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The map label for this gene is lpxA [H]

Identifier: 82703317

GI number: 82703317

Start: 2497349

End: 2498131

Strand: Reverse

Name: lpxA [H]

Synonym: Nmul_A2199

Alternate gene names: 82703317

Gene position: 2498131-2497349 (Counterclockwise)

Preceding gene: 82703324

Following gene: 82703316

Centisome position: 78.45

GC content: 55.56

Gene sequence:

>783_bases
ATGAAGGAAGCCAGTATCCATCCGACAGCCGTTGTTCATCCCGGTGCACAGCTTGGCTCGGGTGTCACCATCGGGGCTTA
TTCCATTGTGGAAGAACATGTCGCGGTTGGCGACGATACCTGGATCGGGCCGCACGTTGTCATTAAGGGGCATACGCGCG
TCGGGGACAATAACCGGATTTTCCAGTTCTGCTCGCTAGGGGATGAGCCCCAGGACAAGAAATACAAGGGTGAACCTACC
CGATTGGAAATAGGCGATCGAAACACGATTCGGGAGTTTTGTACTTTCAATCGGGGTACCGCCCAAGGGGCGGGTGTTAC
TCGCCTCGGAAATGACAATTTCGTGATGGCTTACGTCCATCTGGCGCATGATTGCCAGGTGGGTAACTTCACGACCTTTA
CCAATAACGCTTCCCTGGCCGGCCATGTCCAGGTGGGTGATTACGCGGGACTCGGGGGATTCACCTCCGTTCATCAGTTC
GTTCGCGTGGGCGCCTACAGCTTTACCGGTTTAGGCACCGTGCTGACTCAGGACCTGCCACCTTATCTCCTGGCGGCGGG
AAATCCCGCCATGCCTTACGGTCTCAACTGGAGAGAGCTCAAGCGCCGCGGGTTTTCCGAATCCACCCTTCGCGCACTGA
AAAGTGCTTACAAGCTGGTATACCGGTCCGGCCTTGCATTGAAAGAAGCGGAAGCGCAGCTCATGCAGCTTGCTGGCGAT
ACACCGTCTGTCCAACGCTTTCTTGATTTTATTTCCGTGCGAGGACGTGGAATTATCCGGTGA

Upstream 100 bases:

>100_bases
ATTATCTTAGTCGAGAACCGGGGTTCCTGCTACTGGTGCTTGAAGTACCCGGAGTATCAGGGATTACGCAGGCTCAAGTT
TGTCAGTGCAGGACAGACTC

Downstream 100 bases:

>100_bases
TTGGTTAGCAGGACTGATCTTTTCGGGGCGGCAAGCATGTGGAAAGTTGCAATCAAGACTTCACTTGGTAAAATAAGCCT
TCAGTGCTCAGCGGAAAGGA

Product: acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKEASIHPTAVVHPGAQLGSGVTIGAYSIVEEHVAVGDDTWIGPHVVIKGHTRVGDNNRIFQFCSLGDEPQDKKYKGEPT
RLEIGDRNTIREFCTFNRGTAQGAGVTRLGNDNFVMAYVHLAHDCQVGNFTTFTNNASLAGHVQVGDYAGLGGFTSVHQF
VRVGAYSFTGLGTVLTQDLPPYLLAAGNPAMPYGLNWRELKRRGFSESTLRALKSAYKLVYRSGLALKEAEAQLMQLAGD
TPSVQRFLDFISVRGRGIIR

Sequences:

>Translated_260_residues
MKEASIHPTAVVHPGAQLGSGVTIGAYSIVEEHVAVGDDTWIGPHVVIKGHTRVGDNNRIFQFCSLGDEPQDKKYKGEPT
RLEIGDRNTIREFCTFNRGTAQGAGVTRLGNDNFVMAYVHLAHDCQVGNFTTFTNNASLAGHVQVGDYAGLGGFTSVHQF
VRVGAYSFTGLGTVLTQDLPPYLLAAGNPAMPYGLNWRELKRRGFSESTLRALKSAYKLVYRSGLALKEAEAQLMQLAGD
TPSVQRFLDFISVRGRGIIR
>Mature_260_residues
MKEASIHPTAVVHPGAQLGSGVTIGAYSIVEEHVAVGDDTWIGPHVVIKGHTRVGDNNRIFQFCSLGDEPQDKKYKGEPT
RLEIGDRNTIREFCTFNRGTAQGAGVTRLGNDNFVMAYVHLAHDCQVGNFTTFTNNASLAGHVQVGDYAGLGGFTSVHQF
VRVGAYSFTGLGTVLTQDLPPYLLAAGNPAMPYGLNWRELKRRGFSESTLRALKSAYKLVYRSGLALKEAEAQLMQLAGD
TPSVQRFLDFISVRGRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=259, Percent_Identity=50.5791505791506, Blast_Score=281, Evalue=3e-77,
Organism=Escherichia coli, GI1786376, Length=203, Percent_Identity=26.1083743842365, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28286; Mature: 28286

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEASIHPTAVVHPGAQLGSGVTIGAYSIVEEHVAVGDDTWIGPHVVIKGHTRVGDNNRI
CCCCCCCCEEEECCCHHHCCCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCE
FQFCSLGDEPQDKKYKGEPTRLEIGDRNTIREFCTFNRGTAQGAGVTRLGNDNFVMAYVH
EEEECCCCCCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEE
LAHDCQVGNFTTFTNNASLAGHVQVGDYAGLGGFTSVHQFVRVGAYSFTGLGTVLTQDLP
EHHCCCCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHCCCC
PYLLAAGNPAMPYGLNWRELKRRGFSESTLRALKSAYKLVYRSGLALKEAEAQLMQLAGD
CEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TPSVQRFLDFISVRGRGIIR
CHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKEASIHPTAVVHPGAQLGSGVTIGAYSIVEEHVAVGDDTWIGPHVVIKGHTRVGDNNRI
CCCCCCCCEEEECCCHHHCCCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCE
FQFCSLGDEPQDKKYKGEPTRLEIGDRNTIREFCTFNRGTAQGAGVTRLGNDNFVMAYVH
EEEECCCCCCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEE
LAHDCQVGNFTTFTNNASLAGHVQVGDYAGLGGFTSVHQFVRVGAYSFTGLGTVLTQDLP
EHHCCCCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHCCCC
PYLLAAGNPAMPYGLNWRELKRRGFSESTLRALKSAYKLVYRSGLALKEAEAQLMQLAGD
CEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
TPSVQRFLDFISVRGRGIIR
CHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA