVWSRGELERILRIADKHDLVVFSDEIHADLVYSEARHHILSRLAKTWAGSKANVITAV
HHHCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
APSKTFNIPGLNLSALVVPDSRHREELARTFDILHVSASNPFSIAAFEAAYREGEVWLDE
CCCCEECCCCCCEEEEECCCHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHHCCHHHHHH
LLVYLQETRDFVSEYLATRLPEIHLIEPEGTYLLWFDCHELMNALGMTDIQLRHFFVHEA
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEHHHHHHHHCCCHHHHHHEEEECC
GIGMSPGTLFGAEGSGFMRMNIGAPRSTIEAALESIRKAVHKKAKQGSA
CCCCCCCCEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]