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The map label for this gene is cysM [H]

Identifier: 82703339

GI number: 82703339

Start: 2521091

End: 2521978

Strand: Reverse

Name: cysM [H]

Synonym: Nmul_A2221

Alternate gene names: 82703339

Gene position: 2521978-2521091 (Counterclockwise)

Preceding gene: 82703340

Following gene: 82703338

Centisome position: 79.2

GC content: 57.09

Gene sequence:

>888_bases
ATGTTCAAAACCATAGAAGATTTTGTCGGCAATACGCCTCTGGTCAAGCTCAAACGCCTGCCAGGAAATACTACCAACAC
TGTCCTCCTGAAACTGGAAGGCAACAATCCGGCGGGTTCGGTAAAAGACCGTCCCGCTTTGTCGATGATTACGCGTGCGC
AGGAGCGCGGGGAAATCAAGCCAGGCGATACGTTGATAGAGGCCACCAGCGGCAACACCGGCATCGCGCTCGCCATGGCG
GCGGCAATCATGGGTTACCGCATGGTGCTGGTGATGCCCGAACATCTCAGCGTGGAGCGCCGGCAATCGATGAAGGCGTA
CGGAGCGGAAATCATACTGACTTCCAGAGAGGGCAGCATGGAAGAAGCGCGCGACGTGGCCGAGCGCATGCGCGACGAGG
GGCGGGGAATCATCCTCGACCAGTTTTCCAGTCCCGATAACCCACGCGCCCATTACGAAGGTACTGCTCCCGAAATCTGG
CGGGATACCGAAGGAAAAATTACTCATCTGGTGAGCAGCATGGGCACGACCGGAACGATCATGGGTTGCTCCCGCTACTT
CAAGGAGAAGAAACCCGAGGTCCGGATCATTGGTGTACAGCCGGAAGAAGGCGCCCAGATTCCCGGTATCCGCAAATGGC
CTGAAGCCTATTTGCCAAAAATCTATGACTCGAGCCGGGTAGACCGCATCATGCTGGTTTCCCAGAAGGAAGCCGAAGAA
ATGACGCGGCGACTTGCGTCCGAAGAGGGGATCTTTGCCGGAATTTCGTCGGGCGGCGCGCTCGCCGCGGCGCTCAAGGT
TTCTGCGGAAACAGAAAATGCAACGATCGTCTCGATCGTTTGCGACCGAGGGGATCGTTACCTTTCCACCGGTGTTTTCC
CTGCGTGA

Upstream 100 bases:

>100_bases
CTATCGCTAAGTTACGCTTTCATCTCATCTCCTACGATCACTACGCGCCACTCCGGCTACTGCGGGAATTCGTTGTGACG
TTTCACAAGTCGGACAGGTC

Downstream 100 bases:

>100_bases
TTACTGGTTTCAGGGGATAGACGGGTCGGAGACTATAGCAGGAGAGCAGCAATAGACTGGGGTTAGGCACGAATCCCAAC
ATGGCCAATGGCAGGGGGAC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MFKTIEDFVGNTPLVKLKRLPGNTTNTVLLKLEGNNPAGSVKDRPALSMITRAQERGEIKPGDTLIEATSGNTGIALAMA
AAIMGYRMVLVMPEHLSVERRQSMKAYGAEIILTSREGSMEEARDVAERMRDEGRGIILDQFSSPDNPRAHYEGTAPEIW
RDTEGKITHLVSSMGTTGTIMGCSRYFKEKKPEVRIIGVQPEEGAQIPGIRKWPEAYLPKIYDSSRVDRIMLVSQKEAEE
MTRRLASEEGIFAGISSGGALAAALKVSAETENATIVSIVCDRGDRYLSTGVFPA

Sequences:

>Translated_295_residues
MFKTIEDFVGNTPLVKLKRLPGNTTNTVLLKLEGNNPAGSVKDRPALSMITRAQERGEIKPGDTLIEATSGNTGIALAMA
AAIMGYRMVLVMPEHLSVERRQSMKAYGAEIILTSREGSMEEARDVAERMRDEGRGIILDQFSSPDNPRAHYEGTAPEIW
RDTEGKITHLVSSMGTTGTIMGCSRYFKEKKPEVRIIGVQPEEGAQIPGIRKWPEAYLPKIYDSSRVDRIMLVSQKEAEE
MTRRLASEEGIFAGISSGGALAAALKVSAETENATIVSIVCDRGDRYLSTGVFPA
>Mature_295_residues
MFKTIEDFVGNTPLVKLKRLPGNTTNTVLLKLEGNNPAGSVKDRPALSMITRAQERGEIKPGDTLIEATSGNTGIALAMA
AAIMGYRMVLVMPEHLSVERRQSMKAYGAEIILTSREGSMEEARDVAERMRDEGRGIILDQFSSPDNPRAHYEGTAPEIW
RDTEGKITHLVSSMGTTGTIMGCSRYFKEKKPEVRIIGVQPEEGAQIPGIRKWPEAYLPKIYDSSRVDRIMLVSQKEAEE
MTRRLASEEGIFAGISSGGALAAALKVSAETENATIVSIVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=300, Percent_Identity=40.3333333333333, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295821200, Length=300, Percent_Identity=40.3333333333333, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4557415, Length=300, Percent_Identity=40.3333333333333, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=61.6438356164384, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=42.5396825396825, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=41.7763157894737, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=42.4242424242424, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=40.4605263157895, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=40.0662251655629, Blast_Score=213, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=38.5382059800665, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147552, Length=287, Percent_Identity=37.9790940766551, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=36.5079365079365, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.7358490566038, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=37.8548895899054, Blast_Score=175, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=29.9382716049383, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=37.0491803278689, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=37.0491803278689, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32250; Mature: 32250

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTIEDFVGNTPLVKLKRLPGNTTNTVLLKLEGNNPAGSVKDRPALSMITRAQERGEIK
CCCCHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCC
PGDTLIEATSGNTGIALAMAAAIMGYRMVLVMPEHLSVERRQSMKAYGAEIILTSREGSM
CCCEEEEECCCCCCHHHHHHHHHHHCEEEEEECCHHCHHHHHHHHHCCCEEEEECCCCCH
EEARDVAERMRDEGRGIILDQFSSPDNPRAHYEGTAPEIWRDTEGKITHLVSSMGTTGTI
HHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCH
MGCSRYFKEKKPEVRIIGVQPEEGAQIPGIRKWPEAYLPKIYDSSRVDRIMLVSQKEAEE
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCHHCCCCCCCEEEEECCHHHHH
MTRRLASEEGIFAGISSGGALAAALKVSAETENATIVSIVCDRGDRYLSTGVFPA
HHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MFKTIEDFVGNTPLVKLKRLPGNTTNTVLLKLEGNNPAGSVKDRPALSMITRAQERGEIK
CCCCHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCC
PGDTLIEATSGNTGIALAMAAAIMGYRMVLVMPEHLSVERRQSMKAYGAEIILTSREGSM
CCCEEEEECCCCCCHHHHHHHHHHHCEEEEEECCHHCHHHHHHHHHCCCEEEEECCCCCH
EEARDVAERMRDEGRGIILDQFSSPDNPRAHYEGTAPEIWRDTEGKITHLVSSMGTTGTI
HHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCH
MGCSRYFKEKKPEVRIIGVQPEEGAQIPGIRKWPEAYLPKIYDSSRVDRIMLVSQKEAEE
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCHHCCCCCCCEEEEECCHHHHH
MTRRLASEEGIFAGISSGGALAAALKVSAETENATIVSIVCDRGDRYLSTGVFPA
HHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]